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Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong

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Journal of Pharmaceutical Analysis 2024年第2期14卷 225-243页

作者： Bingjia Zhao qian Zhang Yiqian He Weifang cao Wei song Xiaochun Liang Department of Traditional Chinese Medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China Institute of Basic Medicine Sciences Chinese Academy of Medical SciencesBeijing100005China Medical Research Center Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China

Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, for which effective therapies are currently lacking. Disturbed energy status plays a crucial role in DPN pathogenesis. However, the integrated profile of energy metabolism, especially the central carbohydrate metabolism, remains unclear in DPN. Here, we developed a metabolomics approach by targeting 56 metabolites using high-performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) to illustrate the integrative characteristics of central carbohydrate metabolism in patients with DPN and streptozotocin-induced DPN rats. Furthermore, JinMaiTong (JMT), a traditional Chinese medicine (TCM) formula, was found to be effective for DPN, improving the peripheral neurological function and alleviating the neuropathology of DPN rats even after demyelination and axonal degeneration. JMT ameliorated DPN by regulating the aberrant energy balance and mitochondrial functions, including excessive glycolysis restoration, tricarboxylic acid cycle improvement, and increased adenosine triphosphate (ATP) generation. Bioenergetic profile was aberrant in cultured rat Schwann cells under high-glucose conditions, which was remarkably corrected by JMT treatment. In-vivo and in-vitro studies revealed that these effects of JMT were mainly attributed to the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and downstream peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Our results expand the therapeutic framework for DPN and suggest the integrative modulation of energy metabolism using TCMs, such as JMT, as an effective strategy for its treatment.

关键词： Diabetic peripheral neuropathy JinMaiTong Energy metabolism Targeted metabolomics Adenosine monophosphate-activated protein kinase

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Computed tomography-based radiomics diagnostic approach for differential diagnosis between early-and late-stage pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1256-1267页

作者： Shuai Ren Li-Chao qian Ying-Ying cao Marcus J Daniels Li-Na song Ying Tian Zhong-Qiu Wang Department of Radiology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND One of the primary reasons for the dismal survival rates in pancreatic ductal adenocarcinoma(PDAC)is that most patients are usually diagnosed at late *** is an urgent unmet clinical need to identify and develop diagnostic methods that could precisely detect PDAC at its earliest *** A total of 71 patients with pathologically proved PDAC based on surgical resection who underwent contrast-enhanced computed tomography(CT)within 30 d prior to surgery were included in the *** staging was performed in accordance with the 8th edition of the American Joint Committee on Cancer staging *** features were extracted from the region of interest(ROI)for each patient using Analysis Kit *** most important and predictive radiomics features were selected using Mann-Whitney U test,univar-iate logistic regression analysis,and minimum redundancy maximum relevance(MRMR)*** forest(RF)method was used to construct the radiomics model,and 10-times leave group out cross-validation(LGOCV)method was used to validate the robustness and reproducibility of the *** A total of 792 radiomics features(396 from late arterial phase and 396 from portal venous phase)were extracted from the ROI for each patient using Analysis Kit *** most important and predictive features were selected using Mann-Whitney U test,univariate logistic regression analysis,and MRMR *** method was used to construct the radiomics model with the nine most predictive radiomics features,which showed a high discriminative ability with 97.7%accuracy,97.6%sensitivity,97.8%specificity,98.4%positive predictive value,and 96.8%negative predictive *** radiomics model was proved to be robust and reproducible using 10-times LGOCV method with an average area under the curve of 0.75 by the average performance of the 10 newly built *** The radiomics model based on CT could serve as a promising non-invasive method in differential diag

关键词： Pancreatic ductal adenocarcinoma Radiomics Computed tomography American Joint Committee on Cancer staging

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An Interpretation of a Radiation Damage Phenomenon of the Solar-A CCD

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天文研究与技术 1999年第S1期 139-142页

作者： song qian, cao wenda (Yunnan Observatory, The Chinese Academy of Sciences, Kunming 650011, China) (National Astronomical Observatories, The Chinese Academy of Sciences, Beijing 100012, E mail: qiansong@163. net)

High energy radiation exists in the space natural radiation environment may cause the degradation of the performance of charge coupled devices used in space. The Solar A satellite was launched in 1991. Since then, radiation damage effected phenomena have been reported. The flatband voltage shift resulted from the trapped holes within the insulator layer between the CCD gates and bulk silicon may throw light on the interpretation of some of the radiation damage phenomena.

