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Antimicrobial activities of the tissue extracts of Babylonia spirata Linnaeus,1758 (Mollusca:Gastropoda) from Thazhanguda,southeast coast of India

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Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 36-40页

作者： Periyasamy N srinivasan M Balakrishnan S Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai University

Objective:To investigate the antimicrobial activity of the tissue extracts of Babylonia spirata(***)against nine bacterial and three fungal ***:Crude extract of gastropod was tested for inhibition of bacterial and fungal *** assay was carried out by disc diffusion method and in vitro antifungal activity was determined against Czapex Dox *** antimicrobial activity was measured accordingly based on the inhibition zone around the disc impregnated with gastropod *** size of muscle protein was determined using sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE).And fourier transform infrared spectroscopy(FT1R)spectro photometry analysis was also ***:The maximum inhibition zone(12 mm)was observed against Pseudomonas aeruginosa in the crude ethanol extract of *** and the minimum inhibition zone(2 mm)was noticed against Staphylococcus aureus in the crude methanol extract of *** extract of *** showed the highest activity against Vibrio parahaemolyticus,Staphylococcus aureus and Candida ***,acetone,methanol,chloroform and water extracts showed antimicrobial activity against almost all the bacteria and *** with water extracts,ethanol and methanol extracts showed higher activity against all *** molecular weight of protein of the gastropod sample ranged from 2-110 kDa on *** analysis revealed the presence of bioactive compounds signals at different ***:The research shows that the great medicinal value of the gastropod muscle of *** may be due to high quality of antimicrobial compounds.

关键词： Gastropod Babylonia spirata Antimicrobial activity SDS-PAGE FTIR Antibacterial activity Antifungal activity Inhibition zone Muscle protein Bioactive compound

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Catalysis in biodiesel production-a review

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Clean Energy 2019年第1期3卷 2-23页

作者： Baskar Thangaraj Pravin Raj Solomon Bagavathi Muniyandi srinivasan Ranganathan Lin Lin School of Food and Biological Engineering Jiangsu UniversityZhenjiang-212013Jiangsu ProvinceP.R.China School of Chemical and Biotechnology SASTRA-Deemed UniversityThanjavur-613402Tamil NaduIndia Department of Materials Science School of ChemistryMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia Department of Physics Thiagarajar CollegeMadurai-625009Tamil NaduIndia

Catalysts play a significant role in transesterification of vegetable ***,chemical and biological catalysts are being investigated,and both have their inherent merits and *** large-scale applications,these catalysts are expected to be cost effective and environmentally *** the catalyst is homogeneous in its physical form it is more effective than is the heterogeneous catalyst,but its separation from the mixture is a major *** of the heterogeneous catalysts suffer leaching in harsh reaction *** late,nanocatalysts that demonstrate high efficiency are being *** are used in biological catalysts as solid carriers for lipase *** immobilized on magnetic nanoparticles has proved to be a versatile biocatalyst for biodiesel *** article reviews the role of various catalytic systems commonly used in the transesterification reaction of oils in biodiesel generation.

关键词： transesterification chemical catalysts biological catalysts biodiesel renewable energy

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Inpatient use of racemic epinephrine for children admitted with croup

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World Journal of Pediatrics 2019年第6期15卷 586-594页

作者： Elaine Chiang Omar Afandi Sang Hoon Lee srinivasan Suresh Raymond DPitetti Sriram Ramgopal Division of Pediatric Emergency Medicine Department of PediatricsUniversity of Pittsburgh School of MedicinePittsburghPAUSA Department of Pediatrics University of Pittsburgh School of MedicinePittsburghPAUSA Department of Pediatrics University of CincinnatiCollege of MedicineCincinnatiOHUSA Division of Emergency Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOHUSA Division of Health Informatics Department of PediatricsUniversity of Pittsburgh School of MedicineChildren's Hospital of PittsburghPittsburghPAUSA UPMC Children's Hospital of Pittsburgh PittsburghPAUSA

