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Friction 2024年第6期12卷 1119-1132页

作者： song yuan Xiaoguang GUO Hao WANG Renke KANG Shang GAO State Key Laboratory of High-performance Precision Manufacturing Dalian University of TechnologyDalian 116024China

The roughness of the contact surface exerts a vital role in *** is still a significant challenge to understand the microscopic contact of the rough surface at the atomic ***,the rough surface with a special root mean square(RMS)value is constructed by multivariate Weierstrass–Mandelbrot(W–M)function and the rubbing process during that the chemical mechanical polishing(CMP)process of diamond is mimicked utilizing the reactive force field molecular dynamics(ReaxFF MD)*** is found that the contact area A/A0 is positively related with the load,and the friction force F depends on the number of interfacial bridge *** the surface roughness will increase the friction force and friction *** model with low roughness and high lubrication has less friction force,and the presence of polishing liquid molecules can decrease the friction force and friction *** RMS value and the degree of damage show a functional relationship with the applied load and lubrication,i.e.,the RMS value decreases more under larger load and higher lubrication,and the diamond substrate occurs severer damage under larger load and lower *** work will generate fresh insight into the understanding of the microscopic contact of the rough surface at the atomic level.

关键词： diamond random roughness reactive force field molecular dynamics(ReaxFF MD) friction Weierstrass-Mandelbrot(W-M)function chemical mechanical polishing(CMP)

Ocular surface changes in moderate-to-severe acne vulgaris

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1049-1057页

作者： Ci-Yi Pan Dong-Jie Sun Han-Ling Li Li Ma Min Zhang song-yuan Tang Hui Zhang Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Stomatology the First People’s Hospital of Yunnan ProvinceKunming 650100Yunnan ProvinceChina Institute of Health Studies School of Public HealthKunming Medical UniversityKunming 650500Yunnan ProvinceChina

AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry ***:This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy *** participants completed the Ocular Surface Disease Index(OSDI)*** following ocular surface-related parameters were measured:tear meniscus height(TMH),noninvasive tear breakup time(NIBUT),Schirmer I test(SIT),lipid layer thickness(LLT)score of the tear film,meibum score,meibomian gland orifice obstruction score,the ratio of meibomian gland loss,conjunctival hyperemia score,and corneal fluorescein staining(CFS)***:The stability of the tear film decreased in acne vulgaris *** the acne group,the TMH and NIBUT were lower,whereas the OSDI,meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss,and conjunctival hyperemia score were higher compared with controls(P0.05).In two dry eye groups,the TMH,NIBUT,and LLT score were lower in the acne with dry eye(acne-DE)group,and the meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher(P0.05).CONCLUSION:Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne *** tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.

关键词： acne vulgaris meibomian gland dysfunction dry eye tear film

Facilitating and hindering factors of community nurses'emergency and critical care treatment abilities:A qualitative study

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World Journal of Clinical Cases 2024年第18期12卷 3453-3460页

作者： Wen-Lin Cheng Rui Li Yan song Fei-Hu Qian Si-yuan Sha Shuang-yuan song School of Nursing Beihua UniversityJilin 132013Jilin ProvinceChina Department of Nursing Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study adopts a descriptive phenomenological approach to investigate the facilitators and barriers of community nurses'abilities in managing critical and emergency *** the transition of healthcare systems to the community,the evolution of nursing practices,and the attention from policies and practices,community nurses play a crucial role in the management of critical and emergency ***,there is still a lack of comprehensive understanding regarding the factors that promote or hinder their capabilities in this *** To understand the facilitators and barriers of community nurses in managing critical and emergency conditions,exploring the fundamental reasons and driving forces influencing their treatment *** This study utilized the destination sampling method between May 2023 and July *** employed a descriptive phenomenological approach within qualitative research *** objective sampling,17 community nurses from 7 communities in Changning District,Shanghai,were selected as the study ***-structured interviews were conducted to gather data,which were subsequently organized and analyzed using Colaizzi's seven-step analysis method,leading to the extraction of final *** The barrier factors identified from the interviews encompassed three topics:resource allocation,professional factors,and personal *** facilitators comprised three themes:professionalism,management attention,and training and continuing *** identified that the root causes of the barriers included the lack of practical treatment experience among community nurses,insufficient awareness of self-directed learning,and limited knowledge and technical *** professional quality of community nurses and management attention serve as motivation for them to enhance their treatment *** To enhance the capability of community nurses in treating acute and critical patients,it is

