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Chinese Chemical Letters 2006年第1期17卷 85-88页

作者： Qing song ZHOU xue Hua JIANG Jia Rui YU Ke Jia LI West China School of Pharmacy Sichuan University Chengdu 610041

Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol （PEG） were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scuteUarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scuteUarin.

关键词： Scutellarin PEGylation prodrug physicochcmical properties stability.

Acid-rock reaction kinetics in a two-scale model based on reaction order correction

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Petroleum Science 2024年第3期21卷 2089-2101页

作者： xue-song Li Ning Qi Ze-Hui Zhang Lian Liu Xia-Qing Li Xu-Hang Su School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Key Lab of Unconventional Oil&Gas Development Ministry of EducationChina University of Petroleum(East China)Qingdao26650ShandongChina SINOPEC Northwest Oilfield Branch Company Urumqi830011XinjiangChina Petroleum Engineering Technology Research Institute SINOPEC Shengli Oilfield CompanyDongying257000ShandongChina

The reaction order plays a crucial role in evaluating the response rate of ***,the conventional two-scale model typically assumes that the reaction order is constant as one,which can lead to significant deviations from *** address this issue,this study proposes a novel multi-order dynamic model for acid-rock reaction by combining rotating disk experimental data with theoretical *** numerical simulations,this model allows for the investigation of the impact of acidification conditions on different orders of reaction,thereby providing valuable insights for on-site *** analysis reveals that higher response orders require higher optimal acid liquid flow rates,and lower optimal H+diffusion coefficients,and demonstrate no significant correlation with acid ***,it is recommended to increase the displacement and use high-viscosity acid for reservoirs with high calcite content,while reducing the displacement and using low-viscosity acid for reservoirs with high dolomite content.

关键词： Reaction order Two-scale model Wormhole propagation Carbonate rocks Numerical simulation

Preparation and properties of calcium sulfate bone cement incorporated with silk fibroin and Sema3A-Ioaded chitosan microspheres

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Frontiers of Materials Science 2015年第1期9卷 51-65页

作者： Peng WANG Bin PI Jin-Ning WANG xue-song ZHU Hui-Lin YANG Department of Orthopedic Surgery the First Affiliated Hospital of Soochow University Suzhou 215006 China

To search for new bioactive materials which can be used as the substitute of bone repairing and drug carriers, Sema3A-Ioaded chitosan microspheres （SLCM） and silk fibroin （SF） were mixed with calcium sulfate cement （CSC）. SEM, particle size analysis and swelling rate determination were performed to study properties of the microspheres. The drug loading, encapsulation efficiency and drug release rate were determined by ELISA. Microspheres with different SLCM weight contents （0.5%, 1% and 5%） were prepared to determine which one has the strongest mechanical properties and the appropriate setting time. It was revealed that CSC/SF/0.5SLCM has satisfactory mechanical properties, and its in vitro biocompatibility was assessed by MTS. Chitosan microspheres （5-18 μm） were globular, the surface was smooth, and the swelling rate is （77.02 ± 5.57）%. With this formula, the setting time was increased with the addition of SLCM in CSCISF, and the cumulative drug release rate is 44.62% in 28 d. XRD results demonstrate that the main component is calcium sulfate. Also it was found that CSCiSFI 0.5SLCM supports the growth of MC3T3 cells. Thus the preparation of CSCISFIO.5SLCM was reliable, and the products had good structures, physical properties and biocompatibility, appearing to be a promising bone substitute material.

关键词： Sema3A chitosan microsphere sustained release silk fibroin (SF) bone cement

Positive Effects of Isopropanol as a Co-Precipitant in Glycerol-3-Phosphate Acyltransferase Crystallization

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Journal of Ocean University of China 2019年第1期18卷 227-231页

作者： ZHANG Yunxiu FENG Yanbin WANG Yayue LIU Yinghui CAO Xupeng xue song Marine Bioengineering Group Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

Glycerol-3-phosphate acyltransferase(GPAT) is considered as the rate-limiting enzyme of glycerolipid synthesis pathway and the core element in lysophosphatidic acid(LPA) synthesis. For understanding its catalytic mechanism, the structural biology study is expected, but is always hindered by obtaining crystals for X-ray diffraction analysis. In this study, a progressive strategy to optimize the crystal of microalgae plastidial GPAT was presented. After the expression and purification of GPAT, the crystals were screened by hanging-drop and only clusters were obtained. The crystals were optimized by adjusting temperature, pH, protein concentration, or precipitant, but little improvement. To improve the interaction between protein and precipitant, the isopropanol was applied as co-precipitant. The qualified crystals formed. It's suggested that isopropanol is critical to affect protein crystallization by altering polyethylene glycol(PEG)-water-protein interaction when PEG serves as precipitant. The resulting crystal diffracted to a resolution of 2.75 ? and belonged to space group P1, with unit-cell parameters a = 50.79, b = 80.09, c = 88.21 ?, and α = 62.85, β = 73.04, γ = 80.53?. This work introduced a new strategy to optimize the crystal of the heterogeneous catalysis enzymes like GPAT and provided the fundamental structural information for the oriented synthesis of marine microalgae glycerolipid.

