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Journal of the National Cancer Center 2023年第3期3卷 222-235页

作者： Tejas Girish Agnihotri sagar Salave Tanuja Shinde Induri Srikanth Vijay Gyanani Jeffrey C.Haley Aakanchha Jain Department of Pharmaceutics National Institute of Pharmaceutical Education and Research(NIPER)-AhmedabadPalajIndia Long Acting Drug Delivery Celanese CorporationIrvingUnited States

Glioblastoma is one of the most devastating central nervous system *** a highly vascular brain tumor,it is distinguished by aberrant vessel *** lends credence to the idea that endothelial cells(ECs)linked with glioblastoma vary fundamentally from ECs seen in the healthy human *** effectively design an antiangiogenic treatment,it is crucial to identify the functional and phenotypic characteristics of tumor-associated *** ECs associated with glioblastoma are less prone to apoptosis than control cells and are resistant to cytotoxic ***,ECs associated with glioblastoma migrate more quickly than control ECs and naturally produce large amounts of growth factors such as endothelin-1,interleukin-8,and vascular endothelial growth factor(VEGF).For designing innovative antiangiogenic drugs that particularly target tumor-related ECs in gliomas,it is critical to comprehend these distinctive features of ECs associated with *** review discusses the process of angiogenesis,other factors involved in the genesis of tumors,and the possibility of ECs as a potential target in combating *** also sheds light on the association of tumor microenvironment and ECs with *** review,thus gives us the hope that neuro endothelial targeting with growth factors and angiogenesis regulators combined with gene therapy would open up new doorways and change our traditional perspective of treating cancer.

关键词： Angiogenesis Gene therapy Growth factors Metastasis Neuro endothelial cells

ON FOETUSES WITH CEPHALIC MALFORMATIONS, DELIVERED IN THE PEIPING UNION MEDICAL COLLEGE HOSPITAL FROM JULY 1ST 1922—JAN. 1ST 1934

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Chinese Medical Journal 1935年第7期49卷 624-635+726-731页

作者： kha TI LIM M.D. Department of Obstetrics and Gynecology Peiping Union Medical College

Monstrosities though not common occur frequently enough, and so ignorance of the subject is unwise. There are numerous theories of etiology; but they still remain as theories. Besides the main malformation there are usually other minor associated malformations. Like many other instances in obstetrical work, monstrosities are apt to occur in groups. Hydramnios is a frequent but not a constant associated factor with a monstrosity, and has to be differentiated from a multiple pregnancy. The fate of the child is negligible as shown by the high fetal mortality. Early prenatal diagnosis becomes very important as it not only means relieving the mother from wasting time, energy, and bearing unnecessary suffering, in order to carry an unfruitful pregnancy to term; but it also saves submitting the mother to the danger of dystocia with all its complications. Therefore, whenever the clinical symptoms and signs are suggestive of an abnormal pregnancy, such as hydramnios towards the second half of gestation, inability to palpate the fetal head, indistinct fetal heart, and excessive fetal movements, an X-ray should be taken. Any gestation beyond 4 months should allow of a satisfactory result and should it prove to be a monster, labour should be induced at once, perhaps best of all by puncture of the, membranes. That prevention is better than cure is just as true here as elsewhere.

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Effectiveness of a novel, fixed dose combination of netupitant and palonosetron in prevention of chemotherapy induced nausea and vomiting: A real-life study from India

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World Journal of Clinical Oncology 2020年第8期11卷 606-613页

作者： Bharat Vaswani sagar Bhagat Saiprasad Patil Hanmant Barkate Medical Oncology Yashoda Cancer InstituteSecunderabad 500003India Medical Services Glenmark Pharmaceutical limitedMumbai 400099India

