检索结果-南通市图书馆

Spectral/hp element methods:Recent developments, applications, and perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Hydrodynamics 2018年第1期30卷 1-22页

作者： Hui Xu Chris D.Cantwell Carlos Monteserin Claes Eskilsson Allan P.Engsig-Karup spencer j.sherwin Department of Aeronautics Imperial College London Department of Applied Mathematics and Computer Science Technical University of Denmark Department of Civil Engineering Aalborg University Division Safety and Transport Research Institutes of Sweden (RISE) Center for Energy Resources Engineering (CERE) Technical University of Denmark

The spectral/hp element method combines the geometric flexibility of the classical h-type finite element technique with the desirable numerical properties of spectral methods, employing high-degree piecewise polynomial basis functions on coarse finite element-type meshes. The spatial approximation is based upon orthogonal polynomials, such as Legendre or Chebychev polynomials,modified to accommodate a C~0-continuous expansion. Computationally and theoretically, by increasing the polynomial order p,high-precision solutions and fast convergence can be obtained and, in particular, under certain regularity assumptions an exponential reduction in approximation error between numerical and exact solutions can be achieved. This method has now been applied in many simulation studies of both fundamental and practical engineering flows. This paper briefly describes the formulation of the spectral/hp element method and provides an overview of its application to computational fluid dynamics. In particular, it focuses on the use of the spectral/hp element method in transitional flows and ocean engineering. Finally, some of the major challenges to be overcome in order to use the spectral/hp element method in more complex science and engineering applications are discussed.

关键词： High-precision spectral/hp elements continuous Galerkin method discontinuous Galerkin method implicit large eddy simulation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

湍流的hp型谱元隐式大涡模拟

湍流的hp型谱元隐式大涡模拟

第十一届全国流体力学学术会议

作者：徐辉 Pierre Sagaut spencer j.sherwin 上海交通大学航空航天学院 Department of Aeronautics Imperial College London Aix-Marseille Université CNRSCentrale Marseille

基于高精度hp型谱元法,实施典型壁湍流问题隐式大涡模拟,隐式大涡模型基于正则化谱粘性消去法构建。针对壁湍流的流动特性,讨论了平均流动、雷诺应力、流动的各向异性特征及能谱。与典型的实验及数值模拟的基准结果相比较而言,上述物理... 详细信息

基于高精度hp型谱元法,实施典型壁湍流问题隐式大涡模拟,隐式大涡模型基于正则化谱粘性消去法构建。针对壁湍流的流动特性,讨论了平均流动、雷诺应力、流动的各向异性特征及能谱。与典型的实验及数值模拟的基准结果相比较而言,上述物理量与基准解具有良好的吻合。结果表明,基于正则化的谱粘性消去法所构建的物理模型无关的隐式大涡模型能够取得与经典模型相一致的结果,能够对具有大尺度分离的壁湍流问题实施良好的模拟。

关键词：壁湍流 hp型谱元法隐式大涡模拟

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

可压缩性及分离泡拓扑形状对转捩的影响

可压缩性及分离泡拓扑形状对转捩的影响

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

第十一届全国流体力学学术会议

作者：徐辉 Shahid Mughal spencer j.sherwin 上海交通大学航空航天学院 Department of Aeronautics Imperial College London Department of Mathematics Imperial College London

本文研究了可压缩性对T-S波诱导层流-湍流转捩的影响作用,同时探讨了壁面缺陷诱导分离泡拓扑形状对流动稳定性及转捩的影响机制。文中考虑了两类壁面缺陷(凹陷和凸包)及两类缺陷诱导分离涡的拓扑特征。基于全局稳定性分析,研究了两类缺... 详细信息

本文研究了可压缩性对T-S波诱导层流-湍流转捩的影响作用,同时探讨了壁面缺陷诱导分离泡拓扑形状对流动稳定性及转捩的影响机制。文中考虑了两类壁面缺陷(凹陷和凸包)及两类缺陷诱导分离涡的拓扑特征。基于全局稳定性分析,研究了两类缺陷诱导分离涡对转捩的影响机制。研究表明,w针对可压缩性及分离泡对转捩影响作用的研究对流动控制具有一定的意义。

关键词：可压缩性分离泡转捩

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu sherwin Ho Michael j.Lee jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion spencer j.Allen Stephanie M.Ntoukas Gordon j.Bell jessica McNeil Qinggang Wang Margaret L.McNeely jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau john R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(p<0.001),poor sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(p<0.001),and multiple symptoms(p<0.001).VO_(2peak)demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

Lumped Parameter Outflow Models for 1-D Blood Flow Simulations:Effect on Pulse Waves and Parameter Estimation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2008年第7期4卷 317-336页

作者： j.Alastruey K.H.Parker j.Peiro S.j.sherwin Department of Aeronautics Imperial College LondonSouth Kensington CampusLondon SW72AZU.K Department of Bioengineering Imperial College LondonSouth Kensington CampusLondon SW72AZU.K.

Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the *** this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo *** algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a *** and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.

关键词： Pulse wave propagation one-dimensional modelling lumped parameter outflow models time-domain coupling arterial compliance peripheral compliance peripheral resistance multiscale modelling.

Stability of Projection Methods for Incompressible Flows Using High Order Pressure-Velocity Pairs of Same Degree:Continuous and Discontinuous Galerkin Formulations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2014年第8期16卷 817-840页

作者： E.Ferrer D.Moxey R.H.j.Willden S.j.sherwin ETSIA–School of Aeronautics Universidad Politecnica de MadridPza.Cardenal Cisneros 3MadridE-28040Spain. Department of Aeronautics Imperial College LondonLondonSW72AZUK. Department of Engineering Science University of OxfordParks RoadOxfordOX13PJUK.

This paper presents limits for stability of projection type schemes when using high order pressure-velocity pairs of same *** high order h/p variational methods encompassing continuous and discontinuous Galerkin formulations are used to explain previously observed lower limits on the time step for projection type schemes to be stable[18],when h-or p-refinement strategies are *** addition,the analysis included in this work shows that these stability limits do not depend only on the time step but on the product of the latter and the kinematic viscosity,which is of particular importance in the study of high Reynolds number *** show that high order methods prove advantageous in stabilising the simulations when small time steps and low kinematic viscosities are *** upon this analysis,we demonstrate how the effects of this instability can be reduced in the discontinuous scheme by introducing a stabilisation term into the global ***,we show that these lower limits are compatible with CourantFriedrichs-Lewy(CFL)type restrictions,given that a sufficiently high polynomial order or a mall enough mesh spacing is selected.

关键词： Incompressible Navier-Stokes equations projection methods velocity-correction continuous Galerkin discontinuous Galerkin inf-sup LBB condition.

Himalayan Tectonics:Preface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第3期10卷 791-792页

作者： Kyle Larson Christopher j. spencer Tectonics and Geodynamics Earth Environmental and Geographical Sciences IKBSAS University of British Columbia Earth Dynamics Research Group The Institute for Geoscience Research (TIGeR) Department of Applied Geology Curtin University

The Himalayan-Tibetan orogen system serves as the modern paradigm for understanding convergence-related processes in orogenic belts. The advancements made studying the region have been applied to other ancient orogenic belts leading not only to a better understanding of their development, but also of secular changes in collisional processes. As more advanced methodologies are introduced and utilized in geological research, the type, scale, and quality of data available enable quantification of geological processes not previously possible. These complex and robust datasets now form the core of many of the research projects undertaken across the Himalaya and continue to provide unprecedented insight into the myriad different aspects of the evolution of the collisional system.

关键词： Himalayan-Tibetan system evolution

Sphere-forming corneal cells repopulate dystrophic keratoconic stroma:Implications for potential therapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World journal of Stem Cells 2020年第1期12卷 35-54页

作者： Himanshu Wadhwa Salim Ismail jennifer j McGhee Bert Van der Werf Trevor sherwin Department of Ophthalmology Faculty of Medical and Health SciencesThe University of AucklandAuckland 1023New Zealand Department of Epidemiology and Biostatistics School of Population HealthFaculty of Medical and Health SciencesThe University of AucklandAuckland 1023New Zealand

BACKGROUND Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision *** extracted from peripheral corneas can form stem cell-enriched spheres,which have shown the potential to repopulate the normal peripheral corneal stroma in vitro upon sphere implantation but have not been previously studied in keratoconic *** To investigate the therapeutic potential of stem cell-enriched spheres formed from extracted peripheral human corneal cells when introduced to keratoconic *** Stem cell-enriched spheres were formed from extracts of normal cadaveric human peripheral corneal *** spheres were implanted into incisions created in full thickness and onto the surface of 10μm thin sections of keratoconic and normal stromal tissues in *** sections were used to maximise use of limited keratoconic tissue available for *** cells were stained with Calcein-AM and visualised with stereo and fluorescence microscopy to assess survival and behaviours between the time of implantation day 0 and 14 d(D14)from *** cells in implanted tissues were characterised for stem cell and differentiation markers using immunohistochemistry and droplet digital PCR to assess the potential implications of these characteristics in the use of spheres in keratoconus *** Spheres were successfully implanted into full-thickness central corneal tissue and onto the surface of 10μm thin en face tissue *** observable differences were seen in sphere migration,proliferation or differentiation in keratoconic tissue compared to normal between day 0 and *** stained positively with Calcein-AM up to *** migration increased from day 0 to D14,occurring radially in three dimensions from the sphere and in alignment with tissue *** proliferation marker,EdU,was detected at day *** spheres stained positively for putative stem cell markersΔNp63

关键词： Keratoconus Cell culture Immunohistochemistry Quantitative PCR Digital PCR Spheroid Holoclone Neurosphere Regeneration