检索结果-南通市图书馆

Modulation of Neuroimmune Responses on Glia in the Central Nervous System： Implication in Therapeutic Intervention against Neuroinflammation

引用

Cellular & Molecular Immunology 2009年第5期6卷 317-326页

作者： Raymond Chuen-chung Chang Kin Chiu Yuen-Shan Ho Kwok-Fai so Laboratory of Neurodegenerative Diseases Depamnent of Anatomy LKSFaculty of Medicine University of Hong Kong Pokfulam Hong KongSAR China Research Centre of Heart Brain Hormone and Healthy Aging LKSFaculty of Medicine University of Hong Kong Pokfulam Hong KongSAR China State Key Laboratory for Brain and Cognitive Sciences University of HongKong. Pokfulam Hong Kong SAR China Department of Anatomy LKS Faculty of Miedicine The University of Hong Kong Rm.

It has long been known that the brain is an immunologically privileged site in normal conditions. Although the cascade of immune responses can occur as long as there is a neuronal injury or a potent immune stimulation, how the brain keeps glial cells in a quiescent state is still unclear. Increasing efforts have been made by several laboratories to elucidate how repression oi~ immune responses is achieved in the neuronal environment. The suppression factors include neurotransmitters, neurohormones, neurotrophic factors, anti-inflammatory factors, and cell-cell contact via adhesion molecules or CD200 receptor. This review discusses how these factors affect the cascade of cerebral immune responses because no single factor listed above can fully account for the immune suppression. While several factors contribute to the suppression of immune responses, activation of glial cells and their production of pro-inflammatory factors do occur as long as there is a neuronal injury, suggesting that some neuronal components facilitate immune responses. This review also discusses which signals initiate or augment cerebral immune responses so that stimulatory signals override the suppressive signals. Increasing lines of evidence have demonstrated that immune responses in the brain are not always detrimental to neurons. Attempt to simply clear off inflammatory factors in the CNS may not be appropriate for neurons in neurological disorders. Appropriate control of immune cells in the CNS may be beneficial to neurons or even neuroregeneration. Therefore, understanding the mechanisms underlying immune suppression may help us to reshape pharmacological interventions against inflammation in many neurological disorders.

关键词： neural cell adhesion molecule neurotrophins potassium ions microglia neuroinflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NON-INVASIVE MEASUREMENT OF DEEP TISSUE TEMPERATURE CHANGES CAUSED BY APOPTOSIS DURING BREAST CANCER NEOADJUVANT CHEMOTHERAPY:A CASE STUDY

引用

Journal of Innovative Optical Health Sciences 2011年第4期4卷 361-372页

作者： so HYUN chung RITA MEHTA BRUCE J.TROMBERG A.G.YODH Department of Physics and Astronomy University of Pennsylvania 209 S.33rd StPhiladelphiaPA 19104USA Department of Medicine UC Irvine Healthcare 101 The City Drive SouthOrangeCA 92868USA Beckman Laser Institute Department of Biomedical Engineering University of CaliforniaIrvine1002 Health Sciences Rd IrvineCA 92612USA

Treatment-induced apoptosis of cancer cells is one goal of cancer ***,more heat is generated by mitochondria during apoptosis,especially the uncoupled apoptotic state,^(1,2) compared to the resting *** this case study,we explore these thermal effects by longitudinally measuring temperature variations in a breast lesion of a pathological complete responder during neoadjuvant chemotherapy(NAC).Diffuse Optical Spectroscopic Imaging(DOSI)was employed to derive absolute deep tissue temperature using subtle spectral features of the water peak at 975 nm.^(3)A significant temperature increase was observed in time windows during the anthracycline and cyclophosphamide(AC)regimen but not in the paclitaxel and bevacizumab *** concentration changes generally did not follow temperature,suggesting the measured temperature increases were likely due to mitochondrial uncoupling rather than a direct vascular effect.A simultaneous increase of tissue oxygen saturation with temperature was observed,suggesting that oxidative stress also contributes to *** preliminary,this study indicates longitudinal DOSI tissue temperature monitoring provides information that can improve our understanding of the mechanisms of tissue response during NAC.

