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Prolapse gastropathy syndrome may be a predictor of pathologic acid reflux

World Journal of Gastroenterology 2008年第36期14卷 5601-5605页

作者： Jin-soo Kim Hyung-Keun Kim Young-Seok Cho Hiun-Suk chae Byung-Wook Kim Jin-Il Kim Sok-Won Han Kyu-Yong Choi Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Gyeonggi-do 480-717 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do 403-720 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Yeoeuido St. Mary’s Hospital Seoul 150-713 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do 420-717 South Korea

AIM： To assess the occurrence of gastric acid reflux into the esophagus in endoscopically confirmed prolapse gastropathy syndrome （PGS）. METHODS： Using ambulatory esophageal pH measurement （BRAVOTM wireless esophageal pH monitoring system）, twenty-six patients with PGS were compared with twenty-one patients with erosive esophagitis （EE） as controls. We assessed several reflux parameters, including the percentage of total time at pH 〈 4, and the DeMeester score. RESULTS： There were no statistical differences between the PGS group and the EE group as to mean age, sex ratio and pH recording time. The EE group showed more severe reflux than the PGS group, as evaluated in terms of the longest duration of reflux, the number of reflux episodes, the number of reflux episodes lasting 〉 5 min, the total time with pH 〈 4 during acid reflux episodes, and the DeMeester score, but none of these parameters showed statistically significant difference. Although 53.8% （14/26） of the PGS group and 76.2% （16/22） of the EE group demonstrated pathologic acid reflux （DeMeester score 〉 14.72）, there was no statistically significant difference between the two groups in the incidence of pathologic acid reflux （P = 0.11）. CONCLUSION： There was no statistically significant difference in pathologic acid reflux between the PGS and EE group. These data suggest that endoscopically diagnosed PGS might be a predictor of pathologic acid reflux.

关键词： Prolapse gastropathy syndrome Pathologic acid reflux Erosive esophagitis Ambulatory esophageal pH monitoring Retching

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Implementation of configuration dependent stiffness proportional damping for the dynamics of rigid multi-block systems

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Earthquake Engineering and Engineering Vibration 2003年第1期2卷 87-98页

作者： Yun Byeong chae Jae Kwan Kim R & D Division Chungsuk Engineering57Garak-dongSongpa-kuSeoul138-802Korea Assistant Engineer School of Civil Urban and Geosystem EngineeringSeoul National UniversitySeoul151-742Korea Associate Professor

The distinct element method(DEM)has been used successfully for the dynamic analysis of rigid block sys- *** of many difficulties associated with DEM is modeling of *** this paper,new procedures are proposed for the damping modeling and its numerical implementation in distinct element analysis of rigid muhi-block *** stiff- ness proportional damping is constructed for the prescribed damping ratio,based on the non-zero fundamental frequency ef- fective during the time interval while the boundary conditions remain essentially *** this time interval,the funda- mental frequency can be estimated without complete eigenvalue *** damping coefficients will vary while the damp- ing ratio remains the same throughout the entire analysis.A new numerical procedure is developed to prevent unnecessary energy loss that can occur during the separation *** procedures were implemented in the development of the dis- tinet element method for the dynamic analyses of piled multi-block *** analysis results |or the single-block and two-block systems were in a good agreement with the analytic *** to the seismic analyses of piled four- block systems revealed that the new procedures can make a significant difference and may lead to much-improved results.

关键词： multi-block systems stiffness proportional damping rocking impact distinet element method rigid body dynamics

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Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Journal of Geriatric Cardiology 2020年第11期17卷 680-693页

