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Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes

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Chinese Chemical Letters 2015年第6期26卷 721-726页

作者： Sreekanth Thota srujana Vallala Rajeshwar Yerra Eliezer J.Barreiro National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN) Center for Technological Development in Health (CDTS)Fundao Oswaldo CruzMinistério da SadeAv.Brasil 4036Prédio da Expanso8° AndarSala 814Manguinhos21040-361 Rio de JaneiroRJBrazil Programa de Desenvolvimento de Frmacos Instituto de Ciências BiomédicasUniversidade Federal do Rio de Janeiro S.R. College of Pharmacy Department of Pharmaceutical Chemistry & Toxicology

Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium（ll） arene compounds bearing thiosemicarba- zone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium（ll） arene compounds has been evaluated in several cell lines （Molt 4/C8, LI 210, CEM, HL60 and BEL7402）. Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range.

关键词： Cytotoxic Ligand Ruthenium compounds Structure activity relationships

Comment on“Surgical management of fungal endophthalmitis resulting from fungal keratitis”

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1479-1480页

作者： Dubbaka srujana Reena Singh Koushik Tripathy Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences(AIIMS)New Delhi 110029India

Dear Editor,We read with interest the article by Gao et al on fungal endophthalmitis associated with fungal keratitis in 27 eyes of 27 patients. They have reported[1] that multiple surgeries including penetrating keratoplasty （PKP）, pars plana vitrectomy （PPV）, intracameral or intravitreal antifungals, cataract extraction and evisceration resulted in a final visual acuity better than counting fingers in 55.6% eyes. Most common causative fungal pathogens in their study were Fusarium （44%）, Aspergillus （22%）, and Alternaria （7%）.

关键词： In Comment on

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Eye and Vision 2019年第1期6卷 322-330页

作者： Ke Cao srujana Sahebjada Andrea J.Richardson Paul N.Baird Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalMelbourneAustralia. Department of Surgery OphthalmologyThe University of Melbourne32 Gisborne StreetEast MelbourneVIC 3000Australia

Background:Keratoconus(KC)is a common corneal condition with an unknown gender *** numerous studies have investigated the genetic component of KC,no specific genes have yet been attributed to the *** recently reported posterior segment changes occurring in the eyes of KC ***,it is not clear whether these changes are part of KC pathogenesis or reflect changes in anatomical features of the eye manifested by changes at the *** retinal changes represent the main characteristics observed in agerelated macular degeneration(AMD)and that pleiotropy has been demonstrated between different eye diseases,we wished to assess if known AMD associated genes were also associated with ***:A total of 248 KC subjects and 366 non-KC(control)subjects were recruited from public and private clinics in Melbourne for this *** single nucleotide polymorphisms(SNPs)previously associated with AMD,including rs10490924(ARMS2/HTRA1),rs10737680(CFH),rs13278062(TNFRSF10A),rs1864163(CETP),rs2230199(C3),rs3130783(IER3/DDR1),rs334353(TGFBR1),rs3812111(COL10A1),rs429608(C2/CFB),rs4420638(APOE),rs4698775(CFI),rs5749482(TIMP3),rs6795735(ADAMTS9),rs8017304(RAD51B),rs8135665(SLC16A8),rs920915(LIPC),rs943080(VEGFA),rs9542236(B3GALTL)and rs13081855(COL8A1/FILIP1L),were genotyped in this *** regression was applied to evaluate the association between these SNPs and KC on both genders together,as well as each gender *** regression was also applied to assess the association between SNPs and corneal *** correction was applied to adjust for multiple ***:Genotyping data were available for 18 *** SNP,rs6795735(ADAMTS9)was significantly associated with KC(p=3.5×10−4)when both genders were assessed,whereas rs5749482(TIMP3)was only associated in males(p=7.7×10−4)following Bonferroni multiple ***,when the covariates of age and gender were included,the associations became non-sign

