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Design of 1.9 GHz RF CMOS VCO

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 103-107页

作者： LI En-ling WANG Xue song Lin-hong YUAN Yong-xia YU Fa-da LIU man-cang School of Sciences XJ'an University of Technology Xi'an 710048 China

A voltage controlled oscillator （VCO） module is designed, which can be used for the third generation mobile communication （3G） system. The circuit is simulated by spectre radio frequency （RF） by TSMC 0.25 μm CMOS process. During the simulation, the performance parameters of the designed VCO are as follows： tuning range 1.804 GHz-2.039 GHz, phase noise - 136.457 dBc/Hz @1 MHz, - 146.045 dBc/Hz@3 MHz, supply voltage 2.5 V, voltage output rate of 0.8 V-2.6 V, power consumption 25 roW. The layout of the related circuit is drawn by the Virtuoso Layout Editor.

关键词： LC voltage controlled oscillator on-chip inductor on-chip varactor phase noise

Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese

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Biomedical and Environmental Sciences 2021年第5期34卷 337-347页

作者： ZHANG Jian song Peng Kun ZHAO Li Yun SUN Ye YU Kai YIN Jing PANG Shao Jie LIU Zhen man Qing Qing he Li LI Cheng ARIGONI Fabrizio BOSCO Nabil DING Gang Qiang ZHAO Wen Hua National Institute of Nutrition and health Chinese Center for Disease Control and PreventionBeijing 100050China Nestlw Research Singapore Hub 138567Singapore Nestle Research Center China Beijing 100102China Nestle Research Center Lausanne 1000LausanneSwitzerland

Objective Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary,geographical, and socioeconomic *** A total of 13,987 ≥ 60-year-old persons from the 2010–2013 Chinese National Nutrition and health Survey were included to evaluate various aspects of malnutrition, including underweight,overweight or obesity, and micronutrient *** Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%,respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old(≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, B1, B2, and E, folate, calcium, selenium, potassium, biotin,and choline, with the prevalence of inadequate intake increasing with age for most nutrients. At the population level, the mean intakes of numerous food groups did not meet the recommendations by the Chinese Dietary *** Obesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China.

关键词： Malnutrition Older Chinese Food intake Nutrients National survey

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《灵枢》中2种卫气循环路线的差异与统一

中华医史杂志 2024年第4期54卷 195-202页

作者：宋神秘陈丽云上海中医药大学科技人文研究院上海

《灵枢·卫气行》记载了卫气的2种天人对应循环路线, 第一种对应太阳行二十八宿, 白天和夜晚循行不同的身体部位, 白天循行经络, 夜晚循行五脏;第二种对应漏刻百刻, 不区分白天和夜晚, 形成循行三阳一阴4种部位的25次循环。《灵枢·卫... 详细信息

《灵枢·卫气行》记载了卫气的2种天人对应循环路线, 第一种对应太阳行二十八宿, 白天和夜晚循行不同的身体部位, 白天循行经络, 夜晚循行五脏;第二种对应漏刻百刻, 不区分白天和夜晚, 形成循行三阳一阴4种部位的25次循环。《灵枢·卫气行》试图在数值上将太阳行舍和漏刻下水2种时间计量方式等价, 并暗自用模糊的"阴分"概念分别指代不同的五脏部位, 来统一这2种循环路线, 但由于这2种循环路线本质上的不同, 这种统一的努力只有形式上的弥合, 本质上仍存在差异。临床实践中多用第一种循环路线来解释和治疗打哈欠和失眠的相关疾病, 但解释机理存在细微差别。

