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朝鲜朝文坛对陆游及其诗歌的接受

中国文化研究 2024年第3期 170-180页

作者：朴哲希辽宁师范大学文学院

陆游被朝鲜朝文坛所接受并受到重视,契机在于当时文坛“学唐”与“学宋”两种诗学风气已发生转换,且文人群体不再坚持“诗必学唐”的观念。在宋诗地位得到恢复之后,陆游遂成为朝鲜朝文人学习宋诗的新代表。在陆诗典范作用之下,文人主要... 详细信息

陆游被朝鲜朝文坛所接受并受到重视,契机在于当时文坛“学唐”与“学宋”两种诗学风气已发生转换,且文人群体不再坚持“诗必学唐”的观念。在宋诗地位得到恢复之后,陆游遂成为朝鲜朝文人学习宋诗的新代表。在陆诗典范作用之下,文人主要关注陆游其人与其文坛地位、其诗及其诗学价值,且在他者的视阈下结合自身的诗学实践对陆游观点、作品进行阐释和运用。从中可以发现,受儒家诗教的影响,爱国情怀是文人群体接受陆游以及其诗学典范地位能够最终确立的思想基石;同时,朝鲜朝文人作为第二语言学习者更为看重如何借鉴陆游诗中的词汇、意象,意图模仿其语言风格,展现出不同于中国文人的域外视角。

关键词：陆游朝鲜朝文坛典范地位域外视角接受

难治性癫痫相关皮质发育畸形的病理研究及分类进展

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中华病理学杂志 2024年第5期53卷 419-424页

作者：付永娟朴月善首都医科大学宣武医院病理科、国家神经疾病医学中心、首都医科大学癫痫临床诊疗与研究中心北京100053

随着基因检测技术、神经影像学及神经电生理技术的迅猛发展,我们对皮质发育畸形的认识不断深入和更新,尤其是哺乳动物雷帕霉素靶蛋白(mTOR)信号通路相关的基因突变在局灶性皮质发育不良(FCD)中被陆续发现。同时,2011年国际抗癫痫联盟(IL... 详细信息

随着基因检测技术、神经影像学及神经电生理技术的迅猛发展,我们对皮质发育畸形的认识不断深入和更新,尤其是哺乳动物雷帕霉素靶蛋白(mTOR)信号通路相关的基因突变在局灶性皮质发育不良(FCD)中被陆续发现。同时,2011年国际抗癫痫联盟(ILAE)发布的有关FCD的分类共识在诊断实践中遇到了问题和挑战。因此,2022年ILAE根据分子遗传学10年来的进展,提出了FCD分类的更新版,主要在分类体系中增加了"白质病变",还建议综合病理组织学、影像学及分子检测结果,进行多层次整合诊断,来实现可靠的、临床相关的和治疗性靶向的组织诊断。

关键词：癫痫皮质发育畸形局灶性皮质发育不良病理分类

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基于有限元模型修正技术的刚柔耦合关系研究

计算机集成制造系统 2024年第4期30卷 1213-1225页

作者：朴思扬李特特朴明伟范军郭永正陶宜男大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 大连交通大学机车车辆工程学院辽宁大连116028 大连交通大学机械工程学院辽宁大连116028 中车长春轨道客车股份有限公司国家工程实验室吉林长春130062

为了尽可能避免因车轮形成中央凹陷踏面磨耗而使铝合金车体产生振动疲劳问题,有必要以有效的有限元模型修正技术来合理构建高铁车辆的刚柔耦合关系。针对德国ICE3原型及一次蛇行现象,提出一种高速转向架动态设计方法,以整车稳定性态分... 详细信息

为了尽可能避免因车轮形成中央凹陷踏面磨耗而使铝合金车体产生振动疲劳问题,有必要以有效的有限元模型修正技术来合理构建高铁车辆的刚柔耦合关系。针对德国ICE3原型及一次蛇行现象,提出一种高速转向架动态设计方法,以整车稳定性态分析图来明确自适应改进方向,即λ_(eN)≥λ_(emin)而λ_(emin)=(0.03-0.05)。借用(半)主动车间减振技术,跨越不同速度等级的铁路专线运行亦可实现对中央凹陷踏面磨耗的自清理。拖车TC02/07刚柔耦合仿真与两次跟踪试验在抖车形成机制上得到了具有一致性的分析结论:牵引变流器产生主频约9.2/9.3Hz的横向耦合共振,对车顶的横向角焊缝造成了严重疲劳损伤,但是只要牵引变流器横移模态频率>12 Hz,最好14 Hz,转向架振动报警的安全阈值则可适度提高。

关键词：高铁车辆刚柔耦合系统自适应高速转向架中央凹陷踏面磨耗耦合共振

数字经济与零售业耦合发展对我国经济提质增效的作用机制

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商业经济研究 2024年第17期 104-108页

作者：朴巍太原师范学院山西晋中030619 西安交通大学陕西西安710049

随着全球数字化浪潮的涌现,数字经济正引领着经济结构的深刻变革。作为被数字经济影响的一个重要领域,零售业正在经历着从传统到数字化、智能化的转型。数字经济与零售业的耦合发展已经引发了广泛关注,因其不仅为消费者带来便利,也为企... 详细信息