关键词： isopropanol polyethylene glycol(PEG) optimization glycerol-3-phosphate acyltransferase(GPAT) crystallization

The donor-dependent methoxy effects on the performance of hole-transporting materials for perovskite solar cells

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Journal of Energy Chemistry 2020年第8期29卷 10-17,I0001页

作者： Mengyuan Li Jinhua Wua Guoguo Wang Bingxue Wu Zhe Sun song xue Qiquan Qiao Mao Liang Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion Department of Applied ChemistryTianjin University of TechnologyTianjin 300384.China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Collaborative Innovation Center of Chemical Science and EngineeringCollege of ChemistryNankai UniversityTianjin 300071China Center for Advanced Photovoltaics Department of Electrical EngineeringSouth Dakota State UniversityBrookingsSD 57007 United States

In this work, a comprehensive study on the deliberate molecular design and modifications of electron donors is carried out to elucidate correlations between the methoxy effects and donor configuration of hole-transporting materials(HTMs). Our initial findings demonstrate the donor-dependent methoxy effects. Photovoltaic performance of the HTM with twisted donor highly depends on the methoxy substituent. In contrast, efficiency’s reliance on methoxy is insignificant for the HTM with planar donor. The HTM(M123) featuring the methoxy–substituted carbazole shows a decent power conversion efficiency of 19.33% due to synergistic effects from both planar structure and methoxy. This work gives a guideline to access HTMs reaching both high-performance and good stability.

关键词： Hole-transporting materials Donor configuration Methoxy effect Perovskite solar cells

Photocatalytic Dye Methyl Orange Decomposition on Ternary Sulfide (CdIn2S4) under Visible-light

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Chinese Chemical Letters 2005年第9期16卷 1259-1262页

作者： Xiao Dan YU xue song QU Yi Hang GUO Chang Wen HU Faculty of Chemistry Northeast Normal University Changchun 130024 Department of Chemistry Beijing Institute of Technology Beijing 100081

A novel and efficient photocatalyst, CdIn2S4, was simply prepared by a programmed temperature hydrothermal method. The product had a nanometer size （10-15 nm） and strong absorption in the range of 200 to 580 nm, and... 详细信息

关键词： Ternary sulfides hydrothermal treatment visible-light photocatalysis methyl orange

Ab Initio Calculations on Halogen Bond Between N—Br and Electron-donating Groups

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Chemical Research in Chinese Universities 2007年第3期23卷 355-359页

作者： WANG Yan-hua CHEN xue-song ZOU Jian-wei YU Qing-sen College of Biology and Environment Engineering Zhejiang Shuren University Hangzhou 310015P. R. China Key Laboratory for Molecular Design and Nutrition Engineering of Ningbo City Ningbo Institute of Technology Zhejiang University Ningbo 315100 P. R. China Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China

Ab initio calculations of complexes formed between N-bromosuccinimide and a series of electron-donating groups were performed at the level of MP2/Lanl2DZ^＊ to gain a deeper insight into the nature of the N--Br halogen bonding. For the small complexes, H3 C--Br… NH3 and H2 N--Br…NH3 , the primary calculation has demonstrated that the N--Br in H2 N--Br… NH3 can form a much stronger halogen-bonding complex than the C--Br. A comparison of neutral hydrogen bond complex series reveals that the electron-donating capacities of the atoms decrease in the order, N 〉 O 〉 S; 0 （ sp^3 ）〉 0 （ sp^2 ）, which is adequate for the C--Br halogen bonding. Interaction energies, in conjunction with the geometrical parameters show that the affinitive capacity of trihalide anions X^-3 with N-bromosuccinimide are markedly lower than that of the corresponding X^- with N-bromosuccinimide, even lower than those of neutral molecules with N-bromosueeinimide. AIM analyses further eorffirmed the above results.