关键词：卫气天人对应二十八宿漏刻《灵枢》

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加热卷烟烟气对肺表面活性物质单层膜的影响

环境与健康杂志 2024年第6期41卷 509-512,F0003页

作者：李超李萌范多青管莹李曼焘宋浩然云南中烟工业有限责任公司烟草与健康联合研究院云南昆明650231 昆明理工大学环境科学与工程学院昆明理工大学国土资源工程学院

目的探究加热卷烟烟气入肺后,其对肺表面活性物质(Pulmonary surfactant,PS)单层膜的影响,揭示其可能会对肺功能和健康造成损害。方法本研究采用加热卷烟烟气制备水溶液和从猪肺中提取天然PS作为实验材料,测定加热卷烟烟气暴露前后PS... 详细信息

目的探究加热卷烟烟气入肺后,其对肺表面活性物质(Pulmonary surfactant,PS)单层膜的影响,揭示其可能会对肺功能和健康造成损害。方法本研究采用加热卷烟烟气制备水溶液和从猪肺中提取天然PS作为实验材料,测定加热卷烟烟气暴露前后PS表面张力、起泡性能和相行为等界面化学性质的变化。结果加热卷烟烟气会对PS中的磷脂和蛋白组分产生吸附作用(P<0.05)导致磷脂和蛋白含量下降,进而使表面张力升高和起泡性能下降,在最大暴露量时磷脂和蛋白含量从46.86 mg/L和5.09 mg/L降至28.16 mg/L和3.52 mg/L,表面张力从27.37 mN/m升至37.76 mN/m,起泡性能从48.56 ml降至34.57 ml。由布鲁斯特角显微镜观察得到,烟气组分(颗粒物和有机物)还会嵌入和积累在PS薄膜上,导致PS膜的π-A等温线外扩。结论加热卷烟烟气的暴露可能会影响PS在肺泡内的正常功能,从而对肺部健康造成潜在的危害。

关键词：加热卷烟烟气肺表面活性物质吸附作用肺健康界面性质

Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients

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World Journal of Clinical Cases 2021年第10期9卷 2238-2246页

作者： Hu Zhang Jing Liu song-Lin Ma man-Lin Huang Yan Fan Min song Jing Yang Xiao-Xia Zhang Qi-Long song Jing Gong Ping-Xiao Huang heng Zhang Department of Gastroenterology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Department of Gastroenterology The Eighth Hospital of WuhanWuhan 430014Hubei ProvinceChina

BACKGROUND Four-liter polyethylene glycol(PEG)solutions are effective for bowel cleansing,but their large volume might hinder patient *** to the unique features of Asians,4 L PEG might be a suboptimal bowel preparation in predominantly ethnically Asian *** view of this,a balance should be achieved between the volume and *** ideal bowel cleansing regimen for a colonoscopy has yet to be determined in a Chinese *** To compare the cleansing efficacy of 3 L PEG plus simethicone with 4 L *** A total of 291 patients were randomly allocated to two groups:Group 1(n=145)received 4 L split-dose PEG(4-P);group 2(n=146)received 3 L split-dose PEG plus simethicone(3-PS).Bowel-cleansing efficacy was evaluated by endoscopists using the Boston bowel preparation scale(BBPS)and the bubbles *** Although there were no significant differences in the total BBPS score or the adequate rate of bowel preparation between the two groups,the BBPS score of the right-side colon was significantly higher in the 3-SP group(2.37±0.54 vs 2.21±0.78;P=0.04).Moreover,the use of simethicone significantly reduced bubbles in all colon segments(Phe mean withdrawal time was significantly shorter in the 3-PS group(8.8±3.4 vs 9.6±2.3;P=0.02).Furthermore,significantly more proximal adenomas were detected in the 3-PS group(53.6%vs 45.7%;P=0.03).In addition,the proportions of patients with nausea and bloating were significantly lower in the 3-SP group(Phe 3-PS group expressed willingness to repeat the bowel preparation(87.7%vs 76.6%,P=0.01).CONCLUSION Three-liter PEG shows satisfactory bowel cleansing despite the decrease in dosage,and addition of simethicone with better bubble elimination and enhanced patient acceptance offers excellent potential impact on the detection of proximal adenomas in Chinese patients.

