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Under the surface:Pressure-induced planetary-scale waves,volcanic lightning,and gaseous clouds caused by the submarine eruption of Hunga Tonga-Hunga Ha'apai volcano

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Earthquake Research Advances 2022年第3期2卷 1-13页

作者： David A.Yuen Melissa A.Scruggs Frank J.Spera Yingcai Zheng Hao Hu Stephen R.McNutt Glenn Thompson Kyle Mandli Barry R.Keller songqiao shawn wei Zhigang Peng Zili Zhou Francesco Mulargia Yuichiro Tanioka Columbia University Dept.of Applied Physics and Applied MathematicsNew YorkNY10027USA Ocean University of China School of Computer Science and Marine GeosciencesQingdao266100China University of California Santa BarbaraDept.of Earth Science1006 Webb HallUniversity of CaliforniaSanta BarbaraCA93106USA University of Houston Dept.of Earth and Atmospheric SciencesScience&Research Bldg.13507 Cullen Boulevard#312HoustonTX77004USA University of South Florida School of GeosciencesTampaFLUSA Mission Beach CAUSA Michigan State University Dept.of Earth and Environmental Sciences288 Farm Ln BldgRoom 207East LansingMI48824USA Georgia Institute of Technology School of Atmospheric and Earth SciencesNorth AvenueAtlantaGA30332USA University of Southern California Sonny Astani Dept.of Civil&Environmental EngineeringKaprielian HallLos AngelesCA90089-2531USA University of Bologna Dept.of Geological SciencesVia Zamboni3340126BolognaItaly Hokkaido University Division of Earth System ScienceN10W5SapporoHokkaido060-0810Japan

We present a narrative of the eruptive events culminating in the cataclysmic January 15, 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and lightning data available within the first few weeks after the eruption occurred. The first hour of eruptive activity produced fast-propagating tsunami waves, long-period seismic waves, loud audible sound waves, infrasonic waves, exceptionally intense volcanic lightning and an unsteady volcanic plume that transiently reached-at 58km-the Earth’s mesosphere. Energetic seismic signals were recorded worldwide and the globally stacked seismogram showed episodic seismic events within the most intense periods of phreatoplinian activity, and they correlated well with the infrasound pressure waveform recorded in Fiji. Gravity wave signals were strong enough to be observed over the entire planet in just the first few hours, with some circling the Earth multiple times subsequently. These large-amplitude, long-wavelength atmospheric disturbances come from the Earth’s atmosphere being forced by the magmatic mixture of tephra, melt and gasses emitted by the unsteady but quasicontinuous eruption from 0402±1–1800 UTC on January 15, 2022. Atmospheric forcing lasted much longer than rupturing from large earthquakes recorded on modern instruments, producing a type of shock wave that originated from the interaction between compressed air and ambient(wavy) sea surface. This scenario differs from conventional ideas of earthquake slip, landslides, or caldera collapse-generated tsunami waves because of the enormous(~1000x) volumetric change due to the supercritical nature of volatiles associated with the hot,volatile-rich phreatoplinian plume. The time series of plume altitude can be translated to volumetric discharge and mass flow rate. For an eruption duration of ~12 h, the eruptive volume and mass are estimated at 1.9 km^(3) and~2 900 Tg, respectively, corresponding to a VEI

关键词： Hunga Tonga-Hunga Ha'apai Atmospheric pressure wave Tsunami wave Volcanic lightning Phreatoplinian eruption

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NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner

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Journal of Molecular Cell Biology 2019年第11期11卷 994-1005页

作者： Ran wei Xuguang Liu Courtney Voss Wentao Qin Lina Dagnino Lei Li Marc Vigny shawn Shun-Cheng Li Departments of Biochemistry Schulich School of Medicine and DentistryWestern UniversityLondonOntarioN6A 5C1Canada Dentistry Schulich School of Medicine and DentistryWestern UniversityLondonOntarioN6A 5C1Canada Physiology and Pharmacology and Schulich School of Medicine and Dentistry Western UniversityLondonOntarioN6A 5C1Canada School of Basic Medical Sciences Qingdao UniversityQingdao 266021ShandongChina Universite Pierre et Marie Curie UPMCINSERM UMRS-839ParisFrance Oncology Schulich School of Medicine and DentistryWestern UniversityLondonOntarioN6A 5C1Canada

NUMB is an evolutionarily conserved protein that plays an important role in cell adhesion,migration,polarity,and cell fate *** has also been shown to play a role in the pathogenesis of certain cancers,although it remains controversial whether NUMB functions as an oncoprotein or tumor ***,we show that NUMB binds to anaplastic lymphoma kinase(ALK),a receptor tyrosine kinase aberrantly activated in several forms of cancer,and this interaction regulates the endocytosis and activity of ***,the function of the NUMB-ALK interaction is *** both p66-NUMB and p72-NUMB isoforms are capable of mediating the endocytosis of ALK,the former directs ALK to the lysosomal degradation pathway,thus decreasing the overall ALK level and the downstream MAP kinase *** contrast,the p72-NUMB isoform promotes ALK recycling back to the plasma membrane,thereby maintaining the kinase in its active *** work sheds light on the controversial role of different isoforms of NUMB in tumorigenesis and provides mechanistic insight into ALK regulation.