作者： Myunhee Lee Dae-Won Kim Mahn-Won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae Hoon Ahn Myung Ho Jeong Seung-Woon Rha Hyo-soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull chae Kwon-Bae Kim Young Jo Kim Kwang soo Cha Seok Kyu Oh Jei Keon chae Ji-Hoon Jung 无 KAMIR-NIH registry investigators Division of Cardiology Daejeon St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Division of Cardiology Seoul St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Gachon University Gil Medical CenterIncheonSouth Korea Chonnam National University Hospital GwangjuSouth Korea d Korea University Korea University Guro Hospital SeoulSouth Korea Seoul National University Hospital SeoulSouth Korea Sungkyunkwan Universtiy Samsung Medical CenterSeoulSouth Korea Chungnam National University Hospital DaejeonSouth Korea Chungbuk National University Hospital CheongjuSouth Korea Kyungpook National University Hospital DaeguSouth Korea Keimyung University Dongsan Medical Center DaeguSouth Korea Yeungnam University Hospital DaeguSouth Korea Pusan National University Hospital BusanSouth Korea Wonkwang University Hospital IksanSouth Korea Chonbuk National University Hospital JeonjuSouth Korea Institute of Toxicology DaejeonSouth Korea 不详

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

关键词： Acute myocardial infarction Asian population Gender difference Percutaneous coronary intervention

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A squamous metaplasia in a gastric ulcer scar of the antrum

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World Journal of Gastroenterology 2008年第8期14卷 1296-1298页

作者： Young-Seok Cho Jin-soo Kim Hyung-Keun Kim Jeong-Seon Ji Byung-Wook Kim Hiun-Suk chae Sok-Won Han Kyu-Yong Choi In-Sik Chung Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Kangnam St. Mary’s Hospital Seoul Korea

An 81-year-old man presented with epigastric pain and weight loss for one month. He had a past history of pulmonary tuberculosis, 10 years ago. We performed a gastroscopy, which showed a linear depressed whitish gastric ulcer scar (0.8 cm in length) in the posterior wall of the prepyloric antrum. The result of biopsy was reported as squamous epithelium. Immunohistochemical staining using an antibody to high molecular weight cytokeratin (HMC) revealed positive staining in the squamous epithelium. Two years later, the lesion was followed up. The lesion remained at same site endoscopically, but no squamous epithelium could be seen microscopically.

关键词： Squamous metaplasia Gastric ulcer scar High molecular weight cytokeratin

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Online Approach for Spatio-Temporal Trajectory Data Reduction for Portable Devices

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Journal of Computer Science & Technology 2013年第4期28卷 597-604页

作者： Heemin Park Young-Jun Lee Jinseok chae Wonik Choi Department of Computer Software Engineering Sangmyung University Department of Computer Science and Engineering Incheon National University School of Information and Communication Engineering Inha University

As location data are widely available to portable devices, trajectory tracking of moving objects has become an essential technology for most location-based services. To maintain such streaming data of location updates from mobile clients, conventional approaches such as time-based regular location updating and distance-based location updating have been used. However, these methods suffer from the large amount of data, redundant location updates, and large trajectory estimation errors due to the varying speed of moving objects. In this paper, we propose a simple but efficient online trajectory data reduction method for portable devices. To solve the problems of redundancy and large estimation errors, the proposed algorithm computes trajectory errors and finds a recent location update that should be sent to the server to satisfy the user requirements. We evaluate the proposed algorithm with real GPS trajectory data consisting of 17 201 trajectories. The intensive simulation results prove that the proposed algorithm always meets the given user requirements and exhibits a data reduction ratio of greater than 87% when the acceptable trajectory error is greater than or equal to 10 meters.

关键词： online trajectory sampling moving object tracking data reduction location-based service

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Thalidomide effect in endothelial cell of acute radiation proctitis

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World Journal of Gastroenterology 2008年第30期14卷 4779-4783页

作者： Ki-Tae Kim Hiun-Suk chae Jin-soo Kim Hyung-Keun Kim Young-Seok Cho Whang Choi Kyu-Yong Choi Sang-Young Rho Suk-Jin Kang Department of Radiology College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Department of Pathology College of Medicine The Catholic University of Korea St. Vincent Hospital

