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Incidence of venous thromboembolism and the role of D-dimer as predictive marker in patients with advanced gastric cancer receiving chemotherapy:A prospective study

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World Journal of Gastrointestinal Oncology 2017年第4期9卷 176-183页

作者： Kwonoh park Baek-Yeol Ryoo Min-Hee Ryu sook ryun park Myoung Joo Kang Jeong Hye Kim Seungbong Han Yoon-Koo Kang Medical Oncology and Hematology Department of Internal medicinePusan National University Yangsan Hos-pital Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Clinical Epidemiology and Biostatics Asan Medical CenterUniversity of Ulsan College of Medicine

To investigated the incidence and risk factors of venous thromboembolism (VTE) in patients with advanced gastric cancer (AGC) receiving chemotherapy. METHODSAll consecutive chemotherapy-naïve patients with AGC who would receive palliative chemotherapy between November 2009 and April 2012 in our hospital were recruited. Their pretreatment clinical and laboratory variables, including D-dimer, were recorded. The frequency of VTE development and survival rates during each chemotherapy cycle and regularly thereafter were assessed. RESULTSA total of 241 patients enrolled between November 2009 and April 2012 were analyzed. During a median follow-up duration of 10.8 mo (95%CI: 9.9-11.7), 27 patients developed VTE and the incidence of VTE was 17.5% (95%CI: 10.5-24.0, 12.0 events/100 person-years). The 6-mo and 1-year cumulative incidences were 7.8% (95%CI: 4.2%-11.4%) and 12.4% (95%CI: 7.3-17.2), respectively. Thirteen (48.1%) patients were symptomatic and the other 14 (51.9%) patients were asymptomatic. In multivariate analysis, pretreatment D-dimer level was the only marginally significant risk factor associated with VTE development (hazard ratio = 1.32; 95%CI: 1.00-1.75, P = 0.051). CONCLUSIONThe incidence of VTE is relatively high in patients with AGC receiving chemotherapy, and pretreatment D-dimer level might be a biomarker for risk stratification of VTE.

关键词： Advanced gastric cancer D-dimer Venous thromboembolism

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Gastric cancer patients at high-risk of having synchronous cancer

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World Journal of Gastroenterology 2006年第16期12卷 2588-2592页

作者： Jun Ho Lee Ja Seong Bae Keun Won Ryu Jong Seok Lee sook ryun park Chan Gyoo Kim Myoung Cheorl Kook Il Ju Choi Young Woo Kim Jae-Gahb park Jae-Moon Bae Research Institute & Hospital National Cancer Center809 Madul-dongIlsandong-guGoyang-siGyeonggi-do411-769Korea

AIM： To identify patients with a high-risk of having a synchronous cancer among gastric cancer patients. METHODS： We retrospectively analyzed the prospective gastric cancer database at the National Cancer Center, Korea from December 2000 to December 2004. The clinicopathological characteristics of patients with synchronous cancers and those of patients without synchronous cancers were compared. Multivariate analysis was performed to identify the risk factors for the presence of a synchronous cancer in gastric cancer patients. RESULTS： 111 of 3291 gastric cancer patients （3.4%） registered in the database had a synchronous cancer. Among these 111 patients, 109 had a single synchronous cancer and 2 patients had two synchronous cancers. The most common form of synchronous cancer was colorectal cancer （42 patients, 37.2%） followed by lung cancer （21 patients, 18.6%）. Multivariate analyses revealed that elderly patients with differentiated early gastric cancer have a higher probability of a synchronous cancer. CONCLUSION： Synchronous cancers in gastric cancer patients are not infrequent. The physicians should try to find synchronous cancers in gastric cancer patients, especially in the elderly with a differentiated early gastric

关键词： Synchronous cancer Gastric cancer Colorectal cancer

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Preparation of Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_2 powders for cathode material in secondary battery by solid-state method

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Rare Metals 2006年第z2期25卷 184-188页

作者： park sook Hee KANG Chan Hyoung Department of Advanced Materials Engineering Korea Polytechnic University Shihung Kyonggi-do 429-793 Korea

