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切割函数为常值的曲线的一个结果

河北北方学院学报（自然科学版） 2010年第3期26卷 13-15页

作者：岳崇山宋旭华首都师范大学数学系北京100000 河北北方学院理学院河北张家口075000 宣化科技职业学院数学系河北宣化075100

平面闭曲线的双切圆问题在平面区域的外形识别中占据重要的地位.切割函数在双切圆的研究中起着重要的作用.重新定义了平面曲线和空间曲线的拓广的切割函数,利用微分几何技术,研究了平面曲线的拓广的切割函数恒为常值的情形,得到了一个... 详细信息

平面闭曲线的双切圆问题在平面区域的外形识别中占据重要的地位.切割函数在双切圆的研究中起着重要的作用.重新定义了平面曲线和空间曲线的拓广的切割函数,利用微分几何技术,研究了平面曲线的拓广的切割函数恒为常值的情形,得到了一个充分必要条件,进而得到了空间曲线的拓广的切割函数恒为常值的充分条件.

关键词：曲线双切圆切割函数

Exploration of Gas-Dependent Self-Adaptive Reconstruction Behavior of Cu₂O for Electrochemical CO₂ Conversion to Multi-Carbon Products

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhang, Chaoran Gu, Yichuan Jiang, Qu Sheng, Ziyang Feng, Ruohan Wang, Sihong Zhang, Haoyue xu, Qianqing Yuan, Zijian song, Fang Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO2 reduction reaction (CO2RR), whereas the behavior is by far superficially understood. Here, we report that CO2 accessibility results in a universal self-adaptive structural reconstruction from Cu2O to Cu@CuxO composites, ending with feeding gas-dependent microstructures and catalytic performances. The CO2-rich atmosphere favors reconstruction for CO2RR, whereas the CO2-deficient one prefers that for hydrogen evolution reaction. With the assistance of spectroscopic analysis and theoretical calculations, we uncover a CO2-induced passivation behavior by identifying a reduction-resistant but catalytic active Cu(I)-rich amorphous layer stabilized by *CO intermediates. Additionally, we find extra CO production is indispensable for the robust production of C2H4. An inverse correlation between durability and FECO/FEC2H4 is disclosed, suggesting that the self-stabilization process involving the absorption of *CO intermediates on Cu(I) sites is essential for durable electrolysis. Guided by this insight, we design hollow Cu2O nanospheres for durable and selective CO2RR electrolysis in producing C2H4. Our work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO2 reduction reaction Electrocatalysts Cu2O Reconstruction Self-adaptive electrocatalysis

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

促炎及抗炎细胞因子在脓毒症小鼠肠道相关淋巴组织的表达

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军事医学科学院院刊 2005年第1期29卷 41-44页

作者：赵立陈立军尉承泽曲楠宋旭华孟宪钧军事医学科学院附属医院北京100039 解放军总医院普通外科研究所北京100853

目的:探讨脓毒症时小鼠肠道相关淋巴组织的淋巴细胞促炎及抗炎细胞因子的表达与全身炎症反应的关系.方法:NIH小鼠盲肠结扎穿孔(CLP)造成脓毒症,观察致伤后24 h存活率,并分别在致伤后3、12 h分离小鼠肠上皮间质淋巴细胞(IEL)、Peyer结节... 详细信息

目的:探讨脓毒症时小鼠肠道相关淋巴组织的淋巴细胞促炎及抗炎细胞因子的表达与全身炎症反应的关系.方法:NIH小鼠盲肠结扎穿孔(CLP)造成脓毒症,观察致伤后24 h存活率,并分别在致伤后3、12 h分离小鼠肠上皮间质淋巴细胞(IEL)、Peyer结节淋巴细胞(PPL)及肠系膜淋巴结淋巴细胞(MLNL).采用RT-PCR定量检测促炎细胞因子TNFα、IL-1β、IL-6和抗炎细胞因子IL-4在肠道相关淋巴组织中的表达.致伤后3、12 h分别抽取门静脉血进行细菌培养及鉴定.结果:致伤后24 h内,脓毒症组(CLP)存活率明显低于假手术组(SHAM)(1/10 vs 10/10),死亡高峰时间为致伤后14～16 h.促炎细胞因子TNFα、IL-1β、IL-6基因表达在指定时间点内,CLP组明显高于SHAM组(P0.05),但在致伤后12 h却明显低于致伤后3 h及SHAM组(P<0.01).CLP组门静脉血培养可见肠源性G-菌生长并随致伤时间的延长细菌培养阳性率明显增加,而SHAM组在指定时间点内未见细菌生长.结论:脓毒症时小鼠肠道相关淋巴组织细胞可见促炎细胞因子基因的过度表达而抗炎细胞因子基因明显低表达,促炎/抗炎细胞因子表达失衡,肠道的免疫屏障受损,肠源性细菌及毒素大量移位,加重了全身的炎症反应,表明肠道在脓毒症时可能是参与全身炎症反应的重要器官.