AIM: To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats. METHODS: Fourteen female Wistar rats were used: six in the radiation group, six in the thalidomide group, and two in normal controls. The radiation and thalidomide groups were irradiated at the pelvic area using a single 30 Gy exposure. The thalidomide (150 mg/kg) was injected into the peritoneum for 7 d from the day of irradiation. All animals were sacrificed and the rectums were removed on day 8 after irradiation. The microvessels of resected specimens were immunohistochemically stained with thrombomodulin (TM), von Willebrand Factor (vWF), and vascular endothelial growth factor (VEGF). RESULTS: The microscopic scores did not differ significantly between the radiation and thalidomide groups, but both were higher than in the control group. Expression of TM was significantly lower inthe endothelial cells (EC) of the radiation group than in the control and thalidomide groups (P < 0.001). The number of capillaries expressing vWF in the EC was higher in the radiation group (15.3 ± 6.8) than in the control group (3.7 ± 1.7), and the number of capillaries expressing vWF was attenuated by thalidomide (10.8 ± 3.5, P < 0.001). The intensity of VEGF expression in capillaries was greater in the radiation group than in the control group and was also attenuated by thalidomide (P = 0.003). CONCLUSION: The mechanisms of acute radiation- induced proctitis in the rats are related to endothelial cell injury of microvessel, which may be attenuated with thalidomide.

关键词： Radiation proctitis Von Willebrand factor Thrombomodulin Vascular endothelial growth factor Thalidomide

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Clinical significance of MET gene amplification in metastatic or locally advanced gastric cancer treated with first-line fluoropyrimidine and platinum combination chemotherapy

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Chinese Journal of Cancer Research 2019年第4期31卷 620-631页

作者： Seyoung Seo Min-Hee Ryu Baek-Yeol Ryoo Yangsoon Park Young soo Park Young-soon Na chae-Won Lee Ju-Kyung Lee Yoon-Koo Kang Departments of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Asan Institute for Life Science Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

Objective: To investigate the clinical significance of MET gene amplification in patients with gastric cancer in the palliative ***: MET amplification was assessed using fluorescence in situ hybridization(FISH) in 50 patients and quantitative polymerase chain reaction(qPCR) in 326 patients;259 patients treated with first-line fluoropyrimidine and platinum were included for survival ***: The results of FISH and qPCR indicated that the c-MET/CEP7 ratio was correlated with gene copy number. The optimal cutoff value for the copy number using qPCR to detect MET gene amplification with FISH was 5(κ=0.778, P5 detected by qPCR. MET-amplified gastric cancer was associated with an Eastern Cooperative Oncology Group(ECOG) performance status(PS) score of ≥2(33.3% vs. 10.5% P=0.007), peritoneal metastasis(76.2% vs. 46.2%, P=0.008), and elevated bilirubin levels(28.6% vs. 7.3%, P=0.006). The median overall survival(OS) and progression-free survival(PFS) were 11.9 and 5.6 months, respectively. MET-amplified gastric cancer was not associated with survival outcomes [hazard ratio(HR)=0.68, 95% confidence interval(95% CI): 0.35-1.32,P=0.254 for PFS;HR=0.68, 95% CI: 0.35-1.32, P=0.251 for OS].Conclusions: qPCR can be used to detect MET gene amplification. MET amplification was not a predictor of poor prognosis in patients with metastatic or unresectable gastric cancer.

关键词： MET amplification advanced gastric cancer prognosis quantitative real-time polymerase chain reaction

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Baseline HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine

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World Journal of Gastroenterology 2007年第30期13卷 4085-4090页

作者： Hee Bok chae Hie-Won Hann Liver Disease Prevention Center Division of Gastroenterology and Hepatology Department of Medicine Jefferson Medical College and Thomas Jefferson University Hospital Philadelphia PA 19107 United States Department of Internal Medicine College of Medicine and Medical Institute Chungbuk National University Cheongju 362-711 South Korea

AIM: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). METHODS: Of 79 patients who had received lamivudine therapy for 9-57 mo, 34 were HBeAg-positive and 45 were HBeAg-negative, 24 developed virologic breakthrough and 55 did not. Clinical and virologic factors were compared between the two groups. RESULTS: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When several factors, including gender, duration of infection, baseline HBV DNA, and baseline ALT in HBeAg-positive chronic hepatitis patients were analyzed by logistic regression, the most important predictor of virologic breakthrough was the baseline HBV DNA (r2 = 0.12, P < 0.05). When HBeAg-postitive chronic hepatitis patients were divided into two groups by a point of 6.6 log HBV DNA, the incidence of virologic breakthough between two groups was significantly different. CONCLUSION: Lamivudine may remain an effective first line therapy for those HBeAg-positive patients with a baseline HBV DNA < 6.6 log10 copies/mL.

