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复合材料学报 1998年第2期15卷 113-118页

作者：华宏星 H.sol W.P.DEWILDE 上海交通大学振动冲击噪声国家重点实验室

系统地描述了利用模态分析和有限元分析相结合来识别极坐标各向异性圆板动刚度的方法。该方法取决于：（１）正确的有限元模型；（２）可靠的实验模态分析数据和正确的相关准则；（３）快速又稳健的估算方法。

关键词：振动数据圆板极坐标动刚度各向异向

A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

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Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis Humoral response COVID-19 SARS-CoV-2v

Advanced gastric cancer achieving major pathologic regression after chemoimmunotherapy combined with hypofractionated radiotherapy: A case report

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1096-1104页

作者： Meng-Long Zhou Ruo-ne Xu Cong Tan Zhen Zhang Jue-Feng Wan Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Key Laboratory of Radiation Oncology Fudan UniversityShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

BACKGROUND Currently,chemotherapy combined with immunotherapy is the established firstline standard treatment for advanced gastric cancer(GC).In addition,the combination of radiotherapy and immunotherapy is considered a promising treatment *** SUMMARY In this report,we present a case of achieving nearly complete remission of highly advanced GC with comprehensive therapies.A 67-year-old male patient was referred to the hospital because he presented with dyspepsia and melena for several *** on fluorodeoxyglucose positron emission tomography/computed tomography(FDG PET/CT),endoscopic examination and abdominal CT,he was diagnosed with GC with a massive lesion and two distant metastatic *** patient received mFOLFOX6 regimen chemotherapy,nivolumab and a short course of hypofractionated radiotherapy(4 Gy×6 fractions)targeting the primary *** the completion of these therapies,the tumor and the metastatic lesions showed a partial *** having this case discussed by a multidisciplinary team,the patient underwent surgery,including total gastrectomy and D2 lymph node *** pathology showed that major pathological regression of the primary lesion was *** therapy started four weeks after surgery,and examination was performed every three *** surgery,the patient has been stable and healthy with no evidence of *** The combination of radiotherapy and immunotherapy for GC is worthy of further exploration.

关键词： Gastric cancer Oligometastasis Immunotherapy Hypofractionated radiotherapy Gastrectomy Case report

negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2015年第7期21卷 2030-2039页

作者： Young-Sun Nam Nayoun Kim Keon-Il Im Jung-Yeon Lim Eun-sol Lee Seok-Goo Cho Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital the Catholic University of Korea College of Medicine Department of Hematology Catholic Blood and Marrow Transplantation Center Seoul St. Mary’s Hospital Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease the Catholic University of Korea College of Medicine

AIM:To investigate the effects of mesenchymal stem cells(MSCs)on dextran sulfate sodium-induced inflammatory bowel disease(IBD).METHODS:C57BL/6 mice were fed 3.5%(g/L)dextran sulfate *** day seven,the mice received intraperitoneal injections of 1×106 *** survival rate,disease activity index values,and body weight,were monitored *** day ten,colon lengths and histopathologic changes were *** addition,immunoregulatory changes following MSC administration were evaluated by determining the levels of effector T cell responses in the spleen and mesenteric lymph nodes,and the expression levels of inflammatory cytokines in homogenized ***:Intraperitoneal administration of MSCs did not prevent development of colitis and did not reduce the clinicopathologic severity of *** significant difference was evident in either survival rate or disease activity index score between the control and MSCtreated *** ten-sacrificed mice exhibited no significant difference in either colon length or histopathologic ***,the MSC-treated group exhibited elevated levels of interleukin(IL)-6 and transforming growth factor-β,and a reduced level of IL-10,in spleens,mesenteric lymph nodes,and homogenized *** IL-17 level was lower in the mesenteric lymph nodes of the MSC-treated group(P=0.0126).In homogenized colons,the IL-17 and tumor necrosis factor-α(P=0.0092)expression levels were also lower in the treated ***:MSC infusion provided no significanthistopathologic or clinical improvement,thus representing a limited therapeutic approach for *** enhancement of MSCs is needed in further study.

