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Transitions of care across hospital settings in patients with inflammatory bowel disease

World Journal of Gastroenterology 2019年第17期25卷 2122-2132页

作者： Leigh R Warren Jonathan M Clarke sonal arora Mauricio Barahona Naila Arebi Ara Darzi Patient Safety Translational Research Centre Imperial College London Department of Surgery and Cancer Imperial College London Centre for Health Policy Imperial College London Centre for Mathematics of Precision HealthcareImperial College London Department of Biostatistics Harvard University Department of Mathematics Imperial College London Department of Gastroenterology St.Marks Academic Institute

BACKGROUND Inflammatory bowel disease(IBD) is a chronic, inflammatory disorder characterised by both intestinal and extra-intestinal pathology. Patients may receive both emergency and elective care from several providers, often in different hospital settings. Poorly managed transitions of care between providers can lead to inefficiencies in care and patient safety issues. To ensure that the sharing of patient information between providers is appropriate, timely, accurate and secure, effective data-sharing infrastructure needs to be developed. To optimise inter-hospital data-sharing for IBD patients, we need to better understand patterns of hospital encounters in this *** To determine the type and location of hospital services accessed by IBD patients in *** was a retrospective observational study using Hospital Episode Statistics, a large administrative patient data set from the National Health Service in *** patients with a diagnosis of IBD following admission to hospital were followed over a 2-year period to determine the proportion of care accessed at the same hospital providing their outpatient IBD care, defined as their ‘home provider'. Secondary outcome measures included the geographic distribution of patient-sharing, regional and age-related differences in accessing services, and type and frequency of outpatient ***95055 patients accessed hospital services on 1760156 occasions over a 2-year follow-up period. The proportion of these encounters with their identified IBD‘home provider' was 73.3%, 87.8% and 83.1% for accident and emergency,inpatient and outpatient encounters respectively. Patients living in metropolitan centres and younger patients were less likely to attend their ‘home provider' for hospital services. The most commonly attended specialty services were gastroenterology, general surgery and *** Transitions of care between secondary care settings are common for patients with IBD. E

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Transitions of care Continuity of care Fragmentation Multi-morbidity

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侵入性操作的安全标准警惕执行鸿沟

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英国医学杂志中文版 2016年第2期19卷 677-679页

作者： Nick Sevdalis sonal arora 程志雷陈雷 Centre for Implementation Science Health Service and Population Research Department King's College London London SE5 8AF UK lmperial Patient Safety Translational Research Centre Department of Surgery and Cancer Imperial College London UK 北京大学国际医院肝胆外科北京大学人民医院肝胆外科

英格兰国家健康体系（NHS）最近发布了一系列推荐，旨在保证接受侵人性操作患者的医疗更安全。这些推荐部分基于对未遂事件、严重事故和所谓“绝不该发生的事件”进行的国家和地方性分析得出的教训，展现为一种总体性文件框架。

关键词：侵入性操作医疗安全总体性文件框架英格兰国家健康体系

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Advancements and challenges in neuroimaging for the diagnosis of intracranial aneurysms:Addressing false positive diagnoses and emerging techniques

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World Journal of Clinical Cases 2025年第6期13卷 48-50页

作者： Nanthida arora Sombat Muengtaweepongsa Center of Excellence in Stroke Thammasat UniversityPathum Thani 12120Thailand Center of Excellence in Stroke Division of NeurologyDepartment of MedicineFaculty of MedicineThammasat University Rangsit CampusKlonglaung 12120Pathum ThaniThailand

Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant *** article examines the causes,prevalence,and implications of such false-positive *** discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior *** article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and *** emphasize the im-portance of accurate differentiation to avoid unnecessary surgical *** potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic *** manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.

关键词： Intracranial aneurysms Neuroimaging techniques Computed tomographic angiography Magnetic resonance angiography Digital subtraction angiography False positive diagnoses

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Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice

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Biomedical and Environmental Sciences 2002年第1期15卷 41-47页

作者： ShukY arora EnvironmentalCarcinogenesisDivision IndustrialToxicologyResearchCentreM.G.MargP.O.Box80Lucknow－226001India EnvironmentalCarcinogenesisDivision IndustrialToxicologyResearchCentreM.G.MargP.O.Box80