Background Pediatric patients with croup are frequently admitted if they require two doses of racemic epinephrine(RE)in the emergency department(ED).We aimed to identify factors associated with the need for additional therapy(>2 RE doses)among pediatric patients with *** We performed a single-center retrospective study of consecutive patients admitted from the ED with a diagnosis of croup between January 1,2011 and December 31,*** outcome was need for>2 doses of *** out-comes included time to third RE and 72-hour return *** performed logistic regression to identify factors associated with use of>2 RE doses during hospitalization,and survival analysis to identify time to dosing of 3rd RE from 2nd *** Of 353 included admissions[250(70.8%)males,median age 1.48,interquartile range 0.97-2.51 years],106/353(30.0%)required>2 *** univariate logistic regression,only recent use of steroids within 1 day prior to presentation(4.18,1.48-11.83;P=0.007)was associated with need for>2 *** from third RE was 0.74(95%CI 0.69-0.78),which was similar to the survival at 12 hours(0.70,95%CI 0.65-0.75).Return visits occurred in 19(5.4%)patients,of whom 12/19(63.2%)were given *** Patients hospitalized for croup with recent use of steroids prior to ED presentation have a greater need for>2 RE during *** majority who require inpatient RE will do so within 8-12 *** data provide informa-tion for risk stratification and duration of monitoring for patients hospitalized with croup.

关键词： Laryngotracheobronchitis Racemic epinephrine Spasmodic croup Steroids Viral croup

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Genome-wide Expansion and Expression Divergence of the Basic Leucine Zipper Transcription Factors in Higher Plants with an Emphasis on Sorghum

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Journal of Integrative Plant Biology 2011年第3期53卷 212-231页

作者： Jizhou Wang Junxia Zhou Baolan Zhang Jeevanandam Vanitha srinivasan Ramachandran Shu-Ye Jiang Institute of Botany and Temasek Life Sciences Laboratory Joint Research & Development Laboratory Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Temasek Life Sciences Laboratory 1 Research Link the National University of Singapore Singapore 117604 Singapore

Plant bZIP transcription factors play crucial roles in multiple biological processes. However, little is known about the sorghum bZIP gene family although the sorghum genome has been completely sequenced. In this study, we have carried out a genome-wide identification and characterization of this gene family in sorghum. Our data show that the genome encodes at least 92 bZIP transcription factors. These bZIP genes have been expanded mainly by segmental duplication. Such an expansion mechanism has also been observed in rice, arabidopsis and many other plant organisms, suggesting a common expansion mode of this gene family in plants. Further investigation shows that most of the bZIP members have been present in the most recent common ancestor of sorghum and rice and the major expansion would occur before the sorghum-rice split era. Although these bZlP genes have been duplicated with a long history, they exhibited limited functional divergence as shown by nonsynonymous substitutions （Ka）lsynonymous substitutions （Ks） analyses. Their retention was mainly due to the high percentages of expression divergence. Our data also showed that this gene family might play a role in multiple developmental stages and tissues and might be regarded as important regulators of various abiotic stresses and sugar signaling.

关键词： Transcription factors Transcription Plants Planting Families Genes Sorghum Genomes Stress Data

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Pimavanserin for the treatment of psychosis in Alzheimer’s disease: A literature review

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World Journal of Psychiatry 2020年第7期10卷 162-174页

作者： Shilpa srinivasan Rajesh R Tampi Kripa Balaram Arushi Kapoor Department of Neuropsychiatry and Behavioral Science Palmetto Health USC Medical GroupUniversity of South Carolina School of MedicineColumbiaSC 29203United States Department of Psychiatry and Behavioral Sciences Cleveland Clinic Akron GeneralAkronOH 44307United States MD Department of PsychiatryMetroHealthClevelandOH 44109United States Penn Memory Center at the Penn Neuroscience Center Perelman Center for Advanced MedicinePhiladelphiaPA 19104United States

