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Epidemiological, Clinical and Paraclinical Profile of Osteoarthritis of the Lower Limbs in Obese Patients at the Cocody University Teaching Hospital

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第2期14卷 69-76页

作者： Nzima Brice Kollo Aboubakar Bamba¹ Aboubacar Sidiki Condé Nzima Hilary Ngon Kanbaye Medom Ada Nina Kpami Yaya Coulibaly Kan Joseph Enoch Koffi Ehaulier Soh Christian louis Kouakou Mohamed Diomandé¹ Edmond Eti Rheumatology Department Cocody University Hospital Abidjan C&#244te d&#8217Ivoire Internal Medicine Department Yaounde University Hospital Yaounde Cameroon Rheumatology Department Bouake University Hospital Bouake C&#244te d&#8217Ivoire

Objective: To describe the epidemiological, clinical and paraclinical characteristics of osteoarthritis of the lower limbs in obese patients at the Cocody University Teaching Hospital. Methodology: This was an analytical cross-sectional study carried out in the rheumatology department of the Cocody UTH in Abidjan (Ivory Coast) from March 1 to April 30 2023. Patients who came for rheumatology consultation presenting with mechanical arthralgia of the lower limbs, who were obese, had radiographic images were included. All patients without radiographic images were excluded. Obesity was defined as a body mass index (BMI) greater than or equal to 30 kg/m. The Chi2 test was used to compare proportions and determine the existence of associations between osteoarthristis and obesity, obesity severity and radiographic stage of osteoarthritis as well as the functional impact. A p-value below a predefined threshold (p = 0,05) indicates a significant relationship between the variables. Result: Out of 185 patients received for osteoarthritis of the lower limbs during the study period, 136 were obese (74%). There were 115 women (84.6%) with an average age of 56.03 with a standard deviation of 12.72 years (extremes: 22 and 84 years). The main socio-professional category was the informal sector (30%). The majority of patients had a low socio-economic level (80.2%) and lived in urban areas (92.6%). The most common past medical history was hypertension (33.08%) followed by peptic ulcer disease (16.91%). Patients had a body mass index class 1 (81.6%), class 2 (15.40%) and class 3 (2.90%). The average duration of symptom progression until diagnosis was 11 months. Genu varum was the main static disorder (56.10%) and the knee joint was the dominant topography (90.4%) with a bilateral localization (80%). The average Lequesne index was greater than 8 (59.5%). The Kellgren and Lawrence radiographic stages were stage 1 (9.20%), stage 2 (46.90%), stage 3 (29.20%) and stage 4 (6.90%).

关键词： Osteoarthritis Lower Limbs Obesity Abidjan

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Fhe significance of testosterone for fair participation ol he female sex in competitive sports

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Asian Journal of Andrology 2011年第5期13卷 653-654页

作者： louis Gooren VU Un versity Medical Center Amsterdam 1081HV TheNetherlands

Sex segregation in competitive sports is regarded as fair. Before puberty, boys and girls hardly differ in height, muscle and bone mass. Pubertal testosterone exposure leads to an ultimate average greater height in men of 12-15 centimeters, larger bones, greater musde mass, increased strength and higher hemoglobin levels. Post-pubertal androgen ablation reverses, at least in part, previous anabolic effects of testosterone on musde,1 bone mineral density and hemoglobin, but the bones remain longer and have a wider diameter. As testosterone administra- tion produces a dose-dependent increase in muscle mass and maximal voluntary strength,2＇3 exogenous androgens are banned as performance-enhancing drugs.4 Men with testosterone deficiency are allowed to receive testosterone replacements which do not raise blood testosterone levels above the normal male range,5＇6

关键词： significance testosterone levels

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Joint Management of Shared Resources, Issues and Conflicts of the Nso and Oku Tribes in the Ngongbaa Montane Forest Area, NWR of Cameroon

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Natural Resources（自然资源） 2024年第6期 149页

作者： Jean-louis Tatah Elvis Kah

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Textures and melt-crystal-gas interactions in granites

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Geoscience Frontiers 2015年第5期6卷 635-663页

