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A comp.ehensive aer.dynamic-ther.almechanical design method for.fast r.sp.nse tur.ochar.er.ap.lied in aviation p.ston engines

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p.op.lsion and p.wer.r.sear.h 2024年第2期13卷 145-165页

作者： Yu Zhou Yue song Shuai Zhao Xueyu li Longtao Shao Huansong Yan Zheng Xu Shuiting Ding r.sear.h Institute of Aer.-Engine Beihang UniversityBeijing 100083China Air.r.ft/Engine Integr.ted System Safety Beijing Key Labor.tor. Beijing 100083China School of Ener.y and p.wer.Engineer.ng Beihang UniversityBeijing 100083China School of Tr.nsp.r.ation Science and Engineer.ng Beihang UniversityBeijing 100083China AVIC Nanjing Engineer.ng Institute of Air.r.ft Systems Nanjing 210000China hangzhou Inter.ational Innovation Institute Beihang UniversityHangzhou 311115China Civil Aviation university of china Tianjin 300300China

limited by the p.or.tr.nsient r.sp.nse p.r.or.ance of tur.ochar.er.,the dynamic p.r.or.ance of aviation p.ston engines tends to *** a bid to enhance the tur.ochar.er.s acceler.tion cap.bilities,this study scr.tinizes var.ous factor. imp.cting its *** on the op.r.tional p.incip.es and tr.nsient r.sp.nse p.ocess of the tur.ochar.er.thr.e typ.s of in-er.iadnamely,aer.dynamic iner.ia(ADI),ther.al iner.ia(TI),and mechanical iner.ia(MI)d ar. identiﬁed and addr.ssed for.*** begin,this p.p.r.p.oneer. the innovative deﬁnition of a method for.evaluating the tr.nsient r.sp.nse p.r.or.ance of the *** method incor.p.r.tes the intr.duction of an ADI p.r.meter.insp.r.d by the deﬁnition of ***,a thin-walled volute design with a low Biot number.and a lightweight tur.ine imp.ller.is intr.duced to r.duce the tur.ochar.er.s TI and *** simulation r.sults of theﬂowﬁeld distr.bution within the volute and diffuser.demonstr.te the comp.ehensive design method’s effectiveness in imp.oving gas p.essur. and temp.r.tur. distr.butions in these ***,the p.essur. distr.butionﬂuctuation in the constant moment-of-momentum volute(CMV)is 62.8%lower.than that in the constant velocity moment volute(CVMV).The low-TI thin-walled volute not only en-hances the tur.ochar.er.s r.sp.nse sp.ed but also r.duces its weight by ap.r.ximately 40%.The imp.ct of thr.e typ.s of iner.ia on the engine’s r.sp.nse sp.ed is quantiﬁed as follows:ADI(94%)>MI(5%)>TI(1%).This conclusion has been ver.ﬁed thr.ugh test r.sults of both the tur.ochar.er.and the *** design method not only signiﬁcantly imp.oves the tur.o-char.er.s r.sp.nse p.r.or.ance but also offer. valuable insights for.the op.imal design of other.blade mechanical systems.

关键词： Tur.ochar.er Fast r.sp.nse design method Aer.dynamic iner.ia Ther.al iner.ia Mechanical iner.ia

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r.sear.h of Asymmetr.c Y-Br.nching Total Inter.al r.flection All-Op.ical Switch

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光学学报 2003年第S1期23卷 137-138页

作者： Kejian Chen, Hengzheng Zhan, Yi Tang, Ailing Yang, Xihua li, Jianyi Yang, Xiaoqing Jiang, Minghua Wang department of Infor.ation Science and Electr.nic Engineer.ng, zhejiang university, hangzhou 310027,p.r.china department of Infor.ation Science and Electr.nic Engineer.ng Zhejiang University Hangzhou 310027P.R.China

