检索结果-南通市图书馆

Chinese Chemical Letters 2024年第9期35卷 1-3页

作者： Xinghui Yao Zhouyu Wang da-Gang Yu Department of Chemistry Xihua UniversityChengdu 610039China Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China

Chiral compounds play a crucial role in the development of pharmaceuticals,pesticides,fragrances,and materials due to their unique stereochemical *** catalysis,which employs chiral catalysts to favor the production of one enantiomer over its mirror image,has emerged as a pivotal technique in the synthesis of chiral compounds[1].however,traditional asymmetric methods sometimes rely on environmentally harmful reducing or oxidizing agents,presenting a considerable challenge in the pursuit of green chemistry.

关键词： chiral oxidative catalyzed

A Review on nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第2期40卷 202-212页

作者： CAO Mengyu XING Xiner ShEN Xiaotong OUYANG Jin na na Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875P.R.China Department of Chemistry College of Arts and SciencesBeijing Normal University at ZhuhaiZhuhai519087P.R.China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430074P.R.China

Cancer is a leading cause of death worldwide,and a series of strategies has been reported for tumor-specific ***,chemodynamic therapy(CDT)has become a research hotspot for antitumor treatment due to its advantages of high specificity,endogenous stimulation,and high ***,the therapeutic effects of CDT are normally limited in the complex tumor microenvironment(TME),such as insufficient acidity,tumor hypoxia,low hydrogen peroxide(h2O2),and high glutathione(GSh).Consequently,different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions,which provided more opportunities to improve the efficiency of *** review focuses on nanomaterial-based strategies for enhancing CDT through manipulating *** CDT enhancements,this review would provide a reference for the future development of efficient CDT nanomaterials.

关键词： Chemodynamic therapy Tumor microenvironment nanomaterial Manipulating strategy Fenton/Fenton-like reaction

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-ha Jeong Jarno hiemstra Patrick V.Blokzijl Rebeca damian-Ferrara danilo Martins dos Santos Jéssica h.L.da Fonseca Min-ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands nanotechnology national Laboratory for Agriculture(LNna) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

DLX3(Q178R)mutation delays osteogenic differentiation via h19/miR-29c-3p/KDM5B axis in TDO-iPSCs-derived MSCs

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 49-52页

作者： Liying Dong na Zhao Dongmei Wang Meng Wang Yixin Zhang Liangjie Sun Chong Ding Yixiang Wang Zeyun Ma Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China national Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of StomatologyBeijing 100081China Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of StomatologyBeijing 100081China The Second Clinical Division Peking University School and Hospital of StomatologyBeijing 100081China Department of VIP Service Peking University School and Hospital of StomatologyBeijing 100081China Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental MedicineBostonMA 02115USA Department of Prosthodontics Fudan UniversityShanghai 200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological HospitalFudan UniversityShanghai 200001China

Tricho-dento-osseous(TDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DLX3)mutation.1,2 Accumulative bone density in alveolar bone is a clinically favorable phenotype for TDO ***... 详细信息

关键词： patients clinically alveolar

The Uptake and Distribution Evidence of nano-and Microplastics in vivo after a Single high Dose of Oral Exposure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： hONG Tao SUN Wei DENG Yuan LYU Jian da JIN Cui hong BAI Ying Long na Jun ZhaNG Rui GAO Yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain Management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(Phe 3μm group,the FI only increased in the lung at 2 h(Phe 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(Phe presence of nano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

Enhanced degradation of refractory organics in ORR-EO system with a blue TiO_(2)nanotube array modified Ti-based Ni-Sb co-doped SnO_(2)anode

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第8期35卷 391-395页

作者： Yifen he Chao Qu na Ren dawei Liang Department of Materials Chemistry School of Materials Science&EngineeringBeihang UniversityBeijing 102206China Department of Environmental Science Faculty of Environment&LifeBeijing University of TechnologyBeijing 100124China

