检索结果-南通市图书馆

Edge Cloud Selection in Mobile Edge Computing(MEC)-Aided Applications for Industrial Internet of Things(IIoT)Services

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第11期47卷 2049-2060页

作者： Dae-Young Kim soyeon lee MinSeung Kim Seokhoon Kim Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea Department of Software Convergence Soonchunhyang UniversityAsan31538Korea

In many IIoT architectures,various devices connect to the edge cloud via gateway *** data processing,numerous data are delivered to the edge *** data to an appropriate edge cloud is critical to improve IIoT service *** are two types of costs for this kind of IoT network:a communication cost and a computing *** service efficiency,the communication cost of data transmission should be minimized,and the computing cost in the edge cloud should be also ***,in this paper,the communication cost for data transmission is defined as the delay factor,and the computing cost in the edge cloud is defined as the waiting time of the computing *** proposed method selects an edge cloud that minimizes the total cost of the communication and computing *** is,a device chooses a routing path to the selected edge cloud based on the *** proposed method controls the data flows in a mesh-structured network and appropriately distributes the data processing *** performance of the proposed method is validated through extensive computer *** the transition probability from good to bad is 0.3 and the transition probability from bad to good is 0.7 in wireless and edge cloud states,the proposed method reduced both the average delay and the service pause counts to about 25%of the existing method.

关键词： Industrial Internet of Things(IIoT)network IIoT service mobile edge computing(MEC) edge cloud selection MEC-aided application

3D printing-enabled advanced electrode architecture design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Energy 2021年第3期3卷 424-439页

作者： Tiankuo Chu soyeon Park Kun(Kelvin)Fu Department of Mechanical Engineering University of DelawareNewarkDelawareUSA Center for Composite Materials(CCM) University of DelawareNewarkDelawareUSA

A high-performance energy storage device plays an important role in controlling carbon *** emerging additive manufacturing techniques bring a great revolution of electrode fabrication process and promote the performance of energy storage devices through the advanced electrode architecture *** this paper,recent studies on the three-dimensional(3D)-printed electrode with advanced architecture have been mainly reviewed,including interdigitated structure,through-thickness aligned structure,hierarchical porous structure and fiber and fibric structure of electrodes,and expectations for the development of novel advanced electrode architecture generated and optimized by computational simulation and machine *** strategy of advanced electrode architecture design and fabrication enabled by the 3D printing technique represents a promising direction toward future energy storage devices with high electrochemical and mechanical performance.

关键词： 3D printing additive manufacturing advanced structure battery supercapacitor

Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第10期46卷 2231-2234页

作者： JU HYUNG lee IL-KWON KIM SANG WOO KIM soyeon LIM SEAHYOUNG lee KI-CHUL HWANG BYEONG-WOOK SONG Graduate Program of Biomedical Engineering Yonsei UniversitySeoul03722Korea Institute for Bio-Medical Convergence College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea Department for Medical Science College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea

The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets aretopics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative *** pre-transplantation through post-transplantation, there are many changes in the conditions, both inside andoutside of the stem cells that have not been carefully considered. This has hindered development in the field of celltherapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellularalterations of stem cells in transplanted areas at risk of neurodegenerative disease.

关键词： Cell therapy Microenvironment Neurodegenerative disease Stem cells

Fostering tissue engineering and regenerative medicine to treat musculoskeletal disorders in bone and muscle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第10期40卷 345-365页

作者： soyeon Park Khandoker Asiqur Rahaman Yu-Chan Kim Hojeong Jeon Hyung-Seop Han Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea

The musculoskeletal system,which is vital for movement,support,and protection,can be impaired by disorders such as osteoporosis,osteoarthritis,and muscular *** review focuses on the advances in tissue engineering and regenerative medicine,specifically aimed at alleviating these *** explores the roles of cell therapy,particularly Mesenchymal Stem Cells(MSCs)and Adipose-Derived Stem Cells(ADSCs),biomaterials,and biomolecules/external stimulations in fostering bone and muscle *** current research underscores the potential of MSCs and ADSCs despite the persistent challenges of cell scarcity,inconsistent outcomes,and safety ***,integrating exogenous materials such as scaffolds and external stimuli like electrical stimulation and growth factors shows promise in enhancing musculoskeletal *** review emphasizes the need for comprehensive studies and adopting innovative techniques together to refine and advance these multi-therapeutic strategies,ultimately benefiting patients with musculoskeletal disorders.