BACKGROUND A new,oral fixed dose combination of highly selective neurokinin-1 receptor antagonist,netupitant with 5HT3 receptor antagonist,netupitant and palonosetron(NEPA)was approved in India for prevention of chemotherapy induced nausea and vomiting(CINV).AIM To assess effectiveness of NEPA in real-world *** We retrospectively assessed the medical records and patient dairies of adult patients who received highly emetogenic or moderately emetogenic chemotherapy(HEC/MEC)and treated with NEPA(Netupitant 300 mg+Palanosetron 0.50 mg)for prevention of *** response(CR)was defined as no emesis or no requirement of rescue medication in overall phase(0 to 5 d),acute phase(0-24 h)and delayed phase(2 to 5 d).RESULTS In 403 patients included in the analysis,mean age was 56.24±11.11 years and 55.09%were *** cancer(25.06%)was most common malignancy *** and MEC were administered in 54.6%and 45.4%patients *** in overall phase was 93.79%whereas it was 98.01%in acute CINV and 93.79%in delayed *** CR in HEC and MEC groups was 93.63%and 93.98%*** was more than 90%in different chemotherapy cycles except in group of patients of cycle 4 where CR was 88.88%.CONCLUSION NEPA is a novel combination that is effective in preventing CINV in up to 93%cases treated with highly emetogenic or moderately emetogenic *** study brings the first real-life evidence of its effectiveness in India population.

关键词： Chemotherapy induced nausea vomiting Netupitant Palonosetron Cancer Chemotherapy

Physico-chemical properties of wild edible fruit Meyna laxifora Robyns(Alu):production of Alu fruit powder by using drying aid

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Journal of Future Foods 2024年第4期4卷 353-360页

作者： Rohini Vijay Dhenge Arjun Mohanakumar Suhel Bhendawade Prashant Chavhan sagar Deshpande Pooja Lade Abhijeet Gatade Akshaya kumar Sahoo Deparment of Food and Dnug.University of Parma Parma 43124.Italy Deparoment of Food Science and Technolog Shivaji UniversityKolhapurMaharashtra 416004.India

The study focuses on the physico-chemical characteritics of the wild fruit Meyna laxiflora Robyns(Alu)and fruit powder,which was gathered from the Konkan region of Maharashtra Alu fruit powder is made by using a drying aid called maltodextrin(MD).Powder samples(MP1,MP2,MP3,MP4 and MP5)were made using different amounts of MD(05,10,15,2.0 and 2.5 g).Preliminary phytochemical screening of fnuit pulp and powder showed the presence of some phytoconstituents such as reducing sugar,saponin,flavonoids,and terpenoids,whereas akaloids,tannins,steroids and protein were absent in *** parameters of the powder are durectly infuenced by the amount of MD,as evidenced by the variations in bulk density,total soluble solids,pH,specific gravity and the proximate among the powder *** solubility was found in the sample with a medium of *** highest of particle distribution was found in MD-added samples MP2(1 g),MP3(1.5 g),MP4(2 g)whereas the raw(MPO)showed the *** analysis was done using 9-point hedonic scale,which revealed that MP2,MP3,and MP4 were highly *** study assumed that fresh Alu fuit,palp and in the form of powder can be useful for the development of new products.

关键词： Meyna laxiflora Robyns Maltodextrin Solubility Particle size distribution Sensory analysis

Autologous Stem Cell Therapy for Cerebral Palsy

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Open Journal of Pediatrics 2020年第1期10卷 36-64页

作者： sagar Jawale Vijay Bhaskar Veeresh Nandikolmath Shreedhar Patil Jawale Institute of Pediatric Surgery Jalgaon Maharashtra India