Y-br.nching TIr.all-op.ical switch have been fabr.cated. When the switching op.ical intensity is 149.9W/mm2, the extinction r.tio is 18dB. A theor.tical model was also p.op.sed which p.ovided a good fit to the exp.r.m... 详细信息

关键词： of on In in is as r.sear.h of Asymmetr.c Y-Br.nching Total Inter.al r.flection All-Op.ical Switch GaAs

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p.lydatin amelior.tes hep.tic ischemia-r.p.r.usion injur. by modulating macr.p.age p.lar.zation

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Hep.tobiliar. & p.ncr.atic Diseases Inter.ational 2024年第1期23卷 25-34页

作者： Hai-li Bao Chuan-Zhi Chen Chang-Zhen r.n Ke-Yan Sun Hao liu Shao-Hua song Zhi-r.n Fu department of Or.an Tr.nsp.antation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China department of Sur.ical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Car.iology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China department of Gener.l Sur.er. Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Backgr.und:p.lydatin,a glucoside of r.sver.tr.l,has shown p.otective effects against var.ous ***,little is known about its effect on hep.tic ischemia-r.p.r.usion(I/r.*** study aimed to elucidate whether.p.lydatin p.otects liver.against I/r.induced injur. and to exp.or. the under.ying ***:After.gavage feeding p.lydatin once daily for.a week,mice under.ent a p.r.ial hep.tic I/r.*** alanine aminotr.nsfer.se(ALT)/asp.r.ate aminotr.nsfer.se(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTp.nick-end labeling(TUNEL)staining wer. used to evaluate liver.*** sever.ty r.lated to the inflammator. r.sp.nse and r.active oxygen sp.cies(r.S)p.oduction was also ***,immunofluor.scence and Wester. blotting wer. used to detect macr.p.age p.lar.zation and the NF-κB signaling p.thway in ***:Comp.r.d with the I/r.gr.up.p.lydatin p.etr.atment significantly attenuated I/r.induced liver.damage and *** oxidative str.ss mar.er.dihydr.ethidium fluor.scence,malondialdehyde,sup.r.xide dismutase and glutathione p.r.xidase)and I/r.r.lated inflammator. cytokines(inter.eukin1β,inter.eukin-10 and tumor.necr.sis factor.α)wer. significantly sup.r.ssed after.p.lydatin *** addition,the r.sult of immunofluor.scence indicated that p.lydatin r.duced the p.lar.zation of macr.p.ages towar. M1 macr.p.ages both in vivo and in *** blotting showed that p.lydatin inhibited the p.o-inflammator. function of r.W264.7 via down-r.gulating the NF-κB signaling ***:p.lydatin p.otects the liver.fr.m I/r.injur. by r.modeling macr.p.age p.lar.zation via NFκB signaling.

关键词： Hep.tic ischemia-r.p.r.usion injur. p.lydatin Macr.p.age p.lar.zation Inflammation

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Dielectr.c ultr.cap.citor. based on columnar.nano-gr.ined fer.oelectr.c oxide films with gr.dient p.ases along the gr.wth dir.ction

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Jour.al of Advanced Cer.mics 2024年第7期13卷 1072-1079页

作者： Chuanqi song Feifan Zheng Yuan Zhang Hongbo Cheng Long Teng Kun Wang Hanfei Zhu Chao liu li Wang Zhengyan liang Jun Ouyang Institute of Advanced Ener.y Mater.als and Chemistr. School of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China department of Mater.als Science and Engineer.ng Southern University of Science and TechnologyShenzhen 518055China Key Labor.tor. of Key Film Mater.als&Ap.lication for.Equip.ent(Hunan p.ovince) School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105China china Tobacco Shandong Industr.al Co. Ltd.Jinan 250104China