关键词： ALK NUMB isoform endocytosis degradation recycling

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Questions about NgAgo

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Protein & Cell 2016年第12期7卷 913-915页

作者： shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li wei Li wei Qin Yujie Sun Zhou Songyang Wensheng wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang National Human Genome Research Institute NIH Bethesda MD 20892 USA Division of Hematology in Department of Medicine Johns HopkinsUniversity School of Medicine Baltimore MD 21205 USA Stem Cell Program in the Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Center for Vision Research Eye Hospital Wenzhou Medical University Wenzhou 325035 China Stem Cell and Functional Genomics Laboratory School of LifeSciences Sun Yat-sen University Guangzhou 510275 China HIT Center of Life Sciences Harbin Institute of Technology Harbin 150080 China Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China State Key Laboratory of Stem cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Chemical Biology and Biotechnology Peking Univer- sity Shenzhen Graduate School Shenzhen 518055 China PKU BIOPIC Beijing 100871 China BIOPIC ICG CLS and School of Life Sciences Peking Univer-sity Beijing 100871 China Center for Comparative Biomedicine Institute of SystemsBiomedicine Shanghai Jiao Tong University Shanghai 200240China Institute of Biophysics Chinese Academy of Sciences Beijing100101 China Institute of Molecular Medicine Peking University Beijing100871 China College of Engineering Peking University Beiiing 100871 China Laboratory of Disease Models in Non-Human Primates Instituteof Neuroscience Shanghai Chinese Academy of SciencesShanghai 200031 China College of Life Sciences Peking University Beijing 100871 China

Dear Editor： Gao et al. published data in Nature Biotechnology （Nat Biotechnol. 2016 May 2） showing that DNA-guided genome editing using the Natronobacterium gregoryi Argonaute （NgAgo） protein targeted 47 mammalian genomic loci with a 100% success rate and an efficiency of 21.3%-41.3% at various targets. This report led us to test NgAgo＇s utility in various cells and organisms such as mouse and zebrafish for gene editing.

关键词： Supplementary Information Genomic Locus Genome Editing Gene Editing Online Forum

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The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize

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Molecular Plant 2022年第5期15卷 904-912页

作者： Ce Deng April Leonard James Cahill Meng Lv Yurong Li shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang weiling Zhu wei Xiong Juan Sun Bailin Li Junqiang Ding College of Agronomy Henan Agricultural UniversityZhengzhou 450046China The State Key Laboratory of Wheat and Maize Crop Science and Center for Crop Genome Engineering Henan Agricultural UniversityZhengzhou 450046China Corteva Agriscience JohnstonIA 50131USA Institute of Plant Protection Henan Academy of Agricultural SciencesZhengzhou 450002China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China International Maize and Wheat Improvement Center(CIMMYT) El Batan56237 TexcocoMexico Center of Biotechnology Beijing Lantron SeedZhengzhou 450001China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Henan Dingyou Agricultural Science and Technology Co. LtdZhengzhou 450001China

Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction *** breeding and deployment of resistant hybrids are key to achieving durable control of ***,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait ***-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by *** and triggers RppC-mediated *** variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize ***,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability.

关键词： maize Zea mays RppC AvrRpp Csouthern corn rust SCR

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Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9

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World Journal of Gastroenterology 2015年第21期21卷 6604-6612页

作者： shawn A Ritchie Bassirou Chitou Qingan Zheng Dushmanthi Jayasinghe wei Jin Asuka Mochizuki Dayan B Goodenowe Department of Biomarker Discovery and Validation Phenome- nome DiscoveriesSaskatoonSK S7N 4L8Canada Department of Manufacturing Phenomenome DiscoveriesSaskatoonSK S7N 4L8Canada Phenomenome Laboratory Services Phenomenome Discoveries

AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to ***:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control *** determined CA19-9 levels by *** between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and *** performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression ***:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for *** at 90% specificity was 87% for PC-594 and 71% for *** Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 ***-five of the 99 control subjects(86%) showed normal levels of both ***:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9.