随着全球数字化浪潮的涌现,数字经济正引领着经济结构的深刻变革。作为被数字经济影响的一个重要领域,零售业正在经历着从传统到数字化、智能化的转型。数字经济与零售业的耦合发展已经引发了广泛关注,因其不仅为消费者带来便利,也为企业创造了新的发展机遇。然而,如何将数字经济与零售业的耦合发展与我国经济的提质增效紧密结合起来,以实现经济发展的可持续增长,仍是一个值得深入研究的课题。本文旨在探讨数字经济与零售业耦合发展对我国经济提质增效的作用机制,并分析城镇化建设与技术迭代在其中的中介作用,以期为我国经济高质量发展提供有力支撑。研究结果表明:数字经济与零售业耦合发展对我国经济发展提质增效起到显著的正向促进作用。城镇化建设在数字经济与零售业耦合发展对我国经济发展提质增效的影响中起到中介作用,技术迭代在数字经济与零售业耦合发展对我国经济发展提质增效的影响中起到中介作用。

关键词：数字经济零售业经济发展提质增效城镇化建设技术迭代

Ferroptosis:A therapeutic opportunity of inflammatory bowel disease

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Chinese Medical Journal 2024年第7期137卷 874-876页

作者： Yulin Ye Limin Liu Yang Jing Shuangzhe Yao Mo Yang Xin Dai Meiyu piao Xin Xu Zelin Feng Xiaoli Wang Yifei Liu Junming Miao Xingjie Gao Qingxiang Yu Xiaocang Cao Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300070China Department of Biochemistry and Molecular Biology School of Basic Medical ScienceTianjin Medical UniversityTianjin 300070China

To the Editor:Even to this day,the etiology and pathogenesis of inammatory bowel disease(IBD)are still *** signicant progress in IBD treatment in recent years,some patients remain insensitive or non-responsive towards existing ***,further exploring IBD pathogenesis to develop novel therapeutic drugs or drug combinations is quite *** studies have demonstrated the therapeutic potential of regulating cell death in *** ferroptosis,a novel form of cell death,is also involved in the pathological process of IBD.

关键词： drugs death treatment

The role and research progress of MDSC in immune aging-related diseases

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Biomedical Engineering Communications 2024年第2期3卷 4-9页

作者： Xi-Xing Fang Han-Zhou Li Xue-Mei piao Yu-Ming Wang Yu-Hong Bian Medical School Hubei Minzu UniversityEnshi 445099China College of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Nursing Department People's Hospital of Longjing CityLongjing 133499China

Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and *** individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by *** indicates that MDSC could serve as a potent inducer of immune *** senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and *** achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related ***,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting *** article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.

关键词： MDSC immunosenescence tumor progression pulmonary fibrosis immunosenescence therapy

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TPI缺乏症斑马鱼模型的构建及分析

遗传 2024年第3期46卷 232-241页

作者：孙飘李颖刘帆王璐中国医学科学院血液病医院(中国医学科学院血液学研究所) 实验血液学国家重点实验室国家血液系统疾病临床医学研究中心细胞生态海河实验室天津300020 天津医学健康研究院天津301600

磷酸丙糖异构酶缺乏症(triosephosphate isomerase deficiency,TPI DF)是一种严重的多系统退行性疾病,通常表现为溶血性贫血、神经肌肉功能障碍和易感染,患者多于起病5年内死亡。目前尚不清楚TPI DF的具体发病机制,缺乏有效的临床治疗... 详细信息

磷酸丙糖异构酶缺乏症(triosephosphate isomerase deficiency,TPI DF)是一种严重的多系统退行性疾病,通常表现为溶血性贫血、神经肌肉功能障碍和易感染,患者多于起病5年内死亡。目前尚不清楚TPI DF的具体发病机制,缺乏有效的临床治疗方法。本研究选取TPI DF患者中最常见的突变位点TPI1^(E105D),构建了表达人源性TPI1^(E105D)(hTPI1^(E105D))的转基因斑马鱼(Danio rerio)模型[Tg(Ubi:TPI1^(E105D)-eGFP)]。功能分析表明,过表达TPI1^(E105D)影响红系及髓系细胞发育、导致神经以及肌肉发育异常。综上所述,本研究构建了磷酸丙糖异构酶缺乏症的斑马鱼疾病模型,并能够复现TPI DF患者的大部分临床表型,该模型为后续研究TPI DF的发病机制及药物筛选提供了新的实验动物模型。

关键词：磷酸丙糖异构酶缺乏症 TPI1^(E105D) 斑马鱼疾病模型

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu Sherwin Ho Michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui Liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism