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Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia

World Journal of Gastroenterology 2017年第45期23卷 8053-8061页

作者： Yoon Jin Choi Young soo Park Nayoung Kim Yong Sung Kim Sun Min lee Dong ho lee Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang Hospital Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Gastroenterology Wonkwang Digestive Disease Research InstituteWonkwang University Sanbon Hospital

AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) *** Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang hospital,and classified into control and FD group based on ROME Ⅲ criteria. Questionnaire included assessment for dyspepsia symptoms,Qo L and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male(15.9 fmol/m L vs 10.4 fmol/m L,P = 0.017). Significantly higher m RNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male(P = 0.002 and P = 0.014,respectively) than in female. In contrast,female FD patients had a higher anxiety and depression score than male FD(P = 0.029),and anxiety score was correlated with epigastric pain only in female FD patients(female: Spearman rho = 0.420,P = 0.037). The impairment of overall Qo L was more prominent in female FD patients than male patients(5.4 ± 0.3 vs 6.5 ± 0.3,P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.

关键词： Functional dyspepsia Gender differences Quality of life

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Clinical features of strabismus and nystagmus in bilateral congenital cataracts

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 813-817页

作者： Sung soo Hwang Wan soo Kim soo Jung lee Department of Ophthalmology Haeundae Paik Hospital Inje University College of Medicine Busan 48108 Korea Kim Wan soo Eye Clinic Busan 48266 Korea

AIM：To evaluate the prevalence,clinical features,and the factors affecting onset of strabismus and nystagmus in patients with bilateral congenital ***：This study evaluated 116 eyes of 58 patients who underwent lens removal for the treatment of bilateral congenital cataracts between January 1999 and January *** presence and type of strabismus and nystagmus were determined before and after *** of strabismus and final visual acuity were compared in patients with and without *** were divided into three groups（orthotropia/orthotropia,orthotropia/strabismus,and strabismus/strabismus） according to their preoperative and postoperative ocular *** at cataract surgery and associations of nystagmus and primary intraocular lens（IOL） implantation with strabismus were ***：Six patients（10.3%） had strabismus preoperatively and an additional 11（19.0%） developed postoperative *** was more common than esotropia both preoperatively and *** patients（31.0%） had postoperative nystagmus,with sensory nystagmus being the most common *** the 18 patients with nystagmus,10 had strabismus,with exotropia being more common than *** visual acuity was poor in patients with *** at cataract surgery and rate of primary IOL implantation were significantly lower,and postoperative nystagmus was more common,in the orthotropia/strabismus group than in the other two ***：Exotropia and sensory nystagmus are common in patients with bilateral congenital *** at cataract surgery and rate of IOL implantation are lowerand nystagmus more common in patients with postoperative onset of *** is associated with poor visual prognosis.

关键词： bilateral congenital cataracts strabismus nystagmus

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Endoscopic transcystic stent placement for an intrahepatic abscess due to gallbladder perforation

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World Journal of Gastroenterology 2007年第9期13卷 1458-1459页

作者： Myung soo Kang Do Hyun Park Ki Du Kwon Jeong hoon Park Suck-ho lee hong-soo Kim Sang-Heum Park Sun-Joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University Cheonan HospitalCheonan Korea

Perforation of the gallbladder with cholecystohepatic communication is a rare cause of liver abscess. Because it is a rare entity, the treatment modality has not been fully established. We report for the first time a patient with an intrahepatic abscess due to gallbladder perforation successfully treated by endoscopic stent placement into the gallbladder who had a poor response to continuous percutaneous drainage.

关键词： Liver abscess Gallbladder perforation Endoscopic stent placement Cholecystohepatic communication

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Etching characteristics of thin SiON films using a liquefied perfluorocarbon precursor of C_6F_(12)O with a low global warming potential

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Plasma Science and Technology 2020年第10期22卷 135-144页

作者： Junmyung lee Yunho NAM Jongchan lee Hyun Woo lee Kwang-ho KWON Department of Control and Instrumentation Engineering Korea UniversitySejong 30019Republic of Korea Department of Aeronautic Computer Engineering Hanseo UniversitySeosan 31962Republic of Korea

Perfluorocarbon gas is widely used in the semiconductor ***,perfluorocarbon has a negative effect on the global environment owing to its high global warming potential(GWP) *** alternative solution is ***,we evaluated the possibility of replacing conventional perfluorocarbon etching gases such as CHF_3 with C_6F_(12)O,which has a low GWP and is in a liquid state at room *** this study,silicon oxynitride(SiON) films were plasma-etched using inductively coupled CF4+C_6F_(12)O+O_2 mixed ***,the etching characteristics of the film,such as etching rate,etching profile,selectivity over Si,and photoresist,were investigated.A double Langmuir probe was used and optical emission spectroscopy was performed for plasma *** addition,a contact angle goniometer and x-ray photoelectron spectroscope were used to confirm the change in the surface properties of the etched SiON film ***,the etching characteristics of the C_6F_(12)O mixed plasma exhibited a lower etching rate,higher SiON/Si selectivity,lower plasma damage,and more vertical etched profiles than the conventional CHF_3 mixed *** addition,the C_6F_(12)O gas can be recovered in the liquid state,thereby decreasing global *** results confirmed that the C_6F_(12)O precursor can sufficiently replace the conventional etching gas.

关键词： global warming potential perfluorocarbon silicon oxynitride etching characteristics liquid-state perfluorocarbon

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Wavelength-dependent three-dimensional single-molecule superlocalization imaging for yoctomole detection of thyroid-stimulating hormone on a quantum dot nanobiosensor

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Chinese Chemical Letters 2023年第12期34卷 518-521页

作者： Junghwa lee Seungah lee Seong ho Kang Department of Chemistry Graduate SchoolKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea Department of Applied Chemistry and Institute of Natural Sciences Kyung Hee UniversityYongin-siGyonggi-do 14Republic of Kore

A wavelength-dependent three-dimensional(3D)superlocalization imaging method on gold nanoislands(GNIs)chip was developed as a supersensitive single-molecule thyroid-stimulating hormone(TSH)*** and fluorescent signals from gold nanoislands on the substrate and quantum dots(QDs)nanoprobes were simultaneously isolated and acquired within an evanescent field layer generated by total internal reflection(TIR)of incident light using a dual-view *** 3D TIR fluorescence images of TSH-bound QDs on the GNIs were obtained using z-axis optical sectioning at 10nm intervals before/after immunoreaction to identify the optimal conditions for *** localized centroid position of QD nanoprobes and GNI were distinguished at a subdiffraction limit resolution using 3D Gaussian fitting to the point spread *** QD TSH nanobiosensor using wavelength-dependent 3D TIR fluorescence-based single-molecule localization microscopy(3D TIRF-SLM)imaging technique showed an excellent detection limit of 90 yoctomoles(~54 molecules)and a wide linear dynamic range of 1.14 zmol/L-100 pmol/L for *** detection sensitivity was about 4.4×10^(9)times higher than conventional enzyme-linked immunosorbent assay and could successfully quantify TSH in human *** wavelength-dependent 3D TIRF-SLM technique may emerge as a reliable platform for ultrahigh-sensitive nanobiosensors at the single-molecule level and early diagnosis with quantification of disease-related ultra-tracebiomolecules.

关键词： Single-molecule nanobiosensor Thyroid stimulating hormone Yoctomole detection 3D superlocalization Imaging

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Management of Schemes and Threat Prevention in ICS Partner Companies Security

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Computers, Materials & Continua 2021年第12期69卷 3659-3684页

作者： Sangdo lee Jun-ho Huh Cyber Security Center Korea Midland Power Co.Ltd.BoryeongKorea Department of Data Informatics (National)Korea Maritime and Ocean UniversityBusanKorea

An analysis of the recent major security incidents related to industrial control systems,revealed that most had been caused by company ***,enterprise security management systems have been developed to focus on companies’***,several hacking incidents,involving major companies and public/financial institutions,were actually attempted by the cooperative firms or the outsourced manpower undertaking maintenance ***,institutions that operate industrial control systems(ICSs)associated with critical national infrastructures,such as traffic or energy,have contracted several cooperative ***,ICT’s importance is gradually increasing,due to outsourcing,and is the most vulnerable factor in *** paper proposes a virtualized security management scheme for the resident cooperative firms in the industrial control *** such companies often cannot afford adequate investment in security,the scheme is to let an ICS company provide the virtualized *** of its merits is the convenience of controlling a VDI server at the *** cooperative firms were classified,based on their respective security levels,and statistics were collected throughout a four-year period for the *** paper analyzes the policies and virtualization systems that have been applied to the security of the partner companies,which engaged in ICS security.A suitable model for ICS security was then proposed by analyzing their effects on the system efficiencies,based on the comparisons of the security inspection results obtained before and after *** proposed system is expected to contribute to industrial safety.

