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Lipoma causing Guyon’s canal syndrome: a case report and review

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Plastic and Aesthetic Research 2014年第1期1卷 118-120页

作者： Narayanathu Chellappantilla sreekumar Panambur Laxminarayan Bhandari Lalitha Sreedharan Sreelesh Krishnankutty Rajamma Thushara Department of Plastic Surgery Govt.Medical CollegeCalicut 673017KeralaIndia.

Compression of the ulnar nerve in Guyon’s canal leads to Guyon’s canal *** is a rare cause of such compressions with only 12 cases reported *** report a 55-year-old man who presented with swelling in the left hand with decreased sensation in the ring and littleﬁ*** resonance imaging revealed high signals in T1-weighted and T2-weighted images with suppression of the short T1 inversion recovery signal,suggestive of *** exploration a well-encapsulated,dumbbell-shaped,fatty tumor was seen in the hypothenar space and Guyon’s *** tumor was enucleated in *** 6-month follow-up,the patient had fully regained sensation.A review of the literature is presented for similar cases where a lipoma was the cause of Guyon’s canal syndrome.

关键词： Guyon’s canal lipoma ulnar neuropathy

Autologous Tendon Grafts Used in Upper Limb Surgery

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Open Journal of Orthopedics 2013年第2期3卷 74-78页

作者： Avinash Alva V. Kumar R. sreekumar Chye Yew Ng S. C. Talwalkar Blackpool Victoria Hospital Blackpool UK Department of Orthopaedics Wrightington Hospital Wigan UK

Tendon autografts play an important role in upper limb reconstruction and a working knowledge of tendon autograft options is essential for the surgeon. Although palmaris longus is often the first choice, other options like plantaris, extensor Hallucis longus, flexor carpi radialis are readily available. Advantages of autografts include easy availability, satisfactory biomechanical properties and the human body tends to accept its own tendons than from a donor. This review highlights the various options available and their anatomical and surgical considerations in procuring grafts for upper limb reconstructive work.

关键词： Autologous Tendon Graft Palmaris Longus Plantaris Extensor Digitorum Longus Extensor Hallucis Longus Flexor Carpi Radialis Hamstrings

Caerulomycin A—An Antifungal Compound Isolated from Marine Actinomycetes

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Advances in Microbiology 2014年第9期4卷 567-578页

作者： Vaibhav Ambavane Pradipta Tokdar Rajashri Parab E. S. sreekumar Girish Mahajan Prabhu Dutt Mishra Lisette D’Souza Prafull Ranadive Bioorganic Chemistry Laboratory CSIR-National Institute of Oceanography Dona Paula Goa India Natural Products Department Piramal Enterprises Limited Mumbai India

Actinomycetes have been prolific sources of novel secondary metabolites with a range of biological activities that may ultimately find application as therapeutic compounds. Hence several drug discovery companies are engaged in isolation of novel bioactive metabolites from these microbial sources. Antibiotics form the major class of such bioactive metabolites and have been widely used for treating infectious diseases. One of the most critical problems in clinical practice is the increase of prevalence of drug resistant strains, especially azole resistance among fungi. Due to this, there is a constant need for development of new antifungal antibiotics having novel scaffolds and/or mechanism of action. In our in-house screening program in the quest of novel and superior antifungal compounds, an actinomycetes strain PM0525875 was isolated from a marine invertebrate. The extracts of this microbe showed potent in-vitro antifungal activity against drug resistant fungal strains. The antifungal active peak from the extract obtained by shake flask fermentation was identified by chromatographic and other analytical techniques during bioactivity guided isolation. Later the fermentation conditions were optimized in 30 L fermentor for the production of sufficient amount antifungal compound for complete structural characterization. Consequently the fermented broth extract was subjected to bioactivity-guided fractionation, to isolate the active principle using different preparative chromatographic techniques followed by its characterization. The active principle was characterized to be Caerulomycin A. Minimum inhibitory concentration (MIC) of the compound was found in the range of 0.39 - 1.56 μg/ml against pathogenic fungal test strains. The phylogenetic analysis of producer strain using 16S rRNA sequence showed closest match with Actinoalloateichus cyanogriseus. Herewith we report the isolation of Caerulomycin A from marine invertebrate-associated Actinoalloteichus sp. using optim

