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A combination of immunoadjuvant nanocomplexes and dendritic cell vaccines in the presence of immune checkpoint blockade for effective cancer immunotherapy

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Cellular & Molecular Immunology 2021年第6期18卷 1599-1601页

作者： Manh-Cuong Vo Seo-Yeon Ahn Tan-Huy Chu Saji Uthaman Shammer Pillarisetti Tung Nguyen Thanh Uong Thangaraj Jaya Lakshmi Mihee Kim Ga-Young Song Sung-Hoon Jung Deok-Hwan Yang Jae-sook Ahn Hyeoung-Joon Kim In-Kyu park Je-Jung Lee Institute of Research and Development Duy Tan UniversityDanangVietnam Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalHwasunJeollanamdoRepublic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolGwangjuRepublic of Korea Department of Polymer Science and Engineering Chungnam National UniversityDaejeonRepublic of Korea Department of Biomedical Science Chonnam National University Medical SchoolGwangjuRepublic of Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolGwangjuSouth Korea View author publications

Nanovaccines are used as delivery platforms for antigens and adjuvants, which activate antigen-presenting cells (APCs) and enhance anticancer immune responses.1,2 Researchers have recently developed a self-assembled nanocomplex using a polysorbitol-co-PEI (PSPEI) polymer complexed with poly(I:C) (PIC). By binding to different surface proteins, this nanocomplex enhances the intracellular delivery of cargos and induces potent anticancer immune responses against melanoma cells.3 We have previously demonstrated that PD-1/PD-L1 blockade enhanced the efficacy of DC-based cancer immunotherapy.4,5 Moreover, the combination of nanomedicines and PD-L1 blockade has been reported to enhance CD8+ T cell activation and inhibit immunosuppressive cells within the tumor microenvironment.6 In the present study, we investigated the therapeutic efficacy of a combinatorial treatment comprising the immunoadjuvant nanocomplex PSPEI-PIC, a DC vaccine, and PD-L1 blockade in a murine colon cancer model.

关键词： adjuvant vaccines immunotherapy

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Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

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Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： Thanh-Nhan Nguyen-Pham Mi-Seon Lim Truc Anh Thi Nguyen Youn-Kyung Lee Chun-Ji Jin Hyun Ju Lee Cheol Yi Hong Jae-sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul park Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

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Self-reported Symptoms of Asthma and Exercise-induced Asthma in Korean National Team Athletes

Self-reported Symptoms of Asthma and Exercise-induced Asthma...

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The 6th Asian Conference on Sport Science

作者： Saejong park Young-Soo Kim Jung-Taek Shin Sub Sunoo You-sook Cho Yeon-Mok Oh Korea Institute of Sport Science Kyung Hee University University of Ulsan/Asan Medical Center

The prevalence of exercise-induced asthma（EIA）increases markedly in elite *** has been extensively studied in Caucasian athletes,but little report has been published in Asian *** purpose of this study was to investigate the prevalence of EIA symptoms,asthma diagnosis,and asthma medication in Korean national team athletes.A validated questionnaire was used to determine the prevalence of EIA symptoms,asthma diagnosis,and asthma *** study population was composed of the year 2008 Korean national team athletes who were training in the Taeneung national training *** participants were athletes（n=285）from 16 different summer *** range of each EIA symptom positive responders was 30%to 66%.Cough and excess mucus were most often experienced while wheezing and difficulty of breathing were relatively not quite often *** of EIA symptom was self-reported by about 18%of all the subjects,and all5 EIA symptoms were reported by 9.5%.Asthma diagnosis by a physician was reported 10.9%of all the subjects and use of asthma medication was only6.7%of all the *** rhinitis diagnosis by a physician was 22.5%of all the subjects and use of allergy medication was 11.6%of the *** symptoms were analyzed by specific characteristics of sports such as environment of sports participated（*** *** sports）,team *** *** of these sport characteristics seems to be affecting EIA symptoms in Korean national *** prevalence of asthma diagnosis was similar to other ***,the prevalence of EIA symptoms was relatively high,which might involve undiagnosed *** investigations are needed to EIA diagnosis in Korean athletes.

