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Self-Reported Assessment of Health Status and Psychological Condition among Hospital Medical Residents in Iran

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Health 2015年第7期7卷 824-829页

作者： soheila dabiran Behrooz Nabaei Maede Ghorbany Farahnaz Khajehnasiri Department of Community Medicine School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran

Psychological stress and illness among hospital residences have been subject to increasing scientific scrutiny;however very few studies have been published to describe the extent of health status and psychological stresses in residents in different specialties especially in our country that our study was mainly focused on this subject. Methods: The study subjects were medical residents in public hospitals covering 14 different specialties in Tehran in 2007. A self-administered questionnaire elicited information related to socio-demographic profile, specialty, duty hours, sleep quality, physical activity level, number of night shifts per month, mood changes, sense of depression after night shifts, fatigue, use of antidepressant and tranquilizer, and their opinion regarding their health status on a 4-point Likert scale. Results: 66.7% of participants were male with the mean age of 32.9 ± 4.2 years. 62.1% of the residents felt mood changes after nightly shifts that could adversely affect their daily living, quality of work, and social relationships. The overall prevalence of the use of antidepressant drugs was 20.0% which was significantly higher in women than men. Also, 24.4% of them reported consumption of sedative and hypnotic drugs. 15.6% reported complete healthy status while 9.4% reported partial illness. Complete healthy status was more reported among the residents of anesthesiology and pediatrics while illness was more reported by residents in pathology field. Residents’ satisfaction with their status was positively correlated with the year of residency and marriage, while dissatisfaction was more reported in divorced ones as well as in those with higher number of nightly shifts. Conclusion: Notable number of hospital residents in Iran experience significant stressors and emotional and mental health problems. Among all studies factors type of specialty, year of residency, female gender, number of nightly shifts, and single marital status were more important tha

关键词： Health Status Psychological Residents

Risk Factors of First Acute Myocardial Infarction: Comparison of Elderly and Non-Elderly: A 24-Year Study

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Advances in Aging Research 2015年第1期4卷 13-17页

作者： soheila dabiran Behrooz Khaleghi Manesh Farahnaz Khajehnasiri Department of Community Medicine Faculty of Medicine Tehran University of Medical Sciences Tehran Iran Department of Internal Medicine Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran

Although risk factors of Ischemic Heart Disease (IHD) are well known, knowledge about the distribution of these risk factors in different subgroups of patients can be used for designing preventive programs. The aim of this study was to assess differences of prevalence of IHD risk factors in elderly and non-elderly patients in their first Acute Myocardial Infarction (AMI). In this retros-pective study, elderly (age > 65;n = 1060) and non-elderly (age ≤ 65;n = 2228) patients with first AMI who were admitted into four teaching hospitals in Tehran between 1982 and 2005 were recruited. Risk factors containing male gender, systolic and diastolic hypertension (HTN), diabetes, hypertriglyceridemia, hypercholesterolemia, smoking and family history of IHD were compared between the two groups. Among different risk factors, diabetes and systolic HTN were more common in elderly than their non-elderly counterparts, and male gender, smoking, family history of IHD and dyslipidemia were more common in non-elderly patients than elderly ones (p < 0.05 for all comparison). Diastolic HTN showed no significant difference between the two groups. Findings of this study, stating difference of prevalence of risk factors in two elderly and non-elderly groups, can be used by health policy makers to conduct preventive programs for AMI in this country.

关键词： Acute Myocardial Infarction Risk Factors Elderly

Study of the Prevalence of Hypertension and Complications of Hypertensive Disorders in Pregnancy

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Open Journal of Preventive Medicine 2014年第11期4卷 860-867页

作者： Shahla Khosravi soheila dabiran M. Lotfi Mohammad Asnavandy Reproductive Health and Community Medicine Faculty of Medical Sciences Tehran University of Medical Sciences Tehran Iran Reproductive Health and Community Medicine Faculty of Medical Sciences Tehran University of Medical Sciences Tehran Iran Department of Community Medicine Tehran University of Medical Sciences Tehran Iran Islamic Azad University of Varamin Varamin Iran

Introduction: Hypertension is one of the common problems associated with pregnancy that may be followed by eclampsia, acute renal failure, maternal death, premature delivery, intra-uterine growth restriction and other. This study was conducted to determine the results of pregnancies associated with hypertension in patients visiting in the Delivery Ward of Valiasr Hospital. Methods: A descriptive study was conducted on all the patients admitted to the aforementioned department and who possessed the inclusion criteria for hypertensive pregnancy. Results: Among the 1694 delivery cases examined, 173 cases had hypertension (9.8%). Among these, 75 (45%) had gesta-tional hypertension;24 (14.8%) had preeclampsia-eclampsia;30 (18%) had preeclampsia su-perimposed on chronic hypertension;21 (13.5%) cases had chronic hypertension;and 13 (8%) had pregnancy-aggravated chronic hypertension. Ninety-six point three percent (96.3%) had a systolic blood pressure (BP) of 140 - 190 mmHg, and 3.7% had a systolic BP greater than 190 mmHg. Whereas 61.1% of diastolic blood pressure 90 - 110 mmHg and 38.9% of the mothers had diastolic BP greater than 110 mmHg. The HELLP (Hemolysis, Elevated Liver enzymes & Low Platelet count) syndrome was present in 4.9% of cases;52.6% experienced premature delivery;7.4% had IUFD (intra uterine fetal death);9.9% had IUGR (intrauterine growth retardation);and 17.3% had LBW babies. Conclusions: Based on our results, hypertensive mothers who are younger and have lower weight babies at birth experience more perinatal complications. The unpleasant effects of hypertension in pregnancy warrant the need for training, routine prenatal care, the early detection and treatment of hypertension at younger ages of pregnancy, and follow-up after delivery.

