Inpatient use of racemic epinephrine for children admitted with croup

作     者：Elaine Chiang Omar Afandi Sang Hoon Lee Srinivasan Suresh Raymond DPitetti Sriram Ramgopal 

作者机构：Division of Pediatric Emergency MedicineDepartment of PediatricsUniversity of Pittsburgh School of MedicinePittsburghPAUSA Department of PediatricsUniversity of Pittsburgh School of MedicinePittsburghPAUSA Department of PediatricsUniversity of CincinnatiCollege of MedicineCincinnatiOHUSA Division of Emergency MedicineCincinnati Children's Hospital Medical CenterCincinnatiOHUSA Division of Health InformaticsDepartment of PediatricsUniversity of Pittsburgh School of MedicineChildren's Hospital of PittsburghPittsburghPAUSA UPMC Children's Hospital of PittsburghPittsburghPAUSA 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2019年第15卷第6期

页      面：586-594页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Laryngotracheobronchitis Racemic epinephrine Spasmodic croup Steroids Viral croup 

摘      要：Background Pediatric patients with croup are frequently admitted if they require two doses of racemic epinephrine(RE)in the emergency department(ED).We aimed to identify factors associated with the need for additional therapy(2 RE doses)among pediatric patients with *** We performed a single-center retrospective study of consecutive patients admitted from the ED with a diagnosis of croup between January 1,2011 and December 31,*** outcome was need for2 doses of *** out-comes included time to third RE and 72-hour return *** performed logistic regression to identify factors associated with use of2 RE doses during hospitalization,and survival analysis to identify time to dosing of 3rd RE from 2nd *** Of 353 included admissions[250(70.8%)males,median age 1.48,interquartile range 0.97-2.51 years],106/353(30.0%)required2 *** univariate logistic regression,only recent use of steroids within 1 day prior to presentation(4.18,1.48-11.83;P=0.007)was associated with need for2 *** from third RE was 0.74(95%CI 0.69-0.78),which was similar to the survival at 12 hours(0.70,95%CI 0.65-0.75).Return visits occurred in 19(5.4%)patients,of whom 12/19(63.2%)were given *** Patients hospitalized for croup with recent use of steroids prior to ED presentation have a greater need for2 RE during *** majority who require inpatient RE will do so within 8-12 *** data provide informa-tion for risk stratification and duration of monitoring for patients hospitalized with croup.