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Rice science 2020年第6期27卷 504-514页

作者： Seong-Hui EO song ja kim Department of Biological Sciences College of Natural SciencesKongju National UniversityGongju 32588Republic of Korea

The resveratrol-enriched transgenic rice line Iksan526(IS526),first developed by the Rural Development Administration of Korea using genetic engineering techniques,shows beneficial health effects in mitigating metabolic syndrome and ***,the effects of IS526 on the differentiation of chondrocytes and the underlying mechanism have not been investigated in *** this study,the effects and cellular regulatory mechanisms of IS526 on rabbit articular chondrocytes were *** IS526 callus extract treatment,the expression levels of differentiation-related proteins were detected via western blotting,Alcian blue staining and immune-luorescence ***526 decreased the type Ⅱ collagen and proteoglycan levels in dose-and time-dependent *** further analyzed the effects of IS526 on skeleton genesis in zebrafish larvae using Alcian blue staining,which showed a reduction in cartilage formation along with increased production of matrix metalloproteinase(MMP)-***526 also increased the phosphorylation of ERK1/2 and p38 kinase but inhibited the phosphorylation of *** inhibition of MMP-13 blocked the IS526-induced decrease in type Ⅱ collagen *** of p38 kinase or PI-3K/Akt with SB203580 and LY294002 enhanced the suppression of type Ⅱ collagen,but the blockage of ERK-1/2 by PD98059 rescued IS526-induced *** results suggested that IS526 regulates type Ⅱ collagen and MMP-13 expression via the ERK1/2 and PI-3K/Akt pathways in rabbit articular chondrocytes.

关键词： rice chondrocyte typeⅡcollagen matrix metalloproteinase-13 rice callus extract

In vitro,in vivo and in silico anti-hyperglycemic inhibition by sinigrin

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 352-358页

作者： Qamar Abbas Mubashir Hassan Hussain Raza song ja kim Ki-Wha Chung Gwang-Hoon kim Sung-Yum Seo Department of Biological Sciences College of Natural SciencesKongju National University56 Gongjudehak-Ro 56GongjuChungnam 32588Republic of Korea

Objective:To evaluate the anti-hyperglycemic potential of sinigrin using in *** silico and in riro streptozotocin(STZ) induced hyperglycemic zebrafish ***:The in vitro enzyme inhibition assay was carried out to determine the IC_(50) value against α-glucosidase and α-*** silico molecular docking was performed against both enzymes with PyRx tool and simulations were performed using GROMACS *** was induced in zebrafishes using three intraperitoneal injections on alternating days for one week at 350mg/kg of *** fishes were treated intraperitoncally with 50.100 and 150 mg of sinigrin/kg of body weight for 24 h and glucose levels were ***:The sinigrin showed very strong inhibition against α-glucosidase and α-amylase with 0.248 and0.00124 μM while reference drug acarbose showed IC_(50) value of 73.0700 and 0.0017 μM against α-glucosidase and α-amylase,*** analysis revealed that sinigrin has the mixed type mode of inhibition against α-*** docking results revealed its strong binding affinity with α-glucosidase(-10.00 Kcal/mol) and α-amylase(-8.10 Kcal/mol).Simulations graphs confirmed its stability against both *** hyperglycemic zebrafishes most significant(P<0.001) reduction of glucose was occurred at150 mg/*** significant reduction of glucose was observed at 100 mg/kg and no any significant reduction of glucose was measured at 50 mg/***:It can be evident from the present results that sinigrin has potent anti-hyperglycemic activity and it may prove to be effective treatment for the hyperglycemia.

关键词： Anti-hyperglycemia MD simulations Sinigrin Zebrafish α-amylase α-glucosidase

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei song Lin Xu Jong Seung kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul song Min Sung kim Seungwon Yoo ja Hoon Koo Dae-Hyeong kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

Nuclear Planetology:Especially Concerning the Moon and Mars

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Research in Astronomy and Astrophysics 2012年第10期12卷 1313-1380页

作者： Kyeong ja kim Nobuyuki Hasebe Korea Institute of Geoscience and Mineral Resources Daejeon305-350 Korea Research Institute for Science and Engineering Waseda UniversityShinjukuTokyo 169-8555 Japan

To approach basic scientific questions on the origin and evolution of plan- etary bodies such as planets, their satellites and asteroids, one needs data on their chemical composition. The measurements of gamma-rays, X-rays and neutrons emit- ted from their surface materials provide information on abundances of major elements and naturally radioactive gamma-ray emitters. Neutron spectroscopy can provide sen- sitive maps of hydrogen- and carbon-containing compounds, even if buried, and can uniquely identify layers of carbon-dioxide frost. Nuclear spectroscopy, as a means of compositional analysis, has been applied via orbital and lander spacecraft to extrater- restrial planetary bodies： the Moon, Venus, Mars, Mercury and asteroids. The knowl- edge of their chemical abundances, especially concerning the Moon and Mars, has greatly increased in recent years. This paper describes the principle of nuclear spec- troscopy, nuclear planetary instruments carried on planetary missions so far, and the nature of observational results and findings of the Moon and Mars, recently obtained by nuclear spectroscopy.

