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Radiologic factors related to double-bar insertion in minimal invasive repair of pectus excavatum

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World Journal of Pediatrics 2015年第2期11卷 148-153页

作者： Ki Hwan kim Ki Yeol Lee Jung Bok Lee kyung-sook Yang Jinwook Hwang Bo kyung Je Hyung Joo Park Department of Radiology Korea University College of MedicineAnsanKorea1 Department of Clinical Epidemiology and Biostatics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Biostatistics Korea University College of MedicineSeoulKorea Departmentof Thoracic Surgery Korea University College of MedicineAnsanKorea Department of Thoracic and Cardiovascular Surgery Seoul St.Mary's Hospitalthe Catholic University of KoreaSeoulKorea

Background:Pectus excavatum is the most common congenital chest wall deformity,with a high incidence in live *** study aimed to evaluate the measured factors on CT images related to the number of pectus bars for surgical ***:A total of 497 patients who had undergone minimally invasive repair between April 2007 and July 2011 were classified into single-bar(n=358)and doublebar(n=139)insertion *** measured eight distinct distances and one angle on CT scans to reflect quantitative *** analysis and multivariate logistic regression analysis were performed to detect statistically significant association between radiologic measurements and the pectus bars ***:After adjusting for age and gender,the transverse distance(T),the transverse distance of the depression area(A),the inclined distance of the depression area(B),the AP distance of the depression area(C),the depression angle(G),and the eccentric distance of deformity(E)were significantly correlated with double-bar *** regression model showed that age(,P<0.0001),gender(P<0.0001),depression angle(G)(P<0.0001),direction of the depression(DD)(P<***1)and depression depth(D)(P<0.0001)were significantly associated with doublebar ***:CT scan provides useful factors which can be of assistance in predicting the number of pectus bars for the surgical correction of pectus excavatum.

关键词： computed tomography Nuss procedure pectus excavatum

Pembrolizumab-induced psoriatic arthritis treated with disease-modifying anti-rheumatic drugs in a patient with gastric cancer:A case report

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World Journal of Clinical Cases 2023年第1期11卷 218-224页

作者： Sehan kim Jong Hee Sun Hongsik kim Hee kyung kim Yaewon Yang Jun Su Lee In Ah Choi Hye sook Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Immune checkpoint inhibitor(ICI)-induced rheumatic immune-related adverse events(ir AEs)have been infrequently reported,and the treatment of severe or refractory arthritis as ir AEs has not been established *** SUMMARY The patient was a 67-year-old man with a history of well-controlled foot psoriasis who presented with *** had received pembrolizumab for metastatic gastric adenocarcinoma 2 mo *** examination revealed erythematous swelling in the distal interphalangeal joints,left shoulder,and both *** had plaque psoriasis with psoriatic nail dystrophy and dactylitis in the distal joints of the fingers and *** markers including C-reactive protein and erythrocyte sedimentation rate were elevated but rheumatoid factor and anticyclic citrullinated peptide antibody were *** patient was diagnosed with psoriatic arthritis(PsA)and started on methylprednisolone 1 mg/kg/day after pembrolizumab ***,despite 1 wk of methylprednisolone treatment,PsA worsened;hence,leflunomide and methotrexate were *** 4 wk of steroid treatment,PsA worsened and improved repeatedly with steroid ***,the therapy was intensified to include etanercept,a tumor necrosis factor inhibitor,which ultimately resulted in adequate PsA *** This is the first report of ICI-induced PsA in a gastric cancer *** rheumatic ir AEs with refractory severe arthritis may require disease-modifying anti-rheumatic drugs and long-term management.

关键词： Pembrolizumab Psoriatic arthritis Disease-modifying anti-rheumatic drugs Gastric cancer Case report

MICROMECHANICS OF ROUGH SURFACE ADHESION:A HOMOGENIZED PROJECTION METHOD

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Acta Mechanica Solida Sinica 2009年第5期22卷 377-390页

作者： kyung-Suk kim Division of Engineering Brown UniversityProvidenceRI 02912USA

A quasistatic homogenized projection is made to characterize the effective cohesive zone behavior for rough-surface adhesion. In the context of the homogenized projection, the traction versus separation relation for the homogenized cohesive zone （HCZ） of a rough interface can be highly oscillatory due to instabilities during microscopic adhesion and decohesion processes. The instabilities are found to occur not only individually but also collectively among the adhesive micro-asperity contacts, leading to extensive energy dissipation. Based on the behaviors of the HCZ relations, a framework for describing instability-induced energy dissipation in rough-surface adhesion is proposed to elucidate the effect of roughness on apparent interface adhesion. Two non- dimensional parameters, α related to roughness morphology and n related to flaw distribution, are identified to be most crucial for controlling the energy dissipation. For an interface with a shallow roughness and a strong intrinsic adhesive strength, the interface adhesion can be stronger if we make it rougher （reducing α） or lower its flaw density （increasing n）. The HCZ projection method can be potentially extended and employed to bridge the apparent adhesion from intrinsic adhesion properties for engineering surfaces with multi-scale shallow roughness.

