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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik kim soyeon kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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A comprehensive review on the resynthesis of ternary cathode active materials from the leachate of Li-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 446-463,I0010页

作者： Dongwoo kim Hyeoncheol Joo Chanmin kim Seoa kim Wan-Yi kim Sangwoo Han Joongkil Park soyeon Park Heechul Jung Sanghyuk Park Kyungjung Kwon Department of Energy and Mineral Resources Engineering Sejong UniversitySeoul 05006Republic of Korea LIB Recycling Research Group LIB Materials R&D CenterPOSCO HoldingsPohang 37859Republic of Korea Department of Future Energy Convergence Seoul National University of Science&Technology232 Gongreung-roNowon-guSeoul 01811Republic of Korea Autonomous Intelligent Unmanned Flying Vehicles Institute Sejong UniversitySeoul 05006Republic of Korea

This review highlights the importance of recovering valuable metals from spent Li-ion battery(LIB)cathodes through the resynthesis of cathode active materials(CAMs).The resynthesis process of CAMs,a promising recycling method that directly produces CAM precursors from LIB leachate,is *** process encompasses six key steps,including pretreatment,leaching,purification,adjustment of metal concentrations,precursor synthesis,and *** review also investigates the potential introduction of impurity elements during CAM resynthesis and provides tolerance levels for these impurities based on thorough reference ***,it addresses challenges related to the commercialization of the resynthesis ***,this review represents the first comprehensive assessment of CAM resynthesis,including the systematic evaluation of 12 impurity elements(Fe,Li,Al,Cu,C,P,F,Na,Cl,S,Mg,and Zn).Overall,this comprehensive review is poised to support the commercial development of resynthesized CAMs by offering valuable guidelines for managing impurities and streamlining the purification process.

关键词： Li-ion battery Recycling Resynthesis Leachate Impurity

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Analysis of the Effect of Space Radiations on the Nematode, <i>Caenorhabditis elegans </i>, through the Simulated Space Radiation

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International Journal of Astronomy and Astrophysics 2013年第3期3卷 291-302页

作者： soyeon Yi soyeon kim Jeeyeon Song Korea Advanced Institute of Science and Technology Daejeon Republic of Korea Korea Aerospace Research Institute (KARI) Daejeon Republic of Korea

In this study, we simulated space flight of the nematode, Caenorhabditis elegans, on the ground and examined how it is affected by space radiation and G-forces. We simulated G-forces during launch in a gravity acceleration laboratory device in order to identify and isolate the effects of the G-forces. Following this, we irradiated C. elegans with accelerated protons (MC-50 Cyclotron) and gamma rays (iR 222 machine) at the same physical dose. We calculated the expected radiation dose according to Reitz [1] and simulation programs (NASA AP8MIN [2], NASA AE8MAX [2], and CREAM86 [3]) for 1 month (dose rate: 6 × 10-3 Gy;2.8 × 10-2 Gy), 6 months (dose rate: 36 × 10-3 Gy;16.8 × 10-2 Gy), and 2 years (dose rate: 144 × 10-3 Gy;67.2 × 10-2 Gy) of space flight. There have been several trials that aimed to take C. elegans into orbit on US space shuttle missions including a mission on the shuttle Columbia. In this study, we simulated longer duration space flights and performed a whole-genome microarray analysis to observe phenotype variations whereas most such experiments were carried out during short duration space flights and focused on mutations and genotypic variations. We expect that the results of this study will be useful to predict the effects of long-term exposure of space radiation on living organisms.

关键词： Astronaut International Space Station Space Experiment Space Radiation C. elegans Microarray

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LoRa Backscatter Network Efficient Data Transmission Using RF Source Range Control

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Computers, Materials & Continua 2023年第2期74卷 4015-4025页

作者： Dae-Young kim soyeon Lee Seokhoon kim Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea Department of Software Convergence Soonchunhyang UniversityAsan31538Korea

Networks based on backscatter communication provide wireless data transmission in the absence of a power source.A backscatter device receives a radio frequency(RF)source and creates a backscattered signal that delivers data;this enables new services in battery-less domains with massive Internet-of-Things(IoT)*** is highly energy-efficient in the context of massive IoT ***,long-range(LoRa)backscattering facilitates large IoT services.A backscatter network guarantees timeslot-and contention-based ***-based transmission ensures data transmission,but is not scalable to different numbers of transmission *** contention-based transmission is used,collisions are *** reduce collisions and increase transmission efficiency,the number of devices transmitting data must be *** control device activation,the RF source range can be modulated by adjusting the RF source power during LoRa *** reduces the number of transmitting devices,and thus collisions and retransmission,thereby improving transmission *** performed extensive simulations to evaluate the performance of our method.

关键词： Backscatter communication LoRa backscatter RF source range control activated device control internet of things

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Edge Cloud Selection in Mobile Edge Computing(MEC)-Aided Applications for Industrial Internet of Things(IIoT)Services

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Computer Systems Science & Engineering 2023年第11期47卷 2049-2060页

作者： Dae-Young kim soyeon Lee MinSeung kim Seokhoon kim Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea Department of Software Convergence Soonchunhyang UniversityAsan31538Korea

In many IIoT architectures,various devices connect to the edge cloud via gateway *** data processing,numerous data are delivered to the edge *** data to an appropriate edge cloud is critical to improve IIoT service *** are two types of costs for this kind of IoT network:a communication cost and a computing *** service efficiency,the communication cost of data transmission should be minimized,and the computing cost in the edge cloud should be also ***,in this paper,the communication cost for data transmission is defined as the delay factor,and the computing cost in the edge cloud is defined as the waiting time of the computing *** proposed method selects an edge cloud that minimizes the total cost of the communication and computing *** is,a device chooses a routing path to the selected edge cloud based on the *** proposed method controls the data flows in a mesh-structured network and appropriately distributes the data processing *** performance of the proposed method is validated through extensive computer *** the transition probability from good to bad is 0.3 and the transition probability from bad to good is 0.7 in wireless and edge cloud states,the proposed method reduced both the average delay and the service pause counts to about 25%of the existing method.

关键词： Industrial Internet of Things(IIoT)network IIoT service mobile edge computing(MEC) edge cloud selection MEC-aided application

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Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases

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BIOCELL 2022年第10期46卷 2231-2234页

作者： JU HYUNG LEE IL-KWON kim SANG WOO kim soyeon LIM SEAHYOUNG LEE KI-CHUL HWANG BYEONG-WOOK SONG Graduate Program of Biomedical Engineering Yonsei UniversitySeoul03722Korea Institute for Bio-Medical Convergence College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea Department for Medical Science College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea

The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets aretopics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative *** pre-transplantation through post-transplantation, there are many changes in the conditions, both inside andoutside of the stem cells that have not been carefully considered. This has hindered development in the field of celltherapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellularalterations of stem cells in transplanted areas at risk of neurodegenerative disease.

关键词： Cell therapy Microenvironment Neurodegenerative disease Stem cells

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