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Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β

Cellular & Molecular Immunology 2023年第1期20卷 8-10页

作者： Camille Chauvin sruthi vijaya retnakumar Jagadeesh Bayry Institut National de la Santéet de la Recherche Médicale Centre de Recherche des CordeliersSorbonne UniversitéUniversitéde Paris75006ParisFrance Department of Biological Sciences&Engineering Indian Institute of Technology PalakkadPalakkad678623India

Interleukin(IL)-33 is a nuclear cytokine in the IL-1 family that is constitutively expressed in the epithelial cells of environmentally exposed tissues(skin,gastrointestinal tract and lungs)and endothelial ***-33 is involved in type 2 innate immunity via the activation of eosinophils,basophils,mast cells,group 2 innate lymphoid cells and macrophages through its receptor ST2(also called IL1RL1)[1].Due to the absence of a secretory signal sequence,IL-33 was thought to be passively released during cell necrosis,physical stress or tissue damage and was accordingly considered an alarmin[2].

关键词： immunity Interleukin damage

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A Deep Transfer Learning Approach for Addressing Yaw Pose Variation to Improve Face Recognition Performance

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Intelligent Automation & Soft Computing 2024年第4期39卷 745-764页

作者： M.Jayasree K.A.Sunitha A.Brindha Punna Rajasekhar G.Aravamuthan G.Joselin retnakumar Department of Electronics and Instrumentation Engineering College of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathurChennaiTamil Nadu603203India Department of Electronics and Communication Engineering SRM UniversityAmaravatiMangalagiriAndhra Pradesh522502India Security Electronics and Cyber Technology Bhabha Atomic Research CentreAnushakti NagarMumbaiMaharashtra400085India

Identifying faces in non-frontal poses presents a significant challenge for face recognition(FR)*** this study,we delved into the impact of yaw pose variations on these systems and devised a robust method for detecting faces across a wide range of angles from 0°to±90°.We initially selected the most suitable feature vector size by integrating the Dlib,FaceNet(Inception-v2),and“Support Vector Machines(SVM)”+“K-nearest neighbors(KNN)”*** train and evaluate this feature vector,we used two datasets:the“Labeled Faces in the Wild(LFW)”benchmark data and the“Robust Shape-Based FR System(RSBFRS)”real-time data,which contained face images with varying yaw *** selecting the best feature vector,we developed a real-time FR system to handle yaw *** proposed FaceNet architecture achieved recognition accuracies of 99.7%and 99.8%for the LFW and RSBFRS datasets,respectively,with 128 feature vector dimensions and minimum Euclidean distance thresholds of 0.06 and *** FaceNet+SVM and FaceNet+KNN classifiers achieved classification accuracies of 99.26%and 99.44%,*** 128-dimensional embedding vector showed the highest recognition rate among all *** results demonstrate the effectiveness of our proposed approach in enhancing FR accuracy,particularly in real-world scenarios with varying yaw poses.

关键词： Face recognition pose variations transfer learning method yaw poses FaceNet Inception-v2

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Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19

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World Journal of Virology 2021年第2期10卷 34-52页

作者： Asimina Dominari Donald Hathaway III Abdulhusein Kapasi Trissa Paul Sarabjot Singh Makkar ValeriaCastaneda Sirisha Gara Bishnu Mohan Singh Kuchalambal Agadi Maliha Butt Varadha retnakumar Spandana Chittajallu Rahima Taugir Muhammad Khawar Sana Manish KC Sarah Razzack Niala Moallem Alina Alvarez Michael Talalaev Division of Research and Academic Affairs Larkin Health SystemSouth MiamiFL 33143United States

N-acetylcysteine(NAC)is an abundantly available antioxidant with a wide range of antidotal properties currently best studied for its use in treating acetaminophen *** has a robustly established safety profile with easily tolerated side effects and presents the Food and Drug Administration's approval for use in treating acetaminophen overdose *** has been proven efficacious in offlabel uses,such as in respiratory diseases,heart disease,cancer,human immunodeficiency virus infection,and seasonal *** trials have recently shown that NAC's capacity to replenish glutathione stores may significantly improve coronavirus disease 2019(COVID-19)outcomes,especially in high risk ***,individuals with glucose 6-phosphate dehydrogenase deficiency have been shown to experience even greater *** same study has concluded that NAC's ability to mitigate the impact of the cytokine storm and prevent elevation of liver enzymes,C-reactive protein,and ferritin is associated with higher success rates weaning from the ventilator and return to normal function in COVID-19 *** the background knowledge of biochemistry,current uses of NAC in clinical practice,and newly acquired evidence on its potential efficacy against COVID-19,it is worthwhile to investigate further whether this agent can be used as a treatment or adjuvant for COVID-19.

关键词： N-acetylcysteine Antioxidant COVID-19 SARS-CoV-2 Treatment

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