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Chinese Journal of Aeronautics 2014年第5期27卷 1327-1333页

作者： Liu Jianhua Guo Qiang Yu Mei Li songmei Key Laboratory of Aerospace Materials & Performance (Ministry of Education) School of Materials Science and Engineering Beihang University

To evaluate stress corrosion cracking（SCC） mechanism of low alloy ultra-high strength steel 30CrMnSiNi2 A in environment containing NaCl, SCC behavior of the steel in 3.5wt% NaCl solution is investigated by slow strain rate technique（SSRT） with various strain rates and applied potentials, surface analysis technique, and electrochemical measurements. SCC susceptibility of the steel increases rapidly with strain rate decreasing from 1.· 1. 5s 1.o 5 · 1. 7s 1. and becomes stable when strain rate is lower than 5 · 1. 7s 1. SCC propagation of the steel in the solution at open circuit potential（OCP） needs sufficient hydrogen which is supplied at a certain strain *** surface at OCP has similar characteristics with that at cathodic polarization 1.00 mVSCE, which presents characteristic fractography of hydrogen induced cracking（HIC）.All of these indicate that SCC behavior of the steel in the solution at OCP is mainly controlled by HIC rather than anodic dissolution（AD）.

关键词： Hydrogen NaCl solution Stress corrosion cracking Slow strain rate technique Ultra-high strength steel

Preparation and characterization of the TiO_2-V_2O_5 photocatalyst with visible-light activity

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Rare Metals 2006年第6期25卷 636-642页

作者： LIU Jianhua YANG Rong LI songmei School of Materials Science and Engineering Beihang University Beijing 100083 China

Visible-light responsive TiO2-V2O5 catalyst was prepared using a binary sol-gel and in-situ intercalation method. The TiO2 sol and V2O5 sol were mixed to disperse the V2O5 species in the TiO2 phase at molecular level. The binary sol was then intercalated into interspaces of polyaniline （PANI） by means of in-situ polymerization of aniline. Conglomeration of the TiO2-V2O5 dusters during the calcination process was avoided because of the wrap of polyaniline. The surface mor- phology, the crystal phases, the structure, and the absorption spectra of （PANI）,/TiO2-V2O5 and the composite catalyst were studied using SEM, XRD, FT-IR, and UV-Vis. The photoactivity of the prepared catalyst under UV and visible light irradiation were evaluated by decolorization of methylene blue （MB） solution. The results showed that the composite catalyst displayed a homogeneous anatase phase, and the vanadium pentoxide species was highly dispersed in the TiO2 phase. The composite catalyst responded to visible light because of the narrowed band gap. In this study, the catalyst with the sol volume ratio of TiO2： V2O5 = 1.：1.presented the best photocatalytic activity.

关键词： inorganic non-metal materials visible-light active photocatalyst binary sol-gel synthesis composite catalyst

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肾脏疾病药物创新研发进展及思考

中国药学杂志 2024年第14期59卷 1278-1282页

作者：唐崇淇王娜李杰静王水强谢松梅国家药品监督管理局药品审评中心北京100076

目的探讨肾脏疾病药物创新研发特点、进展及关键技术考虑。方法调研国内外药品监管机构监管进展及相关文献,梳理近1.年国内外肾脏疾病药物上市及在研药物情况,分析研发特点及关键技术难点,并提出建议。结果与结论 201.年至今,中国及... 详细信息

目的探讨肾脏疾病药物创新研发特点、进展及关键技术考虑。方法调研国内外药品监管机构监管进展及相关文献,梳理近1.年国内外肾脏疾病药物上市及在研药物情况,分析研发特点及关键技术难点,并提出建议。结果与结论 201.年至今,中国及欧美批准肾脏疾病新药1.个,近5年该领域新药临床试验申报量持续增长,尤以慢性肾脏病(chronic kidney disease,CKD)、免疫球蛋白A(IgA)肾病适应证申报居多。为更好地促进该领域药物创新研发,需关注以下方面:(1.进一步加强疾病发病机制等基础研究工作,助力筛选并开发新机制、新靶点,具有特异性治疗作用的新药,以期有效延缓乃至逆转疾病进展;(2)建议以患者需求为出发点,开发科学合理的临床结局评估工具,更好地评价患者获益;(3)肾脏疾病病因复杂,可考虑结合疾病流行病学及自然病史特征、药物特点及研究目的,选择具有代表性的患者人群;(4)肾脏疾病早期控制至关重要,但该病进展缓慢,临床终点的考察往往需要长达几年或更长的研发周期和较大的样本量,因此,探索、开发并验证替代指标具有较大的临床意义,但需审慎选择,必要时与监管机构沟通;(5)充分的安全性研究是获益-风险综合权衡的重要支持。

