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Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji Watanabe Mikio Kawai soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Hilar cholangiocarcinoma with intratumoral calcification: A case report

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World Journal of Gastroenterology 2015年第38期21卷 10926-10930页

作者： Kazuho Inoko Takahiro Tsuchikawa Takehiro Noji Yo Kurashima Yuma Ebihara Eiji Tamoto Toru Nakamura soichi murakami Keisuke Okamura Toshiaki Shichinohe Satoshi Hirano Department of Gastroenterological Surgery II Hokkaido University Graduate School of Medicine

This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first,hepatolithiasis was diagnosed,and he underwent endoscopic stone extraction via the transpapillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital,and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification,while no stones were found. To the best of our knowledge,only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here,we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features.

关键词： Cholangiocarcinoma Klatskin tumor Calcification Li

Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory

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分子细胞生物学报:英文版 2015年第3期7卷 253-266页

作者： Hiroshi Tanaka soichi Ogishima Department of Bioinformatics Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan Department of Bioclinical Informatics Tohoku Medical Megabank OrganizationTohoku UniversitySendaiJapan

Epithelial–mesenchymal transition(EMT)plays a critical role in promoting cancer *** this study,cancer EMT is considered as an overall structural change in the gene regulatory network(GRN),and its essential features are elucidated by the network biology *** first defined the state space of GRN as a set of all possible activation patterns of GRN,and then introduced the quasipotential field into this space to show the relative stability distribution of each *** quasi-potential was determined empirically by collecting gene expression profiles from public *** of GRN states during the EMT process were traced in the state space,by using time-course data of gene expression profiles of a cell line inducingEMTfromthe *** wasfound that cancerEMT occurred in three sequential stable stages,each of which formed a potential basin along the EMT *** confirmation,structural changes of GRN were estimated by applying the ARACNe algorithm to the same time-course data,and then applying master regulator analysis to extract the main *** group of master regulators was found to be alternatively active in the subsequent three stages to cause overall structural changes of GRN during cancer EMT.

关键词： epithelial-mesenchymal transition(EMT) Waddington’s epigenetic landscape gene regulatory network GRN network stage space cancer metastasis

Prediction of Aerodynamic Noise in a Ring Fan Based on Wake Characteristics

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Journal of Thermal Science 2011年第2期20卷 144-149页

作者： soichi Sasaki Masaharu Fukuda Masao Tsujino Haruhiro Tsubota Faculty of Engineering Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Graduate School of Science and Technology Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Research Division Komatsu Ltd.1200 Manda Hiratsuka-shi Kanagawa 254-8567 Japan

A ring fan is a propeller fan that applies an axial-flow impeller with a ring-shaped shroud on the blade tip side. In this study, the entire flow field of the ring fan is simulated using computational fluid dynamics (CFD); the accuracy of the CFD is verified through a comparison with the aerodynamic characteristics of a propeller fan of current model. Moreover, the aerodynamic noise generated by the fan is predicted on the basis of the wake characteristics. The aerodynamic characteristic of the ring fan based on CFD can represent qualitatively the variation in the measured value. The main flow domain of the ring fan is formed at the tip side of the blade because blade tip vortex is not formed at that location. Therefore, the relative velocity of the ring fan is increased by the circumferential velocity. The sound pressure levels of the ring fan within the frequency band of less than 200 Hz are larger than that of the propeller fan. In the analysis of the wake characteristics, it revealed that Karman vortex shedding occurred in the main flow domain in the frequency domain lower than 200 Hz ; the aerodynamic noise of the ring fan in the vortex shedding frequency enlarges due to increase in the relative velocity and the velocity fluctuation.

