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Chinese Journal of Chemistry 2016年第12期34卷 1236-1244页

作者： Ling Chen Peiyi Wang Zhenxing Li Lei Zhou Zhibing Wu Baoan song song Yang State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&D of Fine Chemicals of Guizhou University Guiyang Guizhou 550025 China College of Pharmacy East China University of Science & Technology Shanghai 550025 China

In this paper, a series of N-（4-substituted phenyl） acetamide derivatives bearing 1,3,4-oxadiazole moiety were synthesised. Preliminary bioassays revealed that these compounds not only exhibited favourable antiviral activities toward tobacco mosaic virus （TMV） but also demonstrated sustained inhibition activities against plant pathogenic bacteria, including Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. cit- ri. Among the derivatives, TC8 and TC20 exerted the strongest curative activities against TMV, with half-maximal effective concentration （EC50） values of 239.5 and 236.2μg/mL, respectively, which were comparable to that of ningnanmycin （EC50=273.2μg/mL）. Given their simple synthesis, the target compounds can serve as alternative antiviral candidates.

关键词： 1,3,4-oxadiazole acetamide synthesis antiviral antibacterial

Stein’s method for the law of large numbers under sublinear expectations

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Probability, Uncertainty and Quantitative Risk 2021年第3期6卷 199-212页

作者： Yongsheng song RCSDS Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Peng,S.[6]proved the law of large numbers under a sublinear *** this paper,we give its error estimates by Stein’s method.

关键词： Stein’s method Rate of convergence Law of large numbers

Mechanical Dispatch Reliability Prediction for Civil Aircraft Considering Operational Parameters

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1925-1942页

作者： yunwen Feng Zhicen song Cheng Lu School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Department of Aeronautics and Astronautics Fudan UniversityShanghai200433China

To effectively predict the mechanical dispatch reliability(MDR),the artificial neural networks method combined with aircraft operation health status parameters is proposed,which introduces the real civil aircraft operation data for verification,to improve the modeling precision and computing *** relational analysis can identify the degree of correlation between aircraft system health status(such as the unscheduled maintenance event,unit report event,and services number)and dispatch release and screen out themost closely related systems to determine the set of input parameters required for the prediction *** artificial neural network using radial basis function(RBF)as a kernel function,has the best applicability in the prediction of multidimensional,small sample *** status parameters of related systems are used as the input to predict the changing trend ofMDR,under the artificial neural network modeling *** case study collects real operation data for a certain civil aircraft over the past five years to validate the performance of the model which meets the requirements of the *** results show that the prediction quadratic error Ep of the model reaches 6.9×10−*** is to say,in the existing operating environment,the prediction of the number of delay&cancel events per month can be less than *** accuracy of RBF ANN,BP ANN and GA-BP ANN are compared further,and the results show that RBF ANN has better adaptability to such multidimensional small sample *** efforts of this paper provide a highly efficientmethod for theMDR prediction through aircraft system health state parameters,which is a promising model to enhance the prediction and controllability of the dispatch release,providing support for the construction of the civil aircraft operation system.

关键词： Mechanical dispatch reliability GRA-RBF civil aircraft artificial neural network

Carbon Monoxide-induced Stomatal Closure Involves Generation of Hydrogen Peroxide in Vicia faba Guard Cells

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Journal of Integrative Plant Biology 2008年第12期50卷 1539-1548页

作者： Xiao-Ping She Xi-Gui song School of Life Sciences Shaanxi Normal University Xi'an 710062 China

Here the regulatory role of CO during stomatal movement in Vicia faba L. was surveyed. Results indicated that, like hydrogen peroxide （H2O2）, CO donor HemaUn induced stomatal closure in dose- and time-dependent manners. These responses were also proven by the addition of gaseous CO aqueous solution with different concentrations, showing the first time that CO and H2O2 exhibit the similar regulation role in the stomatal movement. Moreover, our data showed that ascorbic acid （ASA, an important reducing substrate for H2O2 removal） and diphenylene iodonium （DPI, an inhibitor of the H2O2-generating enzyme NADPH oxidase） not only reversed stomatal closure by CO, but also suppressed the H2O2 fluorescence induced by CO, implying that CO induced-stomatal closure probably involves H2O2 signal. Additionally, the CO/NO scavenger hemoglobin （Hb） and CO specific synthetic inhibitor ZnPPIX, ASA and DPI reversed the darkness-induced stomatal closure and H2O2 fluorescence. These results show that, perhaps like H2O2, the levels of CO in guard cells of V. faba are higher in the dark than in light, HO-1 and NADPH oxidase are the enzyme systems responsible for generating endogenous CO and H2O2 in darkness respectively, and that CO is involved in darkness-induced H2O2 synthesis in V. faba guard cells.

关键词： carbon monoxide guard cells hydrogen peroxide signaling stomata.

