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Cellular & Molecular Immunology 2017年第11期14卷 895-908页

作者： Kyung-Ah Cho Jun-Kyu Lee Yu-Hee Kim Minhwa Park so-youn woo Kyung-Ha Ryu Department of Microbiology School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea Department of Pediatrics School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea

Effector B cells are central contributors to the development of autoimmune disease by activating autoreactive T cells,producing pro-inflammatory cytokines and organizing ectopic lymphoid ***,IL-10-producing regulatory B(Breg)cells have pivotal roles in maintaining immunological tolerance and restraining excessive inflammation in autoinflammatory ***,regulating the equilibrium between antibody-producing effector B cells and Breg cells is critical for the treatment of autoimmune *** this study,we investigated the effect of human palatine tonsil-derived mesenchymal stem cells(T-MSCs)on estradiol(E2)-induced B-cell responses in vivo and in *** of T-MSC into E2-treated mice alleviated B-cell-mediated immune responses and increased the population of IL-10-producing Breg cells.T-MSCs regulated the B-cell populations by producing Epstein–Barr virus(EBV)-induced 3(EBI3),one of the two subunits of IL-35 that is the well-known inducer of Breg *** demonstrate a critical role of EBI3(IL-35)in vitro by depleting EBI3 in T-MSCs and by adding exogenous IL-35 to the culture *** together,our data suggest that IL-35-secreting MSCs may become an attractive therapeutic to treat B-cell-mediated autoimmune diseases via expanding Breg cells.

关键词： autoimmune disease B cells IL-35 mesenchymal stem cells

Decomposition kinetics of dimethyl methylphospate(chemical agent simulant) by supercritical water oxidation

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Journal of Environmental Sciences 2006年第1期18卷 13-16页

作者： Bambang VERIANSYAH Jae-Duck KIM youn-woo LEE Supercritical Fluid Research Laboratory Korea Institute of Science and Technology(KIST) 39-1 Hawolgok-dong Seoungbuk-gu Seoul 136-791 Korea. School of Chemical and Biological Engineering Seoul National University(SNU) San 56-1 Sillim-dong Gwanak-gu Seoul 151-744 Korea

Supercritical water oxidation （SCWO） has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the decomposition rate of dimethyl methylphosphonate（DMMP）, which is similar to the nerve agent VX and GB（Sarin） in its structure, was investigated under SCWO conditions. The experiments were performed in an isothermal tubular reactor with a H2O2 as an oxidant. The reaction temperatures were ranged from 398 to 633℃ at a fixed pressure of 24 MPa. The conversion of DMMP was monitored by analyzing total organic carbon （TOC） on the liquid effluent samples. It is found that the oxidative decomposition of DMMP proceeded rapidly and a high TOC decomposition up to 99.99% was obtained within 11 s at 555℃. On the basis of data derived from experiments, a global kinetic equation for the decomposition of DMMP was developed. The model predictions agreed well with the experimental data.

关键词： supercritical water oxidation kinetics chemical agent DMMP

Influence of volcanic activity on vegetation succession and growth environment on the hillslope of Sakurajima Volcano in southern Kyushu,Japan

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Journal of Forestry Research 2017年第2期28卷 309-317页

作者： Yukiyoshi Teramoto Etsuro Shimokawa Tsugio Ezaki Kun-woo Chun Suk-woo Kim youn-Tae Lee Faculty of Agriculture Kagoshima UniversityKagoshima 890-0065Japan Faculty of Agriculture Ehime UniversityMatsuyama 790-8566Japan Division of Forest Science Kangwon National UniversityChuncheon 24341Republic of Korea Department of Forestry and Environmental Systems Graduate SchoolKangwon National UniversityChuncheon 24341Republic of Korea