Objective To study the effects of diallyl sulfide (DAS), an organosulfur compoundpresent in garlic (Allium sativum), on the life span of ehrlich ascites (EA) tumor bearingSwiss albino mice, cytotoxicity and angiogenesis. Methods EA tumor cells weremaintained by serial transplantation in peritoneal cavity of male Swiss albino mice. EAtumor cells were inoculated at concentrations of 1× 106 EA cells, 2.5× 106 EA cells and5× 106 EA cells. DAS was given in 0.2 ml normal saline i. p., daily for seven days followedone hour later by inoculation with EA cells in respective groups. Results The resultsrevealed that administration of DAS increased the life span of EA tumor bearing animals bymore than 25 percent. A significant dose dependant cytotoxic response of DAS was alsoobserved on EA tumor cells. DAS was also found to inhibit the angiogenesis in EA tumorbearing mice in a dose dependent manner. Conclusion It is suggested that DAS may exertits anticarcinogenic effects by more than one mechanism and is a useful chemopreventiveand chemotherapeutic agent.

关键词： Garlic Life span Ehrlich ascites EA tumor cells Cytotoxicity Angiogenesis

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Area Estimates of Images of Disks under Analytic Functions

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Acta Mathematica Sinica,English Series 2021年第10期37卷 1533-1548页

作者： Vibhuti arora Swadesh Kumar SAHOO Discipline of Mathematics Indian Institute of Technology IndoreIndore 453552India

Let D_(r):={z=x+iy∈C:|z|0,in principal powers,when f ranges over certain classes of analytic and univalent functions in D.

关键词： Univalent functions starlike functions convex functions spirallike functions Dirichlet finite area problem

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Inhibition of nitrification in soil by metal diethyldithiocarbamates

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Journal of Environmental Sciences 2003年第5期15卷 607-610页

作者： A.arora Bijay Singh Dhiraj Sud T.Srivastava C.L.arora PunjabAgriculturalUniversity PunjabAgriculturalUniversitySantLongowalInstituteofEngineering&TechnologySantLongowalInstituteofEngineering&TechnologyPunjabAgriculturalUniversity Ludhiana141004PunjabIndiaLudhiana141004PunjabIndiaLongowalPunjabIndiaLongowalPunjabIndiaLudhiana141004PunjabIndia

Nitrification acts as a key process in determining fertilizer use efficiency by crops as well as nitrogen losses from soils. Metal dithiocarbamates in addition to their pesticidal properties can also inhibit biological oxidation of ammonium(nitrification) in soil. Metal [M=V(Ⅲ), Cr(Ⅲ), Mn(Ⅱ), Fe(Ⅲ), Ni(Ⅱ), Cu(Ⅱ), Zn(Ⅱ) and Co(Ⅱ)] diethyldithiocarbamates (DEDTC) were synthesized by the reaction of sodium diethyldithiocarbamate with metal chloride in dichloromethane/water mixture. These metal diethyldithiocarbamates were screened for their ability to inhibit nitrification at different concentrations(10 μg/g soil, 50 μg/g soil and 100 μg/g soil). With increasing concentration of the complex, capacity to retard nitrification increased but the extent of increase varied for different metals. At 100 μg/g soil, different complexes showed nitrification inhibition from 22 36% to 46 45%. Among the diethyldithiocarbamates tested, Zn(DEDTC) 2 proved to be the most effective nitrification inhibitor at 100 μg/g soil. Manganese, iron and chromium diethyldithiocarbamates also proved to be effective nitrification inhibitors than the others at 100 μg/g soil. The order of percent nitrification inhibition in soil by metal diethyldithiocarbamates was: Zn(Ⅱ) > Mn(Ⅱ) > Fe(Ⅲ) > Cr(Ⅲ) >V(Ⅲ) > Co(Ⅱ) > Ni(Ⅱ) > Cu(Ⅱ).

关键词： nitrification inhibitor diethyldithiocarbamate metal complexes nitrogenous fertilizers pesticides

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Physical model simulation of rock-support interaction for the tunnel in squeezing ground

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 82-92页

作者： Ketan arora Marte Gutierrez Ahmadreza Hedayat Civil and Environmental Engineering Colorado School of MinesGoldenCO80401USA

The existence of squeezing ground conditions can lead to significant challenges in designing an adequate support system for *** empirical,observational and analytical methods have been suggested over the years to design support systems in squeezing ground conditions,but all of them have some *** this study,a novel experimental setup having physical model for simulating the tunnel boring machine(TBM)excavation and support installation process in squeezing clay-rich rocks is *** observations are made to understand better the interaction between the support and the squeezing *** physical model included a large true-triaxial cell,a miniature TBM,laboratoryprepared synthetic test specimen with properties similar to natural mudstone,and an instrumented cylindrical aluminum support *** were conducted at realistic in situ stress levels to study the time-dependent three-dimensional tunnel support *** tunnel was excavated using the miniature TBM in the cubical rock specimen loaded in the true-triaxial cell,after which the support was *** confining stress was then increased in stages to values greater than the rock’s unconfined compressive strength.A model for the time-dependent longitudinal displacement profile(LDP)for the supported tunnel was proposed using the tunnel convergence measurements at different times and stress *** LDP formulation was then compared with the unsupported model to calculate the squeezing amount carried by the *** increase in thrust in the support was backcalculated from an analytical solution with the assumption of linear elastic *** on the test results and case studies,a recommendation to optimize the support requirement for tunnels in squeezing ground is proposed.

