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Influence of the Fitted Straight Line for Confidence Bands Algorithm in Q-Q Plots

Natural Science（自然科学期刊） 2010年第1期

作者： S. S. Bhatt S. C. Chaudhry Neeraj Sharma sonia Gupta

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Instruments for the assessment of social anxiety disorder: Validation studies

Open Journal of Statistics（统计学期刊） 2021年第6期

作者： sonia Castillo-Gutiérrez María Dolores Estudillo-Martínez Emilio Damián Lozano-Aguilera

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World Journal of Psychiatry 2012年第5期2卷 83-85页

作者： Flávia de Lima Osório José Alexandre de Souza Crippa sonia Regina Loureiro Department of Neuroscience and Behavior Faculty of Medicine of Ribeirao Preto University of Sao Paulo INCT Translational Medicine Hospital das Clínicas FMRP-USP Avenida dos Bandeirantes 3900 Ribeirao Preto SP CEP 14049-900 Brazil

Great progress has been observed in the literature over the last decade regarding the validation of instruments for the assessment of Social Anxiety Disorder in the Brazilian context. Particularly outstanding in this respect is the production of a group of Brazilian investigators regarding the psychometric study of the following instruments: Liebowitz Social Anxiety Scale, Social Phobia Inventory, Brief Social Phobia Scale, Disability Profile, Liebowitz Self-Rated Disability Scale, Social Phobia Safety Behaviors Scale and Self-Statements During Public Speaking Scale, which have proved to be appropriate and valid for use in the adult Brazilian population, representing resources for the assessment of social anxiety in clinical and experimental situations.

关键词： Social anxiety Social phobia,Instruments Validation Scale

A simple model for automatic analysis and diagnosis of environmental thermal comfort in energy efficient buildings

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建筑节能(中英文) 2016年第9期 65-65页

作者： Eduardo Balvís scar Sampedro sonia Zaragoza Angel Paredes Humberto Michinel 侯恩哲《建筑节能》杂志社

We present a mathematical model to diagnose HVAC systems in buildings based upon the analysis of a small number of ambient state variables. In particular, the equations of the model accurately fit recorded data of temperature, relative humidity and carbon dioxide concentration in different workplaces. For validation, data were obtained under different conditions and with different sensors. In particular, we designed and fabricated a wireless sensor that measures and transmits data to a remote device and we also applied our model to data collected using a commercial sensor. For each case, information was obtained that could be used to understand and predict the evolution of ambient variables that impact thermal comfort and energy consumption in buildings. The tools presented here can thus be of great interest to achieve affordable, smart energy-efficient buildings, while adhering to environmental laws and comfort for work spaces.

关键词： Energy efficiency HVAC Environmental comfort

《被天堂遗忘的孩子》——比分离更难的是相聚

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新东方英语（中学版） 2016年第8期 46-49页

作者：索尼娅·纳扎里奥王勣禾摇

索尼娅·纳扎里奥（sonia Nazario,1960-）,美国记者,有20多年的报道经验,专门撰写与社会问题有关的报道。2002年,索尼娅撰写了题为＂Enrique＇s Journey＂的系列报道,发表在《洛杉矶时报》（Los Angeles Times）上,因此获得了美国新闻... 详细信息

索尼娅·纳扎里奥（sonia Nazario,1960-）,美国记者,有20多年的报道经验,专门撰写与社会问题有关的报道。2002年,索尼娅撰写了题为＂Enrique＇s Journey＂的系列报道,发表在《洛杉矶时报》（Los Angeles Times）上,因此获得了美国新闻最高奖普利策奖（Pulitzer Prize）在内的十几项大奖。

关键词：《洛杉矶时报》分离孩子遗忘天堂美国记者报道经验社会问题

新与旧的相互移植打造独一无二的空间体验——塞尔维亚贝尔格莱德老磨坊酒店

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设计家 2015年第3期 92-97页

作者： Lars Kruckeberg Wolfram Putz Thomas Willemeit Andrea Goldel Sascha Kruckeberg Sebastian Gernhardt Stephen Molloy Denis Leo Hegic sonia Wedemeyer Alice Mayer Antonio Luque Tade Godbersen Tobias Hein GRAFT