Recently,a novel 2-electron oxygen reduction reaction(ORR)based electro-oxidation(EO)system was developed,which utilizes a h_(2)O_(2)generation cathode instead of h_(2)evolution cathode.A Ti-based Ni-Sb co-doped SnO_(2)(Ti/naTO)anode was selected for efficient degradation of refractory organics and O_(3)*** synergistic reaction of O3/h_(2)O_(2)further accelerated the generation of hydroxyl radicals(·Oh)in the ORR-EO ***,the catalytic activity and long-term effectiveness of the Ti/naTO anode limited the large-scale application of the ORR-EO *** this study,a blue TiO_(2)nanotube array(blue-TiO_(2)-NTA)inter-layer was introduced into the fabrication process between the Ti substrate and naTO catalyst *** to the Ti/naTO anode,the Ti/blue-TiO_(2)-NTA/naTO anode achieved higher efficiency of organic removal and O_(3)***,the accelerated lifetime of the Ti/blue-TiO_(2)-NTA/naTO anode was increased by 7 times compared to the Ti/naTO *** combined with CNTs-C/PTFE air cathode in ORR-EO system,all anodic oxidation and O_(3)/h_(2)O_(2)processes achieved higher•Oh *** 92%of TOC in leachate bio-effluent was effectively eliminated with a relatively low energy cost of 45 kWh/t.

关键词： Electro-oxidation Blue TiO_(2)nanotube array O_(3)/h_(2)O_(2)process Refractory organics Leachate bio-effluent

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 512-515页

作者： June-ha Shin hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第3期86卷 269-280页

作者： danping Wu Jiaying Zou Junyi Chen Yan Li na Ma Wei dai College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China College of Life Sciences Zhejiang Normal UniversityJinhua321004China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China

Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).however,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood *** this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward *** of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in *** the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different ph values was systematically *** nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred ***,the MSPC exhibited very low toxicity on hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.

关键词： Ornidazole Metronidazole Carbon spheres Sustained-release performance Biocompatibility

A Scalable Pillar Layered Metal-Organic Framework for natural Gas Purification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第4期40卷 675-681页

作者： LU nan LAN Lan GAO Qiang LI na BU Xian-he School of Materials Science and Engineering Nankai UniversityTianjin300350P.R.China State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071P.R.China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212003P.R.China

One-step harvest of high-purity methane(Ch_(4))from ternary propane/ethane/methane(C_(3)h_(8)/C_(2)h_(6)/Ch_(4))mixtures remains a desirable yet challenging goal for natural gas ***,adsorbents either suffer from high capacity and selectivity,or are caught in a dilemma of scalable ***,we demonstrate a scalable pillar layered metal-organic framework Ni-MOF for highly efficient one-step Ch_(4)***-MOF exhibits high C_(2)h_(6)and C_(3)h_(8)uptakes of 83.3 and 86.1 cm^(3)/g at 298 K and 100 kPa and remarkable C_(2)h_(6)/Ch_(4)(50/50,volume ratio,21.5)and C_(3)h_(8)/Ch_(4)(50/50,volume ratio,212.0)***,high C_(2)h_(6)(42.2 cm^(3)/g at 10 kPa)and C_(3)h_(8)(64.7 cm^(3)/g at 5 kPa)capacities in the low-pressure region at 298 K were realized on Ni-MOF,suggesting the strong affinities of Ni-MOF towards C_(2)h_(6)and C_(3)h_(8).Furthermore,the dynamic breakthrough experiments revealed that purifying Ch_(4)from natural gas in one-step can be achieved in Ni-MOF with high-purity(>99.8%)and productivity(346.0 cm^(3)/g).Most significantly,the production of Ni-MOF can be scalably synthesized at room temperature,rendering it promising potential for industrial *** combined advantages of exceptional separation performance,scalability,and cycle stability of Ni-MOF pave the way for one-step Ch_(4)purification from natural gas.

关键词： Metal-organic framework Adsorption and separation natural gas purification Scale-up synthesis

An unexpected approach to enhance specific surface area and mesopore amount of polyaniline by Zn doping

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4585-4594页

作者： Zhi-da Zhu Yu-Zhe han Xiao-Bi Jing School of Mechanical Engineering Yangzhou University School of Chemistry and Chemical Engineering Yangzhou University

Poly-p-anisidine could be easily fabricated via the oxidative polymerization reaction of p-anisidine using h2O2as the green oxidant. It was unexpectedly found that zinc doping could significantly improve the adsorption ability of the material versus heavy metals such as Pb, Cu,Pd, Ag and hg. Results of nitrogen adsorption–desorption experiments demonstrated that Zn doping could enhance the specific surface area and mesopore amount of the prepared material, which might facilitate its absorption to metals. This work not only provides a novel material for the treatment of heavy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synthesis, i.e. the Zn-doped poly-panisidine can be employed as the catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for the oxidative degradation reaction of phenol or Suzuki–Miyaura coupling reactions, respectively. It discloses a new strategy for fabricating the mesoporous polyaniline materials with profound application potential.

关键词： Adsorption Catalysis Porous materials Rare metal concentration Surfaces