Employing Li2CO3, NiO, Co3O4, and MnCO3 powders as starting materials, Li[Ni1/3Co1/3Mn1/3]O2 was synthesized by solid-state reaction method. Various grinding aids were applied during milling in order to optimize the synthesis process. After successive heat treatments at 650 and 950 ℃, the prepared powders were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy, and transmission electron microscopy. The powders prepared by adding salt (NaCl) as grinding aid exhibit a clear R3m layer structure. The powders by other grinding aids like heptane show some impurity peaks in the XRD pattern. The former powders show a uniform particle size distribution of less than 1 μm average size while the latter shows a wide distribution ranging from 1 to 10 μm. Energy dispersive X-ray (EDX) analysiss show that the ratio of Ni, Co, and Mn content in the powder is approximately 1/3, 1/3, and 1/3, respecively. The EDX data indicate no incorporation of sodium or chlorine into the powders. Charge-discharge tests gave an initial discharge capacity of 160 mAh·g-1 for the powders with NaCl addition while 70 mAh·g-1 for the powders with heptane.

关键词： lithium ion battery cathode materials layered structure solid-state method discharge density

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Laparoscopic uncontained power morcellation-induced dissemination of ovarian endodermal sinus tumors:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3212-3218页

作者： Ha Kyung Oh Seong Nam park Byoung ryun Kim Department of Obstetrics and Gynecology Wonkwang University HospitalIksan 54645Jeollabuk-doSouth Korea

BACKGROUND Endodermal sinus tumors(ESTs),which arise primarily in children and adolescents,account for 20%of malignant ovarian germ cell tumors,but constitute only 1%of all ovarian *** of ESTs consists of surgical staging with fertility-sparing surgery and *** SUMMARY A 15-year-old nulliparous patient was diagnosed with disseminated ovarian ESTs after laparoscopic unilateral salpingo-oophorectomy using uncontained power morcellation for treatment of a ruptured solid adnexal mass in another *** laparotomy;total abdominal hysterectomy,right salpingooophorectomy,and lymphadenectomy were performed with optimal debulking,and surgical stage 3C was assigned to the *** In 2014,the Food and Drug Administration noted that power morcellation was probably associated with a risk of disseminating suspected cancerous ***,the use of power morcellation to remove solid adnexal mass is considered a contraindication because of the potential for a malignant *** case report aims to warn of the dangers of using uncontained power morcellation to treat solid adnexal masses.

关键词： Dissemination Endodermal sinus tumor Morcellation Yolk sac tumor Case report

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Environmental influence in the forested area toward human health: incorporating the ecological environment into art psychotherapy

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Journal of Mountain Science 2020年第4期17卷 992-1000页

作者： Ju-hyoung LEE Ji-sook park Sunnam CHOI Department of Forest Resources and Landscape Architecture Yeungnam UniversityGyeongsan 38541South Korea Department of Art Therapy Yeungnam UniversityGyeongsan 38541South Korea

This study on the development of a psychotherapy program based on the relationship between forests and human health focused on actively considering the natural ecological environment. This study categorized and compared an art psychotherapy program that simply moved to an outdoor space and a forest-art therapy program that actively utilized the forest environment as a medium. The characteristics of the natural environment, such as openness, change, and diversity, shortened the amount of time participants took to develop a rapport and open up and played a vital role in recovering mental health. After a bold attempt at integrating forest environment and art psychotherapy by going beyond outdoor art therapy, there were significant results pertaining to improvements in mental disorders in today’s society, including stress vulnerabilities, depression, anxiety, and aggression. The research results verified that the developed forest-art therapy method had greater efficacy in relation to both the Stress Vulnerability-Interpersonal Sensitivity Scale and the Stress Vulnerability-Self-Regulation Scale.