地点：塞尔维亚,贝尔格莱德客户：Soravia Group完成时间：2014年设计理念在贝尔格莱德这座白色之城市里,GRAFT将位于萨瓦河边的一座历史性建筑＂老磨坊＂改造成了一家新酒店。室内设计的理念是用新材料,色彩和形状来改造现存的历史性建... 详细信息

地点：塞尔维亚,贝尔格莱德客户：Soravia Group完成时间：2014年设计理念在贝尔格莱德这座白色之城市里,GRAFT将位于萨瓦河边的一座历史性建筑＂老磨坊＂改造成了一家新酒店。室内设计的理念是用新材料,色彩和形状来改造现存的历史性建筑,激发这栋文化古建筑的原始品质,并因此创造出独一无二的视觉体验,这座地标性的酒店建筑拥有236间客房和位于顶层的14间带阳台的套间,同时还在顶层建造了一个有四间会议室的会议中心,一个巨大的宴会厅,和一个高级商务休息室。

关键词：室内设计文化遗址萨瓦河语境化间带视觉体验地标性空间体验新与旧混凝土结构

Assessment of Trace Metal Levels of Groundwater in Lubumbashi,Kampemba and Kamalondo Communes of Lubumbashi City,Democratic Republic of Congo

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Journal of Environmental Science and Engineering(A) 2021年第1期10卷 9-25页

作者： Bamba Bukengu Muhaya sonia Catherine Mulongo Clarisse Zoza Kunyonga Alexis Woot Mpomanga Emery Mutombo Kalonda Department of Chemistry Faculty of ScienceUniversity of LubumbashiP.O.Box 1825LubumbashiDemocratic Republic of Congo Department of Geology Faculty of ScienceUniversity of LubumbashiP.O.Box 1825LubumbashiDemocratic Republic of Congo Department of Process Chemistry Higher School of Industrial EngineersUniversity of LubumbashiP.O.Box 1825LubumbashiDemocratic Republic of Congo Department of Geography and Environmental Science Faculty of ScienceUniversity of LubumbashiP.O.Box 1825LubumbashiDemocratic Republic of Congo

Trace metal levels of groundwater in Lubumbashi,Kampemba and Kamalondo communes of Lubumbashi city were assessed from October 2016 to February *** hundred forty water samples collected from twenty-two spade-sunk wells and twelve drilled wells in these three communes of Lubumbashi city were analyzed for their metal contents using ICP-SF-MS(Inductively Coupled Plasma-Sector Field Mass Spectrometry).Twenty trace elements including strontium,molybdenum,cadmium,cesium,barium,tungsten,thallium,lead,bismuth,uranium,aluminum,vanadium,chromium,manganese,iron,cobalt,nickel,copper,zinc and arsenic were recorded at varying concentrations in all the water samples and were compared with the WHO(World Health Organization),US EPA(Environmental Protection Agency)and EU(European Union)drinking water MCLs(Maximum Concentration Limits)for cadmium,barium,thallium,lead,uranium,aluminum,chromium,manganese,iron,nickel,copper,zinc and *** cadmium,lead,aluminum,manganese,iron,nickel,zinc and arsenic levels respectively exceeded the WHO,US EPA and EU drinking water MCLs in 6.66%,3.38%,26.67%,5.02%,30.03%,3.38%,1.64% and 5.02% of the samples with the highest mean levels of 116.89μg/L for cadmium,38.162μg/L for lead,2,712.5μg/L for aluminum,1,242.68μg/L for manganese,17,325.98μg/L for iron,64.647μg/L for nickel,9,900.72μg/L for zinc and 65.458μg/L for *** water pH values ranged from 4.7 to 11.1 with 19.17% of the groundwater samples having mean pH values outside the WHO drinking water pH optimum range values of 6.5-8.5,including 5.02% of the water samples which were acidic(mean pH values ranging from 4.7 to 6.4)and 14.15% which were alkaline(mean pH values ranging from 8.6 to 11.1).With such physicochemical and trace metal contamination status of groundwater in the three communes of Lubumbashi city,there is a high risk to the health of people who use that water to meet their drinking water needs.