关键词： Musculoskeletal disorders Tissue engineering Regenerative medicine Bone Muscle

IoTFLiP： IoT-based flipped learning platform for medical education

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2017年第3期3卷 188-194页

作者： Maqbool Ali Hafiz Syed Muhammad Bilal Muhammad Asif Razzaq Jawad Khan Sungyoung lee Muhammad Idris Mohammad Aazam Taebong Choi soyeon Caren Han Byeong Ho Kang Department of Computer Science and Engineering Kyung Hee University Yongin 446-701 Republic of Korea IT4BI Universite Libre de Bruxelles Belgium Carleton University Canada Hanwha Systems as Senior Manager Communication PM Team Seongnam 13524 Republic of Korea School of Engineering and ICT Uniuersity of Tasmania Hobart Tasmania 7005 Australia

Case-Based Learning （CBL） has become an effective pedagogy for student-centered learning in medical education, which is founded on persistent patient cases. Flippped learning and Internet of Things （IoTs） concepts have gained significant attention in recent years. Using these concepts in conjunction with CBL can improve learning ability by providing real evolutionary medical eases. It also enables students to build confidence in their decision making, and efficiently enhances teamwork in the learning environment. We propose an IoT-based Flip Learning Platform, called IoTFLiP, where an IoT infrastrneture is exploited to support flipped case-based learning in a cloud environment with state of the art security and privacy measures for personalized medical data. It also provides support for application delivery in private, public, and hybrid approaches. The proposed platform is an extension of our Interactive Case-Based Flipped Learning Tool （ICBFLT）, which has been developed based on current CBL practices. ICBFLT formulates summaries of CBL cases through synergy between students＇ and medical expert knowledge. The low cost and reduced size of sensor device, support of IoTs, and recent flipped learning advancements can enhance medical students＇ academic and practical experiences. In order to demonstrate a working scenario for the proposed IoTFLiP platform, real-time data from IoTs gadgets is collected to generate a real-world case for a medical student using ICBFLT.

关键词： Internet of things Cloud environment Flipped learning Case-based learning Medical education

Analysis of the Effect of Space Radiations on the Nematode, <i>Caenorhabditis elegans </i>, through the Simulated Space Radiation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Astronomy and Astrophysics 2013年第3期3卷 291-302页

作者： soyeon Yi soyeon Kim Jeeyeon Song Korea Advanced Institute of Science and Technology Daejeon Republic of Korea Korea Aerospace Research Institute (KARI) Daejeon Republic of Korea

In this study, we simulated space flight of the nematode, Caenorhabditis elegans, on the ground and examined how it is affected by space radiation and G-forces. We simulated G-forces during launch in a gravity acceleration laboratory device in order to identify and isolate the effects of the G-forces. Following this, we irradiated C. elegans with accelerated protons (MC-50 Cyclotron) and gamma rays (iR 222 machine) at the same physical dose. We calculated the expected radiation dose according to Reitz [1] and simulation programs (NASA AP8MIN [2], NASA AE8MAX [2], and CREAM86 [3]) for 1 month (dose rate: 6 × 10-3 Gy;2.8 × 10-2 Gy), 6 months (dose rate: 36 × 10-3 Gy;16.8 × 10-2 Gy), and 2 years (dose rate: 144 × 10-3 Gy;67.2 × 10-2 Gy) of space flight. There have been several trials that aimed to take C. elegans into orbit on US space shuttle missions including a mission on the shuttle Columbia. In this study, we simulated longer duration space flights and performed a whole-genome microarray analysis to observe phenotype variations whereas most such experiments were carried out during short duration space flights and focused on mutations and genotypic variations. We expect that the results of this study will be useful to predict the effects of long-term exposure of space radiation on living organisms.

