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Retinal circulation and its role in macular disorders in patients without systemic disease

International Journal of Ophthalmology(English edition) 2015年第3期8卷 585-589页

作者： Priyangshu Chandra Aditya Sudhalkar souvik mandal Jay Chhablani Smt.Kanuri Santhamma Retina Vitreous Centre L.V.Prasad Eye Institute Kallam Anji Reddy Campus L.V.Prasad Marg Banjara Hills Hyderabad Andhra Pradesh500034 India

AIM: To determine whether retinal circulatory changes play a role in the pathogenesis of macular disorders in patients who are otherwise healthy. METHODS: Patients with macular disorders that required angiographic imaging were included in this prospective case series. After a complete ocular exam,fluorescein angiography was performed using a standardized technique on the HRA-II(Heidelberg Engineering, Heidelberg, Germany) with special focus on the posterior pole. Only patients with good quality images were included in the analysis. Circulatory parameters recorded included the arm-choroid time,choroid-retinal artery, and finally the retinal artery-vein time. Zonal asymmetry(between the upper and lower zones divided by a line passing through the centre of the fovea) in transit times, if any was also noted. Appropriate statistical analysis was done. Circulation times were compared with age matched historical controls. Changes in retinal dye transit times relative to historical age matched controls, if any, were noted and compared between various ***: A total of 156 eyes of 156 patients(120 males)were included in the study. Mean age: 49.14 ±14.93 *** disorders studied were age related degeneration,polypoidal vasculopathy, central serous chorioretinopathy(CSCR) and parafoveal telangiectasia. Delayed circulation time was noted in CSCR patients ***: CSCR patients appear to have delayed arterial filling, retinal circulatory disturbances do not seem to contribute to the pathogenesis of other macular disorders.

关键词： fluorescein angiography circulation parafoveal telangiectasia idiopathic polypoidal choroidal vasculopathy age-related macular degeneration central serous chorioretinopathy

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Cellular interplay to 3D in vitro microphysiological disease model:cell patterning microbiota-gut-brain axis

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Bio-Design and Manufacturing 2024年第3期7卷 320-357页

作者： Kamare Alam Lakshmi Nair souvik Mukherjee Kulwinder Kaur Manjari Singh Santanu Kaity Velayutham Ravichandiran Sugato Banerjee Subhadeep Roy Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India Department of Pharmaceutical Sciences Assam UniversitySilchar 788011India Department of Pharmaceutical Sciences Guru Ghasidas UniversityKoniBilaspur 495009C.G.India School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublin D02 YN77Ireland Tissue Engineering Research Group Department of Anatomy and Regenerative MedicineRCSI University of Medicine and Health SciencesDublin D02 YN77Ireland Department of Pharmaceutics National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India Department of Natural Products National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India

The microbiota-gut-brain axis(MGBA)has emerged as a key prospect in the bidirectional communication between two major organ systems:the brain and the *** between the two organ systems allows the body to function without disease,whereas dysbiosis has long-standing evidence of etiopathological *** most common communication paths are the microbial release of metabolites,soluble neurotransmitters,and immune ***,each pathway is intertwined with a complex *** the emergence of in vitro models and the popularity of three-dimensional(3D)cultures and Transwells,engineering has become easier for the scientific understanding of neurodegenerative *** paper briefly retraces the possible communication pathways between the gut microbiome and the *** further elaborates on three major diseases:autism spectrum disorder,Parkinson’s disease,and Alzheimer’s disease,which are prevalent in children and the *** diseases also decrease patients’quality of ***,understanding them more deeply with respect to current advances in in vitro modeling is crucial for understanding the *** of MGBA in the laboratory uses many molecular technologies and biomaterial *** and organoids provide a more realistic picture of the cell and tissue structure than *** them with the Transwell system offers the advantage of compartmentalizing the two systems(apical and basal)while allowing physical and chemical cues between ***-edge technologies,such as bioprinting and microfluidic chips,might be the future of in vitro modeling,as they provide dynamicity.