关键词： An Interpretation of a Radiation Damage SPIE Phenomenon of the Solar-A CCD

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葛根素对妊娠期糖尿病大鼠母体和胎儿的影响

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中国药理学通报 2024年第3期40卷 469-475页

作者：钱坤宋祎一曹莉苏州大学医学院江苏苏州215123 天大药业(珠海)有限公司广东珠海519070

目的观察口服葛根素(puerarin,Pue)对妊娠期糖尿病(gestational diabetic mellitus,GDM)大鼠母体的药效及对其胎儿生长发育的影响,为Pue用于治疗GDM提供参考。方法给已孕母鼠尾静脉注射链脲佐菌素建立GDM大鼠模型,灌胃Pue治疗12 d,记录... 详细信息

目的观察口服葛根素(puerarin,Pue)对妊娠期糖尿病(gestational diabetic mellitus,GDM)大鼠母体的药效及对其胎儿生长发育的影响,为Pue用于治疗GDM提供参考。方法给已孕母鼠尾静脉注射链脲佐菌素建立GDM大鼠模型,灌胃Pue治疗12 d,记录孕鼠体质量及流产情况,检测孕鼠给药治疗前后的空腹血糖,并分别于给药后的第5天和第10天检测母鼠糖耐量;母鼠怀孕第20天行剖腹产,检测胎鼠血糖含量,并观察胎鼠生长发育情况。测定胎鼠体质量、体长、尾长及胎盘和重要脏器的重量,计算脏器指数。结果与模型组相比,Pue可显著降低GDM孕鼠及胎鼠的空腹血糖,改善孕鼠糖耐量,有效缓解GDM导致的孕鼠体质量过度增加和胎鼠体质量过大的状况,降低流产率;并可逆转GDM引起的胎鼠脑、心、肝等脏器指数下降和肾脏脏器指数升高。结论口服Pue可缓解GDM母体及胎儿的高血糖状态,降低流产率,减少巨大儿的发生,促进胎儿重要脏器的发育。

关键词：葛根素妊娠期糖尿病血糖胎鼠生长发育宫内生长受限

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Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease:A Matched Case-Control Study in China

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Environment & Health 2024年第7期2卷 453-464页

作者： Xuejie Chen Wenya Liu Yangjie Liao Xin Xiang Yue Yang Li Tian Xiang Gao qian cao Hong Guo Kang Chao Fengmei song Rongbei Liu Ying Li Shuyu Ye Jiangang Wang Fei Yang Xiaoyan Wang Department of Gastroenterology Third Xiangya HospitalCentral South UniversityChangsha410013China Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang421001China Hunan Provincial Key Laboratory of Clinical Epidemiology Xiangya School of Public HealthCentral South UniversityChangsha410078China Department of Gastroenterology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510510China Department of Gastroenterology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou310018China Department of Gastroenterology Chongqing General HospitalUniversity of Chinese Academy of SciencesChongqing401121China

Microcystin-LR(MC-LR),the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms,has been linked to gastrointestinal ***,we conducted a case-control study across four regions in China to investigate this *** bowel disease(IBD)cases(219)were matched with healthy controls(438)based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD *** used quantitative real-time polymerase chain reaction to measure the expression levels of inflammatory *** levels of protein expression in the colorectum were determined using Western blotting(WB).Compared to the lowest quartile of serum MC-LR levels,the adjusted odds ratios and 95%confidence intervals(CI)for the highest quartiles of serum MC-LR levels were 5.51(2.70,11.21).The RCS was shown the association between serum MC-LR levels and IBD risk was nonlinear(Pnonlinear<0.001).In the animal experiments,MC-LR resulted in colorectal injury via the PI3K/AKT signaling *** study provides the evidence that serum MC-LR exposure is significantly associated with the risk of IBD in *** study results indicate that MC-LR probably causes IBD via the PI3K/AKT signaling pathway.

关键词： Microcystin-LR IBD Nonlinearity Case-Control Study Restricted Cubic Splines

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中日建筑全生命周期碳排放比较

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气候变化研究进展 2024年第2期20卷 220-230页

作者：罗晓予曹星煜宋志茜浙江大学建筑工程学院杭州310012 浙江大学平衡建筑研究中心杭州310063

全生命周期的建筑碳减排在日本已有广泛的应用和发展。由于中日建筑全生命周期碳排放统计口径存在差异,为准确开展中日建筑碳排放对比分析带来了难度。文中首先从计算边界、建材统计精度、碳排放因子数量等方面建立了中日同口径的全生... 详细信息

全生命周期的建筑碳减排在日本已有广泛的应用和发展。由于中日建筑全生命周期碳排放统计口径存在差异,为准确开展中日建筑碳排放对比分析带来了难度。文中首先从计算边界、建材统计精度、碳排放因子数量等方面建立了中日同口径的全生命周期碳排放计算模型,并基于此对中日案例建筑的全生命周期碳排放特征开展比较和分析。发现中国案例的建筑全生命周期碳排放略高于日本,其中运行阶段碳排放明显高于日本。此外建筑建材性能对碳排放影响显著,日本建筑利用低碳建材,生产碳排放低,建材使用寿命长,使维护、废弃阶段碳排放均低于中国建筑案例。

关键词：建筑全生命周期碳排放碳排放因子统计分析对比

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核心技术发展潜力评价及国际竞争态势研判——基于医疗设备产业的分析

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科学学研究 2024年第8期42卷 1607-1621页

作者：琚春华曹倩雯宋雪姣浙江工商大学现代商贸研究中心浙江杭州310018 浙江工商大学管理工程与电子商务学院浙江杭州310018 浙江工商大学工商管理学院(MBA学院) 浙江杭州310018