关键词： Community nurse Acute and critical illness Promoting factors Obstacle factors Qualitative study

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU Yu Mei SHAN Hui TAN Jin Feng ZHOU Jian song yuan Jin LI Si Qi LIU Chen XU Dong Qun YU Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

Origin of the Disparity between the Stability of Transmutated Mix-Cation and Mix-Anion Compounds

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Chinese Physics Letters 2024年第5期41卷 53-60页

作者：野仕伟耿松源梁汉普张燮魏苏淮 Beijing Computational Science Research Center Beijing 100193China Advanced Materials Thrust Function HubHong Kong University of Science and TechnologyGuangzhou 511458China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

Transmutation is an efficient approach for material design. For example, ternary compound CuGaSe_(2) in chalcopyrite structure is a promising material for novel optoelectronic and thermoelectric device applications. It can be considered as formed from the binary host compound ZnSe in zinc-blende structure by cation transmutation(i.e., replacing two Zn atoms by one Cu and one Ga). While cation-transmutated materials are common, aniontransmutated ternary materials are rare, for example, Zn_(2)As Br(i.e., replacing two Se atoms by one As and one Br)is not reported. The physical origin for this puzzling disparity is unclear. In this work, we employ first-principles calculations to address this issue, and find that the distinct differences in stability between cation-transmutated(mix-cation) and anion-transmutated(mix-anion) compounds originate from their different trends of ionic radii as functions of their ionic state, i.e., for cations, the radius decreases with the increasing ionic state, whereas for anions, the radius increases with the increasing absolute ionic state. Therefore, for mix-cation compounds,the strain energy and Coulomb energy can be simultaneously optimized to make these materials stable. In contrast, for mix-anion systems, minimization of Coulomb energy will increase the strain energy, thus the system becomes unstable or less stable. Thus, the trend of decreasing strain energy and Coulomb energy is consistent in mix-cation compounds, while it is opposite in mix-anion compounds. Furthermore, the study suggests that the stability strategy for mix-anion compounds can be controlled by the ratio of ionic radii r3/r1, with a smaller ratio indicating greater stability. Our work, thus, elucidates the intrinsic stability trend of transmutated materials and provides guidelines for the design of novel ternary materials for various device applications.

关键词： stability stability ternary

Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： Xiao-Li WANG Ai-Qing FENG Xi-Yong HOU Qing-Chen CHAO Bai-yuan song Yu-Bin LIU Qi-Guang WANG He XU Yu-Xin ZHANG Dong Li Li-Jie DONG Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

从全称量化的动词短语到频率副词——以“动不动”和“三不知”为例

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语言研究 2024年第3期44卷 51-59页

作者：杨作玲宋云云三峡大学文学与传媒学院/国家语言文字推广基地湖北宜昌443002

频率副词“动不动”和“三不知”都由全称量化义的动词短语发展而来。通过隐喻从量域投射到频率域,语义演变的路径是“全量肯定>高频”、“全量否定>低频”。它们都是在“(S)+动不动/三不知+VP”结构中发生语法化,但演变为副词的机制不... 详细信息

频率副词“动不动”和“三不知”都由全称量化义的动词短语发展而来。通过隐喻从量域投射到频率域,语义演变的路径是“全量肯定>高频”、“全量否定>低频”。它们都是在“(S)+动不动/三不知+VP”结构中发生语法化,但演变为副词的机制不同:“动不动”是小句整合的伴随结果,“三不知”是对话题化操作移位后的结构重新分析的结果。副词“动不动”和“三不知”都有反预期功能,前者源自与常理相背的语用推理,后者源自出乎说话人意料的语义蕴含。

关键词：全量频率小句整合话题化移位反预期

Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： Zi-Ang Ma Li-Xin Wang Hui Zhang Han-Zhou Li Li Dong Qing-Hai Wang yuan-song Wang Bao-ChaoPan Shu-Fang Zhang Huan-Tian Cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