关键词： Microbiota-gut-brain axis Neurodegeneration 3D disease model Organoid Transwell system

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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： souvik Kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar Bushra Khan Luis Gand Arnab Nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut Bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition:Harnessing the power of nanotheranostics

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 79-101页

作者： Sagnik Nag Oishi Mitra Bhanu Maturi Simran Preet Kaur Ankita Saini Muskan Nama Soumik Roy souvik Samanta Leena Chacko Rohan Dutta Suresh Babu Sayana Vetriselvan Subramaniyan Jasvinder Singh Bhatti Ramesh Kandimalla Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia Department of Bio-Sciences School of Bio-Sciences&Technology(SBST)Vellore Institute of Technology(VIT)Tiruvalam RoadVellore 632014Tamil NaduIndia Department of Internal Medicine University of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Delhi(South Campus)Benito Juarez RoadNew Delhi 110021India Department of Biotechnology Indian Institute of TechnologyHyderabad(IIT-H)SangareddyTelangana 502284India BioAnalytical Lab Meso Scale Discovery1601 Research BlvdRockvilleMDUSA Department of Pharmacology Government Medical CollegeSuryapetTelanganaIndia Laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathindaIndia Department of Biochemistry Kakatiya Medical CollegeWarangal 506007India

Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition(DHC),which encompasses a complex range of cardiovascular issues linked to diabetes and associated *** significant progress in reducing mortality rates from cardiovascular diseases(CVDs),heart failure remains a major cause of increased morbidity among diabetic *** cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components,and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and *** a variety of conventional diagnostic and therapeutic strategies are available,DHC continues to present a significant ***-of-care diagnostics,supported by nanobiosensing techniques,offer a promising alternative for these complex *** conventional medications have been widely used in DHC patients,they raise several concerns regarding various physiological *** medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DHC,offering a promising approach to deliver drugs beyond the limitations of traditional *** article aims to explore the potential connections between autophagy,mitophagy and DHC,while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.

关键词： Autophagy Diabetes Diabetic heart condition Mitophagy Nanotheranostics Nanomedicine

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Thermal maturity evaluation using Raman spectroscopy for oil shale samples of USA:comparisons with vitrinite reflectance and pyrolysis methods

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Petroleum Science 2020年第3期17卷 567-581页

作者： MdGolam Kibria souvik Das Qin-Hong Hu Asish R.Basu Wen-Xuan Hu Subhadip mandal Department of Earth and Environmental Sciences The University of Texas at Arlington500 Yates StreetArlingtonTX 76019USA Institute of Energy Sciences Nanjing UniversityNanjing 210093China Integrated Reservoir Solutions Core LaboratoriesHoustonTX 77040USA

Thermal maturity is commonly assessed by various geochemical screening methods(e.g.,pyrolysis and organic petrology).In this contribution,we attempt to establish an alternative approach to estimating thermal maturity with Raman spectroscopy,using 24 North American oil shale samples with thermal maturity data generated by vitrinite reflectance(VRo%)and pyrolysis(Tmax)-based maturity calculation(VRe%).The representative shale samples are from the Haynesville(East Texas),Woodford(West Texas),Eagle Ford and Pearsall(South Texas)Formations,as well as Gothic,Mancos,and Niobrara Formation shales(all from Colorado).The Raman spectra of disordered carbonaceous matter(D1 and G bands separation)of these samples were directly obtained from the rock chips without prior sample *** the Gaussian and Lorentzian distribution approach,thermal maturities from VR were correlated with carbon G and *** found that the Raman band separation(RBS)displayed a better correlation for equivalent VRe%than vitrinite reflectance VRo%.The RBS(D1–G)distance versus total organic carbon,free hydrocarbons from thermal extraction(S1),and the remaining hydrocarbon generating potential(S2)indicate that the RBS(D1–G)distance is also related to kerogen *** presented here from three methods of maturity determination of shale demonstrate that Raman spectroscopy is a quick and valid approach to thermal maturity assessment.

关键词： US shale Raman spectroscopy Vitrinite reflectance Thermal maturity

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Electric-field driven stability control of skyrmions in an ultrathin transition-metal film

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npj Computational Materials 2022年第1期8卷 992-1000页

作者： souvik Paul Stefan Heinze Peter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum Jülich and JARA52425JülichGermany Institute of Theoretical Physics and Astrophysics Christian-Albrechts-Universität zu KielLeibnizstrasse 1524098KielGermany

To realize future spintronic applications with magnetic skyrmions—topologically nontrivial swirling spin structures—it is essential to achieve efficient writing and deleting capabilities of these ***-field assisted nucleation and annihilation is a promising route,however,the understanding of the underlying microscopic mechanisms is still ***,we show how the stability of individual magnetic skyrmions in an ultrathin transition-metal film can be controlled via external electric *** demonstrate based on density functional theory that it is important to consider the changes of all interactions with electric field,i.e.,the pair-wise exchange,the Dzyaloshinskii–Moriya interaction,the magnetocrystalline anisotropy energy,and the higher-order exchange *** energy barriers for electric-field assisted skyrmion writing and deleting obtained via atomistic spin simulations vary by up to a factor of three more than the variations of the interactions calculated from *** surprising effect originates from the electric-field dependent size of metastable skyrmions at a fixed magnetic *** large changes in lifetimes allow the possibility of electric-field assisted thermally activated writing and deleting of skyrmions.