关键词： Nuclear power plant nuclear power plant security virtual machine SCADA ICS ISO27001 VDI based security software engineering

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GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro

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Signal Transduction and Targeted Therapy 2020年第1期5卷 255-257页

作者： Kyung soo hong June hong Ahn Jong Geol Jang Jong ho lee hong Nam Kim Dongha Kim Wonhwa lee Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Laboratory Medicine College of MedicineYeungnam UniversityYeungnam University Medical CenterDaegu 42415Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Department of Anatomy College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea

Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health *** is the first time that the Who has declared a pandemic since H1N1 in *** of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(https://***/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics.

关键词： drugs mortality cytokine

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The photodynamic therapy on Streptococcus mutans biofilms using erythrosine and dental halogen curing unit

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International Journal of Oral Science 2012年第4期4卷 196-201页

作者： Young-ho lee ho-Won Park Ju-Hyun lee Hyun-Woo Seo Si-Young lee Department of Pediatric Dentistry Graduate SchoolCollege of DentistryGangneung-Wonju National University Department of Pediatric Dentistry College of DentistryGangneung-Wonju National University Department of Microbiology and Immunology College of DentistryGangneung-Wonju National University

The purpose of our study was to evaluate the effect of photodynamic therapy （PDT）, using erythrosine as a photosensitizing agent and a dental halogen curing unit as a light source, on Streptococcus mutans in a biofilm phase. The S. mutans biofilms were formed in a 24-well cell culture cluster. Test groups consisted of biofilms divided into four groups： group 1： no photosensitizer or light irradiation treatment （control group）; group 2： photosensitizer treatment alone; group 3： light irradiation alone; group 4： photosensitizer treatment and light irradiation. After treatments, the numbers of colony-forming unit （CFU） were counted and samples were examined by confocal laser scanning fluorescence microscopy （CLSM）. Only group 4 （combined treatment） resulted in significant increases in cell death, with rates of 75% and 55% after 8 h of incubation, and 74% and 42% at 12 h, for biofilms formed in brain-heart infusion （BHI） broth supplemented with 0% or O. 1% sucrose, respectively. Therefore, PDT of S. mutans biofilms using a combination of erythrosine and a dental halogen curing unit, both widely used in dental clinics, resulted in a significant increase in cell death. The PDT effects are decreased in biofilms that form in the presence of sucrose.

关键词： biofilms dental halogen curing unit erythrosine photodynamic therapy Streptococcus mutans

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Intrinsic electrochemical activity of Ni in Ni_(3)Sn_(4) anode accommodating high capacity and mechanical stability for fast-charging lithium-ion batteries

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Journal of Energy Chemistry 2022年第8期31卷 470-477,I0013页

作者： Janghyuk Moon Trung Dinh hoang Seong soo Park Seowan Park Dong Young Rhee Junwon lee Sang A Han Min-Sik Park Jung ho Kim School of Energy Systems Engineering Chung-Ang UniversityHeukseok-RoDongjak-guSeoul 06974Republic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated Education Institute for Frontier Science&Technology(BK21 Four)Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin 17104Republic of Korea Institute for Superconducting&Electronic Materials(ISEM) Australian Institute of Innovative Materials(AIIM)University of WollongongInnovation CampusSquires WayNorth WollongongNSW 2500Australia

Fast interfacial kinetics derived from bicontinuous three-dimensional(3D)architecture is a strategic feature for achieving fast-charging lithium-ion batteries(LIBs).One of the main reasons is its large active surface and short diffusion ***,understanding of unusual electrochemical properties still remain great challenge due to its *** this study,we proposed a nickel–tin compound(Ni_(3)Sn_(4))supported by 3D Nickel scaffolds as main frame because the Ni_(3)Sn_(4) clearly offers a higher reversible capacity and stable cycling performance than bare tin(Sn).In order to verify the role of Ni,atomic-scale simulation based on density functional theory systematically addressed to the reaction mechanism and structural evolution of Ni_(3)Sn_(4) during the lithiation *** findings are that Ni enables Ni_(3)Sn_(4) to possess higher mechanical stability in terms of reactive flow stress,subsequently lead to improve Li storage *** study elucidates an understanding of the lithiation mechanism of Ni_(3)Sn_(4) and provides a new perspective for the design of high-capacity and high-power 3D anodes for fast-charging LIBs.

关键词： Lithium-ion batteries Ni_(3)Sn_(4) High-capacity anode 3D-structured electrode Inverse opal structure Density functional theory

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Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

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Cellular & Molecular Immunology 2023年第7期20卷 820-834页

作者： Myeong-ho Kang JungHyub hong Jinjoo lee Min-Suk Cha Sangho lee Hye-Young Kim Sang-Jun Ha Yong Taik Lim Yong-soo Bae Department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoulRepublic of Korea Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).however,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity

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