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开挖施工中基于边坡安全的爆破震动控制公式

开挖施工中基于边坡安全的爆破震动控制公式

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第一届堆石坝国际研讨会

作者： Kim,Jae Hong park Chal sook Kwater坝安全研究中心 Seongdeok坝施工办事处

除环境因素外,噪音和震动亦会对周围建筑造成影响。在开挖爆破施工期间,噪音和震动是施工现场的一个重要问题。事实上,穿越山区道路的边坡可能会受到因坡面、接缝或大雨所导致落石的影响,但是这样一个事实是不容忽略的,那就是过量震动... 详细信息

除环境因素外,噪音和震动亦会对周围建筑造成影响。在开挖爆破施工期间,噪音和震动是施工现场的一个重要问题。事实上,穿越山区道路的边坡可能会受到因坡面、接缝或大雨所导致落石的影响,但是这样一个事实是不容忽略的,那就是过量震动作业会导致道路掘土作业过程中所切割岩石部位的损坏。为了在大规模料场开挖之后确保边坡的稳定性。需要进行以试验爆破的爆破影响为基础作还原分析研究,以确定从最初挖掘作业开始到岩石爆破的作业过程中所产生的震动对于坡面稳定性的影响.并就爆破震动的情况进行预测。

关键词：爆破震动边坡回归分析

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Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether

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World Journal of Gastroenterology 2019年第39期25卷 5936-5952页

作者： Dong Do You Suk Joon Cho Ok-Hee Kim Jin sook Song Kyu-Seok Hwang Sang Chul Lee Kee-Hwan Kim Ho Joong Choi Ha-Eun Hong Haeyeon Seo Tae Ho Hong Jung Hyun park Tae Yoon Lee Joseph Ahn Jae-Kyung Jung Kwan-Young Jung Say-June Kim Department of Surgery St.Vincent's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247South Korea College of Pharmacy Chungbuk National UniversityCheongju 28644South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Bio and Drug Discovery Division Korea Research Institute of Chemical TechnologyDaejeon 34114South Korea Department of Surgery Daejeon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 34943South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Biomedicine and Health Science College of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Eunpyeong St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 03312South Korea Department of Medicinal Chemistry and Pharmacology University of Science and TechnologyDaejeon 34113South Korea

BACKGROUND The use of methyl-tertiary butyl ether(MTBE)to dissolve gallstones has been limited due to concerns over its toxicity and the widespread recognition of the safety of laparoscopic *** adverse effects of MTBE are largely attributed to its low boiling point,resulting in a tendency to ***,if there is a material with a higher boiling point and similar or higher dissolubility than MTBE,it is expected to be an attractive alternative to *** To determine whether tert-amyl ethyl ether(TAEE),an MTBE analogue with a relatively higher boiling point(102°C),could be used as an alternative to MTBE in terms of gallstone dissolubility and *** The in vitro dissolubility of MTBE and TAEE was determined by measuring the dry weights of human gallstones at predetermined time intervals after placing them in glass containers with either of the two *** in vivo dissolubility was determined by comparing the weights of solvent-treated gallstones and control(dimethyl sulfoxide)-treated gallstones,after the direct infusion of each solvent into the gallbladder in both hamster models with cholesterol and pigmented *** The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%,56.5%and 38.75%for cholesterol,mixed,and pigmented gallstones,respectively,which represented a 1.2-,1.4-,and 1.3-fold increase in dissolubility compared to that of *** the in vitro experiment,the 24 h-dissolubility of TAEE was 71.7%and 63.0%for cholesterol and pigmented gallstones,respectively,which represented a 1.4-and 1.9-fold increase in dissolubility compared to that of *** addition,the results of the cell viability assay and western blot analysis indicated that TAEE had a lower toxicity towards gallbladder epithelial cells than *** We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of *** such,TAEE could present an attractive alternative to MTBE if our findings