关键词： nuclear planetology: planetary remote sensing -- elemental mapping --nuclear science payloads -- chemical abundance

Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 374-379页

作者： Mi-ja kim Hye Kyung kim Department of Food and Biotechnology Hanseo UniversitySeosan 356-706Republic of Korea Department of Pharmacology school of MedicineKyunghee UniversitySeoul 130-701Republic of Korea

Objective:To explore the anti-diabetic activity of Ecklonia cava(EC) in streptozotocin(STZ)-induced diabetic ***:Diabetes was induced by a single intraperitoneal injection of STZ(90 mg/kg).Normal and diabetic mice were treated with 0%,3%,and 5%EC diet for 4 weeks. Serum glucose and insulin concentrations,serum lipid profile,oral glucose tolerance test,and liver and pancreaticβ-cell histopathological observations were *** addition,in vitro glucose-induced insulin secretion was determined using pancreaticβ-islet ***:EC supplementation significantly and dose-dependently decreased serum glucose concentration, and improved glucose homeostasis in diabetic mice by preventing loss ofβ-cell mass resulting in increase of insulin *** triglyceride and total cholesterol concentrations in the serum and liver were markedly reduced by EC treatment in STZ-diabetic ***,LDL-,and HDL-cholesterol levels were ameliorated in EC supplemented diabetic *** steatosis induced by STZ was ameliorated by EC ***,in vitro insulinotrophic effect of EC extract was observed in pancreaticβ-***:This study demonstrated that EC is a potent and efficacious hypoglycemic and hypolipidemic agent,and prevents the loss ofβ-cell mass resulting in increase of insulin secretary capacity.

关键词： Diabetes Streptozotocin Insulin Lipid profile Pancreaticβ-cell

ON TRANSMISSION PROBLEM FOR VISCOELASTIC WAVE EQUATION WITH A LOCALIZED A NONLINEAR DISSIPATION

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Acta Mathematica Scientia 2013年第2期33卷 362-374页

作者： Jeong ja BAE Seong Sik kim Department of Mathematics Dongeui UniversityPusan 614-714Korea

In this article, we consider the global existence and decay rates of solutions for the transmission problem of Kirchhoff type wave equations consisting of two physically different types of materials, one component being a Kirchhoff type wave equation with time dependent localized dissipation which is effective only on a neighborhood of certain part of boundary, while the other being a Kirchhoff type viscoelastic wave equation with nonlinear memory

关键词： Existence of solution uniform decay transmission problem boundary valueproblem localized dissipation

Priority-based adaptive transmission algorithm for medical devices in wireless body area networks(WBANs)

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Journal of Central South University 2015年第5期22卷 1762-1768页

作者： kim Jinhyuk song Inseong CHOI Sangbang Department of Electronic Engineering Inha University

A wireless body area network offers cost-effective solutions for healthcare infrastructure. An adaptive transmission algorithm is designed to handle channel efficiency, which adjusts packet size according to the difference in feature-point values that indicate biomedical signal characteristics. Furthermore, we propose a priority-adjustment method that enhances quality of service while guaranteeing signal integrity. A large number of simulations were carried out for performance evaluation. We use electrocardiogram and electromyogram signals as reference biomedical signals for performance verification. From the simulation results, we find that the average packet latency of proposed scheme is enhanced by 30% compared to conventional method. The simulation results also demonstrate that the proposed algorithm achieves significant performance improvement in terms of drop rates of high-priority packets around 0.3%-0.9 %.

关键词： wireless body area network channel efficiency quality of service

A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair

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Bioactive Materials 2024年第4期34卷 80-97页

作者： Haeun Chung Jung-Kyun Choi Changgi Hong Youngseop Lee Ki Hyun Hong Seung ja Oh Jeongmin kim Soo-Chang song Jong-Wan kim Sang-Heon kim Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and TechnologySeoul02792Republic of Korea Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul08826Republic of Korea Research Institute for Convergence Science Seoul National UniversitySeoul08826Republic of Korea Department of Genetics and Biotechnology College of Life SciencesKyung Hee UniversityYongin-siGyeonggi-do17104Republic of Korea S.Biomedics Co. Ltd.Seoul04797Republic of Korea

Critical limb ischemia(CLI)is a devastating disease characterized by the progressive blockage of blood *** the paracrine effect of growth factors in stem cell therapy made it a promising angiogenic therapy for CLI,poor cell survival in the harsh ischemic microenvironment limited its ***,an imperative need exists for a stem-cell delivery method that enhances cell ***,a collagen microgel(CMG)cell-delivery scaffold(40×20μm)was fabricated via micro-fragmentation from collagen-hyaluronic acid polyionic complex to improve transplantation *** human adipose-derived stem cells(hASCs)with CMG enabled integrin receptors to interact with CMG to form injectable 3-dimensional constructs(CMG-hASCs)with a microporous microarchitecture and enhanced mass ***-hASCs exhibited higher cell survival(p<0.0001)and angiogenic potential in tube formation and aortic ring angiogenesis assays than cell *** of CMG-hASCs intramuscularly into CLI mice increased blood perfusion and limb salvage ratios by 40%and 60%,respectively,compared to cell aggregate-treated *** immunofluorescent analysis revealed that transplanted CMG-hASCs have greater muscle regenerative and angiogenic potential,with enhanced cell survival than cell aggregates(p<0.05).Collectively,we propose CMG as a cell-assembling platform and CMG-hASCs as promising therapeutics to treat CLI.

关键词： Regenerative medicine Stem cell therapy Collagen microgel 3D cell culture Critical limb ischemia

LiTFSI salt concentration effect to digest lithium polysulﬁdes for high-loading sulfur electrodes

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Journal of Energy Chemistry 2023年第3期78卷 574-581,I0015页

作者： Jin-Kwang song Moonsoo kim Seongbae Park Young-Jun kim SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Sulfur utilization improvement and control of dissolved lithium polysulﬁde(LiPS;Li_(2)S x,2 详细信息

Sulfur utilization improvement and control of dissolved lithium polysulﬁde(LiPS;Li_(2)S x,2

关键词： Lithium-sulfur battery Electrolyte concentration Li2S deposition High-loading sulfur electrode