关键词：空气动力特性噪声特性风扇预测计算流体力学空气动力噪声相对速度螺旋桨

Influence of Diffuser on Aerodynamic Noise of a Forward Curved Fan

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Journal of Thermal Science 2013年第5期22卷 433-438页

作者： soichi SASAKI Kota SUZUKI Yuta Onomichi Hidechito Hayashi Division of System Science Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Advanced Engineering Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan

In order to clarify the influence of a diffuser on the characteristics of a forward curved fan,the influence of the bare ratio and the outlet angle on the characteristics of the fan were measured through an experiment performed with an actual fan as well as through a numerical simulation,*** mechanism of the discrete frequency noise generated by the separated flow of the diffuser was *** optimized bare ratio was approximately 17%.The flow separated inside of the diffuser generated discrete frequency noise owing to the interaction between the reversed flow from the diffuser and the impeller rotating at the blade passing *** diffuser outlet angle influenced the pressure ratio more than that by the bare ***,it was confirmed that restraining the separation in the diffuser effectively decreases the fan noise.

关键词：扩散器风扇气动噪声弯曲离散频率噪声分离流动数值模拟旋转叶片

Influence of Separated Vortex on Aerodynamic Noise of an Airfoil Blade

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Journal of Thermal Science 2010年第1期19卷 60-66页

作者： soichi Sasaki Hajime Takamatsu Masao Tsujino Haruhiro Tsubota Hidechito Hayashi Faculty of Engineering Nagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Graduate School of Science and Technology Nagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Research Division Komatsu Ltd.1200MandaHiratsuka-shiKanagawa 254-8567Japan

In order to clarify the mechanism by which aerodynamic noise is generated from separated flow around an airfoil blade,the relation between the attack angle and the aerodynamic noise of the blade was analyzed using a wind tunnel experiment and a CFD *** the case of rear surface separation,the separated vortex which has a large-scale structure in the direction of the blade chord is transformed into a structure that concentrates at the trailing edge with an increase in the attack *** aerodynamic noise level then becomes small according to the vortex scale in the blade *** the flow is separated at the leading edge,a separated vortex of low pressure is formed at the vicinity of the trailing *** pressure fluctuations on the blade surface at the vicinity of the trailing edge become large due to the vortex in the *** is considered that the aerodynamic noise level increases when the flow is separated at the leading edge because the separated vortex is causing the fluctuations due to wake vortex shedding.

关键词：叶片表面气动噪声分离涡翼型空气动力性噪声计算流体力学压力波动噪声水平

Forearm compartment syndrome due to acquired hemophilia that required massive blood transfusions after fasciotomy:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9592-9597页

作者： Takuya Kameda Takeru Yokota soichi Ejiri Shin-ichi Konno Department of Orthopaedic Surgery Fukushima Medical UniversityFukushima 960-1295FukushimaJapan Department of Hand and Limb Reconstructive Surgery Fukushima Medical UniversityFukushima 960-1295FukushimaJapan

BACKGROUND Acquired hemophilia is *** some cases,the bleeding in muscle causes compartment ***,it is not clear whether fasciotomy should be performed for the compartment syndrome caused by acquired hemophilia because of the risk of bleeding and the unknown functional *** SUMMARY A 75-year-old woman was admitted with severe pain of the right forearm with no preceding traumatic *** right forearm was obviously swollen,and stretch pain was *** hematomas were suspected in various parts of the *** pressure was 110 mmHg on the volar *** partial thromboplastin time(aPTT)was prolonged to 54.9 *** was performed,and hematoma was observed in the volar *** laboratory examinations revealed a low level of factor Ⅷ(FⅧ)activity(12.5%)and a high level of FⅧ inhibitor(15.2 bethesda units/mL).Acquired hemophilia A was *** recombinant clotting factors were administered,transfusion of red blood cells reached 46 units(140 mL/unit).Hemostasis was achieved 9 d after *** total cost of the clotting factor concentrates administered reached 28834600 *** prednisolone,FⅧ activity and aPTT recovered *** function of the hand was good in the index finger and excellent in the *** Fasciotomy resulted in good function of the hand in a case of non-traumatic compartment syndrome caused by acquired hemophilia,but life-threatening bleeding occurred,and the cost of clotting factor treatment was *** of sufficient blood transfusion,preoperative administration of recombinant activated clotting factor Ⅶ,and prompt fasciotomy could be ideal for such cases.

关键词： Acquired hemophilia Compartment syndrome Fasciotomy Bleeding Cost Case report

Look into my eyes:What can eye-based measures tell us about the relationship between physical activity and cognitive performance?