关键词： Pancreatic cancer Risk Screening Blood Fatty acid Biomarker Metabolite PC-594

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A 3D-printed magnetic digital microfluidic diagnostic platform for rapid colorimetric sensing of carbapenemase-producing Enterobacteriaceae

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Microsystems & Nanoengineering 2021年第3期7卷 173-184页

作者： Pojchanun Kanitthamniyom Pei Yun Hon Aiwu Zhou Mohammad Yazid Abdad Zhi Yun Leow Nurhidayah Binte Mohamed Yazid Vanessa Lim wei Xun shawn Vasoo Yi Zhang Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore CitySingapore National Center for Infectious Disease Tan Tock Seng HospitalSingapore CitySingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore CitySingapore

Carbapenemase-producing Enterobacteriaceae(CPE)are a group of drug-resistant Gram-negative pathogens that are classified as a critical threat by the World Health Organization(WHO).Conventional methods of detecting antibiotic-resistant pathogens do not assess the resistance mechanism and are often time-consuming and *** have developed a magnetic digital microfluidic(MDM)platform,known as MDM Carba,for the identification of CPE by measuring their ability to hydrolyze carbapenem *** Carba offers the ability to rapidly test CPE and reduce the amount of reagents used compared with conventional phenotypic *** the MDM Carba platform,tests are performed in droplets that function as reaction chambers,and fluidic operations are accomplished by manipulating these droplets with magnetic *** simple droplet-based magnetic fluidic operation allows easy system automation and simplified hands-on *** of the unique“power-free”operation of MDM technology,the MDM Carba platform can also be operated manually,showing great potential for point-of-care testing in resource-limited *** tested 27 bacterial isolates on the MDM Carba platform,and the results showed sensitivity and specificity that were comparable to those of the widely used Carba NP *** Carba may shorten the overall turnaround time for CPE identification,thereby enabling more timely clinical decisions for better clinical *** Carba is a technological platform that can be further developed to improve diagnostics for other types of antibiotic resistance with minor modifications.

关键词： thereby operations consuming

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CD4(＋)CD25(＋) treg induction by an HSP60-derived peptide SJMHE1 from schistosoma japonicum is TLR2 dependent

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南京医科大学学报（自然科学版） 2010年第1期30卷 138-138页

作者： Wang, Xuefeng Zhou, Sha Chi, Ying Wen, Xiaoyun Hoellwarth, Jason He, Lei Liu, Feng Wu, Calvin Dhesi, shawn Zhao, Jiaqing Hu, wei Su, Chuan Nanjing Med Univ Jiangsu Key Lab Pathogen Biol Dept Pharmacol Dept Pathogen Biol & Immunol Nanjing 210029 Jiangsu Peoples R China. Univ So Calif Keck Sch Med Dept Educ Affairs Los Angeles CA 90033 USA. Chinese Ctr Dis Control & Prevent Natl Inst Parasit Dis Shanghai Peoples R China.

Chronic schistosome infection results in the suppression of host immune responses, allowing long-term schistosome survival and restricting *** theories suggest that Treg play an important role in this ***, the mechanism of Treg induction during schistosome infection is still *** aim of this study was to determine the mechanism behind the induction of CD4(+)CD25(+) T cells by Schistosoma japonicum HSP60(SjHSP60)-derived peptide SJMHE1 as well as to elucidate the cellular and molecular basis for the induction of CD4(+)CD25(+) T cells during *** *** immunized with SJMHE1 or spleen and LN cells from naive mice *** SJMHE1 in vitro all displayed an increase in CD4(+)CD25(+) T-cell *** of IL-10 and TGF-beta by SJMHE1 stimulation may contribute to *** transferred SJMHE1induced CD4(+)CD25(+) T cells inhibited delayed-type hypersensitivity in BALB / c ***, SJMHE1-treated APC were tolerogenic and induced CD4(+) cells to differentiate into suppressive CD4(+)CD25(+) ***, our data support a role for TLR2 in SJMHE1-mediated CD4(+)CD25(+) Treg *** findings provide the basis for a more complete understanding of the ***-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response.

