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Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation

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World Journal of Stem Cells 2022年第3期14卷 245-263页

作者： Min-Jung Kim Won Moon jeonghoon Heo Sangwook lim Seung-Hyun Lee Jee-Yeong jeong Sang Joon Lee Department of Biochemistry Cancer Research Institute Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Internal Medicine Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Molecular Biology and Immunology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Radiation Oncology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of General Surgery Kosin University College of MedicineSeogu 49267BusanSouth Korea Department of Ophthalmology Gospel HospitalKosin University College of MedicineSeo-gu 49267BusanSouth Korea

BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to *** concerted efforts,there is no definitive treatment method *** studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are *** We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM *** Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μ*** white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three *** BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in *** The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three *** transplantations of ADSCs delayed the repopulation of BM hematopoietic stem ***-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT *** The results suggested that an optimal amount of MSCs could improve survival rates post-WBI.

关键词： Adipose tissue-derived stem cells Bone marrow suppression Mesenchymal stromal cells Radiation Cell therapy

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Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer

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世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 2032-2041页

作者： Ji Hyeong Song Tae jeong Oh Sungwhan An Kyung Ha Lee Ji Yeon Kim Jin soo Kim Department of Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Genomictree Inc.Daejeon 34027South Korea Department of Surgery College of MedicineChungnam National UniversityDaejeon 35015South Korea

BACKGROUND Early detection of colorectal cancer(CRC)is essential to reduce cancer-related morbidity and *** DNA(sDNA)testing is an emerging method for early CRC ***-2(SDC2)methylation is a potential biomarker for the sDNA *** DNA methylation is an early epigenetic event during tumorigenesis and can occur in the normal colonic mucosa during aging,which can compromise the sDNA test *** In this prospective study,we enrolled 151 patients with CRC who underwent curative surgical resection between September 2016 and May *** stool samples were collected from 123 patients and postoperative samples were collected from 122 patients.A total of 104 samples were collected from both preoperative and postoperative *** promoter methylation of SDC2 in sDNA was assessed using linear target enrichment quantitative methylation-specific real-time polymerase chain *** parameters were analyzed using the results of SDC2 *** Detection rates of SDC2 methylation in the preoperative and postoperative stool samples were 88.6%and 19.7%,*** tumor size(3 cm,P=0.019)and advanced T stage(T3–T4,P=0.033)were positively associated with the detection rate of SDC2 methylation before *** sex was associated with false positives after surgery(P=0.030).Cycle threshold(CT)values were significantly decreased postoperatively compared with preoperative values(P<0.001).The postoperative negative conversion rate for preoperatively methylated SDC2 was 79.3%(73/92).CONCLUSION Our results suggested that the SDC2 methylation test for sDNA has acceptable sensitivity and ***,small size and early T stage tumors are associated with a low detection rate of SDC2 *** the cycle threshold values significantly decreased after surgery,SDC2 methylation test for sDNA might have a diagnostic value for CRC.

关键词： Biomarkers DNA methylation Syndecan-2 Colorectal cancer

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Fibrillary gelation and dedoping of PEDOT:PSS fibers for interdigitated organic electrochemical transistors and circuits

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npj Flexible Electronics 2022年第1期6卷 330-340页

作者： Young Jin Jo soo Young Kim jeong Hun Hyun Byeonghak Park Seunghwan Choy Gyan Raj Koirala Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Korea

As one of conducting polymers,PEDOT:PSS,is commonly used in organic electronics,especially for bioelectronics due to its advantages such as high electrical and ionic conductivity,solution-processability and *** bioelectronics with the PEDOT:PSS requires advanced techniques to obtain physical/chemical modification of the PEDOT:PSS for improved performance and various *** satisfy these demands,fibrillary gelation of PEDOT:PSS by injection to choline acetate,an ionic liquid,with a constant flow rate was used in this study to make a conductive fiber and improve characteristics of PEDOT:*** fibers by fibrillary gelation showed enhanced electrical conductivity of about 400 S cm^(-1) and volumetric capacitance of about 154 F cm^(−3) which would be strongly beneficial to be utilized for organic electrochemical transistors(OECTs),resulting in a high transconductance of 19 mS in a ***,dedoping of the conductive fibers by PEI(polyethyleneimine)enabled the creation of enhancement-mode *** inverters were then fabricated by connecting depletion and enhancement-mode *** results demonstrate that these conductive fibers and electronic-textiles are suitable candidates for applications in bio-integrated electronics.