作者： Jean-louis Vigneresse GeoRessources UMR 7339Universite de Lorraine

Felsic intrusions present ubiquitous *** result from the differential interactions between the magma components(crystal,melt,gas phase) while it flows or when the flow is perturbed by a new magma *** most obvious structure consists in fabrics caused by the interactions of rotating grains in a flowing viscous *** magma inputs through dikes affect the buk massif flow,considered as global within each mineral facies.A review of the deformation and flow types developing in a magma chamber identifis the patterns that could be *** determines their controlling parameters and summarizes the tools for their ***,a brief review of the theology of a complex multiphase magma identifies and suggests interactions between the different *** specific responses each component presents lead to instability *** particular,the change in vorticity orientation,associated with the switch between monoclinic to triclinic flow is a cause of many *** are preferentially *** include fabric development,shear zones and flow *** depend of the underlying rheology of interacting ***,enclaves,schlieren and ladder dikes result from the interactions between the magma components and changing boundary ***,pegmatites,unidirectional solidification textures and miarolitic cavities result from the interaction of the melt with a gaseous *** illustrations examine what is relevant to the bulk flow,local structures or boundary *** each case a field observation illustrates the *** discussion reformulates instability observations,suggesting new trails for ther description and interpretation in terms of local departure to a bulk flow.A brief look at larger structures and at their evolution tries to relate these instabilities on a broader *** helical structures of the Ricany pluton,Czech Republic and by the multiple granitic intrusions of Dolbe

关键词： Granitic magma Instabilities Triclinic flow struct

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Addressing ore formation and exploration

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Geoscience Frontiers 2019年第4期10卷 1613-1622页

作者： Jean-louis Vigneresse GéoRessources UMR 7339Université de Lorraine

Common base and noble metals represent an important economic factor in the actual industrial *** instance the world resources for copper are actually estimated for about the next 30 years *** situation requires rethinking the way major ore deposits form,leading to new guides for *** present paper briefly examines the processes leading to ore formation,in relation with granitic or granodioritic *** identifies the importance of metal enrichment during the magmatic *** the magma chamber that forms porphyry intrusions,metals may incorporate to first formed crystals,becoming inert;concentrate into the residual melt of a mush;or segregate by diffusion into the exsolved magmatic volatile phase(MVP)into which they are transported and precipitated.A competition results between elements partitioning and ***,a specific Peclet number for each metal(Cu,Au,Ag,Mo,W,Sn,and REE)controls the ratio between the diffusive and the advective *** diffusivity in the melt shows differential behavior relative to a threshold of about10 13 m2/*** with slower diffusivity values(***)will not ***,fast diffusive metals(Au,Ag,Cu)may rapidly incorporate the MVP,provided an adequate component(halogens or S)is attractive for *** chemistry of the MVP escaping the magma induces different alteration *** relative content in F,Cl or S,attested by the composition of biotites and apatites,links with the preferential content of metals in o re deposits,representing a valuable tool for *** the model is replaced in a set of coupled mechanical-chemical instabilities,within a three phase material.

关键词： Porphyry ore deposits Metals concentration processes Exploration Alteration pattern

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奥运选手借助科技手段迎战极端高温

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商业周刊（中文版） 2024年第12期 30-34页

作者： Ira Boudway Kendra Pierre-louis Hayley Warren Jin Wu 程玺(译) 孟洁冰(译) 不详

从穿戴式热传感器到充气式冰块池,奥运选手们各显神通,调整训练和比赛方式,以迎战极端高温对于代表美国队参加巴黎奥运会的精英山地自行车运动员克里斯托弗·布莱文斯(Christopher Blevins)来说,不适是比赛的常态。“当你在一个半小时... 详细信息

从穿戴式热传感器到充气式冰块池,奥运选手们各显神通,调整训练和比赛方式,以迎战极端高温对于代表美国队参加巴黎奥运会的精英山地自行车运动员克里斯托弗·布莱文斯(Christopher Blevins)来说,不适是比赛的常态。“当你在一个半小时内拼尽了全力,感觉良好是不可能的,”布莱文斯说,他也参加了上届东京夏季奥运会。

关键词：奥运选手夏季奥运会美国队极端高温克里斯托弗充气式训练和比赛山地自行车运动

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Machine learning for enumeration of cell colony forming units

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 315-322页

作者： louis Zhang Department of Molecular Biosciences College of Natural SciencesUniversity of Texas at AustinAustin TX 78713-8058USA

As one of the most widely used assays in biological research,an enumeration of the bacterial cell colonies is an important but time-consuming and labor-intensive *** speed up the colony counting,a machine learning method is presented for counting the colony forming units(CFUs),which is referred to as *** cellcounting program processes digital images and segments bacterial *** algorithm combines unsupervised machine learning,iterative adaptive thresholding,and local-minima-based watershed segmentation to enable an accurate and robust cell *** to a manual counting method,CFUCounter supports color-based CFU classification,allows plates containing heterologous colonies to be counted individually,and demonstrates overall performance(slope 0.996,SD 0.013,95%CI:0.97–1.02,p valuestinguishable from the gold standard of point-and-click *** CFUCounter application is open-source and easy to use as a unique addition to the arsenal of colony-counting tools.

