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Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

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World Journal of Clinical Cases 2023年第1期11卷 65-72页

作者： Ozlem Celik aydin sonay aydın Sureyya Barun Department of Medical Pharmacology Erzincan Mengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Radiology Erzincan Binali Yıldırım UniversityMengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Medical Pharmacology Gazi University Faculty of MedicineAnkara 06500Turkey

Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental *** in modern society’s food choices,physical inactivity,and obesity are significant factors in the development of type 2 DM(T2DM).The association between changes in intestinal flora and numerous disorders,including obesity,diabetes,and cardiovascular diseases,has been studied in recent *** purpose of this review is to analyze the mechanisms underlying the alteration of the diabetic patients’intestinal flora,as well as their therapeutic *** included is a summary of the antidiabetic benefits of natural compounds demonstrated by *** short-chain fatty acids theory,the bile acid theory,and the endotoxin theory are all potential methods by which intestinal flora contributes to the establishment and progression of *** to an intestinal flora imbalance,abnormalities in shortchain fatty acids and secondary bile acids have been found in diabetic ***,metabolic endotoxemia with altering flora induces a systemic inflammatory response by stimulating the immune system via bacterial *** agenda for diabetes treatment includes the use of short-chain fatty acids,probiotics,prebiotics in the diet,fecal bacteria transplantation,and *** studies have proven the antidiabetic benefits of numerous bioactive substances,including Flavonoids,Alkaloids,Saponin,and ***,further research is required to contribute to the treatment of diabetes.

关键词： Diabetes mellitus Intestinal flora natural products Endotoxemia Bioactive compounds Probiotics

Antenatal imaging:A pictorial review

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World Journal of Clinical Cases 2022年第35期10卷 12854-12874页

作者： Bunyamin Ece sonay aydın Mecit Kantarci Department of Radiology Kastamonu UniversityKastamonu 37150Turkey Department of Radiology Erzincan UniversityErzincan 24142Turkey

Today,in parallel with the use of imaging modalities increases in all fields,the use of imaging methods in pregnant women is *** has become an integral component of routine pregnancy *** provides parents with an early opportunity to learn about the current situation,including prenatal detection of anomalies or diseases,etiology,prognosis,and the availability of prenatal or postnatal *** imaging modalities,especially ultrasonography,are frequently used for imaging both maternal and fetal *** goal of this review was to address imaging modalities in terms of usefulness and safety,as well as to provide demonstrative examples for *** this review provides current information on selecting a safe imaging modality to evaluate the pregnant and the fetus,the safety of contrast medium use,and summarizes major pathological situations with demonstrative son-ographic images to assist radiologists and obstetricians in everyday practice.

关键词： Prenatal Diagnosis Fetal Imaging Ultrasound Pregnancy Fetal Diseases Reliability

Commentary on"Primary orbital monophasic synovial sarcoma with calcification:A case report"

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World Journal of Clinical Cases 2022年第22期10卷 8054-8056页

作者： Oguzhan Tokur sonay aydın Erdal Karavas Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Radiology Erzincan UniversityErzincan 24100Turkey

The present letter to the editor is related to the study titled“Primary orbital monophasic synovial sarcoma with calcification:A case report”.Orbital synovial sarcoma is one of the rare intraorbital masses seen in adult and pediatric *** case reports in the literature revealed that synovial sarcoma may contain ***,it is important to make differential diagnosis among calcified orbital masses in childhood.

关键词： Orbital tumor Synovial sarcoma Calcification Children Histopathology Radiology

Commentary on "Gallstone associated celiac trunk thromboembolisms complicated with splenic infarction: A case report"

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World Journal of Clinical Cases 2022年第32期10卷 12059-12061页

作者： Oguzhan Tokur sonay aydın Mecit Kantarci Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Radiology Erzincan University Medicine FacultyErzincan 24100Turkey

The present letter to the editor is related to the study titled "Gallstone associatedceliac trunk thromboembolisms complicated with splenic infarction: A casereport". Although gallstones are relatively common diseases, its association withthromboembolism is not fully understood. We aim to emphasize the potentialmechanism of this relationship in this letter. In addition, we wanted to contributeto the causes of the spleen infarction and celiac trunk pathologies.