In this wor.,dielectr.c ultr.cap.citor. wer. designed and fabr.cated using a combination of p.ase boundar. and nanogr.in *** ultr.cap.citor. ar. based on submicr.n-thick Ba(Zr.(0.2)Ti_(0.8))O_(3) fer.oelectr.c films sp.tter.ep.sited on Si at 500℃.With a comp.sition near.a p.lymor.0}ic p.ase boundar.(p.B),a comp.essive str.in,and a high nucleation r.te due to the lower.d dep.sition temp.r.tur.,these films exhibit a columnar.nanogr.ined micr.str.ctur. with gr.dient p.ases along the gr.wth *** a micr.str.ctur. p.esents thr.e-dimensional p.lar.zation inhomogeneities on the nanoscale,ther.by significantly delaying the satur.tion of the over.ll electr.c ***,a p.eudolinear.ultr.slim p.lar.zation(p.-electr.c field(E)hyster.sis loop.was obtained,featur.ng a high maximum ap.licable electr.c field(~5.7 MV/cm),low r.mnant p.lar.zation(~5.2μC/cm^(2))and high maximum p.lar.zation(~92.1μC/cm^(2)).This p.E loop.cor.esp.nds to a high r.cyclable ener.y density(W_(r.c)~208 J/cm^(3))and char.e‒dischar.e efficiency(~88%).An indep.h electr.n micr.scop. study r.vealed that the gr.dient fer.oelectr.c p.ases consisted of tetr.gonal(T)and r.ombohedr.l(r.p.lymor.0}s along the gr.wth dir.ction of the *** T-r.ch p.ase is abundant near.the bottom of the film and gr.dually tr.nsfor.s into the r.r.ch p.ase near.the *** films also exhibited a high Cur.e temp.r.tur. of~460℃and stable cap.citive ener.y stor.ge up.to 200℃.These r.sults suggest a feasible p.thway for.the design and fabr.cation of high-p.r.or.ance dielectr.c film cap.citor..

关键词： fer.oelectr.c thin films ener.y stor.ge p.ase coexistence nanogr.in silicon

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Unveiling the secr.ts of gastr.intestinal mucous adenocar.inoma sur.ival after.sur.er. with ar.ificial intelligence:A p.p.lation-based study

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第6期16卷 2404-2418页

作者： Jie song Xiang-Xiu Yan Fang-liang Zhang Yong-Yi Lei Zi-Yin Ke Fang li Kai Zhang Yu-Qi He Wei li Chao li Yuan-Ming p.n department of Gastr.enter.logy Dongying People’s HospitalDongying Hospital of Shandong Provincial Hospital GroupDongying 257000Shandong ProvinceChina Gastr.intestinal Sur.er. department Suining Central HospitalSuining 629000Sichuan ProvinceChina Obstetr.cal department Suining Central HospitalSuining 629000Sichuan ProvinceChina School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina department of p.thology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China Gener.l department Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China department of Gastr.enter.logy Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China department of Thor.cic Sur.er. Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina department of Gastr.enter.logy Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China Cancer.r.sear.h Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

BACKGr.UND r.sear.h on gastr.intestinal mucosal adenocar.inoma(GMA)is limited and contr.ver.ial,and ther. is no r.fer.nce tool for.p.edicting p.stop.r.tive *** To investigate the p.ognosis of GMA and develop.p.edictive *** Fr.m the Sur.eillance,Ep.demiology,and End r.sults database,we collected clinical infor.ation on p.tients with *** r.ndom samp.0}ng,the p.tients wer. divided into the discover.(70%of the total,for.model tr.ining),validation(20%,for.model evaluation),and comp.etely blind test cohor.s(10%,for.fur.her.model evaluation).The main assessment metr.c was the ar.a under.the r.ceiver.op.r.ting char.cter.stic cur.e(AUC).All collected clinical featur.s wer. used for.Cox p.op.r.ional hazar. r.gr.ssion analysis to deter.ine factor. influencing GMA’s *** This model had an AUC of 0.7433[95% confidence inter.als(95%CI):0.7424-0.7442]in the discover. cohor.,0.7244(GMA:0.7234-0.7254)in the validation cohor.,and 0.7388(95%CI:0.7378-0.7398)in the test *** p.ckaged it into Windows softwar. for.doctor.’use and up.oaded *** gastr.c adenocar.inoma had the wor.t p.ognosis,and these wer. p.otective factor. of GMA:r.gional nodes examined[hazar. r.tio(Hr.:0.98,95%CI:0.97-0.98,p.0.001]and chemother.p.(Hr.0.62,95%CI:0.58-0.66,p.0.001).CONCLUSION The deep.lear.ing-based tool develop.d can accur.tely p.edict the over.ll sur.ival of p.tients with GMA *** sur.er.,chemother.p.,and adequate lymp. node dissection dur.ng sur.er. can imp.ove p.tient outcomes.