关键词： fibers doping digit

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Feasibility Study of R134a/R404a Cascade Heat Pump Cycle in Heat Pump Dryers with Electrical Heaters at Low Temperatures

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Journal of Thermal Science 2015年第5期24卷 463-467页

作者： Ji Woo jeong Young lim Lee Dept. of Mechanical Engineering Kongju National University Dept. of Mechanical and Automotive Engineering Kongju National University

Heat pump cycles have been widely applied to dryers for their high efficiency. However, low–efficiency electrical heaters are often used during early drying stage for frozen foods or winter since a standard heat pump cycle cannot operate at low temperature. This study introduced cascade heat pumps replacing electrical heaters to improve dryer performance at low temperatures. Experiments were performed to examine changes in performance of the cascade heat pump dryers in relation to ambient temperature, low-stage cycle mass flow rate, and high-stage cycle mass flow rate. The results showed a significant improvement in low-temperature dryer performance with the introduction of cascade heat pump cycles.

关键词：低温干燥机热泵循环热泵干燥装置 R134a R404A 电加热器热泵干燥器电热水器

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Multiscale Simulation Starting at the Molecular Level for Adsorption Process Development

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Chinese Journal of Chemical Engineering 2008年第1期16卷 108-111页

作者： Hae-jeong Son Young-il lim Laboratory of Functional Analyses of Complex Systems （FACS） Research Center of Chemical Technology Department of Chemical Engineering Hankyong National University Gyonggi-do Anseong-si Jungangno 167456-749 Korea

这篇文章介绍为吸附过程发展在分子的水平开始的一条多尺度的模拟途径。一个宏大正规蒙特卡罗方法在分子的水平在活性炭上被用于甲醇的吸附等温线的预言。在线性区域获得的吸附等温线(或吸附常数) 作为为吸附过程模拟要求的一个模型参... 详细信息

这篇文章介绍为吸附过程发展在分子的水平开始的一条多尺度的模拟途径。一个宏大正规蒙特卡罗方法在分子的水平在活性炭上被用于甲醇的吸附等温线的预言。在线性区域获得的吸附等温线(或吸附常数) 作为为吸附过程模拟要求的一个模型参数被利用。一套偏微分方程(PDE ) 描述的吸附过程模型被使用保存元素和溶液元素方法解决，它生产一快并且 PDE 的一个精确数字答案。从在分子的水平估计的吸附常数获得的模拟结果在对脉搏反应的试验性的结果的好同意。在这研究探讨的系统的多尺度的模拟途径可能是有用的由减少实验的数字加速吸附过程发展。

关键词：吸附过程开发技术分子水平级多尺度模拟

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Supersonic Cavity Based Combustion with Kerosene/Hydrogen Fuel

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Journal of Thermal Science 2015年第2期24卷 164-172页

作者： Rajarshi Das jeong soo Kim Heuy Dong Kim Department of Mechanical Engineering Andong National University School of Mechanical Engineering Pukyong National University

A comparative study with kerosene and hydrogen fuel in a model scramjet combustor has been carried out numerically. The effect of fuel-air equivalence ratio on the flow field properties in a cavity based mixing mechanism at a freestream Mach number of 2.08 has been probed. The investigation has been carried out in a two dimensional numerical model where a cavity of length to depth ratio of 2 is mounted on one of the walls of the flow channel. The flow field shock structure is observed to change with the change in fuel-air equivalence ratio. Total pressure loss is observed to depend both on fuel air equivalence ratio and the fuel type. The spread of fuel in the test section shows marked variation with the equivalence ratio. Performance of injector location on the fuel-air mixing is also probed during the course of the investigation.

关键词：氢燃料燃烧室煤油超音速空气混合流场特性发动机模型当量比

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Solitary acral persistent papular mucinosis nodule:A case report and summary of eight Korean cases

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World Journal of Clinical Cases 2023年第13期11卷 3086-3091页

作者： Yu jeong Park Hui Young Shin Woo Kyoung Choi Ai-Young Lee Seung Ho Lee Jong soo Hong Department of Dermatology Dongguk University Ilsan HospitalCollege of MedicineDongguk UniversityGoyang-siGyeonggi-doKorea 10326South Korea

BACKGROUND Acral persistent papular mucinosis(APPM)is a rare idiopathic subtype of localized lichen *** date,there have been 40 APPM cases reported worldwide;however,only 7 cases have been reported in the Korean *** SUMMARY A 70-year-old man was referred to our hospital with a solitary pinkish nodule on the dorsum of his right *** the absence of symptoms,the patient wanted to know the exact diagnosis;thus,a biopsy was *** examination of a biopsy specimen obtained from the nodule on the dorsum of his hand revealed orthokeratotic hyperkeratosis with patchy parakeratosis,prominent hypergranulosis,and diffuse dissecting mucinous deposition between collagen bundles,along with some bland-looking spindle cells throughout the *** nodule was histologically diagnosed as an APPM,and an intralesional triamcinolone injection(2.5 mg/mL)was started every 2 *** three sessions of treatment,the patient showed marked *** To the best of our knowledge,this is the first case of a Korean APPM presenting as a solitary nodule that showed a marked response to triamcinolone intralesional *** it is a rare disease,we report this case to contribute to future research on the pathogenesis and treatment of APPM.