Introduction: We describe treatment of Cerebral Palsy with adult stem cells derived from bone marrow and fat of the same patient. Adult stem cells are of two types, the mesenchymal and haemopoietic stem cells which have potential to duplicate, indefinitely produce 50 types of growth factors that repair and regenerate tissues in an epigenetic manner. Every organ has its own stem cells, for example kidney stem cells, liver stem cells, etc. When specialized cells in an organ get damaged, the local stem cells come forward and get differentiated into specialized cells and the tissue damage is replenished. But when the stock of this reserve of local stem cell is over, the organ starts failing. In autologous stem cell therapy, we harvest stem cells from other healthy organs like fat and bone marrow which have abundant stem cells and put them into the diseased organ. Adult stem cells differentiate into neurons in vitro when added with nerve growth factor which is present in every nerve tissue. Our stem cell research was done by following all the guidelines set at national and international level. In India the incidence of cerebral palsy is around 5/1000 live births. In cerebral Palsy the upper motor neuron is weak, hence the lower motor neuron becomes hyper active leading to spasticity. The treatment involves mainly physiotherapy and prognosis is poor. Physiotherapy is a palliation and does not repair damage in the brain. The conventional therapy has failed to give any satisfactory results in these children hence something new needs to be done. Materials and Methods: In last 2 years we did stem cell therapy for 21 cases of CP in our center with age of 9 months to 17 years. Out of 21 cases of CP, 7 (33.3%) cases had quadriplegia, 6 (28.57%) paraplegia and 1 (4.76%) monoplegia, 2 (9%) hypotonic, 5 (23.8%) hemiplegia, 4 (19.04%) with mental retardation and 3 (14.28) had features of ADHD and Autism. 18 patients had squint in the eyes, 8 patients had food regurgitation and drool

关键词： Stem Cell Therapy for Cerebral Palsy Autologous Stem Cell Therapy for Cerebral Palsy Stem Cell Treatment for CP

Growth differentiation factor 15 as an emerging novel biomarker in SARS-CoV-2 infection

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World Journal of Methodology 2022年第5期12卷 438-447页

作者： Deepak Parchwani sagar Dholariya CDS Katoch Ragini Singh Department of Biochemistry All India Institute of Medical SciencesRajkot 360001GujaratIndia Department of Pulmonary Medicine All India Institute of Medical SciencesRajkot 360001GujaratIndia

BACKGROUND Growth differentiation factor(GDF)-15 is a member of a transforming growth factor-βcytokine superfamily that regulates metabolism and is released in response to inflammation,hypoxia and tissue *** has evolved as one of the most potent cytokines for predicting the severity of infections and inflammatory conditions,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To investigate the utility of GDF-15 in predicting the severity of SARS-CoV-2 *** PubMed,Reference Citation Analysis,CNKI,and Goggle Scholar were explored by using related MeSH keywords and data such as the first author’s name,study duration,type and place of study,sample size and subgroups of participants if any,serum/plasma GDF-15 level in pg/mL,area under the curve and cut-off value in receiver operating characteristic analysis,method of measurement of GDF-15,and the main conclusion were *** In all studies,the baseline GDF-15 level was elevated in SARS-CoV-2-infected patients,and it was significantly associated with severity,hypoxemia,viral load,and worse clinical *** addition,GDF-15 levels were correlated with C-reactive protein,D-dimer,ferritin and procalcitonin,and it had superior discriminatory ability to detect severity and in-hospital mortality of SARS-CoV-2 ***,GDF-15 might be used to predict the severity and prognosis of hospitalized patients with *** Serial estimation of GDF-15 levels in hospitalized patients with SARS-CoV-2 infection appeared to have useful prognostic value and GDF-15 can be considered a clinically prominent sepsis biomarker for SARS-CoV-2 infection.

