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Can non-typeable Haemophilus influenzae carriage surveillance data infer antimicrobial resistance associated with otitis media?

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Pediatric Investigation 2023年第1期7卷 13-22页

作者： sophia Bowman-Derrick Tegan M.Harris Jemima Beissbarth Mariana Kleinecke Katrina Lawrence Teresa M.Wozniak Amy Bleakley Angela Rumaseb Michael J.Binks Robyn L.Marsh Peter S.Morris Amanda J.Leach Heidi Smith-Vaughan Menzies School of Health Research Charles Darwin UniversityDarwinAustralia Australian e-Health Research Centre CSIRO BrisbaneAustralia Royal Darwin Hospital DarwinAustralia

Importance:In remote communities of the Northern Territory,Australia,children experience high rates of otitis media(OM),commonly caused by non-typeable Haemophilus influenzae(NTHi).Few data exist on antibiotic susceptibility of NTHi from ***:To determine whether population-level nasopharyngeal NTHi antibiotic susceptibility data could inform antibiotic treatment for ***:NTHi isolates(n=92)collected from ear discharge between 2003 and 2013 were selected to time-and age-match NTHi isolates from the nasopharyngeal carriage(n=95).Antimicrobial susceptibility were *** trees and a genome-wide association study(GWAS)were performed to determine the similarity of nasopharyngeal and ear isolates at a population ***:Among 174 NTHi isolates available for antimicrobial susceptibility testing,10.3%(18/174)were resistant to ampicillin and 9.2%(16/174)were resistant to *** numbers of isolates(≤3)were resistant to tetracycline,chloramphenicol,or amoxicillin-clavulanic *** was no statistical difference in the proportion of ampicillin-resistant(P=0.11)or trimethoprim-sulfamethoxazole-resistant isolates(P=0.70)between ear discharge and nasopharynx-derived NTHi *** multi-drug resistant NTHi isolates were *** trees showed no clustering of 187 Haemophilus influenzae isolates based on anatomical niche(nasopharynx or ear discharge),and no genetic variations that distinguished NTHi derived from ear discharge and nasopharyngeal carriage were evident in the ***:In this population-level study,nasopharyngeal and ear discharge isolates did not represent distinct microbial *** results support tracking of population-level nasopharyngeal NTHi antibiotic resistance patterns to inform clinical management of OM in this population.

关键词： Haemophilus influenzae Otitis media Antimicrobial resistance

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A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong

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Virologica Sinica 2016年第1期31卷 41-48页

作者： Cyril C.Y.Yip Carol S.F.Lam hayes K.H.Luk emily Y.M.Wong Rodney A.Lee Lok-Yee So Kwok-Hung Chan Vincent C.C.Cheng Kwok-Yung Yuen Patrick C.Y.Woo Susanna K.P.Lau Department of Microbiology The University of Hong Kong Department of Microbiology Pamela Youde Nethersole Eastern Hospital Department of Paediatrics and Adolescent Medicine Pamela Youde Nethersole Eastern Hospital Research Centre of Infection and Immunology The University of Hong Kong State Key Laboratory of emerging Infectious Diseases The University of Hong Kong

We conducted a six-year epidemiological study on human coronaviruses（HCoVs） circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77（0.93%） of the samples by a pan-HCoV RT-PCR assay. The most frequently detected HCoV species was HCoV-OC43（0.58%）, followed by HCoV-229e（0.15%）,HCoV-HKU1（0.13%） and HCoV-NL63（0.07%）. HCoVs were detected throughout the study period（September 2008–August 2014）, with the highest detection rate from September 2010 to August2011（22/1500, 1.47%）. Different seasonal patterns of each HCoV species in Hong Kong were ***-OC43 was predominant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and summer. HCoV-229 e mainly occurred in winter and spring, while HCoV-NL63 was predominant in summer and autumn. HCoVs most commonly infect the elderly and young children, with median age of 79.5 years（range, 22 days to 95 years）.Intriguingly, the detection rate of HCoV-OC43 in the age group of ＆gt; 80 years（26/2380, 1.09%） was significantly higher than that in the age group of 0–10 years（12/2529, 0.47%）（P 〈 0.05）. These data provides new insight into the epidemiology of coronaviruses.