BACKGROUND Alzheimer’s disease(AD)is among the most prevalent forms of dementia in the world and neuropathological studies suggest similar high prevalence of mixed(AD+vascular)*** 25%-50%of individuals with AD develop psychosis sometime during their *** presence of psychosis in AD worsens *** there are no United States Food and Drug Administration(FDA)approved medications for the treatment of psychosis in ***,a novel atypical antipsychotic medication,was approved by the FDA for the treatment of hallucinations and delusions associated with Parkinson disease psychosis and is currently in clinical trials for the treatment of psychosis in *** To evaluate the existing literature regarding the use of pimavanserin for treating psychosis among individuals with *** A literature review of clinical studies of pimavanserin treatment for psychosis in individuals with AD was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis *** were identified by systematically searching PubMed,MEDLINE,EMBASE,Cochrane Central Register of Controlled Trials,Web of Science,and Scopus through October *** 5-point Jadad scoring system was used to assess the methodologic quality of the randomized placebo-controlled *** A total of 499 citations were retrieved and pooled in EndNote and de-duplicated to 258 *** set was uploaded to Covidence for *** separate screeners(srinivasan S and Tampi RR)evaluated the titles,abstracts,and full text of eligible *** the identified 258 abstracts,98 articles underwent full text review and 2 publications from 1 randomized controlled trial(RCT)were included in the final *** quality of evidence was assessed to be of good methodologic quality,scoring 4 out of 5 using the 5-point Jadad questionnaire with the Jadad Scoring *** systematic review found only one RCT that evaluated the use of pimavanser

关键词： Pimavanserin Alzheimer’s disease Psychosis Psychotic disorders Antipsychotic agents

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(Ni_(0.8)Zn_(0.2)Fe_2O_4)_(epoxy)-PZT双层膜中的磁电效应

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物理学报 2006年第5期55卷 2548-2552页

作者：张茹王淼张宁 srinivasan G 南京师范大学磁电子学实验室南京210097

讨论了Ni0·8Zn0·2Fe2O4(NZFO)与锆钛酸铅(PZT)的双层膜结构样品的磁电(ME)效应.NZFO粉料由溶胶-凝胶法制成,再经900℃热压,并高温烧结.在该双层膜中测量到了很强的磁电相互作用.发现横向的磁电效应比纵向效应大一个数量级,并且随NZFO... 详细信息

讨论了Ni0·8Zn0·2Fe2O4(NZFO)与锆钛酸铅(PZT)的双层膜结构样品的磁电(ME)效应.NZFO粉料由溶胶-凝胶法制成,再经900℃热压,并高温烧结.在该双层膜中测量到了很强的磁电相互作用.发现横向的磁电效应比纵向效应大一个数量级,并且随NZFO烧结温度的提高而增加.当烧结温度从950℃上升到1380℃时,横向ME电压系数(αE)的最大值变化范围为25·6mV Am-2≤αE≤199·6mV Am-2.理论分析显示NZFO-PZT双层膜样品中ME效应源于NZFO与PZT之间相对良好的磁电耦合.

关键词：镍铁氧体 PZT 热压法 ME效应

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基于博弈论的信息安全技术评价模型

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计算机学报 2009年第4期32卷 828-834页

作者：朱建明 srinivasan Raghunathan 中央财经大学信息学院北京100081 德克萨斯大学达拉斯分校管理学院美国德州75083

信息安全在企业信息系统建设中越来越重要,如何评价信息安全技术成为当前的一个研究课题.文中基于博弈论,对由防火墙、入侵检测系统和容忍入侵技术构成的三层安全体系结构进行了分析,提出了对信息安全技术进行评价的模型.在对入侵检测... 详细信息

信息安全在企业信息系统建设中越来越重要,如何评价信息安全技术成为当前的一个研究课题.文中基于博弈论,对由防火墙、入侵检测系统和容忍入侵技术构成的三层安全体系结构进行了分析,提出了对信息安全技术进行评价的模型.在对入侵检测系统分析评价的基础上,重点分析了防火墙、入侵检测与容忍入侵的相互影响和关系.研究表明,IDS的检测率、误报率与防火墙的性能有密切关系,系统安全配置直接影响信息安全机制的性能和成本效益,容忍入侵机制取决于入侵的损失评估、系统的成本和防火墙与IDS的性能.信息安全机制的优化配置对于信息安全的效果具有重要影响.