关键词： Acral persistent papular mucinosis Localized lichen myxedematosus Cutaneous mucinosis Mucin Case report

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Optimal laboratory testing protocol for patients with acne taking oral isotretinoin

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World Journal of Clinical Cases 2023年第11期11卷 2435-2442页

BACKGROUND Isotretinoin is a widely prescribed drug for various dermatological conditions,especially *** tests are routinely performed to monitor its side ***,the optimal testing schedule remains *** To evaluate the laboratory monitoring tests and schedules of patients with acne taking isotretinoin to determine the most efficient testing *** We retrospectively reviewed electronic medical records from the Dermatology Department of Dongguk University Ilsan Hospital from 2005 to 2020 for patients prescribed isotretinoin for acne who underwent monthly blood *** Aspartate aminotransferase(AST),alanine aminotransferase(ALT),and trigly-ceride(TG)levels significantly changed between 5 and 6 mo when the total prescription period and dose variables were considered *** high-density lipoprotein level also significantly changed between 5 and 6 ***,low-density lipoprotein(LDL)and total cholesterol levels significantly changed between 1 and 2 *** We recommend testing AST,ALT,and TG levels once every 5 to 6 *** also suggest testing LDL and total cholesterol levels during the first and second months.

关键词： Acne vulgaris Isotretinoin Clinical laboratory techniques Vitamin A Liver

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Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

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Cellular & Molecular Immunology 2023年第7期20卷 820-834页

作者： Myeong-Ho Kang JungHyub Hong Jinjoo Lee Min-Suk Cha Sangho Lee Hye-Young Kim Sang-Jun Ha Yong Taik lim Yong-soo Bae Department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoulRepublic of Korea Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).However,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity

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Role of multidetector computed tomography in patients with acute infectious colitis

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World Journal of Clinical Cases 2022年第12期10卷 3686-3697页

作者： Seung Jung Yu Jae Hyuk Heo Eun jeong Choi Jong Hyuk Kim Hong Sub Lee Sun Young Kim Jae Hoon lim Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Radiology Myongji HospitalHanyang University College of MedicineGoyang 10475South Korea Department of Cancer Control and Population Health National Cancer CenterGoyang 10408South Korea

BACKGROUND The role of multidetector computed tomography(MDCT)in patients with acute infectious colitis is still *** To examine the usefulness of MDCT in distinguishing the etiology of acute infectious *** Overall,244 patients who met the criteria for acute infectious colitis and visited the Hospital from February 2015 to 2018 were retrospectively enrolled and divided into two groups(bacterial:204,viral:40)according to causes of acute colitis,based on stool *** MDCT parameters,including wall thickening,submucosal edema,mucosal enhancement,serosa involvement,empty colon sign,small bowel involvement,comb sign,continuous distribution,accordion sign,mucosal thickening,and lymph node enlargement,were constructed in a blinded *** MDCT parameters of wall thickening(OR:13.60;95%CI:5.80–31.88;P<0.001),submucosal edema(OR:36.08;95%CI:13.54–96.13;P<0.001),mucosal enhancement(OR:22.55;95%CI:9.28–54.81;P<0.001),serosal involvement(OR:14.50;95%CI:3.33–63.23;P<0.001),empty colon sign(OR:6.68;95%CI: 2.44–18.32;P < 0.001), continuous distribution (OR: 24.09;95%CI: 9.38–61.90;P < 0.001), accordionsign (OR: 9.02;95%CI: 1.12–72.35;P = 0.038), mucosal thickening (OR: 46.41;95%CI: 10.38–207.51;P< 0.001), and lymph node enlargement (OR: 4.39;95%CI: 1.22–15.72;P = 0.023) were significantlyassociated with bacterial colitis. At least one positive finding in four CT outcomes (submucosaledema, mucosal enhancement, continuous distribution, mucosal thickening) in summer showed ahigh probability of bacterial colitis (sensitivity, 41.67;specificity, 92.50;OR: 24.95).CONCLUSIONMDCT provides many clues that can be useful in suggesting a specific etiology of acute infectiouscolitis.

关键词： Colitis Multidetector computed tomography Differential diagnosis Bacterial infections Viral infections

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