关键词： epidemiology human coronaviruses respiratory tract infections

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examination of Common Occupational Hazards among Healthcare Workers in a University Healthcare Center in Southeastern Nigeria

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Health 2022年第8期14卷 833-852页

作者： David Chinaecherem Innocent Chiagoziem Ogazirilem emerole Cosmas Nnadozie ezejindu Ugonma Winnie Dozie sophia Ifechidere Obani Anthony Chinonso Uwandu-Uzoma Chidozie Joachim Nwaokoro Mary Ulumma Udeh Stanley Chinedu eneh Angelica Chinecherem Uwaezuoke Keside Marizu Iwuji Samson Adiaetok Udoewah Promise Nwanyinma Uzowuihe Vivian Chidimma Maduekwe Department of Public Health Federal University of Technology Owerri Nigeria Department of Public Health Abia State University Uturu Nigeria Department of environmental Toxicology University of Port Harcourt Port Harcourt Nigeria Department of Nursing & Healthcare Leadership Faculty of Health Studies University of Bradford West Yorkshire UK Department of Community Health Obafemi Awolowo University Ile-Ife Nigeria Department of Medicine and Surgery University of Nigeria Nsukka Nigeria Department of environmental Management Federal University of Technology Owerri Owerri Nigeria Department of Prosthetics and Orthotics Federal University of Technology Owerri Owerri Nigeria

Background: Healthcare workers are challenged by an imposing group of occupational hazards. These hazards include exposure to biological and non-biological hazards like ionizing radiation, stress, injury, infectious agents, and chemicals. The aim of this study was to assess common occupational hazards among health workers at the Department of Health Services (DHS), Federal University of Technology, Owerri. Methods: A hospital-based cross-sectional study design was employed for the study, and a self-administered questionnaire was used for data collection. The SPSS Version 22.0 software was used for the analysis of the descriptive statistics obtained from the study. This study included both clinical and non-clinical health workers. A purposive sampling technique was used in recruiting a total of 94 respondents who participated in the study from September 2020 to April 2021. Results: A total of 94 respondents who participated in the study and among the participants, 33.3% (31) of the respondents were aged 31 - 40 years, and the majority of the health workers, 43.6% (41) had stayed between 1 - 5 years. Also, 92.6% (87) of the health workers have heard of occupational hazards. The study showed that 84.0% (79) of health workers had good knowledge of common occupational hazards. Biological hazards among health workers are 47.9% (45) cuts and wounds, 29.8% (28) direct contact with contaminated specimens/hazardous materials, and 26.6% (26) sharp related injuries, while for non-biological hazards, 44.7% (42) have slipped, tripped or fallen, and 35.1% (33) have been stressed. Common safety measures include 86.2% (81) washing their hands regularly;78.7% (74) using hand gloves;and 85.1% (80) agreeing they use face masks. Conclusion: Despite good knowledge of occupational hazards, participants at DHS were faced with certain hazards. It is recommended that the university, government, and policymakers revise and implement actions to provide health workers at DHS with equipment to e

关键词： Hazards Occupational Hazards Health Workers Knowledge Safety Risk

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双能量CT血管成像检测肺栓塞:碘图的附加益处

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国际医学放射学杂志 2019年第1期 109-109页

作者： e.K.Weidman A.J.Plodkowski D.F.Halpenny S.A.hayes R.P.Johnston J.Zheng 潘玉坤 Department of Radiology Memorial Sloan -Kettering Cancer Center Department of Radiology Memorial Sloan-Kettering Cancer Center