关键词： Gallstone Spleen Infarct Thrombosis Pain

Imaging of acute appendicitis: Advances

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World Journal of Gastrointestinal Surgery 2022年第4期14卷 370-373页

作者： sonay aydın Erdal Karavas Duzgun Can Senbil Department of Radiology Erzincan Binali Yıldırım University Faculty of MedicineErzincan 24100Turkey

We read with interest the review by Teng et al,who summarized the current approach to the diagnosis and treatment of acute appendicitis(AA).Also,the article summarizes the clinical scoring systems very *** one of the previous studies conducted by our research group,we showed that the use of the Alvarado score,ultrasound and C-reactive protein values in combination provides a safe confirmation or exclusion of the diagnosis of *** tomography is particularly sensitive in detecting periappendiceal abscess,peritonitis and gangrenous *** tomography is not a good diagnostic tool in pediatric patients because of the ionizing radiation it *** is a valuable diagnostic tool to differentiate AA from lymphoid *** of fluid collection in the periappendiceal and lamina propria thickness less than 1 mm are the most effective parameters in differentiating appendicitis from lymphoid *** AA is the most common cause of surgical acute abdomen,it remains an important diagnostic and clinical *** combining clinical scoring systems,laboratory data and appropriate imaging methods,diagnostic accuracy and adherence to treatment can be *** hyperplasia and perforated appendicitis present significant diagnostic challenges in *** ultrasound findings are increasingly defined to differentiate AA from these conditions.

关键词： Acute appendicitis Inflammation Acute abdomen Perforation

Percutaneous management in hepatic alveolar echinococcosis:A sum of single center experiences and a brief overview of the literature

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 398-407页

作者： Suat Eren sonay aydın Mecit Kantarci Volkan Kızılgöz Akın Levent Düzgün CanŞenbil Okan Akhan Department of Radiology Faculty of MedicineAtatürk UniversityErzurum 25100Turkey Department of Radiology Faculty of MedicineErzincan Binali Yıldırım UniversityErzincan 24100Turkey Department of Radiology Hacettepe UniversityAnkara 06090Turkey

BACKGROUnD Hepatic alveolar echinococcosis(HAE)is a serious zoonotic infection that affects *** may have a tumor-like appearance at *** treatment of HAE patients is extremely relaxing for *** is a significant human zoonotic infection caused by the fox tapeworm Echinococcus Multilocularis *** possesses the characteristics of an invasive tumor-like lesion due to its infiltrative growth pattern and protracted incubation *** disease is endemic over central Europe,Asia,and north *** To characterize HAE patients who were treated percutaneously,their outcomes,and the major technical features of percutaneous treatment in *** Patients who were treated with percutaneous cyst drainage and/or percutaneous biliary drainage were included in the *** abnormal coagulation values and solid or non-infected HAE with minor necrotic change were *** Thirty-two patients underwent percutaneous cyst drainage,two patients underwent percutaneous biliary drainage,and four patients underwent percutaneous biliary drainage *** radiology is utilized to drain echinococcal necrosis and abscesses within/without the liver,as well as diseased and clogged bile *** Percutaneous drainage of cyst contents and/or biliary channels using a minimally invasive technique is a very *** cyst drainage with albendazole therapy improves quality of life in patients who are unable to undergo surgery,even when the mass resolves with long-term treatment.

关键词： Interventional Radiology Treatment Alveolar echinococcosis Liver

Type 2 dynamic curves: A diagnostic dilemma

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World Journal of Radiology 2022年第7期14卷 229-237页

作者： Erdal Karavas Bunyamin Ece sonay aydın Department of Radiology Erzincan UniversityErzincan 24142Turkey Department of Radiology Kastamonu UniversityKastamonu 37150Turkey