关键词： Tert-amyl ethyl ether Gallstones Methyl-tert-butyl ether Contact litholytic agent

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战争与女权博物馆

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城市环境设计 2015年第5期92卷 132-139页

作者： sook Hee Chun Young Chul Jang Jiyong park Kuhyeon Kwon Aram Yun Kim Doo-Ho WISE建筑事务所

这个博物馆并没有气派的入口、门厅,亲切信息服务台和大尺度的展览空间。它位于城山洞的住宅区深处,只有一扇门,而且比通常建筑的门还要小。周围也没有明显的指示牌标示博物馆的所在。取而代之的,是一条联通博物馆内外的游客步道,引领... 详细信息

这个博物馆并没有气派的入口、门厅,亲切信息服务台和大尺度的展览空间。它位于城山洞的住宅区深处,只有一扇门,而且比通常建筑的门还要小。周围也没有明显的指示牌标示博物馆的所在。取而代之的,是一条联通博物馆内外的游客步道,引领着游客去了解这里的故事。游客们在这样一种充满不确定性的环境中的体验,在某种程度上与当年被战争挟裹而成为慰安妇的老奶奶们所经历的不安感类似。

关键词：博物馆建筑博物院文化机构 Ho 女权

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Analysis of Cancer Incidence among Korean Nuclear Power Plant Workers

Analysis of Cancer Incidence among Korean Nuclear Power Plan...

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The Second Asian and Oceanic Congress for Radiation Protection

作者： Meeseon JEONG Young-Woo JIN Young Khi LIM Soo Keun KIM Byoung-Il LEE Youn Koun JANG sook Hee SUNG Ill Keun park Yeon Joo LEE Chong-Soon KIM Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea

Epidemiological studies of nuclear industry workers have important role to examine the health effect of low dose and low dose-rate radiation *** this study we analyzed the cohort of Korean nuclear power plants *** cohort consists of 7,459 male workers exposed to ionizing radiation and 6,508 controls without exposure *** paper presents the results of analysis on their cancer incidence between 1993 and 2002.A total of 58 cancers were ascertained for radiation workers and 50 for non-radiation ***-standardized rate ratio for two groups was 1.09（95% CI:0.74,1.62）.Trend test showed that cancer incidence rate in individual dose group was not significantly increased with increasing cumulative dose（p=0.2506）.Excess relative risk for all cancers combined was 6.77（95% CI:-4.02,27.54）per sievert,suggesting no statistically significant association between radiation dose and cancer *** of this study are not conclusive because of considerable *** size of the cohort,small cases of cancer incidence,and young ages of subjects limit the power of the *** we need further follow-up and the expansion of cohort to increase the power and to obtain stable risk estimate.

关键词： radiation workers cohort standardized incidence ratio rate ratio excess relative risk

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ADVANCING THE STATE OF THE ART IN OPERATIONAL TROPICAL CYCLONE FORECASTING AT NCEP

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Tropical Cyclone Research and Review 2018年第1期7卷 51-56页

作者： AVICHAL MEHRA VIJAY TALLAPRAGADA ZHAN ZHANG BIN LIU LIN ZHU Weiguo Wang Hyun-sook Kim NOAA/NWS/NCEP/EMC College ParkMDUSA IMSG at NOAA/NWS/NCEP/EMC College ParkMDUSA

