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有机化学 2024年第2期44卷 584-592页

作者：陈雯雯张琴张松月黄芳芳张馨尹贾建峰山西师范大学化学与材料科学学院磁性分子与磁信息材料教育部重点实验室山西太原030031

报道了一种由可见光促进的炔碘与亚磺酸钠直接交叉偶联构建炔砜的方法.合成方法简便、绿色,不需要任何光催化剂和添加剂,具有良好的官能团耐受性和底物普遍适应性.此外,放大规模实验也能取得良好的收率,进一步证明了该方法的实际应用价值.

关键词：炔基砜可见光炔基碘亚磺酸钠偶联反应

The new SHSMA Patent Ductus Arteriosus Occluder: Single Center Experience

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The new SHSMA Patent Ductus Arteriosus Occluder: Single Cent...

2019年浙江省医学会儿科学分会学术大会

作者： Youyang Shi Jing Huang Tingting Wu songyue zhang Hao Li Qiaoyu Wang Ping Li Rongzhou Wu Children’s Heart Center The Second Affiliated Hospital and Yuying Children’s Hospital Institute of Cardiovascular Development and Translational Medicine Wenzhou Medical University

Objectives: To evaluate the feasibility, safety, and efficacy of the SHSMA patent ductus arteriosus(PDA) occluder for closure of ***: The new type SHSMA patent ductus arteriosus(PDA) occluder is novel, self-shaping Nitinol wire device with nano fabric patches integrated into the shank of the device to assure a better obturation of the ductus. The SHSMA PDA occluder has undergone animal ***: A prospective, randomized pilot study was started in August 2014.13 patients were included until June 2017. Patients weighing less than 6 kg or those with associated cardiac anomalies that required surgery were excluded. All patients were followed up by transthoracic echocardiography, electrocardiogram, and chest radiographs at 24 hours, 30, 90, 180, 360 and 720 days after implantation. All occluders were delivered via 7-9 F long sheaths and PDA closures were performed following standard ***: Thirteen patients(6 nano-film single-rivet, 7 double-rivet), were included. All the 13 patients were closed successfully using SHSMA ductal occluder, 5 patients(83.3%) in nano fabric patches singlerivet group, and 7 patients(100%) in double-rivet group had immediate and complete closure on angiography. Within 24 hours, color Doppler revealed complete closure in all 13 patients, 100% at 30 days, and in 100% of patients at 2 years. There was no device embolization, hemolysis, or obstruction to the pulmonary artery or descending ***: The new type SHSMA PDA occluder is feasible, safe and effective.

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论企业犯罪防控与公安机关职能优化——以企业刑事合规为视角

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辽宁公安司法管理干部学院学报 2020年第6期 6-11页

作者：张嵩悦中国刑事警察学院辽宁沈阳110035

企业刑事合规具有预防犯罪的积极效应,承担着企业经营管理安全性和制度性功能,是法治社会背景下现代企业模式的内在要求。刑事合规基于避免因企业或相关员工的行为给企业带来刑事责任风险的目的,并顺应国家刑事政策方面的正向激励和责... 详细信息

企业刑事合规具有预防犯罪的积极效应,承担着企业经营管理安全性和制度性功能,是法治社会背景下现代企业模式的内在要求。刑事合规基于避免因企业或相关员工的行为给企业带来刑事责任风险的目的,并顺应国家刑事政策方面的正向激励和责任归咎意向,进而促使企业以刑事法律为基准识别、评估和预防刑事风险,制定相应的计划和措施。实践中,由于公安机关存在执法标准、执行力度不统一,执法程序不规范以及执法不作为、执法不到位等问题,导致企业合规管理方面不规范、缺乏系统性,增加了企业合规管理的风险。因此,应当从专业队伍建设、执法程序优化升级、深入开展宣传教育、加强监督机制四个维度,通过优化公安机关职能,强化企业犯罪防控,推进企业刑事合规。

关键词：刑事合规企业犯罪刑事法风险

Survivin protects neonatal mouse cardiomyocytes from CVB3-induced apoptosis in a caspase-dependent manner

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Survivin protects neonatal mouse cardiomyocytes from CVB3-in...