关键词： Polyethylene glycol Simethicone Colonoscopy Bowel preparation Cleansing efficacy

Transgenic Expression of a Functional Fragment of Harpin Protein Hpa1 in Wheat Represses English Grain Aphid Infestation

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Journal of Integrative Agriculture 2014年第12期13卷 2565-2576页

作者： XU man-yu ZHOU Ting ZHAO Yan-ying LI Jia-bao XU heng DONG Han-song ZHANG Chun-ling National Key Laboratory of Integrated management of Crop Diseases and Pests Ministry of Education/College of Plant Protection Nanjing Agricultural University

The harpin protein Hpa1 produced by the rice bacterial blight pathogen promotes plant growth and induces plant resistance to pathogens and insect pests. The region of 10-42 residues （Hpa110-42） in the Hpa1 sequence is critical as the isolated Hpa110-42 fragment is 1.3-7.5-fold more effective than the full length in inducing plant growth and resistance. here we report that transgenic expression of Hpa110-42 in wheat induces resistance to English grain aphid, a dominant species of wheat aphids. Hpa110-42-induced resistance is effective to inhibit the aphid behavior in plant preference at the initial colonization stage and repress aphid performances in the reproduction, nymph growth, and instar development on transgenic plants. The resistance characters are correlated with enhanced expression of defense-regulatory genes （EIN2, PP2-A, and GSL10） and consistent with induced expression of defense response genes （hel, PDF1.2, PR-1b, and PR-2b）. As a result, aphid infestations are alleviated in transgenic plants. The level of Hpa110-42-induced resistance in regard to repression of aphid infestations is equivalent to the effect of chemical control provided by an insecticide. These results suggested that the defensive role of Hpa110-42 can be integrated into breeding germplasm of the agriculturally signiifcant crop with a great potential of the agricultural application.

关键词： Hpa110-42 transgenic wheat resistance aphids chemical control

抑癌止痛散联合曲马多缓释片对原发性肝癌癌性疼痛疗效、肝癌标志物及T细胞亚群的影响

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中西医结合肝病杂志 2024年第1期34卷 20-23,27页

作者：安颂歌王馨曼魏方段倩倩陈琳张海艳安徽省宿州市第一人民医院中医科安徽宿州234000 皖北卫生职业学院护理系

目的:探讨抑癌止痛散联合盐酸曲马多缓释片对原发性肝癌轻中度癌性疼痛患者的治疗效果及对血清肝癌标志物、T细胞亚群的影响。方法:选取我院2021年11月至2022年12月的原发性肝癌轻中度癌性疼痛住院患者60例,按完全随机数字法分为对照组... 详细信息

目的:探讨抑癌止痛散联合盐酸曲马多缓释片对原发性肝癌轻中度癌性疼痛患者的治疗效果及对血清肝癌标志物、T细胞亚群的影响。方法:选取我院2021年11月至2022年12月的原发性肝癌轻中度癌性疼痛住院患者60例,按完全随机数字法分为对照组和观察组各30例。两组患者均给予常规治疗,对照组在常规治疗基础上给予盐酸曲马多缓释片治疗,观察组在常规治疗基础上给予抑癌止痛散外敷联合盐酸曲马多缓释片治疗,共治疗10 d。观察两组患者治疗前后疼痛缓解情况(NRS)评分、生活质量(QOL-LC)评分、血清甲胎蛋白(AFP)、甲胎蛋白异质体(AFP-L3)、T淋巴细胞亚群(CD4^(+)、CD8^(+))水平及治疗结束时两组患者盐酸曲马多缓释片平均剂量,并判定临床疗效。结果:治疗10 d后观察组患者临床疼痛总缓解率96.67%,明显高于对照组的73.33%(P<0.05);治疗后两组患者QOL-LC评分均高于治疗前(P<0.05),且观察组优于对照组(P<0.05);治疗后两组患者血清AFP、AFP-L3水平较治疗前下降(P<0.05),且观察组下降幅度更大(P<0.05);治疗后两组患者血清中CD4^(+)含量均较治疗前上升(P<0.05),且观察组上升更显著(P<0.05);治疗后两组患者血清中CD8^(+)含量均较治疗前下降(P<0.05),且观察组下降更显著(P<0.05);观察组患者治疗结束时盐酸曲马多缓释片平均剂量较对照组明显减少,差异具有统计学意义(P<0.05)。结论:抑癌止痛散外敷联合盐酸曲马多缓释片对于原发性肝癌合并轻中度癌性疼痛患者,能改善临床症状,降低肿瘤标志物水平,改善患者免疫功能,减少止痛药物用量,减轻药物副作用,提高患者生活质量,具有较好的临床疗效,值得推广应用。