关键词： SARS-CoV-2 Growth differentiation factor 15 Biomarker Risk-stratification Prognosis

Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita Panda Subhasis Karmakar Manaswini Dash Swagat Kumar Tripathy Priya Das sagar Banerjee Yiping Qi Sanghamitra Samantaray Pradipta Kumar Mohapatra Mirza J.Baig Kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

Application of convolutional neural networks for computer-aided detection and diagnosis in gastrointestinal pathology: A simplified exposition for an endoscopist

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Artificial Intelligence in Gastrointestinal Endoscopy 2020年第1期1卷 1-5页

作者： Yirupaiahgari KS Viswanath sagar Vaze Richie Bird Department of Upper GI Laparoscopic and Endoscopic Unit James Cook University HospitalCleveland TS43BWUnited Kingdom University of Oxford Oxford OX12JDUnited Kingdom Data Science King's CollegeLondon E140STUnited Kingdom

The application of artificial intelligence(AI),especially machine learning or deep learning(DL),is advancing at a rapid *** need for increased accuracy at endoscopic visualisation of the gastrointestinal(GI)tract is also *** neural networks(CNNs)are one such model of DL,which have been used for endoscopic image analysis,whereby computer-aided detection and diagnosis of GI pathology can be carried out with increased *** this article,we briefly focus on the framework of the utilisation of CNNs in GI endoscopy along with a short review of a few published AI-based articles in the last 4 years.

关键词： Convolutional neural network Gastrointestinal endoscopy Artificial intelligence Deep learning Machine learning

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试论越南芹苴市丐冷水上市场旅游品牌的打造

试论越南芹苴市丐冷水上市场旅游品牌的打造

作者：陈可薇（TRAN kha VY）广西师范大学

学位级别：硕士

芹苴市拥有许多发展旅游业的条件,例如自然资源和人力资源。尽管近年来芹苴市旅游业和服务业取得了长足进步,但仍与其潜力不相称。尤其是丐冷水上市场的旅游。随着旅游业的发展,芹苴市丐冷水上市场已成为吸引国内外游客参观和了解越南... 详细信息

芹苴市拥有许多发展旅游业的条件,例如自然资源和人力资源。尽管近年来芹苴市旅游业和服务业取得了长足进步,但仍与其潜力不相称。尤其是丐冷水上市场的旅游。随着旅游业的发展,芹苴市丐冷水上市场已成为吸引国内外游客参观和了解越南南部河流居民典型活动的吸引人的目的地。但是,近年来,许多旅行和私人服务公司如雨后春笋般涌现,但它们专注于利润,而不追求服务质量的提高。他们不了解需求,片面追求数量,从而失去了信任,对国民经济造成破坏。水卫生状况更为严重,水上市场垃圾的卫生处理是一个迫切需要解决的问题。水上市场旅游被视为芹苴市旅游的亮点,但仍然存在许多影响游客感受的局限性。例如:卫生状况问题、运输工具的安全水平低、服务水平不高、组织管理工作薄弱等等。此外,一个同样重要的问题是如何利用现有的潜力,维持和促进充满河流文明特色的文化活动,数百年没有让它消失并被“商业化”。为了使芹苴市不失去游客,芹苴市旅游业,特别是丐冷水上市场旅游业,都需要制定战略解决方案,以提高服务质量,并更好地满足游客的需求。为了解决这些问题,芹苴市需要发展自己的旅游业模式——水上旅游业,并需要正确的方向来有效利用现有的旅游资源。因此,本文将分析旅游开发的现状以及影响旅游质量和游客满意度的因素,并在此基础上提出越南芹苴市丐冷水上市场旅游品牌打造的对策。本文的研究对象是芹苴市丐冷水上市场,一共分为七个部分。第一部分是绪论,介绍了选题的研究背景和研究目的及意义,对中国和越南相关研究进行了综述。介绍了研究方法,对丐冷水上市场提出相关的概念和理论。第一章是芹苴市的自然地理、旅游资源和旅游业的基本情况。本章主要收集和整理有关材料。第二章是丐冷水上市场及其旅游概况,主要是介绍丐冷水上市场形成的历史和丐冷水上市场主要旅游景点和游览路线。第三章是丐冷水上市场旅游发展取得的成就,主要是论述丐冷水上市场旅游发展取得了一些成就,例如为当地人创造了就业机会和收入、交通系统得到发展、旅游项目对游客富有吸引力等等。第四章是丐冷水上市场旅游发展存在的问题,例如环境污染问题、交通安全问题、水陆旅游线路联动的不足等等。第五章是提出芹苴市丐冷水上市场旅游品牌打造的建议,包括打造丐冷水上市场的特色旅游项目、加强旅游队伍的建设和管理、开发多样化旅游产品、鼓励当地社区参与旅游活动、打造特色旅游节庆品牌等等,最后是总结。本文使用文献调查分析方法和实地调查分析法,以探索构成旅游服务质量的因素,从而找到对丐冷水上市场旅游服务质量影响最大的因素以及游客对游览的满意度。此外,本文还设立了优先顺序,以提高服务质量、旅游者的满意度。本文为有兴趣研究旅游业发展问题的人士提供参考,并为芹苴市丐冷水上市场管理办公室和相关部门提供参考,为保护和开发丐冷水上市场文化旅游服务。

