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Effect of Low Level Subchronic Microwave Radiation on Rat Brain

Biomedical and Environmental Sciences 2016年第12期29卷 858-867页

作者： Pravin Suryakantrao Deshmukh Kanu Megha Namita Nasare basu Dev Banerjee Rafat Sultana Ahmed Mahesh Pandurang Abegaonkar Ashok Kumar Tripathi Pramod Kumari Mediratta Environmental Biochemistry and Molecular Biology Laboratory Department of Biochemistry.University College of Medical Sciences & G.T.B.Hospital(University of Delhi) Department of Pharmacology University College of Medical Sciences & G.T.B.Hospital(University of Delhi) Centre for Applied Research in Electronics(CARE) Indian Institute of Technology

Objective The present study was designed to investigate the effects of subchronic low level microwave radiation （MWR） on cognitive function, heat shock protein 70 （HSP70） level and DNA damage in brain of Fischer rats. Methods Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies： 900, 2800, and 2450 MHz. Animals were divided into 4 groups： Group I： Sham exposed, Group I1： animals exposed to microwave radiation at 900 MHz and specific absorption rate （SAR） 5.953 x 10-4 W/kg, Group II1： animals exposed to 1800 MHz at SAR 5.835 x 20-4 W/kg and Group IV： animals exposed to 2450 MHz at SAR 6.672 x 10-4 W/kg. All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues. HSP70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay. Results Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function, increase in HSP70 level and DNA damage in brain. Conclusion The results of the present study suggest that low level microwave exposure at frequencies 900, 2800, and 2450 MHz may lead to hazardous effects on brain.

关键词： Brain Cognitive function Comet assay DNA damage HSP70 Microwave radiation

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Non-Nutritive Bioactive Compounds in Pulses and Their Impact on Human Health: An Overview

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Food and Nutrition Sciences 2012年第12期3卷 1664-1672页

作者： Jagdish Singh Partha Sarathi basu Division of Basic Sciences Indian Institute of Pulses Research Kanpur India

This review describes the non-nutritive biologically active components in grain legumes and discusses about the bioactivity of phenols, isoflavones, phytosterols, phytic acid, saponins, tannins, protease inhibitors and bioactive complex carbohydrates in different pulse grains. These bioactive components have wide ranging biological activities and conesquently many different targets and mechanism of action. The potential beneficial effect of these compounds especially their antioxidant properties and their role in the prevention of non-communicable chronic diseases such as coronary heart disease, stroke, cancer and diabetes has been discussed.

关键词： Pulses Grain Legumes Bioactive Compounds Anti Nutritional Compounds Phenolics Antioxidants An-tioxidant Activity

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Iodocyclization of Diallyl-Dihydroxy Naphthalenes Using <i>N</i>-Iodosuccinimide vs Molecular Iodine in Aqueous Micelle

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International Journal of Organic Chemistry 2013年第3期3卷 176-184页

作者： Pradipta Kumar basu Amrita Ghosh Department of Chemistry Hooghly Mohsin College Chinsurah India

A number of doubly-fused [1,2] naphthodifurans have been synthesized from the corresponding diallyl-dihydroxy naphthalene precursors involving N-iodosuccinimide in acetonitrile and also by molecular iodine in aqueous micelle using CTAB as surfactant. The electrophilic cyclization occurs regioselectively by a 5-exo-trig mode of cyclization.

关键词： Di-Allyl-Dihydroxy Naphthalene N-Iodosuccinimide CTAB Micelle 5-Exo-Trig Mode Regioselective Cyclization

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Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection

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World Journal of Gastroenterology 2007年第27期13卷 3730-3733页

作者： Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar basu Sujit Kumar Bhattacharya Runu Chakravarty Institute of Blood Transfusion Medicine and Immunohematology Kolkata India ICMR Virus Unit Kolkata India National Institute of Cholera and Enteric Diseases Kolkata India

AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations.