关键词： Crohn’s disease Dextran sulfate sodium Inflammator

The application of aromaticity and antiaromaticity to reaction mechanisms

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Fundamental Research 2023年第6期3卷 926-938页

作者： Qin Zhu Shuwen Chen Dandan Chen Lu Lin Kui Xiao Liang Zhao Miquel solà Jun Zhu State Key Laboratory of Physical Chemistry of solid Surfaces and Collaborative Innovation Center of Chemistry for Energy Materials(iChEM) College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Key Laboratory for Organic Electronics&Information Displays(KLOEID)and Institute of Advanced Materials(IAM) SICAMNanjing University of Posts&TelecommunicationsNanjing 210023China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China Institute of Computational Chemistry and Catalysis and Department of Chemistry University of GironaC/M.Aurèlia Capmany6917003 GironaCataloniaSpain School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China

Aromaticity,in general,can promote a given reaction by stabilizing a transition state or a product via a mobility ofπelectrons in a cyclic ***,such a promotion could be also achieved by destabilizing an antiaromatic ***,both aromaticity and transition states cannot be directly measured in ***,computational chemistry has been becoming a key tool to understand the aromaticity-driven reaction *** this review,we will analyze the relationship between aromaticity and reaction mechanism to highlight the importance of density functional theory calculations and present it according to an approach via either aromatizing a transition state/product or destabilizing a reactant by ***,we will start with a particularly challenging example of dinitrogen activation followed by other small-molecule activation,Csingle bondF bond activation,rearrangement,as well as metathesis *** addition,antiaromaticity-promoted dihydrogen activation,CO_(2)capture,and oxygen reduction reactions will be also briefly ***,caution must be cast as the magnitude of the aromaticity in the transition states is not particularly high in most ***,a proof of an adequate electron delocalization rather than a complete ring current is recommended to support the relatively weak aromaticity in these transition states.

关键词： Aromaticity Antiaromaticity Reaction mechanism Frustrated Lewis pairs Dinitrogen activation Small molecule activation

Phase equilibrium modelling of the amphibolite facies metamorphism in the Yelapa-Chimo Metamorphic Complex, Mexico

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Geoscience Frontiers 2021年第1期12卷 293-312页

作者： Fabian Gutierrez-Aguilar Peter Schaaf Gabriela solís-Pichardo Gerardo F.Arrieta-García Teodoro Hernandez-Trevino Carlos Linares-Lopez Posgrado en Ciencias de la Tierra Instituto de GeofísicaUniversidad Nacional Autonoma de MexicoAv.Universidad 3000Ciudad de Mexico04510Mexico Laboratorio Universitario de Geoquímica Isotopica(LUGIS) Instituto de GeofísicaUniversidad Nacional Autonoma de MexicoAv.Universidad 3000Ciudad de Mexico04510Mexico Laboratorio Universitario de Geoquímica Isotopica(LUGIS) Instituto de GeologíaUniversidad Nacional Autonoma de MexicoAv.Universidad 3000Ciudad de Mexico04510Mexico Instituto de Geofísica Universidad Nacional Autonoma de MexicoAv.Universidad 3000Ciudad de Mexico04510Mexico

The Yelapa-Chimo Metamorphic Complex forms part of the Jalisco Block in western Mexico and exposes a wide range of Early Cretaceous metamorphic rocks;such as paragneiss,orthogneiss,amphibolites,and ***,the pressure-temperature(P-T)conditions of metamorphism and partial melting remain poorly studied in the *** elucidate metamorphic P-T conditions,phase equilibrium modelling was applied to two sillimanite-garnet paragneisses,one amphibole-orthogneiss,and one ***-garnet paragneisses exhibit a lepidoblastic texture with a biotite+sillimanite+kyanite+garnet+quartz+plagioclase+K-feldspar mineral ***-orthogneiss and amphibolite display a nematoblastic texture with an amphibole+(1)plagioclase+quartz+(1)titanite assemblage and an amphibole+(2)plagioclase+(2)titanite+ilmenite retrograde mineral *** calculated for the two sillimanite-garnet paragneiss samples show P-T peak conditions at~6-7.5 kbar and~725-740℃.The results for amphibole-orthogneiss and the amphibolite yield P-T peak conditions at~8.5-10 kbar and~690-710℃.The mode models imply that metasedimentary and metaigneous units can produce up to~20 vol%and~10 vol%of melt,*** within a closed system during isobaric heating suggests that melt compositions of metasedimentary and metaigneous units are likely to have direct implications for the petrogenesis of the Puerto Vallarta *** new data indicate that the Yelapa-Chimo Metamorphic Complex evolved through a metamorphic gradient between~23-33℃km^-1and the metamorphic rocks formed at depths between~22 km and~30 km with a burial rate of~2.0 km Ma^-***,the P-T data for both metasedimentary and metaigneous rocks provide new constraints on an accretionary framework,which is responsible for generating metamorphism and partial melting in the YelapaChimo Metamorphic Complex during the Early Cretaceous.