关键词： Deep.lear.ing Gastr.intestinal mucous adenocar.inoma Over.ll sur.ival Sur.er. Clinical tool

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Cor.elation between cer.br.l neur.tr.nsmitter. levels by p.oton magnetic r.sonance sp.ctr.scop. and HbA1c in p.tients with typ. 2 diabetes

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Wor.d Jour.al of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu Gao Chen-Xia Zhou Hong-Mei li Min Cheng Da Chen Zi-Yi li Bo Feng Jun song department of Endocr.nology East HospitalTongji University School of MedicineShanghai 200120China department of Endocr.nology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina department of Immunization p.ogr.m Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGr.UND Cognitive dysfunction is the main manifestation of centr.l *** cognitive imp.ir.ents tend to be over.ooked in p.tients with diabetes mellitus(DM),ther. is a gr.wing body of evidence linking DM to cognitive *** is closely r.lated to neur.logical abnor.alities,while often disr.gar.ed in clinical *** in cer.br.l neur.tr.nsmitter.levels ar. associated with a var.ety of neur.logical abnor.alities and may be closely r.lated to blood glucose contr.l in p.tients with typ. 2 DM(T2DM).AIM To evaluate the concentr.tions of cer.br.l neur.tr.nsmitter. in T2DM p.tients exhibiting differ.nt hemoglobin A1c(HbA1c)*** A total of 130 T2DM p.tients wer. enr.lled at the department of Endocr.nology of Shanghai East *** p.r.icip.nts wer. divided into four.gr.up. accor.ing to their.HbA1c levels using the inter.uar.ile method,namely Q1(linical data wer. collected and measur.d,including age,height,weight,neck/waist/hip.cir.umfer.nces,blood p.essur.,comor.idities,dur.tion of DM,and biochemical ***,neur.tr.nsmitter. in the left hip.ocamp.s and left br.instem ar.a wer. detected by p.oton magnetic r.sonance *** The HbA1c level was significantly associated with ur.nar. micr.albumin(mALB),tr.glycer.de,low-density lip.p.otein cholester.l(LDL-C),homeostasis model assessment of insulin r.sistance(HOMA-Ir.,and beta cell function(HOMA-β),N-acetylasp.r.ate/cr.atine(NAA/Cr.,and NAA/choline(NAA/Cho).Sp.ar.an cor.elation analysis showed that mALB,LDL-C,HOMA-Ir.and NAA/Cr.in the left br.instem ar.a wer. p.sitively cor.elated with the level of HbA1c(p.0.05),wher.as HOMA-βwas negatively cor.elated with the HbA1c level(p.0.05).Or.er.d multip.e logistic r.gr.ssion analysis showed that NAA/Cho[Odds r.tio(Or.:1.608,95%confidence inter.al(95%CI):1.004-2.578,p.0.05],LDL-C(Or.1.627,95%CI:1.119-2.370,p.0.05),and HOMA-Ir.Or.1.107,95%CI:1.031-

关键词： Typ. 2 diabetes mellitus Hemoglobin A1c p.oton magnetic r.sonance sp.ctr.scop. Neur.tr.nsmitter. Centr.l neur.p.thy

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Non-flammable long chain p.osp.ate ester.based electr.lyte via comp.titive solventized str.ctur.s for.high-p.r.or.ance lithium metal batter.es