关键词： Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Blood donation Occult HBV infection

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Credit Card Fraud Detection Using Weighted Support Vector Machine

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Applied Mathematics 2020年第12期11卷 1275-1291页

作者： Dongfang Zhang basu Bhandari Dennis Black Model Development Department Comerica Bank Dallas USA

Credit card fraudulent data is highly imbalanced, and it has presented an overwhelmingly large portion of nonfraudulent transactions and a small portion of fraudulent transactions. The measures used to judge the veracity of the detection algorithms become critical to the deployment of a model that accurately scores fraudulent transactions taking into account case imbalance, and the cost of identifying a case as genuine when, in fact, the case is a fraudulent transaction. In this paper, a new criterion to judge classification algorithms, which considers the cost of misclassification, is proposed, and several undersampling techniques are compared by this new criterion. At the same time, a weighted support vector machine (SVM) algorithm considering the financial cost of misclassification is introduced, proving to be more practical for credit card fraud detection than traditional methodologies. This weighted SVM uses transaction balances as weights for fraudulent transactions, and a uniformed weight for nonfraudulent transactions. The results show this strategy greatly improve performance of credit card fraud detection.

关键词： Support Vector Machine Binary Classification Imbalanced Data Undersampling Credit Card Fraud

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A Brief Study of the Universe

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International Journal of Astronomy and Astrophysics 2013年第2期3卷 137-152页

作者： Subir Kumar basu Thakur Sudeshna Mukerji Department of Mathematics Jadavpur University Kolkata India

In the present study, an oscillatory model of the universe is proposed wherein the universe undergoes a sequence of big bang, expansion, contraction, big bang—repeated ad infinitum. The universe comprises of a “World” and an “Antiworld” in both of which matter operates in the positive time zone and antimatter in the negative time zone. Big bang is predicted as the violent encounter between matter and antimatter. It is suggested that antimatter has negative mass and is hugely abundant. It is also shown why it is extremely rare in spite of its abundance. It is predicted that a built in transformation converts matter to antimatter and vice versa. Finally, it is established that symmetry between matter and antimatter in the universe is maintained throughout.

关键词： Cosmology

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Unsteady Incompressible Flow of a Generalised Oldroyed-B Fluid between Two Infinite Parallel Plates

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World Journal of Mechanics 2013年第2期3卷 146-151页

作者： D. Bose U. basu Department of Applied Mathematics University of Calcutta Kolkata India

This paper presents a study of visco-elastic flow of an incompressible generalized Oldroyd-B fluid between two infinite parallel plates in which the constitutive equation involves fractional order time derivative. The solutions of field equations are being obtained for the motion of the said fluid between two parallel plates where the lower plate starts to move with steady velocity and the upper plate remains fixed in the first problem and the upper plate oscillates with constant frequency and the other being at rest in the second problem. The exact solutions for the velocity field are obtained by using the Laplace transform and finite Fourier Sine transform technique in terms of Mittag Leffler and generalised functions. The analytical expression for the velocity fields are derived and the effect of fractional parameters upon the velocity field is depicted graphically.

关键词： Oldroyed-B Fluid Laplace Transform Finite Fourier Sine Transform Mittag Leffler Function Generalised Function Fractional Order Derivatives

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Climatological Characteristics of Historical and Future High-Wind Events in Alaska

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Atmospheric and Climate Sciences 2018年第4期8卷 373-394页

作者： Soumik basu John E. Walsh International Arctic Research Center University of Alaska Fairbanks AK USA

High winds cause waves, storm surge, erosion and physical damage to infrastructure and ecosystems. However, there have been few evaluations of wind climatologies and future changes, especially change in high-wind events, on a regional basis. This study uses Alaska as a regional case study of climatological wind speed and direction. Eleven first-order stations across different subregions of Alaska provide historical data (1975-2005) for the observational climatology and for the calibration of Coupled Model Inter comparison Project (CMIP5) simulations, which in turn provide projections of changes in winds through 2100. Historically, winds exceeding 25 and 35 knots are most common in the Bering Sea coastal region of Alaska, followed by northern Alaska coastal areas. Autumn and winter are the seasons of most frequent high-wind occurrences in the coastal sites, while there is no distinct seasonal peak at the interior stations where high-wind events are less frequent. An examination of the sea level pressure pattern associated with the highest-wind event at each station reveals the presence of a strong pressure gradient associated with an extratropical cyclone in most cases. Northern coastal regions of Alaska are projected to experience increased frequencies of high-wind events during the cold season, especially late autumn and early winter, when reduced sea ice cover in the late century will leave coastal regions increasingly vulnerable to flooding and erosion.