关键词： Caerulomycin A Antifungal Non-Polyene Actinoalloateichus cyanogriseus Marine Actinomycetes

The association between body composition and self-reported co-morbidity in subjects with chronic obstructive pulmonary disease

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Open Journal of Internal Medicine 2012年第2期2卷 100-106页

作者： Erica P. A. Rutten Per S. Bakke sreekumar G. Pillai Scott Wagers Thomas B. Grydeland Amund Gulsvik Emiel F. M. Wouters Center of Expertise for Chronic Organ Failure (Ciro) Horn The Netherlands Genetics GlaxoSmithKline R&D Raleigh USA Section of Thoracic Medicine Institute of Medicine University of Bergen Bergen Norway

Background: Differences in body composition are extensively investigated in subjects with COPD as low muscle mass was independently associated with increased morbidity and mortality. Also cardio-vascular co-morbidity is often reported in COPD and the contribution of fat mass in COPD related co-morbidity is gaining interest. We hypothesized that the prevalence of low muscle mass and high fat mass is higher in subjects with COPD compared to a group of current and former smokers without COPD, which result in higher reported cardiovascular co-morbidity in the COPD group. Methods: In 954 subjects with COPD and 955 subjects without COPD, body composition was assessed by bio-electrical impedance analysis and information on self-reported co-morbidity was collected. Participants were stratified for low fat free mass index and high fat mass index (resp. fat free mass index 50th percentile of the subjects without COPD). Results: Subjects with COPD were more likely to have low fat free mass index than current and former smokers without COPD. The prevalence of high fat mass index was comparable between the groups. The percentage of self-reported co-morbidity was higher in subjects with COPD, but only reports of myocardial infarction were disease specific. Conclusion: Low fat free mass index was more common in COPD, but the prevalence of high fat mass index was comparable between subjects with and without COPD. Nevertheless, subjects with COPD reported more myocardial infarction, implying that other factors than the amount of fat mass are involved in the increased co-morbidity in COPD.

关键词： Co-Morbidity Fat Free Mass Fat Mass

Methionine sulfoxide reductase A: Structure, function and role in ocular pathology

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World Journal of Biological Chemistry 2011年第8期2卷 184-192页

作者： Parameswaran G sreekumar David R Hinton Ram Kannan Arnold and Mabel Beckman Macular Research Center Doheny Eye Institute Department of Pathology Keck School of Medicine of the University of Southern California

Methionine is a highly susceptible amino acid that can be oxidized to S and R diastereomeric forms of methionine sulfoxide by many of the reactive oxygen species generated in biological systems. Methionine sulfoxide reductases (Msrs) are thioredoxin-linked enzymes involved in the enzymatic conversion of methionine sulfoxide to methionine. Although MsrA and MsrB have the same function of methionine reduction, they differ in substrate specifi city, active site composition, subcellular localization, and evolution. MsrA has been localized in different ocular regions and is abundantly expressed in the retina and in retinal pigment epithelial (RPE) cells. MsrA protects cells from oxidative stress. Overexpression of MsrA increases resistance to cell death, while silencing or knocking down MsrA decreases cell survival; events that are mediated by mitochondria. MsrA participates in protein-protein interaction with several other cellular proteins. The interaction of MsrAwith α-crystallins is of utmost importance given the known functions of the latter in protein folding, neuroprotection, and cell survival. Oxidation of methionine residues in α-crystallins results in loss of chaperone function and possibly its antiapoptotic properties. Recent work from our laboratory has shown that MsrA is co-localized with αA and αB crystallins in the retinal samples of patients with age-related macular degen- eration. We have also found that chemically induced hypoxia regulates the expression of MsrA and MsrB2 in human RPE cells. Thus, MsrA is a critical enzyme that participates in cell and tissue protection, and its interaction with other proteins/growth factors may provide a target for therapeutic strategies to prevent degenerative diseases.