2019年浙江省医学会儿科学分会学术大会

作者： Tingting Wu Ping Li Hao Li Yi Zhan songyue zhang Youyang Shi Yaoyao Yan Tianhe Xia Zhenquan Wang Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Viral myocarditis(VMC) is a kind of inflammatory cardiomyopathy mainly affecting children and young adults and resulting in heart failure due to dilated cardiomyopathy or cardiac arrest. Cardiomyocyte apoptosis has been shown to play a critical role in the pathogenesis of coxsackievirus B3(CVB3) induced VMC and blocking of this process may contribute to the therapeutic effect towards VMC. Therefore, the aim of this study was to examine whether survivin, one of the strongest antiapoptotic proteins, participates in the apoptotic activity after CVB3 infection and further reveal its related *** and results Herethe cultured neonatal mouse cardiomyocytes(NMCs) were exposed to CVB3 to establish the cell model of VMC and we found a time-dependent manner of survivin expression after CVB3 infection by Western Blot. Lentivirus was next used to mediate survivin expression thereby examine the function of survivin in CVB3-infected NMCs. TUNEL assay demonstrated that survivin overexpression interrupted CVB3-induced apoptosis and significantly decreased the apoptotic rate at 36 h and 60 h after CVB3 infection. It was next examined whether caspase-3 and-9 were involved in the antiapoptotic pathway initiated by survivin via Western Blot. The results showed a reverse relationship between survivin expression and cleaved caspase-3 and-9 expression, suggesting that survivin may inhibit apoptosis by restraining the activity of caspase-3 and-9. Moreover, the supernatant from cultured NMCs was extracted to detect the quantitation of released LDH and a sharp decrease was shown in survivin overexpressed group compared to CVB3 infected group, indicating a protective role of survivin in CVB3-induced cell *** In the present study, we demonstrated that survivin was triggered by CVB3 infection in NMCs in a time-dependent manner and executed its antiapoptotic effects via caspase-3-and caspase-9-dependent signaling pathway.

关键词：

社会纽带理论视角下青少年校园欺凌行为实证研究

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教育测量与评价 2023年第3期 102-112页

作者：张嵩悦王薇中国刑事警察学院侦查与反恐怖学院沈阳110035 中国刑事警察学院公安基础部

以辽宁省S市3所高中的1031名中学生为被试,采用社会纽带问卷和Olweus欺凌问卷进行问卷调查,探究社会纽带与中学生校园欺凌行为之间的关系。研究发现,与父母、教师的依恋水平越低,投入传统社会活动的精力越少,参与课后学习活动的时间越短... 详细信息

以辽宁省S市3所高中的1031名中学生为被试,采用社会纽带问卷和Olweus欺凌问卷进行问卷调查,探究社会纽带与中学生校园欺凌行为之间的关系。研究发现,与父母、教师的依恋水平越低,投入传统社会活动的精力越少,参与课后学习活动的时间越短,暴力信念感越强的学生,越有可能成为校园欺凌的实施者。为预防和减少青少年校园欺凌行为的发生,学校、教师和家长应从以下方面着力:增强情感沟通,提高青少年对家庭和学校的依恋水平;丰富课余生活,注重青少年的学习投入和学习参与;强化信念教育,增强青少年的道德与法治约束力。

关键词：社会纽带理论校园欺凌行为暴力欺凌非暴力欺凌

Interventional treatment of patent ductus arteriosus combined with congenital bronchial artery pulmonary arteriovenous fistula: clinical outcomes and follow-up

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Interventional treatment of patent ductus arteriosus combine...

2019年浙江省医学会儿科学分会学术大会

作者： Ping Li songyue zhang Yaoyao Yan Bo Cheng Yue Ren Xing Rong Zhenquan Wang Huixian Qiu Youyang Shi Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Congenital bronchial artery to pulmonary artery or vein fistula(BA-PAVF) is a rare abnormality which may induce recurrent pulmonary infection, fatal hemoptysis, and respiratory failure and it is even scarcely reported that BA-PAVF coexisted with patent ductus arteriosus(PDA).Therefore, BA-PAVF can be easily neglected or misdiagnosed in clinic without being treated *** and results In our study, 22 children were diagnosed with congenital BA-PAVF and PDA by cardiac catheterization and selective bronchial *** BAPAVF which was greater than the horizontal adjacent bronchial artery, vascular plug, MicroNester embolization coils, and interlock fibered IDC occlusion system were respectively used to close BA-PAVF after the transcatheter closure of PDA. And the size, shape, number, tortuosity degree of the fistula, the location of the lesions, the specific complications and family economic status were seriously considered before the procedure. 2 of the patients respectively existed small atrial septal defect(ASD) and small ventricular septal defect(VSD). Finally, 9 of them accepted transcatheter embolization(TCE) according to the size of the fistula. After intermediate to long-term followup, all patients have no abnormal ***-stage interventional closure of BA-PAVF and PDA can be used safely and effectively in children coexisted with BA-PAV and PDAand selective bronchial arteriography is an optimal examination to precisely localize BA-PAVF, but the establishment of specific therapy criteria needs more clinical data and summary.