Robustness of community networks against cascading failures with heterogeneous redistribution strategies

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Chinese Physics B 2023年第9期32卷 611-618页

作者：宋波吴惠明宋玉蓉蒋国平夏玲玲王旭 School of Modern Posts Nanjing University of Post and TelecommunicationNanjing 210023China College of Automation&College of Artificial Intelligence Nanjing University of Post and TelecommunicationNanjing 210023China Department of Computer Information and Cyber Security Jiangsu Police InstituteNanjing 210023China GBDTC University of Technology SydneySydneyNSW 2007Australia

Network robustness is one of the core contents of complex network security *** paper focuses on the robustness of community networks with respect to cascading failures,considering the nodes influence and community heterogeneity.A novel node influence ranking method,community-based Clustering-LeaderRank(CCL)algorithm,is first proposed to identify influential nodes in community *** results show that the CCL method can effectively identify the influence of *** on node influence,a new cascading failure model with heterogeneous redistribution strategy is proposed to describe and analyze node fault propagation in community *** and numerical simulation results on cascading failure show that the community attribute has an important influence on the cascading failure *** network robustness against cascading failures increases when the load is more distributed to neighbors of the same community instead of different *** the initial load distribution and the load redistribution strategy based on the node influence are the same,the network shows better robustness against node failure.

关键词： community networks cascading failure model network robustness nodes influence identification

Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats

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Chinese Journal of Integrative Medicine 2020年第7期26卷 510-518页

作者： ZHANG Hua-bin TU Xian-kun song Shi-wei LIANG Ri-sheng SHI song-sheng Department of Neurosurgery Fujian Medical University Union HospitalNeurosurgery Research Institute of Fujian ProvinceFuzhou(350001)China

Objective: To evaluate the effect of baicalin on subarachnoid hemorrhage(SAH) in rats and explore the potential mechanisms. Methods: Sprague-Dawley rats underwent experimental SAH and received treatment with baicalin at 10 or 50 mg/kg after 2 and 12 h of SAH. Neurological scores, brain water content, Evans-blue extravasation, and levels of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), myeloperoxidase(MPO), and malondialdehyde(MDA) were measured 24 h after SAH. Expression of nuclear factor erythroid-related factor 2(Nrf2), NAD(P)H: quinone oxidoreductase 1(NQO1), matrix metalloproteinase-9(MMP-9), aquaporin 4(AQP4), occludin, and zonulaoccludens-1(ZO-1) were detected in the brain by Western blot. Heme oxygenase-1(HO-1) was detected by quantitative polymerase chain reaction, and tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) were assessed by enzyme-linked immunosorbent assay. Results: Baicalin attenuated EBI 24 h after SAH in rats(P<0.05). Baicalin elevated neurological scores, GSH-Px, SOD, and increased the expression of Nrf2, NQO1, HO-1, occludin, and ZO-1 in SAH rats(P<0.05 or P<0.01). Baicalin reduced MPO, MDA, and the expression of MMP-9, AQP4, TNF-α, and IL-1β(P<0.05 or P<0.01). Conclusion: Baicalin reduced SAH-induced EBI, partially via activation of the Nrf2/HO-1 pathway and inhibition of MMP-9 and AQP4.

关键词： aquaporin 4 baicalin Chinese medicine early brain injury matrix metalloproteinase-9 subarachnoid hemorrhage

Insights Into the Interfacial Degradation of High-Voltage All-Solid-State Lithium Batteries

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Nano-Micro Letters 2022年第12期14卷 1-13页

作者： Jiawen Li yuchen Ji Haoran song Shiming Chen Shouxiang Ding Bingkai Zhang Luyi Yang Yongli song Feng Pan School of Advanced Material Peking University Shenzhen Graduate SchoolShenzhen 518055People’s Republic of China Guangzhou Key Laboratory of Clean Transportation Energy Chemistry School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 51006People’s Republic of China

Poly(ethylene oxide)(PEO)-based solid polymer electrolyte(SPE)is considered as a promising solid-state electrolyte for all-solid-state lithium batteries(ASSLBs).Nevertheless,the poor interfacial stability with high-voltage cathode materials(e.g.,LiCoO_(2))restricts its application in high energy density solid-state ***,high-voltage stable Li_(3)AlF_(6) protective layer is coated on the surface of LiCoO_(2) particle to improve the performance and investigate the failure mechanism of PEO-based *** phase transition unveils that chemical redox reaction occurs between the highly reactive LiCoO_(2) surface and PEO-based SPE,resulting in structure collapse of LiCoO_(2),hence the poor cycle performance of PEO-based ASSLBs with LiCoO_(2) at charging voltage of 4.2 V vs Li/Li+.By sharp contrast,no obvious structure change can be found at the surface of Li_(3)AlF_(6)-coated LiCoO_(2),and the original layered phase was well *** the charging voltage reaches up to 4.5 V vs Li/Li+,the intensive electrochemical decomposition of PEO-based SPE occurs,leading to the constant increase of cell impedance and directly causing the poor *** work not only provides important supplement to the failure mechanism of PEO-based batter-ies with LiCoO_(2),but also presents a universal strategy to retain structure stability of cathode-electrolyte interface in high-voltage ASSLBs.