关键词： Methionine sulfoxide reductases Hypoxia Protein interaction α crystallins Neuroprotection

Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

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Light(Science & Applications) 2018年第1期7卷 583-592页

作者： Jing Liu Ranhua Xiong Toon Brans Saskia Lippens Eef Parthoens Francesca Cella Zanacchi Raffaella Magrassi Santosh K.Singh sreekumar Kurungot Sabine Szunerits Hannelore Bové Marcel Ameloot Juan C.Fraire Eline Teirlinck Sangram Keshari Samal Riet De Rycke Gaëlle Houthaeve Stefaan C.De Smedt Rabah Boukherroub Kevin Braeckmans Laboratory of General Biochemistry and Physical Pharmacy Faculty of PharmacyGhent UniversityGhent B-9000Belgium Centre for Nano-and Biophotonics Ghent UniversityGhent B-9000Belgium VIB-UGent Centre for Inflammation Research VIBGhent B-9000Belgium VIB Bioimaging Core VIBGhent B-9000Belgium Department of Biomedical Molecular Biology Ghent UniversityGhent B-9000Belgium Nanophysics(NAPH) Istituto Italiano di TecnologiaGenova 16163Italy Biophysics Institute(IBF) National Research Council(CNR)Via De Marini6-16149–GE GenovaItaly Physical and Materials Chemistry Division CSIR-National Chemical LaboratoryDr.Homi Bhabha RoadPune 411008India Academy of Scientific and Innovative Research Anusandhan Bhawan2 RafiMargNew Delhi 110001India Univ.Lille CNRSCentrale LilleISENUniv.ValenciennesUMR 8520-IEMNLille F-59000France Biomedical Research Institute Hasselt UniversityAgoralaan Building CDiepenbeek 3590Belgium Centre for Surface Chemistry and Catalysis KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium Inflammation Research Center Image Core FacilityVIB9052 GhentBelgium Department of Biomedical Molecular Biology Ghent University9052 GhentBelgium Department of Plant Biotechnology and Bioinformatics Ghent University9052 GentBelgium Univ Lille 1 Univ Lille Nord FranceLab Phys Lasers Atomes&MolVilleneuve Dascq UMR 852359655France College of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and ChemicalsNanjing Forestry University(NFU)Nanjing 210037China UMR 8523 Laboratoire de Physique des LasersAtomes et MoléculesUniversitéde LilleVilleneuve d’AscqFrance IEMN UMR 8520Universitéde LilleVilleneuve d’AscqFrance

In the replacement of genetic probes,there is increasing interest in labeling living cells with high-quality extrinsic labels,which avoid over-expression artifacts and are available in a wide spectral *** calls for a broadly applicable technology that can deliver such labels unambiguously to the cytosol of living ***,we demonstrate that nanoparticle-sensitized photoporation can be used to this end as an emerging intracellular delivery *** replace the traditionally used gold nanoparticles with graphene nanoparticles as photothermal sensitizers to permeabilize the cell membrane upon laser *** demonstrate that the enhanced thermal stability of graphene quantum dots allows the formation of multiple vapor nanobubbles upon irradiation with short laser pulses,allowing the delivery of a variety of extrinsic cell labels efficiently and homogeneously into live *** demonstrate high-quality time-lapse imaging with confocal,total internal reflection fluorescence(TIRF),and Airyscan superresolution *** the entire procedure is readily compatible with fluorescence(super resolution)microscopy,photoporation with graphene quantum dots has the potential to become the long-awaited generic platform for controlled intracellular delivery of fluorescent labels for live-cell imaging.

关键词： quantum enable replace

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慢性肺病婴儿的一氧化氮呼出水平

世界核心医学期刊文摘（儿科学分册） 2005年第2期1卷 38-38页

作者： LeiplJ.A. Williams O. sreekumar S. A.Greenough 郭战宏 Department of Child HealthGuy's King's/St. Thomas'Sch.MedKing's College HospitalSE5 9PJ LondonUnited Kingdom

慢性肺病(CLD)为一炎症性疾病,在其他炎症性疾病时患者的一氧化氮(NO)呼出水平升高,本研究的目的是验证患有CLD的早产儿与未患CLD的早产儿及健康足月产儿相比其NO呼出水平升高的假说。

关键词：呼出慢性肺病足月产儿鼻部出生后口唇部监测方法