关键词：

突发公共卫生事件中公安数据信息公开及其程序控制

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广州市公安管理干部学院学报 2020年第1期30卷 3-8页

作者：张豫辰张嵩悦中国刑事警察学院

信息化时代,不论是人、物、事都或多或少以数据的形式被记录在网络虚拟空间之中。重大公共的卫生事件面前,公安机关作为实际掌握这些公民个人数据的重要主体,为了维护特殊背景下的社会秩序、回应民众的需求、维护自身公信力,就需要公开... 详细信息

信息化时代,不论是人、物、事都或多或少以数据的形式被记录在网络虚拟空间之中。重大公共的卫生事件面前,公安机关作为实际掌握这些公民个人数据的重要主体,为了维护特殊背景下的社会秩序、回应民众的需求、维护自身公信力,就需要公开所掌握的数据。为了实现当事人的利益与公共利益的平衡,并履行好自身的职责所在,就需要建立一套行之有效的突发公共卫生事件中公安数据公开程序。

关键词：数据信息公开程序规制公安机关突发公共卫生事件

Prophylactic Transcatheter Bronchial Arterial Embolization in Treatment of Congenital Bronchial Artery to Pulmonary Artery or Vein Fistula

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Prophylactic Transcatheter Bronchial Arterial Embolization i...

2018年浙江省医学会儿科学分会学术年会

作者： songyue zhang Ping Li Youyang Shi Bo Cheng Yue Ren Xing Rong Zhenquan Wang Huixian Qiu Rongzhou Wu Maoping Chu Children’s Heart Center the Second Affiliated Hospital and Yuying Children’s HospitalInstitute of Cardiovascular Development and Translational MedicineWenzhou Medical University

Objective:This study sought to demonstrate that prophylactic transcatheter embolization(TCE) can be used safely and effectively for the treatment of congenital bronchial artery to pulmonary artery or vein(BA-PAV) fistula and selective bronchial arteriography is an optimal examination to precisely localize these abnormal ***:BA-PAV fistula is a rare abnormality and may induce recurrent pulmonary infection,fatal hemoptysis and respiratory ***,there is no recommended treatment experience or protocol in the pediatric population.

关键词：

Transcatheter Closure of Perimembranous Ventricular Septal Defects Using an Occluder: 5-Year Outcomes

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Transcatheter Closure of Perimembranous Ventricular Septal D...

2019年浙江省医学会儿科学分会学术大会

作者： Hao Li Youyang Shi songyue zhang Yue Ren Xing Rong Zhenquan Wang Tianhe Xia Tingting Wu Haitang Xu Yaoyao Yan Yi Zhan Maoping Chu Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Transcatheter closure of perimembranous ventricular septal defects is one of the greatest challenges in interventional cardiology. Long-term follow-up data are limited. This report presents our experience with transcatheter closure of perimembranous ventricular septal defects using an *** 253 patients included in the database of the Second Affiliated Hospital and Yuying Children’s Hospital from January 2011– December 2015 with transcatheter closure of perimembranous ventricular septal defects and discharged from follow-up. All patients were invited for clinical and transthoracic echocardiography, electrocardiogram, and thoracic radiography *** Device implantation was successful in 252 of 253 patients(99.6%). The median age was 42 months(range 27 months–18 years). The patients were followed for 6–60 months. The mean defect diameter was 3.5 ± 1.4 mm and the mean size of the ventricular septal defect rim below the aortic valve was 3.7 ± 1.8 mm. The mean diameter of the devices used was 4 mm. Thirty-seven patients developed arrhythmia after the procedure and recovered within 24 months;four patients had hemolysis and four had moderate tricuspid valve regurgitation. No other serious adverse event occurred during the follow-up *** Transcatheter closure of perimembranous ventricular septal defects using an occluder is safe and effective in most patients. Additional studies with larger cohorts and longer follow-up periods are needed to further evaluate the safety of this method. The use of a smaller occluder may shorten the operation time, decreasing the incidence of postoperative arrhythmia.