This study was conducted in order to examine the influence of long-term volcanic activity on vegetative succession and growth on the slope of Sakurajima in southern Kyushu, Japan. We investigated the vegetation,depth of the volcanic ash layer, and dry density and p H of the surface soil at six places on the north-northwestern slope, 2.3–3.4 km from the Minami-dake crater, where a layer of pumice stone was deposited by the Taisho eruption in 1914. The height and diameter at breast height（DBH） of the trees increased with increasing distance from the Minami-dake crater, as did the number of individuals and species, and basal area. The Shannon–Wiener diversity index（H＇） demonstrates that vegetative succession is significantly affected by distance from the Minami-dake crater, as areas farther from the crater exhibited later seral stages. Comparison of the diversity index and species number of the crater region with that of the climax forest in Kagoshima indicates that vegetative growth alone cannot advance succession in the study area, as the local vegetative community is heavily influenced by the harsh environmental conditions associated with continual exposure to long-term volcanic activity. Seral stage, ash layer depth,dry density, and p H of the soil surface layer are governed by distance from the Minami-dake crater. The results of this study indicate that conditions for vegetative growth and succession improve with increasing distance from the source of constant volcanic activity. Thus, soil development is promoted by the acidification of the soil, which decreases the dry density and p H of the soil surface *** introduction of plant species resistant to volcanic ash and gas is recommended to promote soil development and improve the infiltration capacity of the soil.

关键词： volcanic succession vegetation vegetative northwestern eruption basal leaved gentle harsh

Development of genome engineering technologies in cattle: from random to specific

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Journal of Animal Science and Biotechnology 2018年第2期9卷 285-293页

作者： soo-young Yum Ki-young youn woo-Jae Choi Goo Jang Department of Veterinary Clinical Science College of Veterinary Medicine and the Research Institute of Veterinary Science Seoul National University Farm Animal Clinical Training and Research Center Institute of Green Bio Science Technology Seoul National University Emergence Center for Food-Medicine Personalized Therapy System Advanced Institutes of Convergence Technology Seoul National University College of Veterinary Medicine Seoul National University

The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the ***, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.

关键词： Cattle CRISPR-Cas9 Genome engineering technologies Transgenesis Transposon

Validation of Sea Level Data in the East Asian Marginal Seas: Comparison between TOPEX/POSEIDON Altimeter and In-Situ Tide Gauges

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Advances in Atmospheric Sciences 2003年第4期20卷 650-660页

作者： Yong-Hoon youn Im Sang OH Ki-Hyun KIM young-Hyang PARK Jong woo KIM Meteorological Research Institute/Korea Meteorological Administration SeoulKoreaResearch Institute of OceanographySeoul National UniversitySeoulKoreaDepartment of Earth SciencesSejing UniversitySeoulKoreaLaboratoire d'Oceanographie PhysiqueMuseum National d'Histoire NaturelleParisDepartment of Earth SciencesSejong UniversitySeoulKorea

In an effort to assess the reliability of satellite altimeter systems, the authors conduct a comparative analysis of sea level data that were collected from the TOPEX/POSEIDON (T/P) altimeter and 10 tide gauges (TG) near the satellite passing ground tracks. The analysis is made using datasets collected from marginal sea regions surrounding the Korean Peninsula at T/P cycles of 2 to 230, which correspond to October 1992 to December 1998. Proper treatment of tidal errors is a very critical step in data processing because the study area has very strong tide. When the T/P data are processed, the procedures of Park and Gamberoni (1995) are adapted to reduce errors associated with the tide. When the T/P data are processed in this way, the alias periods of M2, S2, and K1 constituents are found to be 62.1, 58.7, and 173 days repectively. The compatibility of the T/P and TG datasets are examined at various filtering periods. The results indicate that the low-frequency signals of the T/P data can be interpreted more safely with longer filtering periods (such as up to the maximum selected value of 200 days). When RMS errors for the 200-day low-pass filter period are compared with all 10 tidal stations, the values span the range of 2.8 to 6.7 cm. The results of a correlation analysis for this filtering period also show a strong agreement between the T/P and TG datasets across all stations investigated (e.g.,p- values consistently less than 0.001). Hence according to the analysis, the conclusion is made that the analysis of surface sea level using satellite altimeter data can be made safely with reasonably extended filtering periods such as 200 days.