关键词： Hypertension Pregnancy Induced Hypertension Preeclampsia Eclampsia Chronic Hypertension

Common infection and allergy induced biomarkers status in respiratory diseases among Iranian Hajj pilgrims

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Health 2014年第1期6卷 137-140页

作者： Seyed Mansour Razavi Ahmad Masoud Hosein Ziaee Ardakani soheila dabiran Department of Community Medicine Tehran University of Medical Sciences Tehran Iran Department of Community Medicine Tehran University of Medical Sciences Tehran Iran Department of Immunology Tehran University of Medical Sciences Tehran Iran Department of Ophthalmology Shahid Beheshti University of Medical Sciences Tehran Iran

Background: The sources of respiratory disorders commonly occurred during the Hajj ceremony are now challenging and its infectious or allergic nature remained unknown. The present comprehensive study was conducted to assess sources of respiratory disorders in Hajj pilgrims. Method: In this prospective observational study, blood samples of 130 pilgrims were taken for assessment of serum levels of infectious and allergic sources. The measurement of IgA, IgG, IgM was used for assessment of infectious reactions against microbial antigens, NBT test was employed to assess phagocytic functions, and the measurement of gamma interferon was used for assessing immunity status against infections. Also, measurement of IgE and IL-4 was applied as two markers for assessing allergic reactions. The ELISA test was also used to assess serum levels of immunoglobulin A, G, M, E, IL-4 and gamma interferon before and three weeks after returning from Hajj ceremony. All of the volunteers were followed up along the trip and the involved pilgrim’s characteristics were recorded. Results: The present study showed no significant change in the level of allergic biomarkers including IgE and IL-4, however the mean levels of IgM, gamma Interferon and NBT test were increased after the trip compared with before that. Conclusion: Infections play a major role in occurrence of respiratory disorders among Hajj pilgrims and thus the role of allergic sources is doubtful.

关键词： Hajj Respiratory Disorder Nitro Blue Tetrazollium Reduction Test Gamma Interferon Immunoglobulin

Evaluating innovation ecosystem resiliency using agent-based modeling and systems dynamics

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Journal of Safety Science and Resilience 2024年第2期5卷 204-221页

作者： soheila Abdi Mehdi Yazdani Esmaeil Najafi Department of Industrial Engineering Science and Research BranchIslamic Azad UniversityTehranIran Department of Industrial Engineering Qazvin BranchIslamic Azad UniversityQazvinIran

Evaluating the resilience of the innovation ecosystem to maintain its performance,in the sense of resistance to disruption and recovery after it,has recently received more *** studies have been conducted to model different ecosystems and evaluate their ***,modeling the innovation ecosystem from a holistic perspective and performing a quantitative assessment of its resilience have received less *** paper models the innovation ecosystem holistically and evaluates its resilience index using a quantitative approach through five main *** the first step,a case study related to the innovation ecosystem of Iran's Ministry of Energy,called the Power Innovation Ecosystem,is modeled by combining system dynamics and agent-based *** validating the model in the second step,the disruption of the loss of experts is investigated in the third step,and all possible actions to recover each actor are *** the fourth step,the performance of the ecosystem is simulated before and after the disruption using the data gathered in the previous ***,resilience is calculated in two different ways in the fifth *** improvement solutions are also suggested when considering that the resilience index of the innovation ecosystem is at a medium *** research may assist policymakers in observing the resilience level of the innovation ecosystem based on the proposed *** applying strategic changes to this model,they can determine the effects of their policies and make the most appropriate decisions to increase the resilience of the innovation ecosystem.