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Journal of Sport and Health Science 2023年第5期12卷 568-591页

作者： Liye Zou Fabian Herold Sebastian Ludyga Keita Kamijo Notger G.Muller Matthew B.Pontifex Matthew Heath Ryuta Kuwamizu Hideaki Soya Charles H.Hillman soichi Ando Brandon L.Alderman Boris Cheval Arthur F.Kramer Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518060China Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Department of Sport Exerciseand HealthUniversity of BaselBasel 4052Switzerland Faculty of Liberal Arts and Sciences Chukyo UniversityNagoya 466-8666Japan Department of Kinesiology Michigan State UniversityEast LansingMI 48824USA School of Kinesiology Faculty of Health SciencesUniversity of Western OntarioLondon ON N6A 3K7Canada Canadian Centre for Activity and Aging University of Western OntarioLondon ONN6A 3K7Canada Graduate Program in Neuroscience University of Western OntarioLondon ONN6A 3K7Canada Laboratory of Exercise Biochemistry and Neuroendocrinology Faculty of Health and Sport SciencesUniversity of TsukubaTsukuba 305-0006Japan Sport Neuroscience Division Advanced Research Initiative for Human High Performance(ARIHHP)Faculty of Health and Sport SciencesUniversity of TsukubaTsukuba 305-0006Japan Center for Cognitive and Brain Health Department of PsychologyDepartment of Physical TherapyMovementand Rehabilitation SciencesNortheastern UniversityBostonMA 02115USA Graduate School of Informatics and Engineering The University of Electro-CommunicationsTokyo 182-8585Japan Department of Kinesiology and Health Rutgers UniversityNew BrunswickNew BrunswickNJ 08854USA Swiss Center for Affective Sciences University of GenevaGeneva 1205Switzerland Laboratory for the Study of Emotion Elicitation and Expression(E3Lab) Department of PsychologyUniversity of GenevaGeneva 1205Switzerland Department of Psychology Center for Cognitive and Brain HealthNortheastern UniversityBostonMA 02115USA Beckman Institute University of Illinois at Urbana-ChampaignChampaignIL 61820USA

Background:There is a growing interest to understand the neurobiological mechanisms that drive the positive associations of physical activity and fitness with measures of cognitive *** better understand those mechanisms,several studies have employed eye-based measures(e.g., eye movement measures such as saccades,pupillary measures such as pupil dilation,and vascular measures such as retinal vessel diameter)deemed to be proxies for specific neurobiological ***,there is currently no systematic review providing a comprehensive overview of these studies in the field of exercise-cognition ***,this review aimed to address that gap in the ***:To identify eligible studies,we searched 5 electronic databases on October 23,*** researchers independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale,for interventional studies) and the critical appraisal tool from the Joanna Briggs Institute(for cross-sectional studies).Results:Our systematic review(n=35 studies) offers the following main findings:(a) there is insufficient evidence available to draw solid conclusions concerning gaze-fixation-based measures;(b) the evidence that pupillometric measures,which are a proxy for the noradrenergic system,can explain the positive effect of acute exercise and cardiorespiratory fitness on cognitive performance is mixed;(c) physical training-or fitness-related changes of the cerebrovascular system(operationalized via changes in retinal vasculature) are,in general,positively associated with cognitive performance improvements;(d) acute and chronic physical exercises show a positive effect based on an oculomotor-based measure function(operationalized via antisaccade tasks);and(e) the positive association between cardiorespiratory fitness and cognitive performance is partly mediated by the dopaminergic system(operationalized via spo

关键词： Cognition Exercise Fitness Pupil size RetinaTagedAPTARAEnd

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

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World Journal of Gastroenterology 2011年第15期17卷 2003-2006页

作者： Takaaki Fujii Yuichi Tabe Reina Yajima Satoru Yamaguchi soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano Depart ment of General Surgical Science Graduate School of Medicine Gunma University Gunma 371-8511 Japan

AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive ***: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.

关键词：复发间隔大肠癌疾病危险因素入侵 ECI 淋巴结单因素分析