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Journal of Pharmaceutical Analysis 2022年第1期12卷 29-34页

作者： soupar.ika h.manjunath Rajesh K.Thimmulappa Department of Biochemistry Jagadguru Sri Shivarathreeshwara Medical CollegeJagadguru Sri Shivarathreeshwara Academy of Higher Education&Research(JSSAHER)Mysore570015India

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has caused a devastating health crisis *** this review,we have discussed that prophylactic phytochemical quercetin supplementation in the form of foods or nutraceuticals may help manage the COVID-19 *** following evidence supports our ***,nuclear factor erythroid-derived 2-like 2(NRF2)agonists abrogate replication of SARS-CoV-2 in lung cells,and quercetin is a potent NRF2 ***,quercetin exerts antiviral activity against several zoonotic coronaviruses,including SARS-CoV-2,mainly by inhibiting the entry of virions into host ***,inflammatory pathways activated by nuclear factor kappa B,inflammasome,and interleukin-6 signals elicit cytokine release syndrome that promotes acute respiratory distress syndrome in patients with COVID-19,and quercetin inhibits these pro-inflammatory ***,patients with COVID-19 develop thrombosis,and quercetin mitigates coagulation abnormalities by inhibiting plasma protein disulfide *** review provides a strong rationale for testing quercetin for the management of COVID-19.

关键词： COVID-19 Quercetin Immunomodulation Cytokine response syndrome NRF2 Antiviral

CFD simulation of single-phase flow in flotation cells:Effect of impeller blade shape,clearance,and Reynolds number

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International Journal of Mining Science and Technology 2019年第5期29卷 657-669页

作者： manjunath Basavarajappa Sanja Miskovic Department of Metallurgical Engineering University of UtahSalt Lake City 84112United States INEOS Pigments 6752 Baymeadow DriveGlen Burnie 21061United States Norman B.Keevil Institute of Mining Engineering The University of British ColumbiaBritish Columbia V6T 1Z4Canada

A series of numerical simulations of turbulent single-phase flows are performed to understand the flow and mixing characteristics in a laboratory scale flotation *** impeller blade shapes covering a wide range of surface areas and lip lengths are considered to highlight and contrast the flow behavior predicted in the impeller *** mean flow close to the impeller is fully characterized by considering velocity components along the axial direction at different radial *** results suggest the development of a comparatively stronger axial velocity component for a blade design with the smallest lip length,called big-tip impeller *** turbulent kinetic energy profiles close to the impeller reveal the existence of an asymmetric trailing vortex *** highest turbulence kinetic energy dissipation rates are observed close to the impeller blades and stator walls where the radial jet strikes the stator walls ***,liquid phase mixing in the flotation cell is studied using transient scalar tracing simulations providing mixing time ***,pumping capacity and efficiency of different impeller designs are calculated based on which the impeller blade design with a rectangular blade design is found to perform most efficiently.

关键词： Flotation Impeller blade design Turbulent flow Mixing Pumping efficiency

Effect of in-situ formed Al hydrates through long-term aging on enhanced particle destabilization by PACl coagulation

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Journal of Environmental Sciences 2020年第6期32卷 200-210页

作者： Jr Lin Lin Aldeno Rachmad ika Chun Chen Tseng Department of Environmental Engineering Chung Yuan Christian UniversityChinese Taipei

Aging of polyaluminum chloride(PACl) coagulants could significantly influence hydrolyzed Al speciation ruling coagulation *** goal of this study was to investigate Al species transformation through long-term aging and its impact on coagulation *** kinds of commercial coagulants(PACl-1 and PACl-2) were stored for in-situ aging tests in six months to evaluate Al species variation with time and the performance of coagulation with natural turbid *** results showed that CaSO4 precipitation easily occur in a commercial PACl coagulant with time as it contains SO4^2- and Ca^2+.It also activates the precipitation of gibbsite Al(Oh)3 in PACl with *** 180 days aging,both monomeric Al(Ala) and polymeric Al(Alb) substantially transform into colloidal Al(Alc) and precipitated for both PACl *** low turbidity(10 NTU),PACl-1 has a superior turbidity reduction rate than PACl-2,while PACl-2 performs a little better turbidity re duction at high turbidity(1000 NTU) regardless of aging *** aging time,an obvious decrease in turbidity reduction for PACl-1 coagulation is observed at low turbidity of 10 NTU,while the improvement in turbidity reduction for PACl-2 coagulation by enhanced sweep flocculation can be achieved as Alb mostly transform into Alc after 150 days *** is concluded that dominant in-situ formed Alc after a long time hydrolysis can improve PACl coagulation efficiency in turbidity reduction by enhanced sweep flocculation,especially for low turbidity water,but the increase in preformed Alc in PACl would worsen particle destabilization after aging.

关键词： Coagulation PACl Aging Al hydrates

Making Sense of hospital Project MisPerformance: Over Budget, Late, Time and Time Again—Why? And What Can Be Done About It?