关键词： Drinking water groundwater EPA standards EU regulations pH trace metals Lubumbashi city WHO guidelines

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老年人的营养和肠道微生物群

老年人的营养和肠道微生物群

QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

作者： Nuria Salazar Lorena Valdes-Varela sonia Gonzalez Miguel Gueimonde Clara G.de los Reyes-Gavilan 白慧婧赵燕芳复旦大学附属华东医院临床营养中心

肠道微生物群是生活在我们肠道中的微生物的集合,它们的基因组被称为微生物组。这种微生物群的正确组成和功能对于保持"健康状态"是必不可少的。衰老与肠道微生物群的变化有关,肠道微生物群的变化常常与胃肠道的生理改变有关,也与饮食...

肠道微生物群是生活在我们肠道中的微生物的集合,它们的基因组被称为微生物组。这种微生物群的正确组成和功能对于保持"健康状态"是必不可少的。衰老与肠道微生物群的变化有关,肠道微生物群的变化常常与胃肠道的生理改变有关,也与饮食模式的改变有关,并且伴随着认知和免疫功能的下降,这些都是造成虚弱的原因。因此,旨在恢复老年人微生物群的营养战略必须从全局出发,不仅要考虑微生物群,而且要考虑其他肠道外的作用靶点。本综述旨在总结老年人肠道微生物群改变和其他功能受损的最新知识,并通过使用益生菌、益生元或特定营养素来分析实施营养策略的工具,以平衡这些变化。老年人的疾病和功能损害和肠道微生物的变化密切相关,营养影响微生物群的形成;因此,提高对老年人中营养与肠道菌群结构和功能之间相互作用的认识,可以通过设计个性化营养策略来帮助改善老年人群的总体健康状况。

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti sonia Osorio JoséFSánchez-Sevilla Iraida Amaya Centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced Biotechnology Universidad de Málaga29071MálagaSpain Finca el Cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&Co.KG 01108DresdenGermany INVENIO 33800BordeauxFrance Biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural Crop Breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of Bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.Bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de Biología Molecular y Bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-CSIC Biotecnología y Mejora en Fresa 29010MálagaSpain.

Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

关键词： straw cultivar content

New era of personalized medicine:Advanced therapy medicinal products in Europe

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World Journal of Immunology 2021年第1期11卷 1-10页

作者： Javier García-González sonia Marhuenda-Castillo Sheila Romero-Carretero Jesús Beltrán-García Strategy and Market Access Pharmaceutical IndustryMadrid 28012Spain Clinical Research International CROMadrid 28003Spain Department of Physiology Faculty of Medicine and DentistryUniversity of ValenciaValencia 46010Spain Center for Biomedical Research in Rare Diseases Network(CIBERER) Carlos III Health InstituteValencia 46010Spain INCLIVA Institute of Sanitary Research Valencia 46010Spain

Advanced therapy medicinal products are human medical therapies based on genes,cells,or tissues,and due to their characteristics,they offer new innovative opportunities for the treatment of diseases and injuries,especially for diseases beyond the reach of traditional *** therapies are at the forefront of innovation and have historically been very controversial,although in the last decade they have gained prominence while the number of new advanced therapies has increased every *** this regard,despite the controversy they may generate,they are expected to dominate the market in the coming *** based on advanced therapies are the present and future of medicine and bring us closer to the long-awaited precision *** we review the field as it stands today,with a focus on the molecular mechanisms that guided the different advanced therapies approved by the European Medicines Agency,their current status,and their legal approval.

关键词： Advanced therapy Advanced therapy medicinal products Cell therapy Gene therapy Tissue therapy Chimeric antigen receptor T cell