关键词： Keratoconus Gender Genetic Age-related macular degeneration

Assessment of single nucleotide polymorphisms associated with steroid-induced ocular hypertension

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1294-1305页

作者： Lakshmi Badrinarayanan srujana Chitipothu Sharada Ramasubramanyan Sarangapani Sripriya Pukhraj Rishi Ekta Rishi Ronnie George Baddireddi Subhadra Lakshmi Sailaja VElchuri Department of Nano-biotechnology KNBIRVO blockVision Research FoundationChennaiTamilNadu 600006India Department of Biotechnology Anna UniversityChennaiTamilNadu 600025India Central Research Instrumentation Facility KNBIRVO blockVision Research FoundationTamilNadu 600006India RS.Mehta Jain Department of Biochemistry and Cell BiologyKNBIRVO blockVision Research FoundationChennaiTamilNadu 600006India SNONGC Department of Genetics and Molecular Biology KNBIRVO blockVision Research FoundationChennaiTamilNadu 600006India Shri Bhagwan Mahavir Vitreo-Retinal Service Medical Research FoundationChennaiTamilNadu 600006India Smt.Jadhavbai Nathamal Singhree Glaucoma Service Medical Research FoundationChennaiTamilNadu 600006India

AIM:To access the association of forty-eight single nucleotide polymorphisms(SNPs)identified from Caucasian population with steroid-induced ocular hypertension(OHT)in India ***:Fifty-four triamcinolone-acetonide(TA)and for ty-seven dexamethasone(Dex)administered subjects were enrolled in the study after a written *** pressure(IOP)values were recorded for a period of 6-month post steroid injections and patients were grouped as steroid-responders(SR:IOP≥21 mm Hg)and non-responders(NR:IOP≤20 mm Hg).Genomic DNA was isolated from peripheral venous ***-eight SNPs identified in TA treated Caucasian patients by genome wide association study(GWAS)were genotyped using iPLEXTM MassA RRAY among TA as well as Dex administered Indian *** data of 48 general subjects from a previous study were considered as reference controls for statistical *** frequencies were calculated and P-value,Chi-square and odds ratio at 95%confidenceinterval of group A(steroid treated vs controls),group B(SR vs NR),group C(phenotype correlation:influence of time,severity and gender on IOP rise),were calculated.P30 mm Hg)and immediate(<1 wk)among TA-SR patients while it was noticed to be mild(<30 mm Hg)and between 1-2 mo among Dex-SR *** regression for risk factor correlation with OHT remained non-significant,hence these factors were not considered as confounding parameters for further ***133,rs34016742,rs274554,rs10936746,rs274547,rs804854,rs7751500,rs359498,and rs7547448 SNPs significantly varied even after Bonferroni corrections(P<0.0025;group A).rs1879370(TA)and rs6559662(Dex)were significantly(P<0.05)associated with OHT(group B).rs133(severe IOP rise),rs11047639 and rs1879370(male gender),and rs11171569(immediate IOP rise)significantly(P<0.05)infl

关键词： triamcinolone-acetonide dexamethasone ocular hypertension single nucleotide polymorphisms diabetes neurodegeneration myopia

Obstetrician injury whilst managing a shoulder dystocia: A case report

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Open Journal of Obstetrics and Gynecology 2012年第1期2卷 62-63页

作者： Sa’adatu Usman srujana Parupalli Amith Pinto Nicholas Neal Fidelma O’Mahony University Hospital of North Staffordshire Stoke-on-Trent England

Anecdotally, obstetricians have been known to sustain physical injuries whilst assisting deliveries but these are not always reported. This case describes how a mallet finger deformity was sustained by a consultant obstetrician whilst attempting to deliver a fetus with shoulder dystocia. Although this is a rare type of injury, it had significant impact on the consultant’s ability to provide clinical care for some time. Disruptions in service provision have direct financial consequences to the healthcare system. This case report highlights the importance of reporting these injuries at the workplace.

关键词： Shoulder Dystocia Mallet Finger Occupational Injuries