关键词：肾脏疾病药物研发进展作用机制思考

201.—2021.上海某院心血管疾病患者流行病学分析

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中国社区医师 2024年第10期40卷 155-157页

作者：周玉鹏田松枚周松上海市宝山区仁和医院上海200431

目的:分析201.—2021.上海某院心血管疾病患者流行病学特征。方法:选取201.年1.—2021.1.月上海市宝山区仁和医院急诊科收治的296例心血管疾病患者作为研究对象,统计心血管疾病患者疾病种类、时间、性别、年龄分布特征。结果:201.—2... 详细信息

目的:分析201.—2021.上海某院心血管疾病患者流行病学特征。方法:选取201.年1.—2021.1.月上海市宝山区仁和医院急诊科收治的296例心血管疾病患者作为研究对象,统计心血管疾病患者疾病种类、时间、性别、年龄分布特征。结果:201.—2021.心血管疾病患者多为冠心病,其次为心律失常、心力衰竭,心肌缺血、心肌梗死,风湿性心脏病患者相对较少。201.—2021.,冠心病多发于1.3月,发病率具有季节性规律;心律失常与心力衰竭发病每月较平均,未呈现明显的季节性规律。201.—2021.,心血管疾病发病人群女性多于男性。201.—2021.,心血管疾病患者年龄多为66~75岁。结论:201.—2021.上海某院心血管疾病患者女性较多,年龄多为66~75岁,疾病发病率从高到低依次为冠心病、心律失常、心力衰竭,其中冠心病多发于1.3月与7—9月,发病率具有季节性规律。

关键词：心血管疾病流行病学冠心病

SCC evaluation of a 2297 Al-Li alloy rolled plate using the slow-strain rate technique

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Chinese Journal of Aeronautics 2019年第11期32卷 2516-2525页

作者： Kuo ZHAO Jianhua LIU Mei YU songmei LI School of Materials Science and Engineering Beihang University

The stress corrosion cracking(SCC) susceptibility of 2297 Al-Li alloy in 1.M Na Cl +0.01.M H2O2 solution(CP solution) and 1.M NaCl + 0.01.M H2O2+ 0.6 M Na2SO4 solution(CPS solution) was investigated by slow-strain rate tests at various strain rates ranging from 1.-5s(-1. to 1.-7s-1. The roles of H2O2 and SO42-in the corrosion process were estimated by potentiodynamic polarization and electrochemical impedance spectroscopy. 2297 Al-Li alloy does not fracture ascribed to SCC in CP solution, while it undergoes SCC in CPS solution. In CPS solution,with a decreasing strain rate from 1.-5s(-1. to 1.-7s-1. the SCC susceptibility firstly rises and then declines exhibiting a peak value at a strain rate of 1.-6s-1. H2O2 promotes the active dissolution while SO42- lowers the corrosion rate. The SCC fracture is associated with a decline in the dissolution rate of the crack tip by SO42-, which leads to stress concentration. In CPS solution, a reduction in the local dissolution rate of the crack tip leads to stress concentration, resulting in SCC *** the preferred initiation site for a crack, pits also show a noteworthy effect on SCC of 2297 Al-Li alloy.

关键词： Al-Li alloy Dissolution Electrochemical behavior Slow strain rate testing Stress corrosion cracking

中青年2型糖尿病患者饮食行为依从性变化轨迹及影响因素分析

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中华护理杂志 2024年第13期59卷 1592-1599页

作者：蔡佩萱梁怡青王晶晶赵松青张怡曹松梅江苏大学附属医院护理部江苏省镇江市212001 淮安市第一人民医院老年医学科

目的探讨中青年2型糖尿病患者饮食行为依从性变化轨迹的潜在类别及影响因素。方法采用便利抽样法,调查2022年9月—2023年3月在淮安市某三级甲等综合医院内分泌科住院的277例中青年2型糖尿病患者,采用一般资料调查表、2型糖尿病患者饮食... 详细信息