关键词： Solid-state battery Poly(ethylene oxide) Surface modification Interface stability High-voltage cathode

Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2180-2189页

作者： Xu-Hui Deng Jing Li Shi-Jian Chen Yi-Ju Xie Jian Zhang Geng-yu Cen Yi-Ting song Zhi-Jian Liang Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Neurology The Affiliated Yuebei People’s Hospital of Shantou University Medical CollegeShaoguan 512025Guangdong ProvinceChina Department of General Medicine The Affiliated Cancer Center of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The diagnosis of both cancer and intracerebral hemorrhage(ICH)in the same patient is not uncommon,but the clinical features and pathogenesis of patients with colorectal cancer(CRC)and ICH are still not well *** To investigate the clinical features and underlying pathogenesis of ICH in patients with *** A retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was *** data such as laboratory examinations,imaging features,prognosis,and underlying pathogenesis were *** Of 16673 identified CRC patients,20(0.12%)suffered from *** were 13 males and 7 females,with an average age(mean±SD)of 68.45±10.66 *** patients(70%)had distant metastases and most patients(85%)showed an elevation of one or more cancer *** hemorrhagic lesions in 13 patients(65%)were in the intracerebral *** patients were completely dependent and 4 died within 30 days after *** hemorrhage(50%)and coagulopathy(50%)accounted for the majority of *** Patients with ICH and CRC often have clinical features with lobar hemorrhage,distant metastases and poor *** hemorrhage and coagulopathy are the main causes of ICH in patients with CRC.

关键词： Colorectal cancer Intracerebral hemorrhage Clinical features Pathogenesis

E-noise: An increasingly relevant health risk

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Journal of Integrative Medicine 2019年第5期17卷 311-314页

作者： Chun-song Hu Tengiz Tkebuchava Jiangxi Academy of Medical Science Hospital of Nanchang UniversityNanchang UniversityNanchang 330006Jiangxi ProvinceChina oston TransTec LLCBostonMA 02459USA

This article briefly reviews and discusses the current status of major non-communicable diseases(m NCDs), definition of e-noise, its possible link as a risk factor for cardiovascular diseases and other m NCDs, and proposes possible mechanisms and hypotheses on that link, and how to control e-noise in the future. E-noise is defined as signal from electronic products and instruments that emit radiation and electromagnetic fields. It includes not only the acoustic but also non-acoustic noise. Just like road traffic and aircraft noises, e-noise may not only lead to hearing loss and health problems such as fatigue,stress, irritability, headache, and insomnia, but may also endanger cardiovascular health and result in hypertension, ischemic heart disease(myocardial infarction), arrhythmia(atrial fibrillation) and stroke;brain and metabolic problems such as obesity and diabetes;mental and cognitive impairment;as well as changing of humans’ long-evolved cortisol and circadian rhythms after long-term exposure. Even shortterm exposure to excessive e-noise may lead to heightened stress responses and low quality of life. In conclusion, e-noise is a potential danger in our world, and further studies are needed of its effects on mechanisms of aging, disease, and human health.

关键词： Environment E-noise Healthrisk Lifestyle Long-term exposure

Likelihood ratio-type tests in weighted composite quantile regression of DTARCH models

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Science China Mathematics 2019年第12期62卷 2571-2590页

作者： Xiaoqian Liu Xinyuan song Yong Zhou School of Economics and Finance Shanghai International Studies UniversityShanghai 200083China Department of Statistics The Chinese University of Hong KongHong KongChina Academy of Statistics and Interdisciplinary Sciences and School of Statistics Faculty of Economics and ManagementEast China Normal UniversityShanghai 200062China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

The double-threshold autoregressive conditional heteroscedastic(DTARCH) model is a useful tool to measure and forecast the mean and volatility of an asset return in a financial time series. The DTARCH model can handle situations wherein the conditional mean and conditional variance specifications are piecewise linear based on previous information. In practical applications, it is important to check whether the model has a double threshold for the conditional mean and conditional heteroscedastic variance. In this study, we develop a likelihood ratio test based on the estimated residual error for the hypothesis testing of DTARCH models. We first investigate DTARCH models with restrictions on parameters and propose the unrestricted and restricted weighted composite quantile regression(WCQR) estimation for the model parameters. These estimators can be used to construct the likelihood ratio-type test statistic. We establish the asymptotic results of the WCQR estimators and asymptotic distribution of the proposed test statistics. The finite sample performance of the proposed WCQR estimation and the test statistic is shown to be acceptable and promising using simulation studies. We use two real datasets derived from the Shanghai and Shenzhen Composite Indexes to illustrate the methodology.

关键词： DTARCH model quantile weigh ted composite quantile regression modified likelihood ratio test,restricted WCQR estimators unrestricted WCQR estimators