关键词： Forest therapy Human health Healing forest Art therapy Forest environment

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Precise control of surface oxygen vacancies in ZnO nanoparticles for extremely high acetone sensing response

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Journal of Advanced Ceramics 2022年第5期11卷 769-783页

作者： Jihyun LEE Youngmoon CHOI Byoung Joon park Jeong Woo HAN Hyun-sook LEE Jong Hyeok park Wooyoung LEE Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biological Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea

ZnO has been studied intensely for chemical sensors due to its high sensitivity and fast ***,we present a simple approach to precisely control oxygen vacancy contents to provide significantly enhanced acetone sensing performance of commercial ZnO nanopowders.A combination of H_(2)O_(2)treatment and thermal annealing produces optimal surface defects with oxygen vacancies on the ZnO nanoparticles(NPs).The highest response of~27,562 was achieved for 10 ppm acetone in 0.125 MH_(2)O_(2)treated/annealed ZnO NPs at the optimal working temperature of 400℃,which is significantly higher than that of reported so far in various acetone sensors based on metal oxide semiconductors(MOSs).Furthermore,first-principles calculations indicate that pre-adsorbed O formed on the surface of H_(2)O_(2)treated ZnO NPs can provide favorable adsorption energy,especially for acetone detection,due to strong bidentate bonding between carbonyl C atom of acetone molecules and pre-adsorbed O on the ZnO *** study demonstrates that controlling surface oxygen vacancies by H_(2)O_(2)treatment and re-annealing at optimal temperature is an effective method to improve the sensing properties of commercial MOS materials.

关键词： gas sensors acetone metal oxide semiconductors(MOSs) ZnO nanoparticles(NPs) H_(2)O_(2)treatment

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Molecular diagnosis and treatment of drug-resistant hepatitis B virus

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World Journal of Gastroenterology 2014年第19期20卷 5708-5720页

作者： Jeong Han Kim Yong Kwang park Eun-sook park Kyun-Hwan Kim Digestive Disease Center Department of Internal MedicineSchool of MedicineKonkuk UniversitySeoul 143-729South Korea Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine IBSTSchool of MedicineKonkuk UniversitySeoul 143-729South Korea Institute of Functional Genomics Konkuk UniversitySeoul 143-729South Korea

Oral antiviral agents have been developed in the last two decades for the treatment of chronic hepatitis B(CHB).However,antiviral resistance remains an important challenge for long-term CHB *** of the clinically available oral antiviral agents are nucleoside or nucleotide analogues that target the activity of viral reverse transcriptase(RT),and all are reported to have resistant *** the hepatitis B virus(HBV)RT,like other viral polymerases,lacks proofreading activity,the emergence of drug-resistance occurs readily under selective pressure from the administration of antiviral *** molecular diagnosis of drug-resistant HBV is based on sequence variations,and current diagnostic methods include sequencing,restriction fragment polymorphism analysis,and ***,we will discuss the currently available molecular diagnosis tools,in vitro phenotypic assays for validation of drug-resistant HBV,and treatment options for drug-resistant HBV.

关键词： Hepatitis B virus Drug-resistance Molecular diagnosis Antiviral treatment Chronic hepatitis B

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Retrieval of Outgoing Longwave Radiation from COMS Narrowband Infrared Imagery

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Advances in Atmospheric Sciences 2015年第3期32卷 375-388页

作者： Myung-sook park Chang-Hoi HO Heeje CHO Yong-Sang CHOI School of Earth and Environmental Sciences Seoul National UniversitySeoul Korea School of Urban and Environmental Engineering Ulsan National Institute of Science & TechnologyUlsan Korea Computational Science and Technology Seoul National UniversitySeoul Korea Computational Science and Technology Seoul National UniversitySeoul Korea Department of Environmental Science and Engineering Ewha Womans UniversitySeoul Korea