关键词： homogenized cohesive zone interface adhesion roughness effect instability energy dissipation

In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

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Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-kyung Roh Hyun-kyung kim Myeong-Seong kim Dong-Hyun kim kyung Yoon Chung Kwang Chul Roh Kwang-Bum kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

Sarcomatoid carcinoma of the pancreas—multimodality imaging findings with serial imaging follow-up:A case report and review of literature

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World Journal of Clinical Cases 2021年第13期9卷 3102-3113页

作者： Hyun Jae Lim Hye Seon Kang Jeong Eun Lee Ji Hye Min kyung sook Shin Sun Kyoung You kyung-Hee kim Department of Radiology Chungnam National University HospitalDaejeon 35015South Korea Department of Radiology Chungnam National University HospitalChungnam National University College of MedicineDaejeon 35015South Korea Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Pathology Cancer Research InstituteCollege of MedicineChungnam National UniversityDaejeon 35015South Korea

BACKGROUND Sarcomatoid carcinoma of the pancreas is extremely rare and has an extremely poor *** a few cases of sarcomatoid carcinoma of pancreas have been reported,most are focused on a histopathological *** the best of our knowledge,there are no reports documenting multimodality imaging characteristics and chronological changes with emphasis on radiologic *** SUMMARY A 64-year-old woman was admitted to Chungnam National University Hospital with acute ***-enhanced computed tomography of the abdomen revealed a 2.6 cm×2.8 cm multilobular cystic mass in the pancreatic *** pancreatic lesion showed suspected mural nodules and thin ***,mucinous cystic neoplasm of pancreas was *** 7 mo,the patient was readmitted for repeated epigastric abdominal pain and ***-up contrast-enhanced computed tomography of the abdomen and magnetic resonance imaging revealed a marked enlargement(5.4 cm×4 cm),with a predominant internal solid *** mass showed low signal intensity on a T1-weighted image and heterogeneously intermediate high signal intensity on a T2-weighted image. It showed diffusion restriction and peripheral rimenhancement on an arterial phase image, and progressive enhancement on portalvenous and delayed phase images. Distal pancreatectomy was performed. Basedon the morphology and immunohistochemical staining of the specimen,pancreatic sarcomatoid carcinoma was *** present the computed tomography, magnetic resonance imaging, and positronemission tomography computed tomography findings, pathologic features, andchronological changes for preoperative diagnosis.

关键词： Carcinosarcoma Pancreas Computed tomography Magnetic resonance imaging Pancreatectomy Case report

Do brood parasitic Common Cuckoos develop brood patches during the breeding season?

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Avian Research 2024年第3期15卷 363-368页

作者： Jun-Seo Go Hae-Ni kim Sue-Jeong Jin Myeong-Chan Cha Heesoo Lee Jin-Won Lee Korea Institute of Ornithology&Department of Biology Kyung Hee University02447SeoulRepublic of Korea Bird Research SaeZiP 12504YangpyeongRepublic of Korea

Many birds develop brood patches on their ventral apterium under hormonal regulation to effectively transmit body heat to eggs during *** developed patch has several characteristics,including de-feathering,vascularization,and ***,little is known about whether avian brood parasites that do not incubate their eggs exhibit brood patch development during the breeding *** this study,we measured the size of the ventral apterium in 114 Common Cuckoos(Cuculus canorus)captured in the field throughout the breeding season and examined the appearance of the ventral apterium to confirm the development of brood *** also examined whether morphological traits and various factors correlated with the size of the ventral apterium(sternal apterium and abdominal apterium)and how it changed during the breeding *** found no clear signs of brood patch development in Common Cuckoos captured throughout the breeding season,indicating that they likely did not develop brood patches on the ventral apterium during this *** also found that ventral apterium size was positively correlated with wing length and body *** addition,Common Cuckoos with newly growing feathers on the boundary of the ventral apterium with pteryla were frequently observed as seasons progressed to the *** conclusion,Common Cuckoos exhibit neither brood patch development nor the vestigial characteristics of ancestral brood patches,except for the growth of feathers on boundary the ventral *** studies examining brood patches across different groups of avian brood parasites are valuable for enhancing our understanding of the developmental and physiological adaptations of avian brood parasites.