关键词：抑癌止痛散原发性肝癌肿瘤标志物 T细胞亚群

Characterization of C_(30) carotenoid and identification of its biosynthetic gene cluster in Methylobacterium extorquens AM1

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Synthetic and Systems Biotechnology 2023年第3期8卷 527-535页

作者： Xu-Hua Mo Yu-man Sun Yu-Xing Bi Yan Zhao Gui-Hong Yu Ling-ling Tan song Yang School of Life Sciences Qingdao Agricultural University700 Changcheng RoadQingdaoShandong266109China Shandong Province Key Laboratory of Applied Mycology Qingdao Agricultural University700 Changcheng RoadQingdaoShandong266109China Qingdao International Center on Microbes Utilizing Biogas Qingdao Agricultural UniversityQingdaoShandong ProvinceChina

Methylobacterium species,the representative bacteria distributed in phyllosphere region of plants,often synthesize carotenoids to resist harmful UV *** extorquens is known to produce a carotenoid pigment and recent research revealed that this carotenoid has a C_(30) ***,its exact structure remains *** the present study,the carotenoid produced by *** AM1 was isolated and its structure was determined as 4-[2-O-11Z-octadecenoyl-β-glucopyranosyl]-4,4′-diapolycopenedioc acid(1),a glycosylated C_(30) ***,the genes related to the C_(30)carotenoid synthesis were ***,the precursor of the C_(30) carotenoid,is synthesized by the co-occurrence of META1p1815,META1p1816 and *** overexpression of the genes related to squalene synthesis improved the titer of carotenoid *** using gene deletion and gene complementation experiments,the glycosyltransferase META1p3663 and acyltransferase META1p3664 were firstly confirmed to catalyze the tailoring steps from 4,4′-diapolycopene-4,4′-dioic acid to carotenoid *** conclusion,the structure and biosynthetic genes of carotenoid 1 produced by *** AM1 were firstly characterized in this work,which shed lights on engineering *** AM1 for producing carotenoid 1 in high yield.

关键词： C_(30)carotenoid Methylobacterium extorquens Biosynthetic gene cluster Glycosyltransferase Acyltransferase

Protein sequence analysis based on hydropathy profile of amino acids

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第2期13卷 152-158页

作者： Xiao-li XIE Li-fei ZheNG Ying YU Li-ping LIANG man-cai GUO John song Zhi-fa YUAN College of Sciences Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F University Yangling 712100 China College of Animal Science and Technology China Agriculture UniversityBeijing 100193China Department of Animal and Avian Sciences University of MarylandCollege ParkMD 20742USA

Biology sequence comparison is a fundamental task in computational *** to the hydropathy profile of amino acids,a protein sequence is taken as a string with three *** curves of the new protein sequence were defined to describe the protein sequence.A new method to analyze the similarity/dissimilarity of protein sequence was proposed based on the conditional probability of the protein ***,the protein sequences of ND6(NADH dehydrogenase subunit 6)protein of eight species were taken as an example to illustrate the new *** results demonstrated that the method is convenient and efficient.

关键词： Protein sequence Sequence comparison Similarity/dissimilarity Conditional probability