Hourly outgoing longwave radiation （OLR） from the geostationary satellite Communication Oceanography Meteorological Satellite （COMS） has been retrieved since June *** COMS OLR retrieval algorithms are based on regression analyses of radiative transfer simulations for spectral functions of COMS infrared *** study documents the accuracies of OLRs for future climate applications by making an intercomparison of four OLRs from one single-channel algorithm （OLR12.0 using the 12.0 μm channel） and three multiple-channel algorithms （OLR10.8＋12.0 using the 10.8 and 12.0 pm channels; OLR6.7＋10.8 using the 6.7 and 10.8 μm channels; and OLRAll using the 6.7,10.8,and 12.0 μm channels）.The COMS OLRs from these algorithms were validated with direct measurements of OLR from a broadband radiometer of the Clouds and Earth＇s Radiant Energy System （CERES） over the full COMS field of view [roughly （50°S-50°N,70°-170°E）] during April *** results show that the root-mean-square errors of COMS OLRs are 5-7 W m-2,which indicates good agreement with CERES OLR over the vast ***6.7＋10.8 and OLRAll have much smaller errors （～ 6 W m-2） than OLR12.0 and OLR10.8＋12.0 （～ 8 W m-2）.Moreover,the small errors of OLR6.7＋10.8 and OLRAll are systematic and can be readily reduced through additional mean bias correction and/or radiance *** results indicate a noteworthy role of the 6.7 μm water vapor absorption channel in improving the accuracy of the *** dependence of the accuracy of COMS OLRs on various surface,atmospheric,and observational conditions is also discussed.

关键词： outgoing longwave radiation Communication Oceanography and Meteorological Satellite Cloud and Earth's Radiant Energy System

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Congenital retinal macrovessel with intracranial venous malformation in a pediatric patient: a case report

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1214-1216页

作者： Hyeon Jin park sook Hyun Yoon sook Young Kim Donghun Lee Department of Ophthalmology Daegu Catholic University School of MedicineDaegu 42472Republic of Korea

Dear Editor,Congenital retinal macrovessel (CRM) is defined as an abnormal large retinal vessel that encircles the foveal avascular zone (FAZ).Since the first description of a large aberrant vessel crossing the macula by Mauthnerin 1868,there have been several case reports about *** recently,Pichi et alreported clinical manifestations and multimodal retinal imaging of 49 eyes with *** their study,they had identified an association between macrovessel in the retina and venous anomalies of the brain and they emphasized the importance of systemic workups including brain magnetic resonance imaging (MRI).

关键词： venous Congenital malformation

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Sexual dimorphism and sex-differential migration of Little Buntings(Emberiza pusilla)at an East Asian stopover site

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Avian Research 2022年第1期13卷 87-93页

作者： sook-Young Cho Hyun-Young Nam Se-Young park Chang-Yong Choi Bird Research Center Korea National Park Research InstituteJeonnam58863Republic of Korea Division of Zoology Honam National Institute of Biological ResourcesMokpo58762Republic of Korea School of Biological Sciences College of Natural SciencesSeoul National UniversitySeoul08826Republic of Korea Department of Agriculture Forestry and BioresourcesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul08826Republic of Korea

Sex differences in morphology provide key information for understanding a species'morphological adaptations in relation to the evolution of sexual *** migratory birds,morphological traits have adapted to long-distance travel,and sexual dimorphism is typically related to sex-differential migration *** Buntings(Emberiza pusilla)have one of the longest migrations and are the least dichromatic species among the Emberiza *** this study,we measured sexual size dimorphism and sexual dichromatism of Little Buntings in relation to the spring arrival dates at a stopover site in *** length was the most important predictor for identifying sex;the wings of males were longer than those of *** also had a significantly stronger chestnut color of the head feathers than females,but this color difference was more prominent in the spring than in the *** arrived earlier than females by four *** dates correlated with both size and color,but unlike other bunting species previously studied in the same area,there was no clear sex-differential trend in the relationship between arrival date and morphological *** differences in the degree of sexual dichromatism suggest that chestnut plumage coloration can be used as a social or sexual signal of males in the breeding *** correlation of size and color to early arrival regardless of sex may indicate that a preference for assortative mating exists or that a sex-differential migration strategy is not clearly defined in the early stages of northward *** findings on the sexual dimorphism of Little Buntings provide insight into the evolution of the sex-differential migration of buntings in the East Asian Flyway.

关键词： Digital photography Emberiza pusilla Little Bunting Protandrous migration Sexual dichromatism Sexual dimorphism

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