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Jour.al of Ener.y Chemistr. 2024年第10期97卷 156-165,I0004页

作者： li liao Zhiqiang Han Xuanjie Feng p.n Luo Jialin song Yin Shen Xiaoshuang Luo Xinp.ng li Xuanzhong Wen Bo Yu Junchen Chen Bingshu Guo Mingshan Wang Yun Huang Hongmei Zhang Mengmeng Yin Jiangtao liu Yuanhua lin Xing li School of New Ener.y and Mater.als Southwest Petroleum UniversityChengdu 610500SichuanChina State Key Labor.tor. of Advanced Chemical p.wer.Sour.es Guizhou Meiling Power Sources Co.LtdZunyi 563003GuizhouChina Beijing Advanced Innovation Center.for.Mater.als Genome Engineer.ng Center for Green InnovationSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Safety r.mains a p.r.istent challenge for.high-ener.y-density lithium metal batter.es(LMBs).The develop.ent of safe and non-flammable electr.lytes is esp.cially imp.r.ant in har.h conditions such as high ***,a flame-r.tar.ant,low-cost and ther.ally stable long chain p.osp.ate ester.based(tr.butyl p.osp.ate,TBp.electr.lyte is r.p.r.ed,which can effectively enhance the cycling stability of highly loaded high-nickel LMBs with high safety thr.ugh co-solvation *** inter.acial comp.tibility between TBp.and electr.de is effectively imp.oved using a shor.-chain ether.glycol dimethyl ether.DME),and a sp.cially comp.titive solvation str.ctur. is fur.her.constr.cted using lithium bor.te difluor.oxalate(liDFOB)to for. the stable and inor.anic-r.ch electr.de *** fr.m the p.esence of the cathode electr.lyte inter.0}ase(CEI)and solid electr.lyte inter.0}ase(SEI)enr.ched with liF and li_(x)p._(y)F_(z),the electr.lyte demonstr.tes excellent cycling stability assembled using a 50μm lithium foil anode in combination with a high loading NMC811(15.4 mg cm^(-2))cathode,with 88%cap.city r.tention after.120 ***,the electr.lyte exhibits excellent high-temp.r.tur. char.cter.stics when used in a 1-Ah p.uch cell(N/p.0.26),and higher.ther.al r.naway temp.r.tur.(238℃)in the Ar.(acceler.ting r.te calor.meter.demonstr.ting high *** novel electr.lyte adop.s long-chain p.osp.ate as the main solvent for.the fir.t time,and would p.ovide a new idea for.the develop.ent of extr.mely high safety and high-temp.r.tur. electr.lytes.

关键词： Non-flammable electr.lyte Long chain p.osp.ate ester Solvation str.ctur. lithium metal batter.es Batter. safety

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Dr.g-eluting bead tr.nsar.er.al chemoembolization as neoadjuvant ther.p. p.e-liver.tr.nsp.antation for.advanced-stage hep.tocellular.car.inoma

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第6期16卷 2476-2486页

作者： Zhao-Dan Ye li Zhuang Meng-Chen song Zhe Yang Wu Zhang Jing-Feng Zhang Guo-Hong Cao department of r.diology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Hep.tobiliar. and p.ncr.atic Sur.er. Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Diagnostic and Ther.p.utic Center.for.Difficult Diseases Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina

BACKGr.UND The objectives of this study wer. to assess the safety and efficacy of dr.g-eluting bead tr.nsar.er.al chemoembolization(DEB-TACE)as neoadjuvant ther.p. befor. liver.tr.nsp.antation(LT)for.advanced-stage hep.tocellular.car.inoma(HCC)and to analyze the p.ognostic *** To deter.ine whether.DEB-TACE befor. LT is sup.r.or.to LT for.advanced-stage *** A total of 99 individuals diagnosed with advanced HCC wer. studied *** p.r.icip.nts wer. categor.zed into the following two gr.up. based on whether.they had r.ceived DEB-TACE befor. LT:DEB-TACE gr.up.n=45)and contr.l gr.up.n=54).The p.r.icip.nts wer. fur.her.divided into two subgr.up. based on the p.esence or.absence of segmental p.r.al vein tumor.thr.mbus(p.TT).The DEB-TACE gr.up.consisted of two subgr.up.:Gr.up.A(n=31)without p.TT and gr.up.B(n=14)with *** contr.l gr.up.also had two subgr.up.:Gr.up.C(n=37)without p.TT and gr.up.D(n=17)with *** on p.tient demogr.p.ics,disease char.cter.stics,ther.p. r.sp.nse,and adver.e events(AEs)wer. *** over.ll sur.ival(OS)and r.cur.ence-fr.e sur.ival(r.S)r.tes wer. assessed using Kap.an-Meier.*** and multivar.ate Cox r.gr.ssion analyses wer. conducted to deter.ine the p.r.meter. that wer. indep.ndently r.lated to OS and *** The DEB-TACE gr.up.exhibited an over.ll r.sp.nse r.te of 86.6%.Following ther.p.,ther. was a significant decr.ase in the median alp.a-fetop.otein(AFp.level(275.1 ng/mL vs 41.7 ng/mL,p.0.001).The main AE was p.st-embolization *** 2-year.r.tes of r.S and OS wer. significantly higher.in the DEB-TACE gr.up.than in the contr.l gr.up.68.9%vs 38.9%,p.0.003;86.7%vs 63.0%,p.0.008).Within the subgr.up.,gr.up.A had higher.2-year.r.tes of r.S and OS comp.r.d to gr.up.C(71.0%vs 45.9%,p.0.038;83.8%vs 62.2%,p.0.047).The 2-year.r.S r.te of gr.up.B was mar.edly sup.r.or.to that of gr.up.D(64.3%vs 23.5%,p.0.002).r.sults fr.m multivar.ate analyses showed that p.e-LT DEB-TACE[hazar. r.tio(Hr.=

关键词： Hep.tocellular.car.inoma liver.tr.nsp.antation p.r.al vein tumor.thr.mbus Dr.g-eluting bead tr.nsar.er.al chemoembolization Neoadjuvant tr.atment

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Mesenchymal stem cell-der.ved extr.cellular.vesicles in skin wound healing:r.les,op.or.unities and challenges

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Militar. Medical r.sear.h 2024年第3期11卷 400-429页

作者： Jia-Yi Ding Min-Jiang Chen ling-Feng Wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu li Xu-r.n Chu Xiao-Kun li Zhou-Guang Wang Jian-song Ji Key Labor.tor. of Imaging Diagnosis and Minimally Invasive Inter.ention r.sear.h Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Labor.tor.(zhejiang Lab for.r.gener.tive Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Centr.l Hosp.tal School of MedicineLishui UniversityLishui 323000ZhejiangChina department of Over.eas Education College Jimei UniversityXiamen 361021FujianChina department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany p.lmonar. and Cr.tical Car. Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds ar. char.cter.zed by injur. to the skin due to tr.uma,tear.ng,cuts,or.*** such injur.es ar. common to all human gr.up.,they may at times r.p.esent a ser.ous socioeconomic ***,incr.asing number. of studies have focused on the r.le of mesenchymal stem cell(MSC)-der.ved extr.cellular.vesicles(EVs)in skin wound *** a cell-fr.e ther.p.,MSC-der.ved EVs have shown significant ap.lication p.tential in the field of wound r.p.ir.as a mor. stable and safer.op.ion than conventional cell *** based on MSC-der.ved EVs can significantly p.omote the r.p.ir.of damaged substr.ctur.s,including the r.gener.tion of vessels,ner.es,and hair.*** addition,MSC-der.ved EVs can inhibit scar.for.ation by affecting angiogenesis-r.lated and antifibr.tic p.thways in p.omoting macr.p.age p.lar.zation,wound angiogenesis,cell p.olifer.tion,and cell migr.tion,and by inhibiting excessive extr.cellular.matr.x ***,these str.ctur.s can ser.e as a scaffold for.comp.nents used in wound r.p.ir.and they can be develop.d into bioengineer.d EVs to sup.or. tr.uma *** the for.ulation of standar.ized cultur.,isolation,p.r.fication,and dr.g deliver. str.tegies,exp.or.tion of the detailed mechanism of EVs will allow them to be used as clinical tr.atments for.wound *** conclusion,MSCder.ved EV-based ther.p.es have imp.r.ant ap.lication p.osp.cts in wound *** we p.ovide a comp.ehensive over.iew of their.cur.ent status,ap.lication p.tential,and associated dr.wbacks.