目的探讨中青年2型糖尿病患者饮食行为依从性变化轨迹的潜在类别及影响因素。方法采用便利抽样法,调查2022年9月—2023年3月在淮安市某三级甲等综合医院内分泌科住院的277例中青年2型糖尿病患者,采用一般资料调查表、2型糖尿病患者饮食行为依从性量表、糖尿病控制自我效能量表、糖尿病知识问卷、健康信念问卷、家庭关怀度指数问卷收集患者的基线资料,在患者出院前1.d(T0)、出院后1.(T1.、出院后1.月(T2)、出院后3个月(T3)评估患者的饮食行为依从性水平,采用潜变量增长混合模型识别轨迹类别,采用单因素及多元Logistic回归分析中青年2型糖尿病患者的饮食依从性轨迹的影响因素。结果共识别出3个中青年2型糖尿病患者饮食行为依从性变化轨迹类别,分别是低依从-波动起伏组(49.8%)、高依从-缓慢回落组(31.4%)、中依从-持续上升组(1..8%);年龄、文化程度、自我效能、健康信念、家庭关怀度是中青年2型糖尿病患者饮食行为依从性潜在类别的影响因素。结论中青年2型糖尿病患者饮食行为依从性轨迹存在异质性,医护人员可根据轨迹类别的影响因素,制订针对性的干预措施,以提升其依从性水平。

关键词：中青年 2型糖尿病饮食行为依从性影响因素分析潜在类别护理

Hemicellulose in corn straw:Extracted from alkali solution and produced5-hydroxymethyl furfural in HCOOH/HCOONa buffer solution

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Chinese Journal of Chemical Engineering 2016年第12期24卷 1786-1792页

作者： Yan Li Hongxian Fan Xueqing Yu songmei Zhang Gang Li Hebei Provincial Key Lab of Green Chemical Technology and High Efficient Energy Saving School of Chemical Engineering and Technology Hebei University of Technology

Hemicellulose in corn straw is a group of complex heteropolysaccharides which are composed of different sugar units, including mannans, xylans, arabinans and galactans. This study developed a simple and practical process for production of 5-hydroxymethyl furfural(HMF) using hemicellulose that was extracted from corn straw. In the hemicellulose degradation process HCOOH/HCOONa was used as buffer solution, and the optimum conditions for maximum HMF yield were explored. Various extraction conditions including NaOH concentration, reaction time,temperature, solid-to-liquid ratio and precipitant were tested for hemicellulose obtaining, giving the optimum condition of 55 °C, 4 h, solid-to-liquid ratio of 1.1., 1.5 mol·L^(-1. NaOH solution and ethanol as precipitant with the yield of 34.1.%. Dehydration of hemicellulose under HCOOH/HCOONa buffer solution process, using solution medium of pH = 0.8 hydrolyzed hemicellulose in corn straw at 1.0 °C after 1.0 min and 82% of HMF yield was achieved.

关键词： Hemicellulose HMF Degradation Buffer solution ELSD

Chinese expert consensus on the diagnosis and treatment of balanoposthitis

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Chinese Medical Journal 2024年第13期137卷 1519-1521页

作者： Li Zhang Amer A.A.Abdulrahman Hao Guo Jia’an Zhang Xinghua Gao Weihua Pan Gang Wang Jinhua Xu Yuling Shi Liuqing Chen Hongxiang Chen songmei Geng Yuping Ran Hongwei Wang Xiaoyong Man Jianmin Chang Furen Zhang Litao Zhang Guangwen Yin Jianzhong Zhang Wei Lai Zhibin Niu Hongkun Jiang Haibo Liu Yaolong Chen Jianjian Wang Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of Immunodermatology Ministry of Education and NHCNational Joint Engineering Research Center for Theranostics of Immunological Skin DiseasesShenyangLiaoning 110001China Department of Dermatology Chinese Academy of Medical Science and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200443China Department of Dermatology Wuhan No.1 HospitalWuhanHubei 430022China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518052China Department of Dermatology Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Huadong HospitalFudan UniversityShanghai 200040China Department of Dermatology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Dermatology Beijing HospitalBeijing 100730China Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250061China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Dermatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Dermatology Peking University People’s HospitalBeijing 100044 China Department of Dermatology Third Affi

Balanoposthitis(BP),a common male genitalia inflammation,is managed by clinicians from different specialties,including urology,pediatrics,dermatology,and *** to this diverse array of clinicians involved,there exists a lack of consistent,evidence-based recommendations for *** development of the consensus engaged 1. representative hospitals and it adhered to rigorous protocols,encompassing international registration(IPGRP-2021.N003)and the application of evidence grading criteria and recommendation standards[Appendix S1.Supplementary File,http://***/CM9/C42].Over the period from December 2020 to October 2022,consensus on 1. clinical issues was reached through comprehensive evidence searches and two iterations of Delphi surveys[Supplementary File,http://***/CM9/C42].

关键词： Delphi diagnosis rigorous

皮下非对称减张联合真皮埋没成角褥式缝合在婴幼儿面部良性色素性皮损手术治疗中的应用

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中华皮肤科杂志 2024年第1期57卷 54-57页

作者：闫娜陈婷耿松梅李政霄刘燕马迎新谭宣丰汉中市中心医院皮肤科汉中723000 空军军医大学第一附属医院皮肤科西安710032 西安交通大学第二附属医院皮肤科西安710004

目的探讨皮下非对称减张联合真皮埋没成角褥式缝合在婴幼儿面部良性色素性皮损手术治疗中应用的临床效果.方法回顾201.年1.至201.年1.于汉中市中心医院及西安交通大学第二附属医院皮肤科就诊的1.0例面部色素性皮损患儿的临床资料,... 详细信息

目的探讨皮下非对称减张联合真皮埋没成角褥式缝合在婴幼儿面部良性色素性皮损手术治疗中应用的临床效果.方法回顾201.年1.至201.年1.于汉中市中心医院及西安交通大学第二附属医院皮肤科就诊的1.0例面部色素性皮损患儿的临床资料,其中男性59例,女性41.,年龄3个月至5岁,平均1.个月.行门诊局麻手术,术前使用镇静药物,根据皮损面积一次或分次切除皮损,先采用皮下非对称缝合方法减少张力,再采用真皮埋没成角褥式缝合切口,术后使用医用硅酮凝胶及减张器半年至1.并随访.结果 1.0例患儿术后均随访1.以上,4例术后2个月内出现排线反应,线结排出后切口完全愈合;3例术后1.拆线时切口上下两端有小猫耳形成,未予处理,随访1.后猫耳逐渐变平;1.术后4 d出现脂肪液化,拆除内缝线,引流,1.后重新缝合,切口愈合良好;1.术后3 d出现感染,拆除内缝线,予引流和抗感染治疗,待切口红肿完全消退后重新缝合,切口愈合良好;4例术后3~6个月出现瘢痕增生,曲安奈德封闭治疗后较前变平.余患儿切口愈合后均表现为线状细小白线,切口两端凹陷及隆起均变平,无明显五官牵拉及猫耳形成.结论皮下非对称减张联合真皮埋没成角褥式缝合术在婴幼儿面部精细手术中可有效地进行两次减张,避免切口拉宽及瘢痕增生,长期随访显示可获得良好的远期疗效和美学效果.

关键词：面部皮肤病色素沉着异常痣婴儿皮下非对称减张缝合埋没成角褥式缝合精细手术

超高强度不锈钢1.Cr1.Co1.Mo5Ni3W1.E微观组织对局部腐蚀行为的影响

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材料工程 2024年第5期52卷 103-116页

作者：滕鹏钟锦岩匡效禹赵振江张淑琦蔡嘉辉李松梅刘建华于美钟平北京航空航天大学材料科学与工程学院北京100191 中国航发北京航空材料研究院钢与稀贵金属所北京100095

采用未时效、200、400℃以及500℃时效状态下1.Cr1.Co1.Mo5Ni3W1.E(S280)马氏体超高强度不锈钢为研究对象,通过X射线衍射(XRD)、透射电子显微镜(TEM)、背散射电子衍射(EBSD)等测试方法,结合电化学测试手段与X射线光电子能谱仪(XPS)测试... 详细信息

采用未时效、200、400℃以及500℃时效状态下1.Cr1.Co1.Mo5Ni3W1.E(S280)马氏体超高强度不锈钢为研究对象,通过X射线衍射(XRD)、透射电子显微镜(TEM)、背散射电子衍射(EBSD)等测试方法,结合电化学测试手段与X射线光电子能谱仪(XPS)测试,分析S280的微观组织结构特征演变与钝化膜结构成分与耐蚀性能,研究钝化膜稳定性特征与材料微观组织结构的关系。结果表明:500℃时效温度下的S280钢有细小弥散的富含Cr,Mo元素的析出相,分布在马氏体板条中。随着时效温度升高,无明显的残余奥氏体及逆转变奥氏体析出。在成膜电位(0.1.0.85 V)下,S280钝化膜在pH=8.5的硼酸盐缓冲液中呈p型半导体性质,表现为双层膜结构,外部由疏松多孔的Fe/Cr氢氧化物组成,内层由致密的Cr/Fe氧化物构成,其成分主要是Cr_(2)O_(3)。通过电化学阻抗测试结合Mott-Schottky分析,探明S280在200℃时效下耐蚀性最好,其耐蚀性能由晶界取向特性与沉淀相导致的元素偏析共同影响。

关键词：超高强度不锈钢S280 微观组织钝化膜局部腐蚀

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