关键词： Hepatitis B Lamivudine Virologic breakthrough HBV DNA

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Hybrid algorithm for modeling of fluid-structure interaction in incompressible, viscous flows

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Acta Mechanica Sinica 2012年第4期28卷 1030-1041页

作者： Eun Jung chae Deniz Tolga Akcabay Department of Naval Architecture and Marine Engineering University of Michigan

The objective of this paper is to present and to validate a new hybrid coupling （HC） algorithm for modeling of fluid-structure interaction （FSI） in incompressible, viscous flows. The HC algorithm is able to avoid numerical instability issues associated with artificial added mass effects, which are often encountered by standard loosely coupled （LC） and tightly coupled （TC） algorithms, when modeling the FSI response of flexible structures in incompressible flow. The artificial added mass effect is caused by the lag in exchange of interfacial displacements and forces between the fluid and solid solvers in partitioned algorithms. The artificial added mass effect is much more prominent for light/flexible struc- tures moving in water, because the fluid forces are in the same order of magnitude as the solid forces, and because the speed at which numerical errors propagate in an incom- pressible fluid. The new HC algorithm avoids numerical instability issues associated with artificial added mass effects by embedding Theodorsen＇s analytical approximation of the hydroelastic forces in the solution process to obtain better initial estimates of the displacements. Details of the new HC algorithm are presented. Numerical validation studies are shown for the forced pitching response of a steel and a plastic hydrofoil. The results show that the HC algorithm is able to converge faster, and is able to avoid numerical insta- bility issues, compared to standard LC and TC algorithms, when modeling the transient FSI response of a plastic hydrofoil. Although the HC algorithm is only demonstrated for a NACA0009 hydrofoil subject to pure pitching motion, the method can be easily extended to model general 3-D FSI response and stability of complex, flexible structures in turbulent, incompressible, multiphase flows.

关键词： Fluid-structure interaction Viscous Incom- pressible Computational Added Mass Stability

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Multiple malignant extragastrointestinal stromal tumors of the greater omentum and results of immunohistochemistry and mutation analysis:A case report

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World Journal of Gastroenterology 2007年第24期13卷 3392-3395页

作者： Jong-Han Kim Yoon-Jung Boo Cheol-Woong Jung Sung-soo Park Seung-Joo Kim Young-Jae Mok Sang-Dae Kim Yang-Suk chae Chong-Suk Kim Kim Korea University Hospital Seoul 136-705 Korea Deparment of Surgery Pathology KoreaUniversity College of medicine Seoul 136-705 Korea

To report an extragastrointestinal stromal tumor （EGIST） that occurs outside the gastrointestinal tract and shows unique clinicopathologic and immunohistochemical features. In our case, we experienced multiple soft tissue tumors that originate primarily in the greater omentum, and in immunohistochemical analysis, the tumors showed features that correspond to malignant EGIST. Two large omental masses measured 15 cm×10 cm and 5 cm×4 cm sized and several small ovoid fragments were attached to small intestine, mesentery and peritoneum. On histologic findings, the masses were separated from small bowel serosa and had high mitotic count （115/50 HPFs）. In the results of immunohistochemical stains, the tumor showed CDl17 （c-kit） positive reactivity and high Ki-67 labeling index. On mutation analysis, the c-kit gene mutation was found in the juxtamembrane domain （exon 11）and it was heterozygote. Platelet-derived growth factor receptor （PDGFR） gene mutation was also found in the juxtamemembrane （exon 12） and it was polymorphism. From above findings, we proposed that there may be several mutational pathways to malignant EGIST, so further investigations could be needed to approach this unfavorable disease entity.

关键词： Extragastrointestinal stromal tumor Greater omentum c-kit Platelet-derived growth factor receptor Mutation

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