关键词： Halogen bond N-bromosuccinimide Ab initio AIM theory Interaction energy

Solitary fibrous tumor of the prostate:a case report and 5-year follow-up

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Asian Journal of Andrology 2019年第4期21卷 421-422页

作者： Ya-Ting Liu Fei-xue song Lin Xiang Hong Chang Department of Medical Oncology Lanzhou University Second Hospital Lanzhou 730030 China Department of Pathology Lanzhou University Second Hospital Lanzhou 730030 China Department of Urology Lanzhou University Second Hospital Lanzhou 730030 China Institute of Urology Lanzhou University Second Hospital Key Laboratory of Urological Diseases in Gansu Province Gansu Nephro-Urological Clinical Center Lanzhou 730030 China Department of Clinical Laboratory Center The Second Clinical Medical College of Lanzhou University Lanzhou 730030 China

Dear Editor, Solitary fibrous tumors (SFTs) originating from the prostate are extremely rare. The prognosis of patients with SFTs who undergo surgical treatment is good, but aggressive SFTs can recur, so patients should be closely followed up.1 Here, we report a 46-year-old male patient with prostatic SFT who was followed up for 5 years after surgical treatment. This study was approved by the Ethics Committee of Lanzhou University Second Hospital (Lanzhou, China). The patient provided written informed consent.

关键词： Solitary fibrous tumors(SFTs) prostate Ethics Committee

Prognostic role of chromogranin A in ：astration-resistant prostate cancer： a meta-analysis

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Asian Journal of Andrology 2018年第6期20卷 561-566页

作者： Peng Hong Run-Qi Guo Gang song Kai-Wei Yang Lei Zhang xue-song Li Kai Zhang Li-Qun Zhou Department of Urology Peking University First Hospital and Institute of UrologyNational Research Centre for Genitourinary OncologyBeijing 100034China.These authors contributed equally to this work.

We aimed to investigate the prognostic value of chromogranin A （CgA） in castration-resistant prostate cancer （CRPC）. We conducted a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described CgA and CRPC and performed a standard meta-analysis on survival outcomes. Our meta-analysis included eight eligible studies with 686 patients. The results were as follows： progression-free survival （PFS） was associated with CgA level （hazard ratio [HR] = 2.47, 95% confidence interval [CI]： 1.47-4.14, P = 0.0006）; PFS was relative to CgA change （HR = 9.22, 95% Ch 3.03-28.05, P〈 0.0001）; and overall survival （OS） was relative to CgA level （HR = 1.47, 95% Ch 1.15-1.87, P= 0.002）. When we divided the patients into two groups according to therapy status, the result for OS relative to CgA level was an HR of 1.26 （95% CI： 1.09-1.45, P = 0.001） in the first-line hormonal therapy group, and an HR of 2.33 （95% Ch 1.40-3.89, P = 0.001） in the second-line hormonal therapy or chemotherapy group. This meta-analysis indicated that a high CgA level had a negative influence on OS and PFS in CRPC patients. In addition, CRPC patients with a rising CgA had a shorter PFS. Further studies are needed to verify the prognostic value of CgA in CRPC.

关键词： castration-resistant prostate cancer chromogranin A prognosis

Development and Evaluation of a PCR Kit for Authentication of Panax quinquefolius *** PCR-Restriction Fragment Length Polymorphism

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Journal of Analysis and Testing 2022年第4期6卷 424-430页

作者： xue-song Wang Li-Mei Liu Li-Yuan Sun Ming-Cheng Li School of Laboratory Medicine College of Medical TechnologyBeihua UniversityJilin132013China Innovation Center for Detection Technology on DNA Fingerprint of Traditional Chinese Medicine Jilin ProvinceJilin132013China

Panax quinquefolius L.(American ginseng)and Panax ginseng *** are famous herbal *** authentication of the species has grown to be a significant *** study aims to develop a PCR kit for the authentication of Panax quinquefolius *** Panax ginseng based on the nuclear internal transcribed spacer 2(ITS2)gene with the improved PCR-restriction fragment length polymorphism(PCR-RFLP)*** reagent components in the development work were prepared and determined by the kit consisting of the DNA extraction,PCR amplification,and restriction enzyme digestion systems.A total of 21 batches of Panax quinquefolius *** Panax ginseng samples collected from different areas were *** specificity,stability,and repeatability were *** purity of genomic DNA extracted was 1.73±0.13 according to the ratio of A_(260)/A_(280),and the mass concentration was 3.15±0.22μg/g(using the kit).PCR amplicons of Panax quinquefolius *** Panax ginseng were 122 bp in *** the PCR products were digested by restriction enzyme Hinf I,a distinct pattern exhibited in the species of Panax quinquefolius *** two fragments of 40 bp and 80 bp respectively,whereas those from Panax ginseng in addition to adulterated samples could *** confirmed that the DNA kit results were stable and repeatable after 10,15,and 20 freeze-thaw cycles:the evaluation was 100%*** DNA kit proposed in the study can be used for the identification of Panax quinquefolius L.

关键词： Panax quinquefolius L. Authentication Nuclear internal transcribed spacer 2 PCR