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METTL5 promotes gastric cancer progression via sphingomyelin metabolism

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： Ya-Qiong Zhang Jian Li Zhe Qin De-Ming Li Fang-Zhou Ye song-hua bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

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PD-1/PD-L1 antagonists in gastric cancer:Current studies and perspectives

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World Journal of Meta-Analysis 2019年第3期7卷 101-109页

作者： Jian Li Xiao-Hong Zhang song-hua bei Li Feng Endoscopy Center Minhang Branch of Zhongshan HospitalFudan University

Immune checkpoints release suppressive signals for T cells,which enable the tumors to escape from immune destruction and provide a new concept that uses the capabilities of the immune system as a therapeutic target for *** present,programmed death receptor 1(PD-1)/programmed death ligand-1(PDL1) has become the most promising therapeutic ***-1/PD-L1 blockades exhibit long-lasting antitumor efficacy and safety in patients with various cancers,such as melanoma and non-small-cell lung ***,PD-L1 is highly expressed in the peripheral blood and tumor specimens of patients with cancer,and the expression of PD-L1 is positively correlated with various pathological features and may serve as a predictor of poor prognosis or a diagnostic *** trials have verified that PD-1/PD-L1 blockade therapy benefits patients with advanced gastric cancer or gastroesophageal junction ***,there are many molecules involved in the regulation of PD-1/PD-L1 expression,and the modification of these molecules via drugs and combinations with PD-1/PD-L1 inhibitors may further improve the efficacy of immunotherapy for gastric *** this review,the efficacy,safety,and possible combination treatment options of PD-1/PD-L1 in gastric cancer are reviewed in experimental and clinical settings.

关键词： Immunotherapy PD-1/PD-L1 inhibitors Programmed death-ligand 1 Gastric cancer

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变压器油色谱在线监测在状态检修中的应用

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华东电力 2009年第7期37卷 1195-1197页

作者：汪倩张黎琳宋蓓华上海超高压输变电公司上海200063

介绍变压器油色谱在线监测系统的工作原理,结合实例数据对比分析说明了该系统的工作流程和技术现状,并针对该系统现存的问题进行了展望。

关键词：状态检修变压器油色谱在线监测

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Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu song Gu Fulong Chen Zhe Zhao Peng Liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang Shuai Feng Xuan Cao Yaping Zhang Zhongyuan Lu Yingze song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3D graphene-iron based promotor Electrocatalysis

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Increasing multicast transmission rate with localized multipath in software-defined networks

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Frontiers of Computer Science 2019年第2期13卷 413-425页

作者： Siyuan TANG bei hua School of Computer Science and Technology University of Science and Technology of China (USTC) Hefei 230027 China Suzhou Institute for Advanced Study USTC Suzhou 215123 China

Network layer multicast is a highly efficient oneto ?many transmission mode. Data rates supported by different group members may differ if these members are located in different network environments. Currently there are roughly two types of methods solving the problem, one is limiting the data rate so that every group member can sustain transmissions, and the other is building multiple trees to increase the provision of network bandwidth. The former is inefficient in bandwidth usage, and the latter adds too many states in the network, which is a serious problem in Software-Defined Networks. In this paper, we propose to build localized extra path(s) for each bottleneck link in the tree. By providing extra bandwidth to reinforce the bottleneck links, the overall data rate is increased. As extra paths are only built in small areas around the bottleneck links, the number of states added in the network is restrained to be as small as possible. Experiments on Mimnet verify the effectiveness of our solution.

关键词： software-defined networking network layer multicast localized multipath

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Lightweight,Flexible Cellulose-Derived Carbon Aerogel@Reduced Graphene Oxide/PDMS Composites with Outstanding EMI Shielding Performances and Excellent Thermal Conductivities

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Nano-Micro Letters 2021年第6期13卷 126-142页

作者： Ping song bei Liu Chaobo Liang Kunpeng Ruan hua Qiu Zhonglei Ma Yongqiang Guo Junwei Gu MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions Shaanxi Key Laboratory of Macromolecular Science and TechnologySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072P.R.China Xi’an ESWIN Silicon Wafer Technology Co.Ltd Xi’an 710100P.R.China