关键词： Squeezing ground Tunnel support system Longitudinal displacement profile Rock-support interaction

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Recent progress in contact, mobility, and encapsulation engineering of InSe and GaSe

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InfoMat 2021年第6期3卷 662-693页

作者： Himani arora Artur Erbe Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Faculty of Physics and Center for Advancing Electronics Dresden Technische Universität DresdenDresdenGermany

The field of two-dimensional(2D)materials has stimulated considerable interest in the scientific *** to quantum confinement in one direction,intriguing properties have been reported in 2D materials that cannot be observed in their bulk *** advent of semiconducting 2D materials with a broad range of electronic properties has provided fascinating opportunities to design and configure next-generation *** such emerging class is the family of III-VI monochalcogenides,the two prominent members of which are indium selenide(InSe)and gallium selenide(GaSe).In contrast to transition metal dichalcogenides,their high intrinsic mobility and the availability of a direct bandgap at small thicknesses have attracted researchers to investigate the underlying physical phenomena as well as their technological ***,the sensitivity of InSe and GaSe to environmental influences has limited their exploitation in functional *** lack of methods for their scalable synthesis further hinders the realization of their *** review article outlines recent advancements in the synthesis and understanding of the charge transport properties of InSe and GaSe for their integration into technological applications.A detailed summary of the improvements in the device structure by optimizing extrinsic factors such as bottom substrates,metal contacts,and device fabrication schemes is ***,various encapsulation techniques that have been proven effective in preventing the degradation of InSe and GaSe layers under ambient conditions are thoroughly ***,this article presents an outlook on future research ventures with respect to ongoing developments and practical viability of these materials.

关键词： 2D materials 2D transistors electronic properties gallium selenide indium selenide vdW semiconductors

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Esophageal melanosis:Two case reports and review of literature

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World Journal of Gastroenterology 2024年第42期30卷 4557-4565页

作者： Liubou Kazacheuskaya Kshitij arora Department of Pathology Louisiana State University HealthShreveportLA 71103United States

Esophageal melanosis(EM)is a rare condition characterized by melanin pigmentation in the esophageal *** is not well understood and has been documented in less than 100 cases *** SUMMARY We report two cases of African American patients who complained of significant weight loss(over 20 pounds in approximately six months)and abdominal pain during their first *** first case involves a 54-year female with a history of hepatic steatosis and polysubstance abuse,who also experiences nausea and *** second case is a 59-year-old male with hypertension and gastroesophageal reflux disease(GERD),who was diagnosed with esophageal squamous cell *** cases show benign melanocytes in the basal layer on the esophagus biopsy and are diagnosed as *** It is important to note that EM has been associated with malignancies such as carcinoma and ***,accurate diagnosis and appropriate management are *** with EM,especially those with concurrent risk factors(e.g.,GERD,smoking),should be carefully monitored for any signs of malignancy.

关键词： Esophagus Melanoblasts Esophageal melanosis Gastroesophageal reflux disease Case report

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Biological therapy for ulcerative colitis

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Gastroenterology Report 2015年第2期3卷 103-109页

作者： Zubin arora Bo Shen Department of Internal Medicine the Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology and Hepatology the Cleveland Clinic FoundationClevelandOHUSA

Ulcerative colitis(UC)is a major form of inflammatory bowel disease(IBD)*** understanding of the pathogenesis of UC has led to the development of novel therapeutic agents that target specific mediators of the inflammatory cascade.A number of biological agents have been approved by the *** and Drug Administration(FDA)for the treatment of UC and several more are currently in various phases of drug *** commonly used agents include TNFa antagonists(***,adalimumab,and golimumab)and anti-integrin agents(vedolizumab).These biological agents have profoundly influenced the management of UC patients,especially those with refractory *** paper reviews the currently available knowledge and evidence for the use of various biological agents in the treatment of UC.

关键词： ulcerative colitis biological therapy TNFαantagonists anti-integrin agents

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