多级孔ZSM-5分子筛催化餐厨废油制备轻质芳烃的研究

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粮食与油脂 2024年第2期37卷 53-59页

作者：罗文博郝松源袁红北方民族大学化学与化学工程学院宁夏银川750021 国家民委化工技术重点实验室宁夏银川750021

采用水热法合成不同硅铝摩尔比的多级孔ZSM-5分子筛,并对其结构进行表征,考察不同硅铝摩尔比多级孔ZSM-5分子筛对餐厨废油模型化合物(WCOMC)制备苯、甲苯和二甲苯(3种物质统称BTX)的影响。结果表明:L-赖氨酸的加入提高了多级孔ZSM-5分... 详细信息

采用水热法合成不同硅铝摩尔比的多级孔ZSM-5分子筛,并对其结构进行表征,考察不同硅铝摩尔比多级孔ZSM-5分子筛对餐厨废油模型化合物(WCOMC)制备苯、甲苯和二甲苯(3种物质统称BTX)的影响。结果表明:L-赖氨酸的加入提高了多级孔ZSM-5分子筛的传质效率,其硅铝摩尔比的变化有效地调节了多级孔ZSM-5分子筛的酸性,且多级孔ZSM-5分子筛的酸性影响目标产物的分布和反应体系的稳定性。随着温度的升高,芳烃的相对含量提高,在600℃条件下多级孔ZSM-5-40分子筛催化WCOMC制备BTX的相对含量最高,为20.3%。

关键词：多级孔ZSM-5分子筛餐厨废油模型化合物轻质芳烃

暗挖隧道SRG拱架节点抗弯性能及参数影响机制研究

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中国公路学报 2024年第4期37卷 286-296页

作者：宋远黄明利张旭东李然安徽理工大学土木建筑学院安徽淮南232001 北京交通大学城市地下工程教育部重点实验室北京100044 中铁十一局集团有限公司湖北武汉430061 中铁四局集团有限公司安徽合肥230023

为解决软弱围岩暗挖隧道变形控制技术难题,满足高承载力和高稳定性的支护需求,研发出了一种新型装配式空间网架(SRG)支护结构。节点作为整环结构受力及变形的薄弱部位,其力学特性对准确评价整体承载性能至关重要,为了探明不同节点形式... 详细信息

为解决软弱围岩暗挖隧道变形控制技术难题,满足高承载力和高稳定性的支护需求,研发出了一种新型装配式空间网架(SRG)支护结构。节点作为整环结构受力及变形的薄弱部位,其力学特性对准确评价整体承载性能至关重要,为了探明不同节点形式的性能差异,针对SRG拱架开展了螺栓端板节点、组合套筒节点和无节点构件的纯弯室内足尺试验和数值模拟,对比分析了各构件的变形过程和破坏形态,建立了弯矩-曲率函数方程,定量评价了节点抗弯刚度及承载力。系统分析了端板厚度、套筒长度、钢管壁厚等参数对螺栓端板节点、组合套筒节点及无节点试件力学性能的影响规律,明确了节点参数影响机制,提出了拱架节点参数合理取值及设计建议。此外,依托广州地铁暗挖隧道工程开展了SRG拱架的现场应用。结果表明:螺栓端板节点具有较高的韧性和承载能力,在加载过程中节点力系传递明确,受力变形稳定,可作为SRG拱架优选的节点类型;组合套筒节点具有较好的延展性和后期变形能力,在加载过程中组合套筒受力状态良好,未产生明显变形;端板厚度增加,试件的屈服承载力增幅明显,厚度由15 mm增至25 mm,承载力相应提高了14.6%;采用“上3下4”螺栓布置方式的节点构件,其屈服承载力与“上5下6”螺栓布置方式仅相差3.1%;相较于格栅拱架支护,SRG拱架的整体性有所增强,围岩控制效果得到明显改善,拱顶沉降值和周边收敛分别减少了31.6%和31.4%,研究结果可为今后类似工程的设计与施工提供借鉴。

关键词：隧道工程空间网架模型试验抗弯性能螺栓端板节点组合套筒节点

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