摘要目的研究使用双能量(De)CT碘图诊断肺栓塞(Pe)是否比常规CT血管成像有更多益处。材料与方法回顾性分析了2014年1月—9月在肿瘤转诊中心进行的

关键词：血管成像 Pe 肺栓塞 CT

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溶组织内阿米巴eLISA试剂盒在阿米巴病调查的应用

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中国热带医学 2006年第11期6卷 1931-1932页

作者：孙晓东 sophia Manue 张晓阳刘惠邓艳杨亚明汪丽波李春富郭晓芳张苍林云南省寄生虫病防治所云南思茅665000 英国伦敦卫生与热带病学院思茅市人民医院检验科云南思茅665000

目的了解景洪市爱尼族人群阿米巴病流行情况,为阿米巴病监测和防治提供依据,并评价eLISA试剂盒在阿米巴病调查应用的效果。方法以整群随机抽样爱尼族村寨,逐户收集新鲜粪便标本,用观察法、碘液涂片镜检法和TeCHLAB第二代溶组织内阿米巴e... 详细信息

目的了解景洪市爱尼族人群阿米巴病流行情况,为阿米巴病监测和防治提供依据,并评价eLISA试剂盒在阿米巴病调查应用的效果。方法以整群随机抽样爱尼族村寨,逐户收集新鲜粪便标本,用观察法、碘液涂片镜检法和TeCHLAB第二代溶组织内阿米巴eLISA试剂盒对照检测粪便标本溶内阿米巴。结果镜检278例,e·h/e·d感染为9·71%;eLISA检测366例,e·h感染率为9·29%;镜检和eLISA共同阳性15例,占镜检阳性的55·56%;粪便观察和eLISA检测结果诊断5例为肠阿米巴病,发病率为1·37%,e·h致病率为14·71%。结论景洪爱尼族阿米巴病流行严重,应加强阿米巴病的监测和防治工作,同时积极推广新技术。

关键词：阿米巴病爱尼族溶组织内阿米巴/迪斯帕内阿米巴溶组织内阿米巴 TeCHLAB第二代溶组织内阿米巴eUSA试剂盒

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Glycodelin对卵丘细胞血管内皮生长因子产生的影响

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 24-24页

作者： hayes e.C. Dominguez C.e. Voelkel S. A.A. Murphy 马艳华 emory Center for Reproductive Medicine and Fertility Division of Reproductive Endocrinology and Infertility Department of Gynecology and Obstetrics Atlanta GA United States Dr.

Glycodelin modulates vascular endothelial growth factor (VeGF) production in cumulus cells in vitro. Patients with normal gonadotropin responses who were undergoing IVF demonstrated increased VeGF production to glycod... 详细信息

关键词：卵丘细胞 Glycodelin 体外受精促性腺激素反应者

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Cell:研究揭示SIRT3在调节线粒体健康中的关键作用

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现代生物医学进展 2017年第6期17卷 I0004-I0004页

作者： Wen Yang Koji Nagasawa Christian Münch Yingjie Xu Kyle Satterstrom Seungmin Jeong Sebastian D. hayes Mark P. Jedrychowski F. Sejal Vyas elma Zaganjor Virginia Guarani Alison e. Ringel Steven P. Gygi J. Wade Harper Marcia C. Haigis Vascular Biology Program Boston Children’s Hospital Harvard Medical School Boston MA 02115 USA

就蛋白而言，去乙酰化酶（sirtuin）是令人喜欢的，而且因它们与衰老和年龄相关疾病相关联而受到人们的广泛关注。作为去乙酰化酶的来源，线粒体，也因在健康和疾病中的作用而闻名于世。来自美国哈佛医学院的Marcia Haigis和她的团队从... 详细信息

就蛋白而言，去乙酰化酶（sirtuin）是令人喜欢的，而且因它们与衰老和年龄相关疾病相关联而受到人们的广泛关注。作为去乙酰化酶的来源，线粒体，也因在健康和疾病中的作用而闻名于世。来自美国哈佛医学院的Marcia Haigis和她的团队从事基础研究。提出了一个较为深刻的问题：在细胞中。哪些蛋白与去乙酰化酶进行交谈？

关键词：线粒体 Cell 健康去乙酰化酶相关疾病基础研究医学院蛋白

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IT计划:停止还是继续?