关键词： sea level TOPEX/POSEIDON altimeter tide gauge

Brassinosteroids enhance salicylic acid-mediated immune responses by inhibiting BIN2 phosphorylation of clade I TGA transcription factors in Arabidopsis

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Molecular Plant 2022年第6期15卷 991-1007页

作者： Yeong-woo Kim Ji-Hyun youn Jeehee Roh Jeong-Mok Kim Seong-Ki Kim Tae-Wuk Kim Department of Life Science Hanyang UniversitySeoul 04763Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06973Republic of Korea Research Institute for Convergence of Basic Science Hanyang UniversitySeoul 04763Republic of Korea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoul 04763Republic of Korea

Salicylic acid (SA) plays an important role in plant immune response, including resistance to pathogens and systemic acquired resistance. Two major components, NONEXPRESsoR OF PATHOGENESIS-RELATED GENES (NPRs) and TGACG motif-binding transcription factors (TGAs), are known to mediate SA signaling, which might also be orchestrated by other hormonal and environmental changes. Nevertheless, the molecular and functional interactions between SA signaling components and other cellular signaling pathways remain poorly understood. Here we showed that the steroid plant hormone brassinosteroid (BR) promotes SA responses by inactivating BR-INSENSITIVE 2 (BIN2), which inhibits the redox-sensitive clade I TGAs in Arabidopsis. We found that both BR and the BIN2 inhibitor bikinin synergistically increase SA-mediated physiological responses, such as resistance to Pst DC3000. Our genetic and biochemical analyses indicated that BIN2 functionally interacts with TGA1 and TGA4, but not with other TGAs. We further demonstrated that BIN2 phosphorylates Ser-202 of TGA4, resulting in the suppression of the redox-dependent interaction between TGA4 and NPR1 as well as destabilization of TGA4. Consistently, transgenic Arabidopsis overexpressing TGA4-YFP with a S202A mutation displayed enhanced SA responses compared to the wild-type TGA4-YFP plants. Taken together, these results suggest a novel crosstalk mechanism by which BR signaling coordinates the SA responses mediated by redox-sensitive clade I TGAs.

关键词： brassinosteroid salicylic acid immune responses BIN2 clade I TGA

Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel

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China Foundry 2010年第2期7卷 178-182页

作者： youn-soo Ham Jeong-Tae Kim Si-young Kwak Jeong-Kil Choi woo-young Yoon Daeyang R-Tech.Co. Ltd290-28Daehwa-DongDaeduk-GuDaejeonKorea e-Design Center KITECH7-47Songdo-DongYeonsu-GuIncheon 406-800Korea Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul 136-701Korea

Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy,image analyzer and numerical *** efficient heat treatment analysis program including temperature-dependent material properties was developed for the prediction of cooling rate and probability of carbide precipitation during quenching by finite difference ***-dependent heat transfer coefficient was adopted to achieve more precise *** ratio of carbide precipitation was measured by image analyzer to determine the critical point of carbide ***-dependent critical cooling rate at that point was calculated by the developed numerical ***,the probability of carbide precipitation on the whole area of specimen can be predicted by the proposed numerical program and the numerical result of a specimen was compared with the experimental result.

关键词： austenitic manganese steel carbide precipitation quenching critical cooling rate

Effects of torrefied wood chip and vermicompost application on vegetation growth and nutrient uptake in the Saemangeum reclaimed land

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Ecological Processes 2020年第1期9卷 74-82页

作者： Aung Aung Jeong Min Seo Si Ho Han Ji young An Huong Thi Thuy Dao woo Bin youn Byung Bae Park Department of Environment and Forest Resources College of Agriculture and Life SciencesChungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Environmental Conservation Department Ministry of Natural Resources and Environmental ConservationNaypyitaw 15011Myanmar Institute of Agricultural Science College of Agriculture and Life SciencesChungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea.

