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Antioxidant activity of curcumine as protector on methylmercury inducedpancreas damage in mice

Journal of Chinese Pharmaceutical Sciences 2017年第3期26卷 196-201页

作者： sri agus sudjarwo Koerniasari Eraiko Giftania Wardani sudjarwo Koerniasari Department of Pharmacology Faculty of Veterinary Medicine Airlangga University Surabaya 60115 Indonesia Department of Conservative Dentistry Faculty of Dentistry Airlangga University Surabaya 60115 Indonesia Faculty of Pharmacy Hang Tuah University Surabaya 60115 Indonesia Study Program of Environmental Health Polytechnic of Health Surabaya 60115 Indonesia

Curcumin has been reported to have a strong antioxidant activity. In recent years, use of antioxidant in reducing heavy metal toxicities has been increased worldwide. In this study, we investigated the protective effects of curcumin on methylmercury-induced pancreas damage in mice. Briefly, 50 male mice were divided into five groups as follows: negative control(mice were given daily with aquadest); positive control(mice were orally given 2 mg/kg BW methylmercury daily for 35 d); and the treatment groups(mice were orally adminstered with curcumin 100 mg; 200 mg; 400 mg/kg BW daily for 35 d, and from 5th day, animals were given 2 mg/kg BW methylmercury daily 1 h after curcumin administration for 30 d). On day 35, levels of glucose, insulin, MDA, SOD and GPx were measured. Pancreas also was fixed in 10% neutral buffered formalin solution for histopathological examination. The results revealed that methylmercury toxicity induced a significant increase in the levels of glucose and MDA. Moreover, a significant decrease in insulin, SOD and GPx levels was observed, and pancreas tissues showed degeneration and necrotic changes in the islets of Langerhans. Treatment with curcumin(400 mg/kg BW but not 200 mg/kg BW and 100 mg/kg BW) significantly(P<0.05) decreased glucose and MDA levels in pancreas in mercury-induced mice. Treatment with curcumin 400 mg/kg BW also significantly increased insulin, SOD and GPx levels and reversed the histopathological damage in methylmercury-induced mice. Taken together, curcumin could be a potent natural herbal product, which had pancreas protective effect against methylmercury-induced pancreas damage in mice.

关键词： Curcumin Methylmercury Glucose Insulin MDA SOD GPx

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Antioxidant and anti-caspase 3 effect of chitosan-Pinus merkusii extract nanoparticle against lead acetate-induced testicular toxicity in rat

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Asian pacific Journal of Reproduction 2019年第1期8卷 13-19页

作者： sri agus sudjarwo Chairul Anwar Giftania Wardani Koerniasari Eraiko Koerniasari Department of Pharmacology Faculty of Veterinary MedicineAirlangga UniversitySurabayaIndonesia Department of Histology Faculty of Veterinary MedicineAirlangga UniversitySurabayaIndonesia Department of Pharmacy Biology Faculty of PharmacyHang Tuah UniversitySurabayaIndonesia Department of Conservative Dentistry Faculty of DentistryAirlangga UniversitySurabayaIndonesia Department of Microbiology Study Program of Environmental HealthPolytechnic of HealthSurabayaIndonesia

Objective: To investigate the antioxidant and anti-caspase 3 effect of chitosan-Pinus merkusii extract nanoparticle on lead acetate-induced toxicity in rat testis. Methods: Chitosan-Pinus merkusii nanoparticles were identified by dynamic light scattering and scanning electron microscope. The male rats were divided into control group (rats were given with distilled water);lead acetate group [rats were injected with lead acetate 20 mg/kg body weight (BW) i.p.], and the treatment group (rats were given the chitosan-Pinus merkusii nanoparticle 150 mg;300 mg;600 mg/kg BW orally and were injected with lead acetate 20 mg/kg BW). The testis tissues were collected to evaluate the malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), histological evaluations of testis damage, and the caspase 3 mRNA expression was measured by reverse transcription-polymerase chain reaction. Results: The dynamic light scattering showed that the size of chitosan-Pinus merkusii nanoparticle was (530.2±38.2) nm. The scanning electron microscope images of the chitosan-Pinus merkusii nanoparticles showed an irregular shape, and the morphology surface showed the rough surface. The treatment with lead acetate resulted in significantly increasing MDA level and caspase 3 mRNA expression, and significantly decreasing level of SOD and GPx when compared with control group. The treatment with the chitosan-Pinus merkusii nanoparticle 600 mg/kg BW but not 150 and 300 mg/kg BW significantly decreased the MDA levels, caspase 3 mRNA expression, and also increased level of SOD and GPx when compared with lead acetate group. The lead acetate induced loss of the normal structure of testicular cells and necrosis, whereas treatment with chitosan-Pinus merkusii nanoparticle inhibited testicular cell necrosis. Conclusions: It can be concluded that chitosan-Pinus merkusii nanoparticle protects rat testis from oxidative damage and apoptosis caused by lead acetate, through increasing antioxidant