关键词：血吸虫病治疗方法临床分析细胞

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Erratum to： Questions about NgAgo

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Protein & Cell 2017年第1期8卷 77-77页

作者： shawn Burgess Linzhao Cheng Feng Gu Junjiu Huang Zhiwei Huang Shuo Lin Jinsong Li wei Li wei Qin Yujie Sun Zhou Songyang wensheng wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang National Human Genome Research Institute NIH Bethesda MD USA Division of Hematology in Department of Medicine Johns Hopkins University School of Medicine Baltimore MD 21205 USA Stem Cell Program in the Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Center for Vision Research Eye Hospital Wenzhou Medical University Wenzhou 325035 China Stem Cell and Functional Genomics Laboratory School of Life Sciences Sun Yat-sen University Guangzhou 510275 China HIT Center of Life Sciences Harbin Institute of Technology Harbin 150080 China Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China State Key Laboratory of Stem cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 China PKU BIOPIC Beijing 100871 China BIOPIC ICG CLS and School of Life Sciences Peking University Beijing 100871 China Center for Comparative Biomedicine Institute of Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Institute of Molecular Medicine Peking University Beijing 100871 China College of Engineering Peking University Beijing 106871 China Laboratory of Disease Models in Non-Human Primates Institute of Neuroscience Shanghai Chinese Academy of Sciences Shanghai 200031 China College of Life Sciences Peking University Beijing 100871 China

In the original publication of this article the Figure 1E legend has been incorrectly published.

关键词： Erratum Questions NgAgo

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南昌市高中生童年期不良经历与自杀相关行为的研究

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现代预防医学 2020年第3期47卷 441-445页

作者：文小桐陈飞宇郑辉烈徐雯艳李旭阳贾至慧林毅翔 Sergio Trejo Jr shawn Thomas Bianca Irimia 杨维袁兆康南昌大学公共卫生学院江西省预防医学重点实验室江西省抚州市东乡区疾病预防控制中心美国内华达大学里诺分校

目的了解高中生自杀意念、自杀计划现状及童年期不良经历,探索童年期不良经历与自杀意念、自杀计划的关系,掌握童年期不良经历对自杀意念、自杀计划的累积效应。方法 2015年5月,采取分层整群随机抽样方法,将南昌市城区34所高中按中考录... 详细信息

目的了解高中生自杀意念、自杀计划现状及童年期不良经历,探索童年期不良经历与自杀意念、自杀计划的关系,掌握童年期不良经历对自杀意念、自杀计划的累积效应。方法 2015年5月,采取分层整群随机抽样方法,将南昌市城区34所高中按中考录取分数线由高到低排序随机抽取5个学校,共调查高中生884名。结果 884名高中生中125人(14.14%)有自杀意念,55人(6.22%)有自杀计划。logistic分析表明,躯体虐待(OR=3.002,P<0.001),家庭成员有精神异常者(OR=3.465,P<0.001)与自杀意念呈正性相关;性虐待(OR=3.105,P=0.008)、躯体虐待(OR=3.439,P<0.001),家庭成员有精神异常者(OR=5.295,P<0.001)与自杀计划呈正性相关。累积效应分析发现,随着童年期不良经历数目的增加,自杀意念、自杀计划发生的风险增加,有三种及以上不良经历者产生自杀意念OR=10.836,产生自杀计划OR=22.660。结论童年期不良经历是高中生自杀意念、自杀计划发生的危险因素,加强对有童年期不良经历青少年的干预可有效防控高中生自杀相关行为。

关键词：高中生童年期不良经历自杀意念自杀计划累积效应

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南昌市高中生健康危险行为及其聚集共发现象研究

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现代预防医学 2019年第13期46卷 2405-2409页

作者：文小桐陈飞宇李旭阳徐雯艳林毅翔贾至慧 Sergio Trejo Jr shawn Thomas Bianca Irimia 党宇松杨维袁兆康南昌大学公共卫生学院江西省预防医学重点实验室江西省抚州市东乡区疾病预防控制中心美国内华达大学

目的了解高中生健康危险行为情况,研究其聚集特征,为青少年健康危险行为综合性干预措施提供科学依据。方法采取多阶段随机抽样方法,抽取南昌市884名高中生进行问卷调查。结果 884名高中生中肢体暴力检出率9.95%;吸烟检出率7.35%;饮酒检... 详细信息

目的了解高中生健康危险行为情况,研究其聚集特征,为青少年健康危险行为综合性干预措施提供科学依据。方法采取多阶段随机抽样方法,抽取南昌市884名高中生进行问卷调查。结果 884名高中生中肢体暴力检出率9.95%;吸烟检出率7.35%;饮酒检出率26.92%;过早性行为检出率4.86%。不同性别(■=16.025,P=0.003)、不同学校类型(■=85.736,P<0.001)南昌市高中生单一及多种健康危险行为共存情况存在统计学差异。884高中生中23.53%存在两种健康危险行为,19.12%存在3种健康危险行为,16.74%存在5种及以上健康危险行为。结论及早发现青少年的健康危险行为并予以纠正,是有效防止其进一步发展、蔓延和加重最为有效的重要措施之一。关注其共发的重点人群,高效干预健康危险行为的发生。

关键词：高中生健康危险行为共存聚集性

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