Regional Hurricane modeling systems developed and implemented into operations at National Centers for Environmental Prediction(NCEP)of National Oceanic and Atmospheric Administration(NOAA)National Weather Service(NWS)are now used for tropical cyclone forecast guidance in all ocean basins of the ***,HWRF(Hurricane Weather Research and Forecast)modeling system has made significant improvements to the state of the art in numerical guidance for tropical cyclone track,intensity,size,structure and rainfall *** improvements come from advances in various components of the modeling system that are incorporated into the model in yearly upgrade ***/NCEP/Environmental Modeling Center’s hurricane team has also developed another non-hydrostatic hurricane model in NOAA Environmental Modeling System(NEMS)framework known as HMON(Hurricanes in a Multi-scale Ocean-coupled Non-hydrostatic)model which was implemented at NCEP operations this past *** of HMON is consistent with,and a step closer to developing Next Generation Global Prediction System(NGGPS)chosen Finite Volume Cubed-Sphere(FV3)dynamic core based global to local scale coupled models in a unified modeling *** this paper,operational configuration details of this new HMON model are discussed along with operational HWRF model upgrades,and their forecast performance is compared to other *** also discuss plans for hurricane model improvements in the next two to five years.

关键词： operational models forecasting tropical cyclones

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住院患儿的家庭适应及相关因素分析

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中国实用护理杂志 2014年第19期30卷 21-23页

作者：鞠庆梅刘洋朴仁淑沈曲北京市煤炭总医院 100028 厦门大学医学院护理系韩国忠南大学

目的以家庭复原力理论为基础探讨复原力因子对住院患儿家庭适应的影响。方法用家庭压力（FSI）、家庭价值观（FW）、家庭强韧性（FHI）、家庭适应量表（FWBI）对中国某8所医院的330位住院患儿的父母进行问卷调查，并对调查结果进行分析... 详细信息

目的以家庭复原力理论为基础探讨复原力因子对住院患儿家庭适应的影响。方法用家庭压力（FSI）、家庭价值观（FW）、家庭强韧性（FHI）、家庭适应量表（FWBI）对中国某8所医院的330位住院患儿的父母进行问卷调查，并对调查结果进行分析。结果多因素回归分析显示，对家庭影响最大的复原力因子是家庭强韧性，其次是家庭价值观。结论当家庭处于危机或压力事件中时，家庭强韧性，家庭价值观可对家庭适应起到保护作用，从而为今后的护理干预研究提供理论基础。

关键词：家庭压力家庭价值观家庭强韧性家庭适应家庭复原力

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雪莲薯提取物及其成分的促精子发生作用

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中国临床药理学与治疗学 2007年第10期12卷 1187-1187页

作者： park Jeong-sook YANG Jae-sik HWANG Bang-yeon College of Pharmacy CBITRC Chungbuk National University Cheongju Heungdukgu Gaeshindong San 12 Chungbuk 361-763 S. Korea College

AIM: Smallanthus sonchifolius (Yacon) has been used as a food and folk medicine in the Andes region. It was screened the pharmacological effects of a 50% ethanol extract of Yacon on spermatogenesis in rats. This study is carried out to evaluate the possibility of using Yacon tubers extracts as a fertility agent to treat infertility caused by spermatogenic disorders. METHODS: The dried, pulverized Yacon tubers were extracted with 50% ethanol at 50 ℃ for 5 h under sonication. The Yacon extracts were analyzed by using HPLC system on a Kromasil C18 column (250 mm×4.6 mm). The Yacon tubers extracts, chlorogenic acid and ferulic acid were administrated to rats once daily by oral gavage. The number of sperm heads in the testis was assessed by counting the number of sperm heads using slight modification of the procedure reported by Toth et al (1989). RESULTS: After administration of chlorogenic acid and Yacon tuber extracts to rat for 5 weeks, the number of sperm in epididymis were increased by 20.33% and 34.48%, respectively. The ferulic acid which was reported as a metabolite of chlorogenic acid and constituent of Yacon to estimate the spermatogenic activity was also administered. After administration of ferulic acid and Yacon tubers extracts, the sperm number were increased by 37.87% and 43.33%, respectively. Spermatogenic effects of chlorogenic acid and ferulic acid were 0.59 times and 0.87 times of Yacon tubers extracts, respectively. CONCLUSION: The spermatogenic effect of Yacon tubers extracts may result from the combined effect of chlorogenic acid or its analogues and their metabolites.

关键词：雪莲薯提取物成分促进作用精子发生

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