关键词： field stability film

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Sequence Stratigraphic Model of Middle Permian Barakar Formation from a Marginal Gondwana Basin, India

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Journal of Earth Science 2018年第4期29卷 745-754页

作者： Joyjit Dey souvik Sen Coal India Limited Central Mine Planning and Design Institute (CMPD1) Regional Institute-3 Jharkhand 829 103 India Geologix Limited Dynasty Building Level-4 Wing-A Andheri Kurla Road Andheri (E) Mumbai 400 059 India

Gondwana deposits are extensively found across the continents. Here we study the Mid- dle Permian Barakar Formation from the marginal Gondwana Basin, eastern India, being deposited in a normal fault setting. Availability of extensive cores as well as geophysical log suites （gammaresistivity-density from drilled wells） from the study area helped us achieving high resolution interpretation. Core study identifies fluvial sedimentary architectures, which were correlated with the geophysical logs and modeled field-wide to understand vertical and horizontal facies disposition. The facies analysis has been used to establish a sequence stratigraphic model of the cyclic Barakar deposition. Four major fining upward depositional sequences were identified, each sequence comprises of low accommodation system tract （LAST） at base and high accommodation system tract （HAST） at top. LAST is characterized by vertically stacked, multistory amalgamated channel sandstone dominated facies, while floodplain dominated facies characterizes HAST, reflecting a gradual shift from braided to meandering depositional system from bottom to top of each cycle. Study reveals depocenter to be in the western part, supported by eastward thinning of sediment packets, all being deposited in a halfgraben setting.

关键词： fluvial sequence stratigraphy Gondwana sediment Middle Permian Barakar Formation.

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From Mantle Transition Zone with Microstructures: A New Paradigm in Ophiolite Studies

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Acta Geologica Sinica(English Edition) 2020年第S1期94卷 53-54页

作者： souvik DAS Department of Earth and Environmental Sciences University of Texas at ArlingtonTX 76019USA

The SE Ladakh(India) area displays one of the best-preserved ophiolite sections in this planet, in places up to 10 km thick, along the southern bank of the Indus River. Recently, in situ ultra-high pressure(UHP) microstructural evidences from mantle transition zone(MTZ ~ 410–660 km) with diamond and reduced fluids were discovered from two peridotite bodies in the basal mantle part of this Indus ophiolite(Das et al., 2015;2017). Ultrahigh-pressure phases were also found by early workers from podiform chromitites of another equivalent Neo–Tethyan ophiolite in southern Tibet(e.g., Yang et al., 2007;Yamamoto et al., 2009). However, the MTZ phases in the Indus ophiolite are found in silicate peridotites not metallic chromitites and the peridotitic UHP phases show systematic and contiguous phase transitions from the MTZ to shallower depth, unlike the discrete ultrahighpressure inclusions, all in Tibetan chromitites. The gradual change in oxygen fugacity(fo2) and fluid composition from(C-H + H2) to(CO2 + H2O) in the upwelling peridotitic mantle causing melting to produce MORB. At shallow depths(< 100 km) the free water stabilizes into hydrous phases, such as amphiboles and serpentines, capable of storing water and prevent melting(Fig. 1). The results from Indus ophiolite provide unique insights into deep sub-oceanic mantle processes, and link deep mantle upwelling and MORB genesis(Fig. 1). The tectonic setting of Neo-Tethyan ophiolites has been a difficult problem since the birth of plate tectonics concept. This problem for the origin of ophiolites in mid-ocean ridge versus supra subduction-zone settings clearly confused the Geoscience community. However, Indian Ocean –type isotopic characteristics are present in Neo-Tethyan ophiolites(Zhang et al., 2005). Recently, continental materials(quartz, k-feldspar etc.) bearing old zircons(up to 2700 Ma) are also recovered from UHP chromitite of Tibetan ophiolite(Yamamoto et al., 2013). Eventually, the presence of older continenta

关键词： mantle transition zone Neo-Tethyan ophiolites diamond oxygen fugacity historical contingency