关键词： Brood parasitism Brood patch Common Cuckoo Pterylosis Re-feathering Ventral apterium

Species delimitation in the green algal genus Codium (Bryopsidales) from Korea using DNA barcoding

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Acta Oceanologica Sinica 2015年第4期34卷 114-124页

作者： LEE Hyung Woo kim Myung sook Department of Biology Jeju National University

Codium, one of the largest marine green algal genera, is difficult to delimit species boundary accurately based on morphological identification only. DNA barcoding is a powerful tool for discriminating species of seaweeds. The plastid elongation factor TU （tufA） is considered as maker to perform DNA barcoding of green algal species than rbcL gene due to universality and rapid evolution rate. We conducted DNA barcoding application to Codium specimens from the Jeju Island, Korea to overcome the limit of morphological identification and to confirm the species diversity. As a result of applying tufA marker, we newly generated fifty-five tufA barcodes to resolve eight species. TufA marker exhibited 6.1%–21.8% interspecific divergences, wider than the gap of rbcL exon 1, 3.5%–11.5%. Molecular analysis of rbcL exon 1 sequences of Codium revealed eight distinct species like tufA analysis separated in five phylogenetic groups. DNA barcoding of the genus Codium using tufA marker is more helpful to overcome the limit of morphological identification, and this is more potential to reveal cryptic species and to resolve the relationships among subspecies than rbcL analysis alone. The complement of tufA barcoding and rbcL analyses including morphology for the genus Codium in the northwestern Pacific will give much more reliable achievement for discovering species diversity and resolving the phylogenetic relationships.

关键词： Codium DNA barcoding rbcL Species delimitation tufA

A Study on the Influences of the COVID-19 Pandemic-Related Depression, Anxiety, Stress, and Treatment-Crisis on Quality of Life in Cancer Patients - A Secondary Publication

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Proceedings of Anticancer Research 2024年第2期8卷 73-87页

作者： So Hyoung kim kyung Hee Lim Kungpook National University Chilgok Hospital DaeguRepublic of Korea College of Nursing Keimyung UniversityDaeguRepublic of Korea

Objective:To investigate the factors affecting the quality of life of cancer patients by examining the degree of the COVID-19 pandemic-related depression,anxiety,stress,and treatment ***:Data were collected from 132 cancer patients undergoing surgery,chemotherapy,radiotherapy,and hormone therapy at K University Hospital in D City using a structured *** period of data collection was from May 6 to May 28,*** collected data were analyzed using descriptive statistics,t-test,ANOVA,Pearson’s correlation,and stepwise multiple ***:The mean scores of quality-of-life,depression,anxiety,stress,and treatment crisis during the COVID-19 pandemic were 84.64±29.09,15.14±6.49,4.66±5.27,75.83±17.70,and 78.52±19.95,*** terms of factors affecting the quality of life related to the COVID-19 pandemic,COVID-19 pandemic-related stress(β=0.41,P<0.001)appeared to have the greatest impact,followed by COVID-19 pandemic-related treatment-crisis(β=0.28,P=0.002),anxiety(β=0.21,P=0.002),and gender(β=0.14,P=0.009),with a total explanatory power of 67.6%.Conclusion:To improve the quality of life during the COVID-19 pandemic,COVID-19 pandemic-related stress,treatment-crisis,and anxiety should be periodically monitored and nursing interventions such as education on infection prevention,management,and emotional support programs should be provided to decrease the COVID-19 pandemic-related stress,treatment-crisis,and anxiety.

关键词： Cancer COVID-19 Quality of life

A novel isoxazole compound CM2-II-173 inhibits the invasivephenotype of triple-negative breast cancer cells

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肿瘤学研究(英文) 2023年第6期31卷 867-875页

作者： EUN sook kim SANGHEE kim AREE MOON Duksung Innovative Drug Center College of PharmacyDuksung Women’s UniversitySeoul03169Korea College of Pharmacy Seoul National UniversitySeoul08826Korea

Invasion and metastasis are important hallmarks of breast cancer and are the leading cause of patient ***-negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a poor prognosis and a lackof effective targeted therapies. The present study investigated the inhibitory effect of a novel FTY720 derivative on theinvasive phenotype of TNBC cells. Here, we showed that a novel compound with an isoxazole ring, 4-(3-Decylisoxazol-5-yl)-1-hydroxy-2-(hydroxymethyl)butan-2-aminium chloride (CM2-II-173), significantly inhibitedinvasiveness of MDA-MB-231 TNBC cells. Expression of matrix metalloproteinase (MMP)-9 and invasiveness ofMCF10A normal breast cells induced by sphingosine-1-phosphate (S1P) were reduced by CM2-II-173 *** of pMEK1, pAkt, pERK, and p38 MAPK by S1P were inhibited by treatment with *** and anchorage-independent growth of MDA-MB-231 TNBC cells were significantly decreased by CM2-II-173. CM2-II-173 efficiently induced apoptosis in MDA-MB-231 TNBC cells. CM2-II-173 significantly inhibitedinvasive phenotypes of breast, liver, prostate, and ovarian cancer cells. CM2-II-173 exhibited a more potent effect onthe invasiveness of MDA-MB-231 TNBC cells compared to FTY720. Taken together, this study demonstrated thatCM2-II-173 has the potential to be a lead compound that can inhibit cancer progression of not only TNBC cells, butalso of liver, prostate, and ovarian cancer cells.

关键词： MMP-9 Cell invasion Breast cells