In order to ensure the operational reliability and infor-mation security of sophisticated electronic components and to protect human health,efficient electromagnetic interference(EMI)shielding materials are required to attenuate electromagnetic wave *** this work,the cellulose solution is obtained by dissolving cotton through hydrogen bond driving self-assembly using sodium hydroxide(NaOH)/urea solution,and cellulose aerogels(CA)are prepared by gelation and ***,the cellulose carbon aerogel@reduced graphene oxide aerogels(CCA@rGO)are prepared by vacuum impregnation,freeze-drying followed by thermal annealing,and finally,the CCA@rGO/polydimethylsiloxane(PDMS)EMI shielding composites are prepared by backfilling with *** to skin-core structure of CCA@rGO,the complete three-dimensional(3D)double-layer con-ductive network can be successfully *** the loading of CCA@rGO is 3.05 wt%,CCA@rGO/PDMS EMI shielding composites have an excellent EMI shielding effectiveness(EMI SE)of 51 dB,which is 3.9 times higher than that of the co-blended CCA/rGO/PDMS EMI shielding composites(13 dB)with the same loading of *** this time,the CCA@rGO/PDMS EMI shielding composites have excellent thermal stability(T_(HRI) of 178.3℃)and good thermal conductivity coefficient(λ of 0.65 W m^(-1) K^(-1)).Excellent comprehensive performance makes CCA@rGO/PDMS EMI shielding composites great prospect for applications in lightweight,flexible EMI shielding composites.

关键词： Polydimethylsiloxane Electromagnetic interference shielding Cellulose carbon aerogel Reduced graphene oxide

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Effect of Open Porosity of Y2O3 Ceramic on the Apparent Contact Angles and Interactions Between Ti47Al Alloys and Y2O3 Ceramic

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Acta Metallurgica Sinica(English Letters) 2017年第5期30卷 456-463页

作者： Chao Ran hua-rui Zhang Hu Zhang bei-bei Wan Peng Bai School of Materials Science and Engineering BeihangUniversityBeijing 100191China beijing Key Laboratory for Advanced Functional Materialand Thin Film Technology Beihang UniversityNo.37 Xueyuan RoadBeijing 100191China

The effect of open porosity of Y2O3ceramic on the apparent contact angle and interaction between molten Ti47 Al alloy and Y2O3ceramic substrates under pure Ar was investigated by using a sessile drop method at 1600 °C. As the open porosity increased from 9.6% to 30.3%, the spreading rate of molten Ti47 Al alloys on Y2O3ceramic substrates reduced from 2.3 to 1.1°/s; meanwhile, the final equilibrium contact angles increased from 55.8° to 63.6°. The microstructure observations revealed that with increasing the open porosity of the Y2O3substrates, the thickness of sand adhesion at the interfaces of the alloy droplets increased from 5.4 to 15.7 lm, and ceramic particles in the alloy matrix increased as well. The increasing contact area between the molten alloy and the substrate played a dominant role in determining the interaction on Ti Al/Y2O3interface.

关键词： Contact angle Yttria Titanium aluminides Interaction Open porosity

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Effect of Trace O Element on High-temperature Wettability Between Ni_3Al Melt and Y_2O_3 Ceramic

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Acta Metallurgica Sinica(English Letters) 2018年第5期31卷 552-560页

作者： Peng Bai hua-Rui Zhang bei-bei Wan Chao Ran Hu Zhang School of Materials Science and Engineering Beihang University beijing Key Laboratory for Advanced Functional Material and Thin Film Technology Beihang University

Effect of trace O element on the high-temperature wettability between Ni3Al scrap melt and Y2O3 ceramic at 1873 K is investigated. With the increase in O content in Ni3Al scrap melt from 6 to 21 ppm, the equilibrium contact angle decreases from 93.3° to 88.9°. The initial surface tension and adhesive work of molten Ni3Al scrap drop from 3153.5 to 807.4 mN m^-1 and from 2974.6 to 882.2 mN m^-1, respectively. The average spreading rate increases from 0.03° s^-1 to 0.17° s^-1. The whole wetting processes are divided into four periods. The main driving force for spreading in period（1） is the adsorption and diffusion of active atoms around the interface. Trace O content in Ni3Al scrap has a significant impact on interfacial reactions which mostly take place in the second stage, and can accelerate the spreading process on Y2O3 substrate. The reaction products during wetting process are Y3Al5O12, YAlO3 and Al2O3.

关键词： Ni3Al scrap Wetting Interaction Yttria Oxygen content

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