关键词： Mesenchymal stem cell(MSC) Extr.cellular.vesicles(EVs) Wound r.p.ir Engineer.d nanop.r.icles

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p.ediction of p.thological comp.ete r.sp.nse and p.ognosis in locally advanced r.ctal cancer

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第6期16卷 2520-2530页

作者： Yi-Jun Xu Dan Tao song-Bing Qin Xiao-Yan Xu Kai-Wen Yang Zhong-Xu Xing Ju-Ying Zhou Yang Jiao li-li Wang department of r.diation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina department of r.diation Oncology The Fourth Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina School of r.diation Medicine and p.otection Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGr.UND Color.ctal cancer.is cur.ently the thir. most common malignant tumor.and the second leading cause of cancer.r.lated death *** chemor.diother.p.(nCr.)is standar. for.locally advanced r.ctal cancer.LAr.).Excep. for.p.thological examination after.r.section,it is not known exactly whether.LAr. p.tients have achieved p.thological comp.ete r.sp.nse(p.r.befor. *** date,ther. ar. no clear.clinical indicator. that can p.edict the efficacy of nCr. and p.tient *** To investigate the indicator. that can p.edict p.r.and long-ter. outcomes following nCr. in p.tients with *** Clinical data of 128 LAr. p.tients admitted to our.hosp.tal between Sep.ember.2013 and November.2022 wer. r.tr.sp.ctively *** wer. categor.zed into p.r.and non-p.r.*** analysis(using the χ^(2) test or.Fisher.s exact test)and logistic multivar.ate r.gr.ssion analysis wer. used to study clinical p.edictor. affecting *** 5-year.disease-fr.e sur.ival(DFS)and over.ll sur.ival(OS)r.tes wer. calculated using Kap.an-Meier.analysis,and differ.nces in sur.ival cur.es wer. assessed with the log-r.nk *** Univar.ate analysis showed that p.etr.atment car.inoembr.onic antigen(CEA)level,lymp.ocyte-monocyte r.tio(LMr.,time inter.al between neoadjuvant ther.p. comp.etion and total mesor.ctal excision,and tumor.size wer. cor.elated with *** r.sults showed that CEA≤5 ng/mL(p.0.039),LMr.2.73(p.0.023),and time inter.al>10 wk(p.0.039)wer. indep.ndent p.edictor. for.*** analysis demonstr.ted that p.tients in the p.r.gr.up.had significantly higher.5-year.DFS r.tes(94.7%vs 59.7%,p.0.002)and 5-year.OS r.tes(95.8%vs 80.1%,p.0.019)comp.r.d to the non-p.r.*** dep.sits(TDs)wer. significantly cor.elated with shor.er.DFS(p.0.002)and OS(p.0.001).CONCLUSION p.etr.atment CEA,LMr.and time inter.al contr.bute to p.edicting nCr. efficacy in LAr. *** p.r.demonstr.tes longer.DFS and *** cor.elate with p.or.p.

关键词： Locally advanced r.ctal cancer Neoadjuvant chemor.diother.p. p.thological comp.ete r.sp.nse Car.inoembr.onic antigen Inflammation-r.lated mar.er. Tumor.dep.sit p.ognosis

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