关键词：安全入侵检测评估博弈论

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Surgical portosystemic shunts to facilitate major intrabdominal surgery

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 488-490页

作者： Michail Pizanias Elissaios Kontis Evangelos Prassas Parthi srinivasan Andreas Prachalias Department of Liver Transplantation Hepatobiliary Pancreatic Surgery King’s Healthcare Partners King’s College Hospital NHS FT Institute of Liver Studies

The effective management of patients with chronic liver disease (CLD) and portal hypertension (PHT) has significantly prolonged their survival. Hence, there is an emerging number of patients who will require major ele... 详细信息

关键词： chronic liver disease(CLD) portal hypertension(PHT) patients

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Mineralogical and geochemical variation in hydrothermal sulfides from Vienna Woods field,Manus Basin,Papua New Guinea：constraints on their evolution

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Acta Oceanologica Sinica 2018年第4期37卷 22-33页

作者： RAY Durbar BANERJEE Ranadip MAZUMDER Aninda PAROPKARI Anil L. MUKHOPADHYAY Subir BALAKRISHNAN srinivasan CSIR-National Institute of Oceanography Dona Paula Goa 403004 India Department of Geological Sciences Jadavpur University Kolkata 700032 India Department of Earth Sciences Pondicherry University Puducherry 605014 India

Polymetallic sulfides from two hydrothermal chimneys and talus deposit from the Vienna Woods field of Manus Basin were studied for mineralogy,elemental composition,and S-isotope ratio to understand their *** factors including the nature of source fluid,mineral paragenesis,and related geochemical processes have been *** and elemental concentration of Cu and Fe-rich large chimney at the central part of this hydrothermal field was completely different from the smaller Zn-rich peripheral chimney and Fe-rich talus deposit,suggesting the variable degree of alterations generate physico-chemically different source fluids responsible for these hydrothermal ***,S-isotope ratios also indicate chemically diverse fluids and different modes of precipitation were involved in their *** mineral zonings and associated elemental and isotopic compositions within individual deposit confirm paragenetic shifts were involved during their growth process.

关键词： Manus Basin hydrothermal chimney talus geochemistry mineralogy

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50种中药甲醇提取物对嗜水气单胞菌的体外抑菌及抗生物膜活性的评价

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药物评价研究 2023年第1期46卷 64-71页

作者：傅钰瑛陈小萌 srinivasan Ramanathan 李珍刘柱林向民福建船政交通职业学院安全与环境学院福建福州350007 福建农林大学生命科学学院福建省农业生态过程与安全监控重点实验室福建福州350002 漳州卫生职业技术学院福建漳州363000 海南大学生命与药物学院分子生物实验室海南海口570228

目的评价50种中药甲醇提取物对嗜水气单胞菌的体外抑菌效果以及抗生物膜生成活性。方法采取甲醇浸提的方法制备中药甲醇提取物,计算提取率;利用多功能酶标仪检测600 nm处的吸光度(A600)值测定各提取物(0.1、0.2、0.4、0.8、1.6、3.2 m... 详细信息

目的评价50种中药甲醇提取物对嗜水气单胞菌的体外抑菌效果以及抗生物膜生成活性。方法采取甲醇浸提的方法制备中药甲醇提取物,计算提取率;利用多功能酶标仪检测600 nm处的吸光度(A600)值测定各提取物(0.1、0.2、0.4、0.8、1.6、3.2 mg·mL^(-1))作用16 h对嗜水气单胞菌的抑菌率;结晶紫染色法结合多功能酶标仪测定各提取物的抗生物膜活性。结果苏木、白芍、侧柏叶等32种中药甲醇提取物对嗜水气单胞菌抑菌效果明显,其中苏木甲醇提取物的抑菌效果最显著,最大抑菌率达95.56%,起效质量浓度为0.1 mg·mL^(-1);石菖蒲、大青叶、广藿香等20种中药甲醇提取物明显抑制嗜水气单胞菌生物被膜的生成,其中白芍的最大抑制率达96.78%。结论夏枯草、野菊花、大青叶、赤芍、石菖蒲、地肤子、连翘、苏木、肉桂、女贞子、白芍、甘草、肉豆蔻、鸡血藤、乌药、莪术、侧柏叶17种中药对嗜水气单胞菌同时具有抑菌和抑制生物膜生长活性。

关键词：中药嗜水气单胞菌体外抑菌抗菌活性抗生物膜活性苏木白芍

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