关键词： Astronaut International Space Station Space Experiment Space Radiation C. elegans Microarray

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo Jung Haesong lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae lee Wonsik Kim soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第8期38卷 486-498页

作者： Seo-Hyeon Bae soyeon Yoo Jisun lee Hyo-Jung Park Sung Pil Kwon Harin Jin Sang-In Park Yu-Sun lee Yoo-Jin Bang Gahyun Roh Seonghyun lee Sue Bean Youn In Woo Kim Ho Rim Oh Ashraf K.El-Damasy Gyochang Keum Hojun Kim Hyewon Youn Jae-Hwan Nam Eun-Kyoung Bang Department of Medical and Biological Sciences The Catholic University of KoreaGyeonggi-doBucheonRepublic of Korea BK Four Department of Biotechnology The Catholic University of KoreaGyeonggi-doBucheonRepublic of Korea Center for Brain Technology Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)SeoulRepublic of Korea SML Biopharm Gwangmyeong14353Republic of Korea KHU-KIST Department of Converging Science and Technology Graduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Cancer Research Institute Seoul National University College of MedicineSeoul03080Republic of Korea Department of Nuclear Medicine Cancer Imaging CenterSeoul National University HospitalSeoul03080Republic of Korea

The rapid development of messenger RNA(mRNA)vaccines formulated with lipid nanoparticles(LNPs)has contributed to control of the COVID-19 ***,mRNA vaccines have raised concerns about their potential toxicity and clinical safety,including side effects,such as myocarditis,anaphylaxis,and *** this study,we investigated the potential of trehalose glycolipids-containing LNP(LNP S050L)to reduce the risks associated with ionizable *** glycolipids can form hydrogen bonds with polar biomolecules,allowing the formation of a stable LNP structure by replacing half of the ionizable *** efficacy and safety of LNP S050L were evaluated by encapsulating the mRNA encoding the luciferase reporter gene and measuring gene expression and organ toxicity,***,mice immunized with an LNP S050L-formulated mRNA vaccine expressing influenza hemagglutinin exhibited a significant reduction in organ toxicity,including in the heart,spleen,and liver,while sustaining gene expression and immune efficiency,compared to conventional LNPs(Con-LNPs).Our findings suggest that LNP S050L,a trehalose glycolipid-based LNP,could facilitate the development of safe mRNA vaccines with improved clinical safety.

关键词： Trehalose glycolipid Lipid nanoparticle mRNA vaccine Toxicity Immunogenicity

A comprehensive review on the resynthesis of ternary cathode active materials from the leachate of Li-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第8期95卷 446-463,I0010页

作者： Dongwoo Kim Hyeoncheol Joo Chanmin Kim Seoa Kim Wan-Yi Kim Sangwoo Han Joongkil Park soyeon Park Heechul Jung Sanghyuk Park Kyungjung Kwon Department of Energy and Mineral Resources Engineering Sejong UniversitySeoul 05006Republic of Korea LIB Recycling Research Group LIB Materials R&D CenterPOSCO HoldingsPohang 37859Republic of Korea Department of Future Energy Convergence Seoul National University of Science&Technology232 Gongreung-roNowon-guSeoul 01811Republic of Korea Autonomous Intelligent Unmanned Flying Vehicles Institute Sejong UniversitySeoul 05006Republic of Korea

This review highlights the importance of recovering valuable metals from spent Li-ion battery(LIB)cathodes through the resynthesis of cathode active materials(CAMs).The resynthesis process of CAMs,a promising recycling method that directly produces CAM precursors from LIB leachate,is *** process encompasses six key steps,including pretreatment,leaching,purification,adjustment of metal concentrations,precursor synthesis,and *** review also investigates the potential introduction of impurity elements during CAM resynthesis and provides tolerance levels for these impurities based on thorough reference ***,it addresses challenges related to the commercialization of the resynthesis ***,this review represents the first comprehensive assessment of CAM resynthesis,including the systematic evaluation of 12 impurity elements(Fe,Li,Al,Cu,C,P,F,Na,Cl,S,Mg,and Zn).Overall,this comprehensive review is poised to support the commercial development of resynthesized CAMs by offering valuable guidelines for managing impurities and streamlining the purification process.

关键词： Li-ion battery Recycling Resynthesis Leachate Impurity