Antitumorigenic Potential of Diallyl Sulfide in Ehrlich Ascites Tumor Bearing Mice

作     者：ShukY ArorA 

作者机构：EnvironmentalCarcinogenesisDivisionIndustrialToxicologyResearchCentreM.G.MargP.O.Box80Lucknow－226001India EnvironmentalCarcinogenesisDivisionIndustrialToxicologyResearchCentreM.G.MargP.O.Box80 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2002年第15卷第1期

页      面：41-47页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：The authors wish to extend their thanks to Dr. P. K. Seth, Director, Industrial Toxicology Research Centre, Lucknow, for his keen interest in the study The authors are also thankful to Mr. Nikhil Garg,scientist for statistical analysis of the data 

主　　题：Garlic Life span Ehrlich ascites EA tumor cells Cytotoxicity Angiogenesis 

摘      要：Objective To study the effects of diallyl sulfide (DAS), an organosulfur compoundpresent in garlic (Allium sativum), on the life span of ehrlich ascites (EA) tumor bearingSwiss albino mice, cytotoxicity and angiogenesis. Methods EA tumor cells weremaintained by serial transplantation in peritoneal cavity of male Swiss albino mice. EAtumor cells were inoculated at concentrations of 1× 106 EA cells, 2.5× 106 EA cells and5× 106 EA cells. DAS was given in 0.2 ml normal saline i. p., daily for seven days followedone hour later by inoculation with EA cells in respective groups. Results The resultsrevealed that administration of DAS increased the life span of EA tumor bearing animals bymore than 25 percent. A significant dose dependant cytotoxic response of DAS was alsoobserved on EA tumor cells. DAS was also found to inhibit the angiogenesis in EA tumorbearing mice in a dose dependent manner. Conclusion It is suggested that DAS may exertits anticarcinogenic effects by more than one mechanism and is a useful chemopreventiveand chemotherapeutic agent.