关键词：脓毒症肠道肠杆菌科感染细胞因子类基因表达

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糖尿病性白内障超声乳化术后角膜的变化

眼科新进展 2017年第9期37卷 860-862页

作者：宋绪华陈梨萍郑振优陈小燕海南医学院附属医院眼科海南省海口市570102

目的评价超声乳化白内障吸除术对糖尿病性白内障术后角膜内皮及厚度等指标的影响。方法96例(96眼)2型糖尿病性白内障患者(糖尿病组)以及252例(252眼)老年性白内障患者(老年组)接受超声乳化白内障吸出联合后房型人工晶状体植入术,比较两... 详细信息

目的评价超声乳化白内障吸除术对糖尿病性白内障术后角膜内皮及厚度等指标的影响。方法96例(96眼)2型糖尿病性白内障患者(糖尿病组)以及252例(252眼)老年性白内障患者(老年组)接受超声乳化白内障吸出联合后房型人工晶状体植入术,比较两组患者术前及术后1周、4周、8周泪膜破裂时间、基础泪液分泌、角膜内皮细胞密度以及中央角膜厚度。结果术后1周、4周、8周糖尿病组患者的泪膜破裂时间、基础泪液分泌、角膜内皮细胞密度以及中央角膜厚度与术前差异均有统计学意义(均为P0.05)。与老年组相比,糖尿病组患者术前及术后1周、4周、8周泪膜破裂时间、基础泪液分泌、角膜内皮细胞密度以及中央角膜厚度差异均有统计学意义(均为P<0.05)。结论糖尿病患者泪膜稳定性、基础泪液分泌以及角膜内皮细胞密度均显著降低,白内障超声乳化吸出术后这些眼部体征更加显著,术中及术后加强保护角膜内皮及眼表面组织,控制术后组织反应是减少糖尿病性白内障术后并发症的重要手段。

关键词：糖尿病性白内障超声乳化白内障吸出术泪膜角膜内皮角膜厚度

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei song Lin xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

海口市眼部真菌感染流行病学与病原学特征分析

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南方医科大学学报 2010年第8期30卷 1880-1882页

作者：宋绪华邢健强陈海毛海燕陈梨萍海南医学院附属医院眼科海南海口570102

目的探讨海口市眼部真菌感染的流行病学与病原学特征。方法采集眼科门诊及住院患者角膜、结膜、前房、泪囊等部位标本进行真菌培养，对真菌培养的阳性率、季节分布、菌属分布等进行统计学分析。结果共检查683例眼疾患者，真菌培养阳性率... 详细信息

目的探讨海口市眼部真菌感染的流行病学与病原学特征。方法采集眼科门诊及住院患者角膜、结膜、前房、泪囊等部位标本进行真菌培养，对真菌培养的阳性率、季节分布、菌属分布等进行统计学分析。结果共检查683例眼疾患者，真菌培养阳性率为27．96％，其中男、女阳性率分别为33．42％和21．52％，差异有显著性（P〈0．01）。角膜、结膜、前房、泪囊、其他标本（眶周、玻璃体等）的阳性率依次为31．42％、11．32％、10．8l％、21．28％、29．17％，差异有显著性（P〈0．01）。不同职业人群眼部真菌培养阳性率依次为：农民34．88％、工人22．58％、教师11．76％、机关干部4．11％、学生21．43％、其他职业13．33％，差异有显著性（P〈0．01）。不同年龄人群阳性率以21-40岁、41-60岁两个年龄组较高，依次为32．30％、31．72％；不同月份的阳性率以3月最低，8、9、10、11、12月份普遍较高，每月均高于30％。分离出的真菌经鉴定共有9属，以念珠菌属构成比最高（49．21％），曲霉菌属19-37％；共发现念珠菌94株，其中白色念珠菌排第1位，有63株，占67．02％；其次为热带念珠菌14株，占14．89％。结论海口地区眼部真菌感染多见于男性，以角膜炎患者感染多见。感染的真菌以念珠菌为主，此与国内其他地区不同，可能与本地区热带气侯有关。

关键词：眼部真菌海口念珠菌

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang xu Jiang-hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

糖尿病视网膜病变与血糖、血脂等相关因素的关系及影响因素分析

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海南医学院学报 2018年第21期24卷 1930-1933页

作者：李雷郑振优宋绪华海南医学院第一附属医院眼科海南海口570102

目的:探讨不同分期的糖尿病视网膜病变与血糖、血脂、血压、尿微量白蛋白/肌酐比值等的相关关系,为糖尿病视网膜病变的发病机制及综合防治提供科学依据。方法:收集我院内分泌科住院的2型糖尿病患者196例,将其分为无视网膜病变组180例,... 详细信息

目的:探讨不同分期的糖尿病视网膜病变与血糖、血脂、血压、尿微量白蛋白/肌酐比值等的相关关系,为糖尿病视网膜病变的发病机制及综合防治提供科学依据。方法:收集我院内分泌科住院的2型糖尿病患者196例,将其分为无视网膜病变组180例,非增殖期视网膜病变组11例,增殖期视网膜病变组5例,并设正常人群对照组40例。每个被调查对象均进行眼底彩照或荧光素眼底血管造影检查、体格和血液检查,并将结果进行统计分析。结果:4组间的体质指数、收缩压、糖化血红蛋白、空腹血糖、餐后2h血糖、血清甘油三酯、血清高密度脂蛋白、尿微量白蛋白/肌酐比值均有统计学差异(P<0.05);收缩压、糖化血红蛋白、餐后2h血糖、TG、尿微量白蛋白/肌酐比值均与不同分期糖尿病视网膜病变呈正相关关系;高密度脂蛋白与不同分期糖尿病视网膜病变呈负相关关系。结论:收缩压、糖化血红蛋白、餐后2h血糖、血清甘油三酯、血清高密度脂蛋白、糖尿病肾病患病率、尿微量白蛋白/肌酐比值均是糖尿病视网膜病变分期的影响因素,收缩压、糖化血红蛋白和餐后2h血糖、甘油三酯、尿微量白蛋白/肌酐比值越高、高密度脂蛋白越低,糖尿病视网膜病变越严重。

关键词：糖尿病视网膜病变血糖血脂尿微量白蛋白/肌酐比值