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Biological characteristics and clinical management of uveal and conjunctival melanoma

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Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA KAŠTELAN ANA DIDOVIĆpaVIČIĆ DARIA paŠALIĆ TAMAra NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETra KOVAČEVIĆ SUZANA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia department of Ophthalmology Zadar General HospitalZadar23000Croatia department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen Simone Margaard Offersen Anders Brunse Mattia Pirolo soumya Kanti Kar Luca Guadabassi Thomas Thymann department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all Ppared to CON(Pparaclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

Overcoming fixation:Shaping BPS to fit into design practice

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Building Simulation 2024年第7期17卷 1037-1041页

作者： Pieter de Wilde Clarice Bleil de Souza Division of Energy and Building design Lund UniversitySweden Welsh School of Architecture Cardiff UniversityUK

Problem definition The use of Building Performance Simulation(BPS)to support building design has long been the‘holy grail’of building science *** can also be used during construction and operation of buildings,for instance supporting rating and certification,optimal control,or fault emulation,but design support is particularly interesting as this is where the foundations for future building performance are *** underlying premise is that good predictions of future building performance can inform and improve design decision-making,and thus help to create buildings that are more energy efficient,more comfortable,and overall perform better than buildings that are designed without such *** on BPS for design support has been carried out since the emergence of building science as a separate area of research in the 1960s(Markus et al.1972;Clarke 2001;Maver 2002;Augenbroe et al.2004).

关键词： supporting design instance

particle Size Optimization of Thermochemical Salt Hydrates for High Energy density Thermal Storage

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Energy & Environmental Materials 2024年第2期7卷 326-333页

作者： Andrew Martin Drew Lilley raνi Prasher Sumanjeet Kaur Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA department of Mechanical Engineering UC BerkeleyBerkeleyCA 94720USA

Thermal energy storage(TES)solutions offer opportunities to reduce energy consumption,greenhouse gas emissions,and ***,they can help reduce the peak load and address the intermittency of renewable energy sources by time shifting the load,which are critical toward zero energy *** materials(TCMs)as a class of TES undergo a solid-gas reversible chemical reaction with water vapor to store and release energy with high storage capacities(600 kWh m^(-3))and negligible self-discharge that makes them uniquely suited as compact,stand-alone units for daily or seasonal ***,TCMs suffer from instabilities at the material(salt particles)and reactor level(packed beds of salt),resulting in poor multi-cycle efficiency and high-levelized cost of *** this study,a model is developed to predict the pulverization limit or Rcrit of various salt hydrates during thermal *** is critical as it provides design rules to make mechanically stable TCM composites as well as enables the use of more energy-efficient manufacturing process(solid-state mixing)to make the *** model is experimentally validated on multiple TCM salt hydrates with different water content,and effect of Rcrit on hydration and dehydration kinetics is also investigated.

关键词： high energy density hydration kinetics long-term cycling thermal energy storage thermochemical materials

Photometric and Spectroscopic Study of Ten Low Mass ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium Line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.Wadhwa Adam Popowicz raúl Michel Petar Kostić Oliver Vince Nick F.H.Tothill Ain Y.de Horta Miroslav D.Filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

Low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available Large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

Interplay of RNA-binding proteins controls germ cell development in zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 889-899页

作者： de-Li Shi Laboratory of developmental Biology CNRS-UMR7622Institut de Biologie Paris-Seine(IBPS)Sorbonne University75005 ParisFrance

The specification of germ cells in zebrafish mostly relies on an inherited mechanism by which localized maternal determinants,called germ plasm,confer germline fate in the early *** studies have partially allowed the identification of key regulators governing germ plasm formation and subsequent germ cell ***-binding proteins,acting in concert with other germ plasm components,play essential roles in the organization of the germ plasm and the specification,migration,maintenance,and differentiation of primordial germ *** loss of their functions impairs germ cell formation and causes sterility or sexual *** is emerging that they instruct germline development through differential regulation of mRNA fates in somatic and germ ***,the challenge remains to decipher the complex interplay of maternal germ plasm components in germ plasm compartmentalization and germ cell *** failure to control the developmental outcome of germ cells disrupts the formation of gametes,it is important to gain a complete picture of regulatory mechanisms operating in the germ cell *** review sheds light on the contributions of RNA-binding proteins to germ cell development in zebrafish and highlights intriguing questions that remain open for future investigation.