关键词： Chitosan-Pinus merkusii nanoparticle Lead acetate Antioxidant Caspase 3

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Optimizing Sorghum Productivity Using Balanced Fertilizers on Dryland

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1403-1420页

作者： Samijan Samijan Endah Nurwahyuni sri Minarsih agus Supriyo Sodiq Jauhari Yulis Hindarwati Meinarti Norma Setiapermas Raden Heru Praptana Endah Winarni Vina Eka Aristya Research Center for Food Crops Research Organization for Agriculture and FoodNational Research and Innovation Agency(BRIN)Cibinong Science CenterJl.Raya Jakarta-Bogor Km.46Bogor16911Indonesia

Sorghum is theﬁfth most required cereal crop *** bicolor has the advantage of being adaptive to both lowland and dryland,with drought-tolerant and wide *** low nutrient availability in dryland requires additional effective fertilizers to increase sorghum *** research aimed to assess the appli-cation of organic,inorganic,and biofertilizers for sorghum productivity on *** in Central Java,Indonesia as dryland sorghum areas,from November 2022 to February *** experiment cooperates with the farmers in a split-plot design,the main plot was two varieties and subplots of four *** enhanced sorghum yield(21.38%–36.06%)with combined fertilizer was greater than the existing *** con-trol does not rely on inorganic fertilizers but also on applying *** sorghum farming economic value farming indicated that combinations of fertilizer treatments and varieties provide beneﬁts of USD 929.81–1955.81 with a revenue-cost ratio(R/C)value>*** is an essential food commodity that faces the threat of the global crisis and an unfavorable *** study indicated balanced fertilizers could provide sufﬁ-cient nutrients to the soil and increase nutrient absorption availability for sorghum growth and *** fertilization increases the uptake of N,P,and K nutrients correlates with an increase in yield of 21.38%–36.06%.

关键词： Biofertilizer dryland adaptability economic value sorghum potential yield

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Adding chitosan nanoparticles of green tea extract in diluent and thawing temperatures ameliorate the post-thawed quality of Boer buck semen

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Asian pacific Journal of Reproduction 2024年第1期13卷 42-48页

作者： Suherni Susilowati Imam Mustofa Tri Wahyu Suparyogi Adeyinka Oye Akintunde Djoko agus Purwanto Wurlina Wurlina Suzanita Utama sri Mulyati Division of Veterinary Reproduction Faculty of Veterinary MedicineUniversitas AirlanggaKampus C UnairMulyorejoSurabaya 60115Indonesia Department of Agriculture and Industrial Technology Babcock UniversityIlishan-RemoOgun State 121103Nigeria Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas AirlanggaKampus C MulyorejoSurabaya 601155East JavaIndonesia

Objective:To improve the quality of post-thawing Boer buck semen for artificial insemination by adding green tea extract chitosan nanoparticles to skimmed egg yolk diluent,and the proper thawing ***:The ejaculate of Boer buck was added to skimmed egg yolk diluent without(the control group)and with adding 1μg of chitosan nanoparticles of green tea extract per mL of diluent(the treatment group).Then,the diluted semen was filled in French mini straws containing 60×106 live sperm per straw,frozen in a standard protocol,and stored as frozen semen at−196℃for a *** replicates from each group were diluted for 30 s at 37℃or 39℃sterile water to evaluate the semen ***:Post-thawing(at 37℃or 39℃)of live sperm,progressive motility,and plasma membrane integrity were lower compared to those of the pre-freezing stage(P0.05).The live sperm,progressive motility,and plasma membrane of the treatment group in the pre-freezing stage,and post-thawed at 39℃were higher compared to those of the control group(P0.05).Conclusions:Higher quality post-thawing Boer buck semen is achieved by adding 1μg/mL of chitosan nanoparticles of green tea extract to the skimmed egg yolk diluent and thawing at 39℃.

关键词： Boer buck semen Chitosan nanoparticles Semen diluent Higher post-thawing semen quality Prevent undernutrition

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Zeolite A Synthesized from Geothermal Waste Using Conventional and Microwave Heating for the Hydrothermal Treatment

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Fluid Dynamics & Materials Processing 2021年第2期17卷 385-395页

作者： Sulardjaka Sulardjaka sri Nugroho Norman Iskandar agus P.Adi Deni F.Fitriyana Diponegoro University Semarang50275Indonesia Universitas Negeri Semarang GunungpatiSemarang50229Indonesia

Zeolite A has been successfully synthesized from geothermal waste with natrium aluminate and natrium silicate using conventional(C-H)and microwave heating(M-H)for the hydrothermal *** products obtained for different aging times have been characterized using X-Ray Diffraction(XRD),Fourier transformation infrared spectroscopy(FTIR),and scanning electron microscopy(SEM).It is shown that with the M-H process,zeolite can be formed at relatively low temperature(100°C)in a relatively short time(40 min).The crystallization of zeolite A has been found to be generally promoted by an increase of aging and synthesis time;however,it has also been observed that relative long aging times can transform it into *** A produced through the M-H process generally displays a smaller and more homogeneous crystal size with respect to that obtained with the C-H method.