关键词： Phase equilibrium modelling Yelapa-Chimo Metamorphic Complex Amphibolite facies Partial melting

Microenvironment and endocrine resistance in breast cancer:Friend or foe?

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World Journal of Clinical Oncology 2015年第6期6卷 207-211页

作者： sol Recouvreux Rocío Sampayo María Inés Díaz Bessone Marina Simian Instituto de Oncología "Angel H. Roffo" Escuela de Humanidades and Instituto de Nanosistemas Universidad Nacional de San Martín

Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However,about one third eventually develop resistance and cancer reappears. In the last decade our vision of cancer has evolved to consider it more of a tissuerelated disease than a cell-centered one. This editorial argues that we are only starting to understand the role the tumor microenvironment plays in therapy resistance in breast cancer. The development of new therapeutic strategies that target the microenvironment will come when we clearly understand this extremely complicated scenario. As such,and as a scientific community,we have extremely challenging work ahead. We share our views regarding these matters.

关键词： Breast cancer Tumor microenvironment Endocrine resistance Tamoxifen Stroma Estrogen receptor Aromatase inhibitors Cancer stem cells

Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-LED EBL simulation

Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple

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Horticulture Research 2020年第1期7卷 889-902页

作者： Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa Plant Breeding Research Division AgroscopeWädenswilZurichSwitzerland IRHS INRAEAgrocampus-OuestUniversitéd’AngersSFR 4207 QuaSaVBeaucouzéFrance Department of Genomics and Biology of Fruit Crops Research and Innovation CentreFondazione Edmund Mach(FEM)Via E.Mach 138010 San Michele all’AdigeItaly Department of Agriculture Food and Environment(Di3A)University of CataniaCataniaItaly Research Centre Laimburg Laimburg 639040 AuerItaly Center Agriculture Food Environment University of TrentoVia Mach 138010 San Michele all’AdigeItaly Present address:GAFL INRAE84140 MontfavetFrance

Texture is a complex trait and a major component of fruit quality in *** the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly *** further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore *** this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit *** of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP *** best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family *** adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation *** allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’×‘Pink Lady’*** results therefore identified key genetic parameters to consider when deploying genomic selection for texture in *** particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population.

关键词： prediction optimization fir

Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study

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World Journal of Gastroenterology 2019年第40期25卷 6129-6144页

作者： Jae Ryang Chu Saem-Yi Kang Sung-Eun Kim sol-Ji Lee Young-Chul Lee Mi-Kyung Sung Department of Food and Nutrition Sookmyung Women’s UniversitySeoul 04310South Korea Unigen Inc.Cheonan 31257South Korea

BACKGROUND Constipation is a common functional gastrointestinal disorder and its etiology is *** evidence suggests that intestinal dysbiosis is associated with the development of *** are subjected to bacterial fermentation in the gut to produce short-chain fatty acids(SCFAs),which can help relieve constipation *** prebiotic UG1601 consists of inulin,lactitol,and aloe vera gel,which are known laxatives,but randomized,controlled clinical trials that examine the effects of this supplement on gut microbiota composition are *** To assess the efficacy of the prebiotic UG1601 in suppressing constipation-related adverse events in subjects with mild *** Adults with a stool frequency of less than thrice a week were randomized to receive either prebiotics or a placebo supplement for 4 *** participants provided their fecal and blood samples at baseline and at the end of *** symptoms and stool frequency were *** concentrations of serum endotoxemia markers and fecal SCFAs were *** relative abundance of SCFA-producing bacteria and the gut microbial community in the responders and non-responders in the prebiotics supplementation group were *** There were no significant differences in gastrointestinal symptoms between groups,although the prebiotic group showed greater symptom ***,after prebiotic usage,serum cluster of differentiation(CD)14 and lipopolysaccharide(LPS)concentrations were significantly decreased(CD14,P=0.012;LPS,P<0.001).The change in LPS concentration was significantly larger in the prebiotic group than in the placebo group(P<0.001).Fecal SCFAs concentrations did not differ between groups,while the relative abundance of Roseburia hominis,a major butyrate producer,was significantly increased in the prebiotic group(P=0.045).The abundances of the phylum Firmicutes and the family Lachnospiraceae(phylum Firmicutes,class Cl

关键词： Prebiotics Constipation Gut microbiota Endotoxemia Short-chain fatty acids