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Engineering 2022年第5期8卷 183-201页

作者： Peter E.D.Love Lavagnon A.ika School of Civil and Mechanical Engineering Curtin UniversityPerthWA 6845Australia Telfer School of Management University of OttawaOttawaON KIN 6N5Canada

hospital projects worldwide often experience misperformance,showing a tendency to exceed their estimated cost,miss their deadline,suffer quality problems,and yield benefit *** this ubiquitous problem,this paper aims to make sense of this phenomenon by addressing the following research question:how can we make sense of hospital project misperformance,and what can be done to mitigate its occurrence?We use an illustrative case study approach and the analytical lens of sense-making to examine the misperformance of three mega-hospital *** research reveals issues such as scope changes,an inability to adapt and respond to risk and uncertainty,ineffectual project management and governance,and optimism bias,which combine to impact project performance *** suggest that the two prominent theoretical perspectives dominating the literature in this field fall short of adequately explaining hospital project *** provide suggestions for improving the procurement process of hospitals and submit there is a need to develop a robust and balanced theory of project misperformance.

关键词： Cost hospital Optimism bias Procurement Project management Performance Sense-making

Tropical pyomyositis presenting as sepsis with acute respiratory distress syndrome

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 325-327页

作者： Siddalingana Gouda TG h.manjunath hande Weena Stanley Ragini Bargur Department of Medicine Kasturba Medical College

Tropical pyomyositis is an underdiagnosed *** reported a 35 year old male farmer,who presented with septicemia and acute respiratory distress syndrome due to pyomyositis involving the paraspinal *** of the pus grew methicillin sensitive Staphylococcus aureus, and the patient recovered after surgical drainage and antibiotic treatment Diagnostic delays can be avoided if tropical pyomyositis is considered as a differential diagnosis in patients with septicemia.

关键词： Tropical pyomyositis Staphylococcus aureus Sepsis Acute respiratory distress syndrome

Rauvolfia serpentina-Mediated Green Synthesis of CuO Nanoparticles and Its Multidisciplinary Studies

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Acta Metallurgica Sinica(English Letters) 2015年第9期28卷 1134-1140页

作者： K.Lingaraju h.Raja Naika K.manjunath G.Nagaraju D.Suresh h.Nagabhushana Department of Studies and Research in Environmental Science Tumkur University Centre for Nano and Material Sciences Jain University Department of Chemsitry Siddaganga Institute of Technology Department of Studies and Research in Chemistry Tumkur University Prof. C.N.R. Rao Center for Advanced Materials Tumkur University

Copper oxide nanoparticles （CuO Nps） were successfully synthesized by solution combustion method using aqueous leaf extract of Rauvolfia serpentina as a fuel. The structure and morphology of the CuO nanoparticles （Nps） were characterized by powder X-ray diffraction （PXRD）, UV-visible spectroscopy （UV-visible）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, etc. The PXRD patterns reveal the formation of monoclinic phase with crystallite structure. SEM images indicate that the particles have sponge-like structure being highly porous and agglom- erated with large surface area. The average crystallite sizes were found to be in the range of 10-20 nm by Scherrer＇s method. The CuO Nps size was further confirmed by TEM. Further, CuO Nps exhibit good photocatalytic activity for the photodegradation of trypan blue dye, indicating that it acts as a promising semiconducting material. The antibacterial properties of CuO nanoparticles were investigated against pathogenic bacterial strains, namely Gram -ve Escherichia coli （NCIM-5051） and Pseudomonas desmolyticum （NCIM-2028） and Gram ＋ve bacteria Staphylococcus aureus （NCIM- 5022） using the agar well diffusion method.

关键词： CuO Nanoparticles Rauvolfia serpentina Photocatalytic activity Antibacterial activity

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Graphene-and Multi-Walled Carbon Nanotubes-Coated Tapered Plastic Optical Fiber for Detection of Lard Adulteration in Olive Oil

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Photonic Sensors 2022年第4期12卷 1-10页

作者： ika PUSPITA Ninik IRAWATI Kartika Anoraga MADURANI Fredy KURNIAWAN Sekartedjo KOENTJORO Agus Muhamad hATTA Department of Engineering Physics Faculty of Industrial Technology and System EngineeringInstitut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Physics National Taiwan UniversityTaipei 10617China Department of Chemistry Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh NopemberSurabaya 60111Indonesia

A rapid and high-performance sensor for lard adulterant in edible oil was developed using the tapered plastic optical fiber(POF)coated with graphene and multi-walled carbon *** coating material was deposited onto a tapered POF with a taper waist diameter and a taper length of 0.45 mm and 1 cm,*** addition of the coating material was used to increase the sensitivity and selectivity coefficient of the tapered POF toward the lard *** sensing mechanism is based on a simultaneous interaction of lard substance and an evanescent wave of tapered POF with the coating *** results showed that graphene coating on the tapered POF increased the selectivity coefficient of the tapered POF towards lard substance from 33.54 to 324.19,and it gave a sensitivity of 0.427 dBm/%.In comparison,multi-walled carbon nanotubes coating increased the selectivity coefficient to 71.65 and increased its sensitivity to 1.189 dBm/%.Thus,the proposed configuration of the tapered POF with the coating material offered a simple configuration for a rapid,high sensitivity and selectivity detection of lard adulterant in edible oils.

关键词： Lard adulteration tapered optical fiber sensor graphene carbon nanotubes food safety