关键词： Geothermal waste microwave-hydrothermal conventional-hydrothermal zeolite A

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An Intonation Speech Synthesis Model for Indonesian Using Pitch Pattern and Phrase Identification

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Journal of Signal and Information Processing 2014年第3期5卷 80-88页

作者： Yohanes Suyanto Subanar agus Harjoko sri Hartati Department of Computer Science and Electronics Gadjah Mada University Yogyakarta Indonesia

Prosody in speech synthesis systems (text-to-speech) is a determinant of tone, duration, and loudness of speech sound. Intonation is a part of prosody which determines the speech tone. In Indonesian, intonation is determined by the structure of sentences, types of sentences, and also the position of the word in a sentence. In this study, a model of speech synthesis that focuses on its intonation is proposed. The speech intonation is determined by sentence structure, intonation patterns of the example sentences, and general rules of Indonesian pronunciation. The model receives texts and intonation patterns as inputs. Based on the general principle of Indonesian pronunciation, a prosody file was made. Based on input text, sentence structure is determined and then interval among parts of a sentence (phrase) can be determined. These intervals are used to correct the duration of the initial prosody file. Furthermore, the frequencies in prosody file were corrected using intonation patterns. The final result is prosody file that can be pronounced by speech engine application. Experiment results of studies using the original voice of radio news announcer and the speech synthesis show that the peaks of?F0?are determined by general rules or intonation patterns which are dominant. Similarity test with the PESQ method shows that the result of the synthesis is 1.18 at MOS-LQO scale.

关键词： Speech Synthesis PESQ Intonation Indonesian

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Preprocessing Model of Manuscripts in Javanese Characters

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Journal of Signal and Information Processing 2014年第4期5卷 112-122页

作者： Anastasia Rita Widiarti agus Harjoko Marsono sri Hartati Department of Informatics Engineering Sanata Dharma University Yogyakarta Indonesia Department of Computer Science and Electronics Gadjah Mada University Yogyakarta Indonesia Department of Nusantara Literature Gadjah Mada University Yogyakarta Indonesia

Manuscript preprocessing is the earliest stage in transliteration process of manuscripts in Javanese scripts. Manuscript preprocessing stage is aimed to produce images of letters which form the manuscripts to be processed further in manuscript transliteration system. There are four main steps in manuscript preprocessing, which are manuscript binarization, noise reduction, line segmentation, and character segmentation for every line image produced by line segmentation. The result of the test on parts of PB.A57 manuscript which contains 291 character images, with 95% level of confidence concluded that the success percentage of preprocessing in producing Javanese character images ranged 85.9% - 94.82%.

关键词： Binarization Characters Segmentation Line Segmentation Noise Reduction Manuscript Image Preprocessing

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Development of Broadband LHCP Pyramidal Horn Antenna with Septum Gaussian Profile Polarizer for CP-SAR Sensor Onboard Microsatellite

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Open Journal of Antennas and Propagation 2018年第4期6卷 73-83页

作者： agus Hendra Wahyudi Cahya Edi Santosa Josaphat Tetuko sri Sumantyo Josaphat Microwave Remote Sensing Lab Chiba University Chiba Japan Indonesian National Institute of Aeronautics and Space (LAPAN) DKI Jakarta Indonesia

Horn Antenna has many applications such as communication, radar, and standard reference antenna for measurement. In this research, we designed a pyramidal horn for a Circularly Polarized Synthetic Aperture Radar (CP-SAR) sensor onboard a microsatellite. We utilized a 3D printer with Fused Deposition Modelling (FDM) technology for fast, low-cost, and low-weight production. Polylactide (PLA) material was used to construct 3D structures, and a copper conductive coating was painted on its surface. Gaussian distribution function was employed to create a septum polarizer profile. NPC-220 A with 1.6 thickness and 2.17 dielectric constant was used to make a microstrip monopole antenna and stripline feeding to feed the pyramidal horn to generate TE01 mode at one side of the waveguide. The design, parametric studies, and measurements are discussed in this paper. The designed antenna can achieve wide bandwidth 28% of 3 dB axial ratio, and more than 22% of s11 ≤ −10 dB in working frequency that is acceptable for CP-SAR requirement on the microsatellite.