关键词： Extreme Winds Station Data CMIP5 Wind Climatology Alaskan Climate

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Development of a Novel Reusable Real Time Monitoring Glucose Sensor Based on Nanostructured Conducting Polyaniline (NSPANI)

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International Journal of Organic Chemistry 2013年第1期3卷 87-103页

作者： Ruchika Chauhan Deepshikha Saini Tinku basu Amity Institute of Biotechnology Amity University Noida India. Amity Institute of Nanotechnology Amity University Noida India.

A novel mediatorless reusable glucose biosensor with a remarkable shelf life has been fabricated on electrodeposited film of chemically synthesized nanostructured polyaniline (NSPANI) on indium tin oxide (ITO) coated glass plates using cyclic voltammetry. Glucose oxidase has been covalently immobilized on electrodeposited NSPANI film to fabricate a glucose bioelectrode (GOx/NSPANI-SDS/ITO). The results of linear sweep voltammetry and the high value of heterogeneous rate constant as obtained using Laviron equation indicates that GOx/NSPANI-SDS/ITO bioelectrode can detect glucose in the range of 0.5 to 10.00 mM with high sensitivity of 13.9 μA?mM?1 with a fast response time of 12 seconds. The linear regression analysis of bioelectrode reveals standard deviation and correlation coefficient of 6 μA and 0.994, respectively. The low value of Michaelis-Menten constant (Km) estimated as 0.28 mM using Lineweaver-Burke plot indicates high affinity of glucose oxidase enzyme to glucose and transfer rate. The GOx/NSPANI-SDS/ITO bioelectrode exhibits uniform activity for 12 weeks under refrigerated conditions;however the study is further going on. Attempts have been made to utilize this electrode for estimation of glucose in blood serum and results are found to be within 11% error. The unique features of this novel electrode lie on its reusability, real time monitoring, reproducibility and remarkable shelf life apart from the wide linear range, high sensitivity, low Km value, high heterogeneous electron-transfer constant etc.

关键词： Glucose Biosensor Nanostructured Polyaniline Reusability Real Time Monitoring and Electrodeposition

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DNA origami mediated electrically connected metal–semiconductor junctions

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Nano Research 2020年第5期13卷 1419-1426页

作者： basu R.Aryal Dulashani R.Ranasinghe Tyler R.Westover Diana G.Calvopia Robert C.Davis John N.Harb Adam T.Woolley Department of Chemistry and Biochemistry Brigham Young UniversityProvoUT 84602USA Department of Chemical Engineering Brigham Young UniversityProvoUT 84602USA Department of Physics and Astronomy Brigham Young UniversityProvoUT 84602USA

DNA-based nanofabrication of inorganic nanostructures has potential application in electronics,catalysis,and *** DNA metallization has generated conductive DNA-assembled nanostructures;however,the use of semiconductors and the development of well-connected nanoscale metal-semiconductor junctions on DNA nanostructures are still at an early ***,we report the first fabrication of multiple electrically connected metal-semiconductor junctions on individual DNA origami by location-specific binding of gold and tellurium *** attachment to DNA origami was via DNA hybridization for Au and by electrostatic interaction for *** gold plating was used to create nanoscale metal-semiconductor interfaces by filling the gaps between Au and Te ***-point electrical characterization indicated that the Au-Te-Au junctions were electrically connected,with current-voltage properties consistent with a Schottky ***-based nanofabrication of metal-semiconductor junctions opens up potential opportunities in nanoelectronics,demonstrating the power of this bottom-up approach.

关键词： current-voltage measurement DNA nanofabrication electroless plating gold nanorods nanoelectronics tellurium nanorods

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