Background:In reclaimed land,the growth environment for plants may be unfavorable and the initial establishment and growth of seedlings could be limited because of low nutrient and water *** and control of understory vegetation that competes with seedlings may be of help in ameliorating soil physical and chemical properties,resulting in better seedling growth and reclamation ***,the amount of nutrients understory vegetation absorbs in this ecological process has been rarely ***,we aimed to investigate the effect of soil amendment on biomass production and nutrient uptake by weeds in the nutrient-poor reclaimed *** applied three levels of torrefied wood chip(TWC;0,2.5,and 5 Mg ha^(−1))and two levels of vermicompost(VC;0 and 2.7 Mg ha^(−1))as soil physical improvements and organic soil amendments in reclaimed land in the Republic of Korea,with Populus euramericana used as the crop ***:TWC did not influence weed biomass,but 2.7 Mg ha^(−1) VC significantly increased weed biomass by 21%compared to 0 Mg ha^(−1) VC ***(N),phosphorus(P),potassium(K),calcium(Ca),magnesium(Mg),and sodium(Na)concentrations in weeds were the highest in control,but there was no statistical difference among ***,VC treatment did marginally increase nutrient uptake in weeds,especially P,K,Ca,and *** treatments influenced crop tree ***:We conclude that VC can be used as an organic source of nutrients in reclaimed soil and that weed management is necessary to increase treatment effects on crop trees in this salt-affected reclaimed land.

关键词： Nutrient content Populus euramericana Saemangeum soil amendment Weed biomass

Gastric choriocarcinoma admixed with an α-fetoprotein-producing adenocarcinoma and separated adenocarcinoma

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World Journal of Gastroenterology 2009年第40期15卷 5106-5108页

作者： Bang wool Eom so-youn Jung Hongman Yoon Myeong-Cherl Kook Keun Won Ryu Jun Ho Lee young-woo Kim Center for Gastric Cancer National Cancer Center

We report a case of gastric choriocarcinoma admixed with an α-fetoprotein (AFP)-producing adeno-carcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomywith D2 lymph node dissection and Billroth gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemotherapy were initiated. No recurrence or distant metastasis was observed at 4 years postoperatively.

关键词： α-fetoproteins Adenocarcinoma Choriocarcinoma Stomach neoplasms

Fermentation of mulberry leaves with Cordyceps militaris enhanced anti-adipogenesis activity in 3T3-L1 cells through down-regulation of PPAR-γ pathway signaling

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Asian Pacific Journal of Tropical Medicine 2020年第12期13卷 557-565页

作者： Lu Guo Jum soon Kang young Hoon Park Beong Il Je Dae youn Hwang woo Hong Joo young Whan Choi Department of Horticultural Bioscience Pusan National UniversityMiryang 50463Republic of Korea Department of Biomaterials Science Pusan National UniversityMiryang 50463Republic of Korea Department of Biology and Chemistry Changwon National UniversityChangwon 51140Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang 50463Republic of Korea

Objective:To establish an efficacious and efficient fermentation method of enhancing the anti-adipogenesis effect of mulberry(Morus alba) leaves using Cordyceps ***:Dried mulberry leaves,dried mulberry leaves with50% raw silkworm pupa and raw silkworm pupa were fermented with Cordyceps militais for 4 weeks at 25℃,after which the dried mulberry leaves and fermented product were extracted with 70%ethanol and subjected to high performance liquid chromatography(HPLC).The contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid were *** then used the 3 T3-L1 cells to investigate whether extracts of fermentation enhanced anti-adipogenesis activity in ***:HPLC showed that fermentation changed the contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic ***,fermented dried mulberry leaves with 50% raw silkworm pupa had a better efficacy of anti-adipogenesis than dried mulberry leaves,fermented dried mulberry leaves and fermented silkworm pupa and inhibited triglycerides accumulation and glucose ***,fermented dried mulberry leaves with50% raw silkworm pupa inhibited PPAR-γ ***:Fermentation with Cordyceps militaris enhanced antiadipogenesis efficacy of mulberry leaves.

关键词： dried fermentation silkworm