关键词：

硫化氢对柯萨奇病毒B3心肌炎小鼠血红素加氧酶-1/一氧化碳通路的影响

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中华心血管病杂志 2017年第9期45卷 765-769页

作者：张松跃吴婷婷任跃夏天和吴蓉洲温州医科大学附属第二医院育英儿童医院儿童心脏中心温州医科大学心脏发育与转化医学研究所 325027

目的探讨硫化氢（H2S）对柯萨奇病毒B3（CVB3）心肌炎小鼠血红素加氧酶-1（HO-1）/一氧化碳通路的影响.方法清洁级近交系雄性Balb/c小鼠70只,分为正常组（n=10）、心肌炎组（n=20）、炔丙基甘氨酸组（PAG组,n=20）和硫氢化钠组（NaHS... 详细信息

目的探讨硫化氢（H2S）对柯萨奇病毒B3（CVB3）心肌炎小鼠血红素加氧酶-1（HO-1）/一氧化碳通路的影响.方法清洁级近交系雄性Balb/c小鼠70只,分为正常组（n=10）、心肌炎组（n=20）、炔丙基甘氨酸组（PAG组,n=20）和硫氢化钠组（NaHS组,n=20）.心肌炎组、PAG组和NaHS组分别在第0天每只小鼠腹腔注射0.1 ml10-5 69TCID50m·ml-1的CVB3建立心肌炎模型,从第0天起PAG组予以炔丙基甘氨酸（PAG）40 mg·kg-1·d-1腹腔注射,NaHS组予以硫氢化钠（NaHS） 50 μmol·kg-1·d-1腹腔注射,心肌炎组予以等量磷酸盐缓冲液（PBS）腹腔注射.对照组从第0天起每只小鼠每日腹腔注射不含病毒的等量灭菌PBS液.观察至接种后第10天各组取10只小鼠,记录小鼠体重,采血后处死留取心脏标本并记录其质量.采用心脏质量/体重比值衡量心肌水肿程度,以反应心肌炎症程度.苏木素伊红染色观察小鼠心肌病理改变并计算炎症积分.检测各组小鼠血清碳氧血红蛋白（COHb）表达水平.逆转录聚合酶链反应检测心肌细胞中HO-1 mRNA的表达水平.结果（1）各组小鼠心肌病理学特征：正常组小鼠心肌细胞结构正常,心肌纤维排列整齐,胞浆丰富均匀,横纹清晰,间质无水肿.心肌炎组、PAG组和NaHS组小鼠心肌内均可见心肌细胞坏死崩解,周围伴有大量炎症细胞浸润,以单核细胞和淋巴细胞为主,PAG组心肌细胞坏死及炎症浸润更为明显,坏死灶内可见蓝色钙化颗粒,胞核和细胞轮廓消失,NaHS组炎症较轻,心肌炎症细胞浸润范围较心肌炎组和PAG组小.（2）各组小鼠心脏质量/体重比值和心肌炎症积分：心肌炎组、PAG组和NaHS组小鼠心脏质量/体重比值均明显高于正常组（P均＜0.05）,其中PAG组又明显高于心肌炎组（P＜0.05）,而NaHS组则明显低于心肌炎组（P=0.001）.心肌炎组、PAG组和NaHS组小鼠心肌炎症积分均明显高于正常组（P均＜0.05）,但NaHS组明显低于心肌炎组（P =0.006）,PAG组则明显高于心肌炎组（P =0.038）.（3）各组小鼠血清COHb的表达水平：心肌炎组、PAG组和NaHS组小鼠血清COHb表达水平均明显高于正常组（P均＜0.05）,其中PAG组又明显低于心肌炎组（P=0.000）,NaHS组则明显高于心肌炎组（P =0.000）.（4）各组小鼠心肌HO-1 mRNA的表达水平：心肌炎组、PAG组和NaHS组小鼠心肌HO-1 mRNA的表达水平均明显高于正常组（P均＜0.05）,但PAG组明显低于心肌炎组（P＜0.05）,NaHS组则明显高于心肌炎组（P＜0.05）.（5）小鼠全血COHb表达水平、心肌细胞HO-1 mRNA表达水平及心肌炎症积分三者间的相关性：小鼠全血COHb表达水平与心肌细胞HO-1 mRNA表达水平呈正相关（r=0.927,P=0.000）,心肌炎症积分与全血COHb表达水平呈负相关（r=-0.753,P=0.000）,心肌炎症积分与心肌细胞HO-1 mRNA表达水平呈负相关（r=-0.754,P=0.000）.结论 H2S可诱导CVB3心肌炎小鼠心肌组织HO-1的表达从而上调HO-1/一氧化碳通路,进而发挥心肌保护作用.

关键词：心肌炎硫化氢碳氧血红蛋白血红素加氧酶-1 一氧化碳