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中国电子商务 2003年第5期 76-76页

作者： Frank hayes 徐丽萍

当我们都认为IT预算的钱袋开始松开时，又有传言说，那些人正在将钱袋控制的更紧。不久前．摩根斯坦利的首席经济学家Stephen Roach告诉他的顾客，他已经预言了在2003年将会出现一个世界范围内的经济衰退，而这主要是由美伊战争和现在... 详细信息

当我们都认为IT预算的钱袋开始松开时，又有传言说，那些人正在将钱袋控制的更紧。不久前．摩根斯坦利的首席经济学家Stephen Roach告诉他的顾客，他已经预言了在2003年将会出现一个世界范围内的经济衰退，而这主要是由美伊战争和现在快速蔓延的神秘病毒SARS引起的。

关键词： IT计划预算项目实施经济

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进食天然富含ω-3多不饱和脂肪酸食物后的ω-3指数和血压反应:一项随机对照试验

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中华高血压杂志 2021年第1期29卷 76-76页

作者：袁源(摘译) 练桂丽(审校) Stanton AV James K Brennan MM O’Donovan F Buskandar F Shortall K el-Sayed T Kennedy J hayes H Fahey AG Pender N Thom SAM Moran N Williams DJ Dolan e 不详

缺乏ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)的膳食很普遍。这种膳食近期被列为第六大膳食危险因素。缺乏PUFAs导致全球150万例死亡和330万伤残调整生命年。野生油性鱼的贮存量不足以供给全球人口,饲养鱼二十碳五烯酸... 详细信息

缺乏ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)的膳食很普遍。这种膳食近期被列为第六大膳食危险因素。缺乏PUFAs导致全球150万例死亡和330万伤残调整生命年。野生油性鱼的贮存量不足以供给全球人口,饲养鱼二十碳五烯酸和二十二碳六烯酸(docosahexaenoic acid,DHA)水平在过去20年减少过半。该研究报道一项双盲对照试验,其中161名正常血压的健康成年人随机分配食用富含ω-3PUFAs(或对照)的鸡肉至少3份/周,和食用富含ω-3PUFAs(或对照)的鸡蛋至少3份/周,持续6个月。

关键词：伤残调整生命年正常血压二十二碳六烯酸二十碳五烯酸健康成年人贮存量随机对照试验 PUFAs

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Upon the Delivery Properties of a Polymeric System Based on Poly(2-Hydroxyethyl Methacrylate) Prepared with Protective Colloids

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Journal of Biomaterials and Nanobiotechnology 2013年第4期4卷 357-364页

作者： Loredana e. Nita Aurica P. Chiriac Manuela Nistor Tatiana Budtova “Petru Poni” Institute of Macromolecular Chemistry Iasi Romania Centre de Mise en Forme des Matériaux Mines ParisTech UMR CNRS 7635 Sophia-Antipolis France.

A comparative study related to the preparation of poly(2-hydroxyethyl methacrylate) (pHeMA) through radical polymerization process in the presence of three different protective colloid substances, respectively poly(vinyl alcohol) (PVA), β-cyclodextrin, or poly(aspartic acid) (PAS), is presented. The dependence of the thermal behavior of the polymers as well as their morphological aspect, on the protective colloids used in synthesis was evidenced by polymers characterization. It is also demonstrated that the swelling capacity is dependent on the protective colloid variant present during the pHeMA preparation. This behavior induces as well interdependence on the ability to load bioactive compounds onto the polymeric matrices. The distribution of the indomethacin (INN), as model drug, into the pHeMA network was put into evidence by near infrared chemical imaging (NIR-CI), a non-destructive technique and with its correspondingly statistical analysis.

关键词： Biocompatible Polymers Polymer Network β Cyclodextrin Poly(Aspartic Acid)

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