关键词： Germplasm Primordialgerm cell Germlinestem cell Gametogenesis Zebrafish RNA-binding protein Posttranscriptional gene expression Translational activation and repression

高校竞技健美操运动员落地偏侧性和稳定性的生物力学研究

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中国运动医学杂志 2024年第4期43卷 266-274页

作者：王莉莉 Wan Ahmad Munsif Bin Wan pa 王宇轩李风雷颉梦宁许春莲马来西亚国立大学教育学院吉隆坡43600 东华理工大学体育学院南昌330032 南昌交通学院体育学院南昌330100

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和... 详细信息

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和动力学数据,比较优势侧和非优势侧的触地时刻关节角度、关节活动度(ROM)、地面反作用力(GRF)、负载率、压力中心(COP)位移和包络面积的差异,计算对称指数(代表偏侧性),并采用多元逐步回归方法分析指标偏侧性和COP包络面积的关系。结果:与非优势侧相比,优势侧在触地时刻具有更大的膝外旋和髋外展角(P<0.05),在落地过程中具有较大的踝屈伸、髋屈伸、髋内收-外展及较小的踝旋转ROM(P<0.05);优势侧的伸膝力矩峰值大于非优势侧(P<0.01);垂直方向负载率和伸膝力矩峰值的对称指数与COP包络面积呈显著正相关(P<0.05);垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以解释COP包络面积差异的83.6%。结论:竞技健美操运动员落地动作存在肢体间的偏侧性,垂直方向负载率和伸膝力矩峰值的偏侧性越大,则落地稳定性越差。此外,垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以作为落地稳定性的预测因子。

关键词：健美操落地生物力学偏侧性稳定性

Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de la Pinta radiation Oncology department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to december *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy pancreatic adenocarcinoma radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

ZnO/CeO_(2)/carbon xerogel composites with direct Z-scheme heterojunctions:Enhancing photocatalytic remediation of 4-chlorophenol under visible light

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Journal of rare Earths 2024年第2期42卷 314-322,I0003页

作者： Nicolas Perciani de Moraes Maite Birkett de Campos Sanmartin Robson da Silva Rocha Abner de Siervo Marcos Roberto de Vasconcelos Lanza D.Amaranatha Reddy Lianqing Yu Liana Alvares Rodrigues Escola de Engenharia de Lorena-EEL/USP Estrada Municipal do Campinho S/NCEP 12602-810LorenaSao PauloBrazil Institute of Physics"Gleb Wataghin" Applied Physics DepartmentState University of Campinas13083-859CampinasSPBrazi Instituto de Quimica de Sao Carlos Universidade de Sao PauloAv.Trab.Sao Carlense400-Parque Arnold SchimidtSao CarlosSP13566-590Spain department of Sciences Indian Institute of Information Technology Design and ManufacturingKurnoolAndhra Pradesh518007India School of Materials Science and Engineering China University of PetroleumQingdao266580China

This paper aims to create visible light driven ternary photocatalysts using zinc oxide(ZnO),cerium(IV)oxide(CeO_(2)),and carbon xerogel(CX) as constituent *** use of CeO_(2) is based on the creation of direct-Z-scheme heterojunctions with the ZnO and the consequent diminishing of charge recombination,whereas the carbon xerogel inclusion is predicted to minimize bandgap energy,decrease electro n-hole reco mbination,and boost specific surface *** re,the choice of the black-wattle tannin as a carbonaceous precursor was targeted at the development of an environmentally friendly and affordable *** existence of the hexagonal phase of zinc oxide and cubic structure of the cerium(IV) oxide in the ternary material was confirmed by X-ray diffractometry and X-ray photoelectron spectroscopy,with the latter also suggesting chemical bonding between the ZnO and the CX due to the creation of zinc oxycarbide *** inclusion of the carbon xerogel provokes a significant modification in the morphology of the ternary material,resulting in an increased surface area and smaller particle *** CX/ZnO-CeO_(2) ternary composite obtains the highest photocatalytic efficiency among all the materials studied,degrading 100% of 4-chlorophenol under simulated sunlight and 68% under visible radiation,after 5 *** increased photocatalytic activity can be attributed to the formation of direct Z-scheme heterojunctions between the semiconductors,higher visible light response,and higher specific surface area,as evidenced by the results obtained by active radical scavenging,chronoamperometry,diffuse reflectance spectroscopy,and N_(2) adsorption-desorption isotherms.

关键词： Zinc oxide Cerium(Ⅳ)oxide Carbon xerogel Photocatalysis Direct Z-scheme heterojunction 4-Chlorophenol rare earths