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Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?

Neural Regeneration Research 2022年第9期17卷 1945-1954页

作者： sofia fernanda gonçalves zorzella-pezavento Luiza Ayumi Nishiyama Mimura Marina Bonifácio Denadai William Danilo Fernandes de Souza Thais fernanda de Campos Fraga-Silva Alexandrina Sartori Department of Chemical and Biological Sciences Institute of BiosciencesSão Paulo State University(UNESP)BotucatuSão PauloBrazil

Multiple sclerosis is an autoimmune treatable but not curable *** are a multiplicity of medications for multiple sclerosis therapy,including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease *** all patients respond well to these therapies,and minor to severe adverse effects have been *** D,called sunshine vitamin,is being studied as a possible light at the end of the *** this review,we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis,the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis ***,based on our and other groups’experimental findings,we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.

关键词： central nervous system cytokines experimental autoimmune encephalomyelitis immunomodulation immunopathogenesis inflammation multiple sclerosis neuroprotection regulatory T cells vitamin D

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Should mast cells be considered therapeutic targets in multiple sclerosis?

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Neural Regeneration Research 2020年第11期15卷 1995-2007页

作者： Karen Henriette Pinke sofia fernanda goncalves zorzella-pezavento Vanessa Soares Lara Alexandrina Sartori Institute of Biosciences Department of Microbiology and ImmunologySao Paulo State University(UNESP)BotucatuSao PauloBrazil Bauru School of Dentistry Department of SurgeryStomatologyPathology and RadiologyUniversity of Sao PauloBauruSao PauloBrazil

Mast cells are immune cells of the myeloid lineage that are found throughout the body,including the central nervous *** perform many functions associated with innate and specific immunity,angiogenesis,and vascular ***,they have been implicated in a series of pathologies(e.g.,hypersensitivity reactions,tumors,and inflammatory disorders).In this review,we propose that this cell could be a relevant therapeutic target in multiple sclerosis,which is a central nervous system degenerative *** support this proposition,we describe the general biological properties of mast cells,their contribution to innate and specific immunity,and the participation of mast cells in the various stages of multiple sclerosis and experimental autoimmune encephalomyelitis *** final part of this review is dedicated to an overview of the available mast cells immunomodulatory drugs and their activity on multiple sclerosis and experimental autoimmune encephalomyelitis,including our own experience related to the effect of ketotifen fumarate on experimental autoimmune encephalomyelitis evolution.

关键词： central nervous system degenerative disease experimental autoimmune encephalomyelitis immunity immunomodulatory drugs inflammatory disease ketotifen fumarate mast cells multiple sclerosis therapeutic target

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C57BL/6 and DBA/1 Mice Differ in Their Response to Supplementation with 1,25D and Paricalcitol

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Biomedical and Environmental Sciences 2018年第8期31卷 613-618页

作者： Aline Parisoto Missio Thais fernanda de Campos Fraga-Silva Larissa Lumi Watanabe Ishikawa Luiza Ayumi Nishiyama Mimura Thais Graziela Donega Franga Larissa Ragozo Cardoso de Oliveira Alexandrina Sartori sofia Femanda goncalves zorzella-pezavento Department of Microbiology and Immunology Sao Paulo State University(UNESP)Institute of BiosciencesBotucatuSao PauloBrazil

Active vitamin D (1,25D) is a fat-soluble vitamin that is mainly produced in the skin by the conversion of 7-dehydrocholesterol under ultraviolet light *** role in calcium homeostasis,bone growth, and prevention of ri... 详细信息

关键词： DBA BL C57BL/6 and DBA/1 Mice Differ in Their Response to Supplementation with 1,25D and Paricalcitol

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Electromagnetic Stimulation Combined with Aloe vera Increases Collagen Reorganization in Burn Repair

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Journal of Pharmacy and Pharmacology 2018年第7期6卷 633-646页

作者： sofia Poletti Leticia D. Lucke fernanda O Bortolazzo Renata M. Acunha Marcos G. Mattos Femanda OG. Gaspi Thiago A. M. Andrade Maria Esmeria C. Amaral Andrea A .Aro Edson R Pimentel Marcelo AM. Esquisatto fernanda A. S. Mendonga Glaucia M. T. Santos Graduate Program in Biomedical Sciences of the Herminio Ometto University Center UIVIARARAS Araras Sao Paulo13607-339 Brazil Department of Structural and Functional Biology Institute of Biology University of Campinas-UNICAMP Campinas Sao Paulo13083-970 Brazil

Objectives： Burns are shown as a clinical problem for their severity and multiple complications due to the time required to heal. Therapies that improve their healing are of great importance, especially for being minimally invasive, of low cost and best performance, all related to the speed and quality of healing. This study investigated the effects of the magnetic electro stimulator Haihuá CD9 isolated or in association with Aloe vera in rats skin burns. Methods： Experimental groups （n = 30/group） were：（C） Carbopol gel; （F） A. vera/Carbopol gel; （H） Haihuá＋Carbopol gel; （H＋F） Haihuá＋A. vera/Carbopol gel. Samples were collected on the 7th, 14th, and 21st experimental days for structural and morphometric analysis, hydroxyproline and glycosaminoglycans quantification, zymography for MMP-2 and MMP-9 and Western Blotting for TGF-β1, VEGF, Collagen I and III. Key findings： The expression of TGF-β1 in H＋F was increased on the 7th day and of MMP-9 on the 7th and 14th days. The expression of VEGF increased in the first experimental periods and decreased in the last for the treated groups. There was an increase in the fibroblasts and birefringent collagen fibers in groups treated with Haihuá isolated or in association with A. vera in all periods. The quantification of collagen I increased, while collagen III decreased in H＋F. The higher amount of GAGs and MMP-2 active isoform was detected in H and H＋F during all periods. Conclusions： Considering the results of the present study, electromagnetic stimulation in association with the A. vera extract promoted an increase in the number of fibroblasts, GAGs content, MMP-2 activity, the deposition and organization of collagen fibers, favoring the repair of injuries to second degree burns, and may also present therapeutic potential in this injury type.

关键词： Burns repair herbal medicine electromagnetic stimulation rats

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