关键词： Resilience index innovation ecosystem System dynamics Agent-based modeling

Proteomics techniques in protein biomarker discovery

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Quantitative Biology 2024年第1期12卷 53-69页

作者： Mahsa Babaei soheila Kashanian Huang-Teck Lee Frances Harding Department of Biology Faculty of ScienceRazi UniversityKermanshahIran Faculty of Chemistry Sensor and Biosensor Research Center(SBRC)Razi UniversityKermanshahIran Nanobiotechnology Department Faculty of Innovative Science and TechnologyRazi UniversityKermanshahIran Centre for Marine Bioproducts Development Flinders UniversityAdelaideSouth AustraliaAustralia Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneNew South WalesAustralia

Protein biomarkers represent specific biological activities and processes, so they have had a critical role in cancer diagnosis and medical care for more than 50 years. With the recent improvement in proteomics technologies, thousands of protein biomarker candidates have been developed for diverse disease states. Studies have used different types of samples for proteomics diagnosis. Samples were pretreated with appropriate techniques to increase the selectivity and sensitivity of the downstream analysis and purified to remove the contaminants. The purified samples were analyzed by several principal proteomics techniques to identify the specific protein. In this study, recent improvements in protein biomarker discovery, verification, and validation are investigated. Furthermore, the advantages, and disadvantages of conventional techniques, are discussed. Studies have used mass spectroscopy (MS) as a critical technique in the identification and quantification of candidate biomarkers. Nevertheless, after protein biomarker discovery, verification and validation have been required to reduce the false-positive rate where there have been higher number of samples. Multiple reaction monitoring (MRM), parallel reaction monitoring (PRM), and selected reaction monitoring (SRM), in combination with stable isotope-labeled internal standards, have been examined as options for biomarker verification, and enzyme-linked immunosorbent assay (ELISA) for validation.

关键词： biomarker discovery cancer biomarker gel-based methods gel-free methods mass spectroscopy proteomics

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1699-1700页

作者： Seyed Mojtaba Hosseini soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CentreRady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada Manitoba Multiple Sclerosis Research Center WinnipegMBCanada Children Hospital Research Institute of Manitoba WinnipegMBCanada

Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).

关键词： peroxidation Fischer injury

ORGANOSOLUBLE AND THERMALLY STABLE POLYIMIDES DERIVED FROM A NEW DIAMINE CONTAINING BULKY-FLEXIBLE TRIARYL PYRIDINE PENDENT GROUP

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Chinese Journal of Polymer Science 2011年第4期29卷 465-474页

作者： Mousa Ghaemy soheila Khajeh Faculty of Chemistry University of MazandaranBabolsarIran

A novel kind of aromatic diamine, N-（4-（4-（2,6-diphenyl pyridine-4-yl） phenoxy） phenyl）-3,5-diaminobezamide （DPDAB）, was synthesized via aromatic nucleophilic substitution of 3,5-dinitrobenzoylchloride with 4-（4-（2,6- diphenylpyridine-4-yl）phenoxy）aniline （DPPA）, followed by palladium-catalyzed hydrazine reduction. This monomer was used to prepare polyimides （PIs） based on reaction with several commerically avaiable tetracarboxylic dianhydrides such as pyromellatic dianhydride （PMDA）, benzophenone tetracarboxylic acide dianhydride （BTDA） and bicycle [2.2.2] oct-7-ene- 2, 3,5,6-tetracarboxylic dianhydride （BCDA）. These PIs had inherent viscosity in the range of 0.34-0.76 dL/g and showed good solubility in various aprotic polar solvents. The glass-transition tempratures （Tgs） of the PIs were in the range of 184-302℃, and showed high thermal stability with 10% weight loss in the temperature range of 360-500℃ under nitrogen atmosphere.

关键词： Polyimides Inherent viscosity Solubility Thermal stability DSC.

Metal-organic framework-based materials as key components in electrocatalytic oxidation and reduction reactions

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Journal of Energy Chemistry 2023年第12期87卷 540-567,I0014页

作者： soheila Sanati Ali Morsali Hermenegildo García Department of Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14115175Iran Instituto Universitario de Tecnología Química Universidad Politecnica de ValenciaConsejo Superior de Investigaciones CientíficaSUniversitat Politècnica de ValènciaValència 46022Spain

Studies have extensively addressed the development of electrocatalytic technologies for energy storage and conversion,fuel production,and environmental *** processes such as different oxidation and reduction reactions play a vital and significant role in these *** this regard,efficient,inexpensive,and stable electrocatalysts capable can significantly promote electrochemical *** features of metal–organic frameworks(MOFs)such as their high porosity,tunable structure,size,and pore shape,high surface area,and redox properties have introduced them as an ideal electrocatalyst *** review is thus aimed at elucidating the role of MOF-based materials(pristine,derivatives and composites)as efficient electrocatalysts in energy and sensing-related oxidation and reduction reactions such as oxygen reduction reaction(ORR),hydrogen oxidation reaction(HOR),carbon dioxide reduction reaction(CO_(2)RR),urea oxidation reaction(UOR),alcohol oxidation reaction(AOR),nitrogen reduction reaction(NRR),and glucose oxidation reaction(GOR)in advanced energy and sensing ***,the structure–property relationship of the electrocatalyst was elaborated for each electrocatalytic ***,perspectives on the potential research topics for practical use of MOF-based electrocatalysts are *** present review can improve the interest in MOF-based electrocatalysts to study different oxidation and reduction reactions in energy and sensing systems.

关键词： Metal-organic frameworks Electrocatalyst Oxidation reaction Reduction reaction