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First report on chlorophyllin to protect mammalian and fish muscle cells from pesticide toxicity via activation of p53 and PARP

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Aquaculture and Fisheries 2021年第4期6卷 393-399页

作者： Asmita Samadder Swatilekha Das Bakul Pal Sweta Das Anindita mandal Priyanka Biswas Sujoy Ghosh Shamim Hossain mandal Priyanka Sow Ruchira Das souvik Biswas Ashis Kumar Panigrahi Cytogenetics and Molecular Biology Laboratory Department of ZoologyUniversity of KalyaniKalyaniNadia741235India Cell and Developmental Biology Special Department of ZoologyUniversity of KalyaniKalyaniNadia741235India Department of Zoology Dum Dum Motijheel CollegeKolkata700074India Eco-Toxicology Fisheries and Aquaculture Extn.LaboratoryDepartment of ZoologyUniversity of KalyaniKalyaniNadia741235India

Objectives:Pesticide toxicity has become one of the major environmental menaces affecting all types of life forms of the *** get washed off from agricultural fields into nearby water bodies and enter the aquatic *** bio-accumulated form finally reaches the human race,through consumption of pesticide infested aquatic animals,causing several physiological *** it becomes necessary to find a therapeutic cure/a preventive measure to stop the health hazard issues of *** this projection a search for a phyto-based-product was made whose primary objective would be to lower the pesticidal toxicity in fish and simultaneously in the human ***:In this study we tried to check whether the phyto-chemical,Chlorophyllin(CHL),known for its anti-genotoxic,anti-oxidant activities,could render any kind of protection against Cypermethrin(CM)induced-toxicity in fish model and mammalian cell line *** the model L6 and fish were pre-treated with CHL prior to exposure of *** scientific parameters like%cellular cytotoxicity,reactive oxygen species(ROS)generation,nuclear condensation,etc were checked to validate the possibility of CHL in protecting CM-induced ***:The overall results revealed that pre-treatment with CHL could restrict the ROS generation leading to modulation in associated cytokine proteins expression NFkβand IFNγ.Further,CHL lowered nuclear condensation and elevated expression of DNA repair proteins p53 and PARP,showing a kind of pre-activation of signalling cascades for overall protection against the severity of pesticidal ***:Thus,this phyto-based preventive approach would possibly solve many areas of human health issues related to pesticide toxicity in future.

关键词： Cypermethrin Chlorophyllin Fish L6 cells DNA damage ROS generation

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Influence of land cover features on avian community and potential conservation priority areas for biodiversity at a Ramsar site in India

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Ecological Processes 2022年第1期11卷 345-359页

作者： souvik Barik Goutam Kumar Saha Subhendu Mazumdar Department of Zoology University of Calcutta35Ballygunge Circular RoadKolkata 700019India Department of Zoology Shibpur Dinobundhoo Institution(College)ShibpurHowrahIndia

Background:Wetlands provide diverse ecological services to sustain rich biodiversity,but they are recklessly exploited around the *** Kolkata Wetlands(EKW;Ramsar site No.1208,~125 km^(2))was once very rich in faunal diversity that declined over the years due to various anthropogenic *** such scenarios,effective management plans need to contemplate local and landscape level initiatives and prioritize areas for *** the foraging guild structure and spatial patterns of relationship between bird and its environment provides important insight of ecological processes of ***,we carried out extensive surveys in 142 point count stations to explore the diversity and foraging guild structure of birds in *** addressed two important questions that how bird diversity varied from the outer periphery of the city towards the wetlands and how bird diversity is influenced by land cover features at local and landscape level in wetland *** goal of this study was to prepare a spatial map of avian diversity and to find the conservation priority areas for birds in this internationally recognized wetland ***:We recorded 94 species of birds and the Shannon diversity index values ranged between 1.249 and *** found that the avian diversity increased with increasing distance from city *** and insectivores were the dominant foraging guilds,followed by carnivores,granivores,frugivores and *** Linear Models revealed that bird communities were positively influenced by areas of wetlands,dikes and banks,agricultural field and emergent vegetation,and negatively influenced by built-up *** the projected spatial map of species diversity,74.15 km^(2)area has high ***,we identified 12.82 km^(2) of top 10%conservation priority ***:Low bird diversity near city periphery is related to habitat degradation due to anthropogenic *** of omnivores and insectivores

关键词： Bird diversity Spatial mapping FRAGSTATS ZONATION Wetland management East Kolkata Wetlands

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