关键词：丐冷水上市场旅游品牌打造对策

Prophylactic role of Premna herbacea,a dietary leafy vegetable in managing hepatic steatosis via regulating AMPK/SREBP1/ACC/HMGCR signaling pathway

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Food Bioscience 2022年第4期48卷 53-62页

作者： Simanta Bharadwaj Shalini Gurumayum Devi Pranamika Sarma Barsha Deka sagar Ramrao Barge Bhaswati Kashyap Yunus Sheikh Prasenjit Manna Jagat C.Borah Narayan Chandra Talukdar Chemical Biology Lab 1 Institute of Advanced Study in Science and Technology(IASST)Paschim BoragaonGuwahati781035AssamIndia Molecular Biology and Biotechnology(MBBT)Department Cotton UniversityGuwahati781001AssamIndia Assam Downtown University PanikhaitiAssam781068India Biological Science and Technology Division CSIR-North East Institute of Science and Technology(CSIR-NEIST)Jorhat785006AssamIndia

Non-alcoholic fatty liver disease(NAFLD)includes a broad spectrum of liver dysfunction ranging from hepatic steatosis(intracellular triglyceride accumulation)to *** study investigated the beneficial effect of Premna herbacea(a dietary leafy vegetable of North East India)and its active constituent in managing hepatic steatosis using high fat diet(HFD)-fed male Wistar rat and hepatocyte(CC1)cell culture *** with methanolic leaf extract of Premna herbacea(PHME)(250 mg/kg body weight,oral gavage,20 weeks)reduced the gain in body weight and rise in serum lipid(triglyceride and total cholesterol)levels and enzymes(alkaline phosphatase and aspartate aminotransferase)responsible for liver dysfunction in high fat diet(HFD)-fed *** administration further upregulated the phosphorylation of AMPK,ACC,and HMGCR,downregulated SREBP1 signaling pathways of lipid metabolism,and prevented hepatic steatosis in liver tissues of HFD-fed ***,studies on cultured hepatocytes revealed that treatment with both crude extract and its ethyl acetate fraction(PHEA)significantly reduced intracellular lipid accumulation in palmitate(PA,0.75 mM)-treated *** profiling(HPLC,HRMS,^(1)H and^(13)C NMR)of PHEA demonstrated the presence of Verbascoside,a caffeoyl phenylethanoid glycoside as a major phyto-constituent,which prevented cellular lipid accumulation and regulated the alteration in AMPK/SREBP/ACC/HMGCR signaling pathways of lipid metabolism in PA-treated *** conclusion,this study showed the prophylactic role of Premna herbacea and its active molecule,Verbascoside as a potential functional food in ameliorating hepatic steatosis by regulating AMPK/SREBP/ACC/HMGCR signaling cascade.

关键词： Intracellular lipid accumulation Hepatic steatosis Premna herbacea Dietary leafy vegetable of North East India Verbascoside AMPK/SREBP/PPARαsignaling pathways Hepato-protection