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Association of fluoride exposure with disease burden and neurodevelopment outcomes in children in South Korea

World Journal of Pediatrics 2024年第10期20卷 1029-1042页

作者： Won Seok lee Ju Hee Kim Boeun Han Gi Chun lee Hye Ri Jung Ye Jin Shin Eun Kyo Ha Eun lee soonchul lee Man Yong Han Department of Pediatrics CHA Ilsan Medical CenterCHA University School of MedicineGoyangRepublic of Korea Department of Pediatrics Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea Department of Pediatrics CHA Bundang Medical CenterCHA University School of Medicine59 Yatap-RoBundang-GuSeongnam-siGyeonggi-do13496Republic of Korea Multi-Omics Research Center CHA Future Medicine Research InstituteSeongnamRepublic of Korea Department of Computer Science and Engineering Konkuk UniversitySeoulRepublic of Korea School of Medicine CHA UniversityPocheonRepublic of Korea Department of Pediatrics Hallym University Kangnam Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Pediatrics Chonnam National University HospitalChonnam National University Medical SchoolGwangjuRepublic of Korea Department of Orthopaedic Surgery CHA Bundang Medical CenterCHA University School of Medicine59 Yatap-RoBundang-GuSeongnam-siGyeonggi-do13496Republic of Korea

Background Community water fluoridation is an effective public health strategy for preventing dental caries,*** exist about potential health *** study explores associations between tap water fluoride levels and pediatric disease burden,as well as neurodevelopmental outcomes at 6 years of *** This nationwide population-based cohort study included children born in Korean cities with and without tap water fluoridation projects,between 2006 and 2012,aiming for a fluoride concentration of 0.8±0.2 mg/L in treated tap *** from the National Health Insurance Service were used,spanning from birth to *** relationship between exposure to fluoridated tap water and incidence of 16 childhood diseases that were previously identified as potentially linked to fluoride exposure were ***,we evaluated the neurodevelopmental outcomes across various domains,including gross motor,fine motor,cognition,language,social skills,and self-help *** assessments were performed using data from a comprehensive national health screening program for children aged six *** A fluoride-unexposed group included 22,881 children,whereas a fluoride-exposed group comprised 29,991 children(52%males).Children in the fluoride-exposed group had a decreased risk of dental caries and bone fractures[hazard ratio(95%confidence interval,CI),0.76(0.63–0.93)and 0.89(0.82–0.93),respectively]and increased risk of hepatic failures[1.85,(1.14–2.98)]compared to those in the unexposed ***,the risk ratio of abnormal neurodevelopmental screening outcomes increased by 9%,but this was statistically uncertain(95%CI,0.95–1.26).Conclusions Fluoridated tap water was associated with an increased risk of hepatic failure but a decreased risk of bone fractures in *** association between fluoridated tap water and neurodevelopmental screening outcomes at 6 years remains unclear,highlighting the need for further studies to clarify this associ

关键词： Children-Fluoride.Hepatic failure.Neurodevelopment

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Imperceptive and reusable dermal surface EMG for lower extremity neuro-prosthetic control and clinical assessment

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npj Flexible Electronics 2023年第1期7卷 48-58页

作者： Jaeu Park Jinwoong Jeong Minseok Kang Nagwade Pritish Youngjun Cho Jeongdae Ha Junwoo Yea Kyung-In Jang Hyojin Kim Jumin Hwang Byungchae Kim Sungjoon Min Hoijun Kim soonchul Kwon ChangSik John Pak HyunSuk Peter Suh Joon Pio Hong Sanghoon lee Department of Robotics and Mechatronics Engineering DGISTDaegu 42899Republic of Korea Department of Plastic and Reconstructive Surgery Asan Medical CenterSeoul 05505Republic of Korea Hugo Dynamics HUGOHwaseong-siGyeonggi-do 18468Republic of Korea Department of Smart Convergence Kwangwoon UniversitySeoul 01897Republic of Korea

Surface electromyography(sEMG)sensors play a critical role in diagnosing muscle conditions and enabling prosthetic device control,especially for lower extremity robotic ***,challenges arise when utilizing such sensors on residual limbs within a silicon liner worn by amputees,where dynamic pressure,narrow space,and perspiration can negatively affect sensor *** commercial sEMG sensors and newly developed sensors are unsuitable due to size and thickness,or susceptible to damage in this *** this paper,our sEMG sensors are tailored for amputees wearing sockets,prioritizing breathability,durability,and reliable recording *** employing porous PDMS and Silbione substrates,our design achieves exceptional permeability and adhesive *** serpentine electrode pattern and design are optimized to improve stretchability,durability,and effective contact area,resulting in a higher signal-to-noise ratio(SNR)than conventional ***,our proposed sensors wirelessly enable to control of a robotic leg for amputees,demonstrating its practical feasibility and expecting to drive forward neuro-prosthetic control in the clinical research field near future.

关键词： durability utilizing exceptional

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