关键词： CP-SAR Microsatellite Pyramidal Horn 3D Printer

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Relocation of hypocenters from DOMERAPI and BMKG networks： a preliminary result from DOMERAPI project

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Earthquake Science 2017年第2期30卷 67-79页

作者： Mohamad Ramdhan sri Widiyantoro Andri Dian Nugraha Jean-Philippe Métaxian Asep Saepuloh Said Kristyawan Andry Syaly Sembiring agus Budi Santoso Antoine Laurin Ahmad Ali Fahmi Study Program of Earth Sciences Faculty of Earth Science andTechnology Institute of Technology Bandung Jalan Ganesa No.10 Bandung 40132 Indonesia Agency for Meteorology Climatology and Geophysics(BMKG) Jakarta Indonesia Global Geophysics Research Group Faculty of Mining andPetroleum Engineering Institute of Technology Bandung JalanGanesa No. 10 Bandung 40132 Indonesia Research Center for Disaster Mitigation Institute of TechnologyBandung Jalan Ganesa No. 10 Bandung 40132 Indonesia ISTerre IRD R219 CNRS Universite de Savoie Mont BlancLe Bourget-du-Lac France Faculty of Earth Sciences and Technology Institute of Technology Bandung Jalan Ganesa No. 10 Bandung 40132Indonesia Center for Volcanology and Geological Hazard Mitigation Geological Agency Jalan Diponegoro No. 57 Bandung 40122Indonesia

Merapi volcano located in central Java, Indonesia,is one of the most active stratovolcanoes in the world. Many Earth scientists have conducted studies on this volcano using various methods. The geological features around Merapi are very attractive to be investigated because they have been formed by a complex tectonic process and volcanic activities since tens of millions of years ago. The southern mountain range, Kendeng basin and Opak active fault located around the study area resulted from these processes. DOMERAPI project was conducted to understand deep magma sources of the Merapi volcano comprehensively. The DOMERAPI network was running from October 2013 to mid-April 2015 by deploying 46 broad-band seismometers around the volcano. Several steps, i.e., earthquake event identification,arrival time picking of P and S waves, hypocenter determination and hypocenter relocation, were carried out in this study. We used Geiger＇s method（Geiger 1912） for hypocenter determination and double-difference method for hypocenter relocation. The relocation result will be used to carry out seismic tomographic imaging of structures beneath the Merapi volcano and its surroundings. For the hypocenter determination, the DOMERAPI data were processed simultaneously with those from the Agency for Meteorology, Climatology and Geophysics（BMKG） seismic network in order to minimize the azimuthal gap. We found that the majority of earthquakes occurred outside the DOMERAPI network. There are 464 and 399 earthquakes obtained before and after hypocenter relocation, respectively. The hypocenter relocation result successfully detects some tectonic features, such as a nearly vertical cluster of events indicating a subduction-related backthrust to the south of central Java and a cluster of events to the east of Opak fault suggesting that the fault has an eastward dip.

关键词： Earthquake Relocation DOMERAPI BMKG Tectonic feature

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The Effect of Salinity on Growth, Dry Weight and Lipid Content of the Mixed Microalgae Culture Isolated from Glagah as Biodiesel Substrate

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Journal of Life Sciences 2015年第5期9卷 229-233页

作者： Eko agus Suyono Winarto Haryadi Muhammad Zusron Matin Nuhamunada sri Rahayu Andhika Puspito Nugroho Faculty of Biology Universitas Gadjah Mada Yogyakarta 55281 Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada Yogyakarta 55281 Indonesia

Microalgae use photosynthesis to convert solar energy into chemical energy, such as lipid and they can be a replacement for oil-based fuels. They are among the fastest growing plants in the world, and about 50% of their weight is oil. This lipid oil can be used to make biodiesel. Unfortunately, there are only some of potential strains isolated from Indonesia and most of the biodiesel productions are usually using a single strain. Then, although they are rich of oils, their biomass productivity is still low. Salinity treatment can be used to increase their biomass as well as their lipid content. Therefore, the research aim was to study the effect of salinity on the growth, dry weight and lipid content of mixed microalgae isolated from Glagah, Yogyakarta. The mixed microalgae were cultured in 3NBBM medium with different salinities or types of water (sea water, brackish water, and fresh water). The cultures were incubated at light intensity 3,000 lux under dark: light exposure of 12:12 h for 7 days. The number of cells was counted every 24 h with a Haemocytometer, and the biomass was calculated based on the dry weight. The lipid content was measured on days 0, 3, and 7 using NR (Nile Red) staining, and then the amount of lipid was analyzed using a fluorescence microscope and measured with CellProfiler 2.0 software. The highest dry weight and lipid content were found in seawater medium, they accounted for 3.42 mg/mL and 13.58% at day 7, respectively. Whereas, the highest number of cells was found in freshwater medium, this was 9.8 × 106 cells/mL.

关键词：微藻培养生物柴油脂质含量盐度干重经济增长混合分离

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