全球技术竞争日益激烈,技术垄断层出不穷,评估核心技术发展潜力及国际竞争态势,识别技术突破机会,对我国突破技术壁垒、提升技术竞争力至关重要。论文从专利技术性和商业性两个方面筛选核心专利,构建核心专利的国际专利分类号共现网络,... 详细信息

全球技术竞争日益激烈,技术垄断层出不穷,评估核心技术发展潜力及国际竞争态势,识别技术突破机会,对我国突破技术壁垒、提升技术竞争力至关重要。论文从专利技术性和商业性两个方面筛选核心专利,构建核心专利的国际专利分类号共现网络,基于节点中心性和热门度识别核心技术,应用技术系统进化理论进行技术生命周期拟合以确定具有发展潜力的核心技术,并针对此类技术选取国家专利占有数量、专利被引频次、专利技术覆盖、专利合作排名和合作网络地位5个指标加权评估各国的技术竞争力,研判竞争态势。通过对医疗设备产业的实证研究发现,技术发达国家借助供应链上游优势,占据重要技术地位,我国在医疗设备产业潜力技术领域短板明显,应有针对性地投入资源,结合政策牵引,构建完备的产业配套体系,保障我国医疗设备产业高效可持续发展。

关键词：核心技术技术潜力评价竞争态势医疗设备产业

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基于时空优化模型的PM_(2.5)遥感估测研究

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中国环境科学 2024年第7期44卷 3625-3636页

作者：张娜陈文倩白雪松曹肖奕青岛理工大学信息与控制学院山东青岛266520 兰州大学大气科学学院半干旱气候变化教育部重点实验室甘肃兰州730000

为了获得连续的PM_(2.5)浓度时空分布并提高估算精度,提出了一种新的基于时空因子优化的PM_(2.5)估测模型(SFRF).SFRF模型是时空因子通过卷积特征融合到随机森林算法(RF)体系中,通过集成高分辨率(1km)卫星反演的气溶胶光学厚度(AOD)产... 详细信息

为了获得连续的PM_(2.5)浓度时空分布并提高估算精度,提出了一种新的基于时空因子优化的PM_(2.5)估测模型(SFRF).SFRF模型是时空因子通过卷积特征融合到随机森林算法(RF)体系中,通过集成高分辨率(1km)卫星反演的气溶胶光学厚度(AOD)产品以及气象数据、夜间灯光数据和植被数据构建SFRF模型来进行对2019年的山东省地区PM_(2.5)浓度的准确预测,生成山东省高空间分辨率(1km)的PM_(2.5)浓度.采用十折交叉验证法,评估了SFRF模型的性能,并与BPNN、SVM、XGBoost、RF、PCA-RF模型进行对比.结果表明:SFRF模型验证的决定系数和均方根误差(RMSE)值分别为0.85和8.10µg/m^(3),优于其他模型.SFRF模型可以在日、季、年尺度上以较高的空间分辨率来估测山东省PM_(2.5)浓度.

关键词： PM_(2.5) 时空优化模型 AOD 山东省地区

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Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World Journal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren Li-Chao qian Xiao-Jing Lv Ying-Ying cao Marcus J Daniels Zhong-Qiu Wang Li-Na song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

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固定化c-ω-转氨酶催化合成(4S)-四氢萘酮

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精细化工 2024年第5期41卷 1152-1160页

作者：高嵩邵小芙果波李前王佩曹阳江苏海洋大学江苏省海洋药物活性分子筛选重点实验室江苏连云港222005 南京师范大学食品与制药工程学院江苏南京210023

以T4噬菌体衣壳为载体,探索了海绵假弧菌-ω-转氨酶(P-ω-TA)的自组装固定化,以将P-ω-TA与T4噬菌体非必需小外壳蛋白(Soc)融合的方式实现了P-ω-TA在T4噬菌体衣壳上的亲和固定及较高的位点结合数。对固定化P-ω-TA的适应性、回收性能、... 详细信息

以T4噬菌体衣壳为载体,探索了海绵假弧菌-ω-转氨酶(P-ω-TA)的自组装固定化,以将P-ω-TA与T4噬菌体非必需小外壳蛋白(Soc)融合的方式实现了P-ω-TA在T4噬菌体衣壳上的亲和固定及较高的位点结合数。对固定化P-ω-TA的适应性、回收性能、(S)-型异构体选择性拆分及(1S,4S)-去甲基舍曲林的催化能力进行了测试。结果表明,固定化的P-ω-TA保持了完整的活性及适应性,可通过离心操作轻松地回收,并进行重复使用。在5次回收和重复使用过程中,每次酶活回收率均>91%,经5次催化,最终酶活保持率约为84%。固定化P-ω-TA保持了在底物手性中心处的(S)-型异构体选择性拆分以及对(1S,4S)-去甲基舍曲林的催化能力。

关键词：海绵假弧菌-ω-转氨酶 T4噬菌体手性拆分酶固定化舍曲林精细化工中间体

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