BACKGROUnD Magnetic resonance imaging(MRI)with multiparametric dynamic contrast plays a critical role in the assessment of breast *** curves are a critical parameter in determining the benign or malignant nature of *** curves of type 1 are known to represent benign masses,while dynamic curves of type 3 are known to identify malignant *** 2 dynamic curves have a sensitivity of 42.6%and specificity of 75%for malignancy *** To investigate the pathological diagnosis of lesions with type 2 dynamic *** We evaluated breast MRI examinations performed between 2020 and 2021 retrospectively and included lesions with type 2 dynamic *** included 38 lesions from 33 *** lesions were evaluated for their pathological diagnosis and morphological *** Twenty-six lesions were malignant,while twelve were *** most frequently encountered benign lesion(7/12,58.3%)was sclerosing adenosis,while the most frequently encountered malignant diagnosis was invasive ductal *** presence of a type 2 dynamic curve had a sensitivity of 40.2%and specificity of 73.4%for predicting *** combining type 2 curves and morphological features,the sensitivity and specificity were *** The high rates of malignancy detected histopathologically among patients with type 2 dynamic curves in our study are *** 2 dynamic curves can be detected in benign breast masses,especially in sclerosing adenosis *** morphological features can increase the diagnostic accuracy in cases with type 2 dynamic curves.

关键词： Type 2 Dynamic curve Benign Malignant Breast Magnetic resonance imaging

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World Journal of Clinical Cases 2023年第5期11卷 1031-1039页

作者： Fahri aydin Mecit Kantarci sonay aydın Erdal Karavaş Gökhan Ceyhun Hayri Ogul ÇağrıEminŞahin Suat Eren Department of Radiology Ataturk UniversityErzurum 25000Turkey Department of Radiology Erzincan Binali Yidirim UniversityErzincan 24000Turkey Department of Radiology Bandirma Onyedi Eylul UniversityBalikesir 10200Turkey Department of Cardiology Ataturk UniversityErzurum 25000Turkey General Directorate of Public Health Ministry of Health in TürkiyeAnkara 06100Turkey

BACKGROUnD no study on dual energy computed tomography(DECT)has been found in the literature to evaluate possibly fatal cardiac/myocardial problems in corona virus disease 2019(COVID-19)*** perfusion deficits can be found in COVID-19 patients even without any significant coronary artery occlusion,and these deficits can be shown via DECT with a perfect interrater *** To assess lung perfusion alterations in COVID-19 *** our knowledge,no study using DECT has been performed to evaluate possibly fatal cardiac/myocardial problems in COVID-19 *** purpose of this study is to evaluate the role of DECT in the detection of COVID-19-related cardiac *** Two blinded independent examiners evaluated CT images using the 17-segment model according to the American Heart Association’s classification of the segmentation of the left ventricular ***,intraluminal diseases and abnormalities in the main coronary arteries and branches were *** segment-by-segment analysis,perfusion deficiencies identified on the iodine map pictures on DECT were *** The study enrolled a total of 87 ***-two of these individuals were classified as COVID-19 positive,and 45 were classified as *** deficits were identified in 66.6%(n=30)of the *** control patients had a normal iodine distribution *** deficits were found on DECT iodine map images with subepicardial(n=12,40%),intramyocardial(n=8,26.6%),or transmural(n=10,33.3%)anatomical locations within the left ventricular *** was no subendocardial involvement in any of the *** Myocardial perfusion deficits can be found in COVID-19 patients even without any significant coronary artery *** deficits can be shown via DECT with a perfect interrater ***,the presence of perfusion deficit is positively correlated with D-dimer levels.

关键词： Dual energy computed tomography COVID-19 Heart Perfusion D-dimer

Possible agent for COVID-19 treatment:Rifampicin

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World Journal of Virology 2022年第5期11卷 391-393页

作者： Ozlem Celik aydin sonay aydın Sureyya Barun Department of Medical Pharmacology Erzincan UniversityMengucek Gazi Education and Research HospitalErzincan 24100Turkey Department of Pharmacology Gazi UniversityAnkara 06500Turkey Department of Radiology Erzincan UniversityErzincan 24100Turkey

Rifampicin is a promising drug for the treatment of coronavirus disease 2019 based on its antiviral properties and recent in silico *** silico studies can serve as a foundation for further studies.

关键词： Rifampicin COVID-19 Treatment In silico Drug-drug interaction Therapeutic potential