关键词： Colony forming unit Enumeration Image analysis Blue/white screen Colony count

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Should cross-sex hormone treatment of transsexual subjects vary with ethnic group？

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Asian Journal of Andrology 2014年第6期16卷 809-810页

作者： louis J Gooren Department of Endocrinology VU University MedicalCenter Amsterdam the Netherlands Androconsult ChiangMai Thailand

Guidelines for cross-sex hormone treatment of transsexual people have been developed, but no attention has been paid to the specifics of ethnic groups. South East （SE） Asian male-to-female （MtoF） transsexual people may be able to transition to the female sex with lower doses of estrogens/progestins than Caucasians thus reducing health risks. Female-to-male （FtoM） may virilize less profoundly with standard doses of androgens, but this is probably sufficient to pass acceptably as men in view of the less pronounced sex differences in physique in Asians compared with Caucasians. It is timely that studies in Asians are conducted to get a better insight into their specific needs and risks of cross-sex hormone treatment.

关键词： FAT

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Evaluation of the Care of Children Aged 0 to 10 Years Hospitalized for Severe Malaria at the Tambacounda Health Center, Senegal

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Advances in Infectious Diseases 2024年第3期14卷 581-594页

作者： Tidiane Gadiaga Aminata Fall Alioune Badara Gueye Siré Sagna Bayal Cissé Mouhamadou Faly Ba Médoune Ndiop Babacar Gueye Samba Cor Sarr Sylla Thiam Elhadji Ba Konko Ciré Jean louis Abdou Ndiaye Issa Wone Directorate of Research Planning and statistics Ministry of Health and Social Action Dakar Senegal Faculty of Medicine Assane Seck University of Ziguinchor Ziguinchor Senegal Presidents Malaria Initiative USAID Dakar Senegal Tambacounda Health District Ministry of Health and Social Action Tambacounda Senegal Institute of Health and Development Faculty of Medicine Cheikh Anta Diop University Dakar Senegal National Malaria Control Program (NMCP) Dakar Senegal UFR Sant Faculty of Medicine Iba Der Thiam University of This This Senegal

Introduction: Malaria remains a public health priority in Senegal, particularly in Tambacounda, where it is one of the main causes of child mortality. The objective of this work was to evaluate the care of children under 10 years of age hospitalized at the Tambacounda Health Center and the factors associated with recovery. Methods: An analytical, retrospective, and descriptive cross-sectional study with exhaustive recruitment of children 0 to 120 months hospitalized at the Tambacounda reference health center for severe malaria (according to WHO criteria) between 1 January 2018 and 31 December 2021 was performed. Data collection was done through a questionnaire. Records, hospitalization records, and treatment records were the sources of collection. Data entry and analysis were performed on Epi Info 7.2 and R. Results: A total of 481 children hospitalized with severe malaria were recruited. The highest number of cases was recorded in 2018 (33.05%). In the four years of the study, peaks were always observed between October and November and the highest peak in November 2020 with 95 cases. The mean age was 65.64 months with a standard deviation of 29.28 months and a predominance of male (53.43%). The majority of people were admitted from the outpatient clinic (57.79%) and the rest (42.21%) on the recommendation of a peripheral health post. All hospitalized patients had a positive RDT and/or a positive thick drop. However, the sharp decline at admission or during hospitalization was positive in 93.80% of patients in our series, negative in 5.20% and not achieved in 1.00%. Seizures and severe anemia topped the list of signs of severity with 45.94% and 8.11%, respectively. In terms of evolution, for all hospitalized patients, there were 81.29% recovery, 10.19% referral to the Tambacounda regional hospital center for hospitalization, 4.99% death, 0.83% discharge and 2.70% unknown evolution. There was a statistically significant association between recovery without referral f

关键词： Severe Malaria Children Tambacounda Senegal

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Hepatic progenitor cells in human liver tumor development

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World Journal of Gastroenterology 2006年第39期12卷 6261-6265页

作者： louis Libbrecht Liver Research Unit of the Laboratory of Morphology and Molecular Pathology University of Leuven Leuven Belgium

In recent years, the results of several studies suggest that human liver tumors can be derived from hepatic progenitor cells rather than from mature cell types. The available data indeed strongly suggest that most combined hepatocellular-cholangiocarcinomas arise from hepatic progenitor cells that retained their potential to differentiate into the hepatocytic and biliary lineages. Hepatic progenitor cells could also be the basis for some hepatocellular carcinomas and hepatocellular adenomas, although it is very difficult to determine the origin of an individual hepatocellular carcinoma. There is currently not enough data to make statements regarding a hepatic progenitor cell origin of cholangiocarcinoma. The presence of hepatic progenitor cell markers and the presence and extent of the cholangiocellular component are factors that are related to the prognosis of hepatocellular carcinomas and combined hepatocellular- cholangiocarcinomas, respectively.

关键词： Hepatic progenitor cell Hepatocellular carcinoma Liver tumor

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