关键词： Deep tissue temperature Diffuse Optical Spectroscopic Imaging apoptosis neoadjuvant chemotherapy breast cancer Bound Water Index NIR water absorption spectrum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

引用

Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi song Yao Wang Jacqueline Pui Wah chung Tak Hang Chan Roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integration of 1H-NMR-Based Metabolomics Approach with Traditional Chinese Pulse Diagnosis to Evaluate the Qi-Enhancing Activity of Herbal Tea

引用

Chinese Medicine 2024年第3期15卷 49-74页

作者： Chia-Hsin Lin Po-Jung Huang chung-Hsuan Wang Mo-Rong Xu Sheng-Yang Wang Department of Forestry Chung Hsing University Taichung Fu Kang Traditional Chinese Medicine Clinic Nantou Special Crop and Metabolome Discipline Cluster Academy Circle Economy Chung Hsing University Taichung Agricultural Biotechnology Research Institute Academia Sinica Taipei City

Human metabolism is intricately linked to an individual’s health status. Regardless of living habits, it will be reflected in the metabolic characteristics of urine. The utilization of the 1H NMR-based metabolomics method has enabled examine the metabolomic changes in urine under various physiology conditions, providing valuable insights into metabolites. In this particular study, volunteers were divided into two groups based on the strength of their spleen pulses, using the pulse diagnosis method employed in traditional Chinese medicine. Subsequently, their urine samples were analyzed, revealing notable variances in urea, creatinine, citric acid, succinic acid, trimethylamine-N-oxide (TMAO), alanine, hippuric acid, and glycine between the two groups. Interestingly, individuals with weak spleen pulses showed significant improvements after consuming herbal tea. Furthermore, we conducted LC-MS analysis on herbal tea and performed adenosine triphosphate (ATP) activity tests on the C2C12 mouse skeletal muscle cell line. The results indicated that within a reasonable concentration range, exposure to herbal tea led to an increase in the mitochondrial ATP production capacity of C2C12 cells. These findings shed light on the relationship between traditional Chinese medicine pulse diagnosis and urine metabolites, highlighting their potential as non-invasive and straightforward health assessment indicators. They can aid in the preliminary determination of necessary dietary and lifestyle changes to enhance overall bodily health.

关键词： 1H-NMR Metabolomics Traditional Chinese Pulse Diagnosis Qi-Enhancing Herbal Tea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier

引用

Neural Regeneration Research 2020年第12期15卷 2344-2352页

作者： Xue-song Mi Qian Feng Amy Cheuk Yin Lo Raymond Chuen-chung Chang sookja Kim chung Kwok-Fai so Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Changsha Academician Expert Workstation Aier Eye Hospital GroupChangshaHunan ProvinceChina State Key Laboratory of Brain and Cognitive Sciences Hong Kong Special Administrative RegionChina Department of Ophthalmology The University of Hong KongHong Kong Special Administrative RegionChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administrative RegionChina School of Biomedical Science LKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Our previous study verified the protective effects of Lycium barbarum polysaccharides(LBP)on retinal neurons and blood vessels in acute ocular hypertension(AOH)*** investigate the effect of LBP on the reactivity of retinal glial cells,an AOH mouse model was established in one eye by maintaining ocular hypertension of 90 mm Hg for 60 *** LBP solution(1 mg/kg)or phosphate-buffered saline was administrated to the mice by gavage daily,starting 7 days before the AOH insult and continuing until the mice were sacrificed for specimen collection on day 4 *** AOH insult,increased numbers of astrocytes and microglia were observed,together with decreased expression of the following glial cell biomarkers in the retinal ganglion cells of AOH mice:glial fibrillary acidic protein,glutamine synthetase,aquaporin-4,S-100 proteins,ionized calcium-binding adaptor molecule 1,amyloid precursor protein and receptor of advanced glycosylation *** intervention with LBP,the above changes were significantly ***,morphological remodeling of blood vessel-associated retinal astrocytes,marked by glial fibrillary acidic protein,was also *** results,taken together,suggest that LBP regulated the production of amyloid-βand expression of receptor of advanced glycosylation end-products,as well as mediating the activity of retinal glial cells,which may lead to the promotion of better maintenance of the blood-retinal barrier and improved neuronal survival in AOH *** study was approved by the Committee for the Use of Live Animals in Teaching and Research(approval ***-#1664-08).

关键词： astrocyte blood-retinal barrier glial cell Lycium barbarum microglia model plasticity remodel retina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ocular image-based deep learning for predicting refractive error:A systematic review

引用

Advances in Ophthalmology Practice and Research 2024年第3期4卷 164-172页

作者： Samantha Min Er Yew Yibing Chen Jocelyn Hui Lin Goh David Ziyou Chen Marcus Chun Jin Tan Ching-Yu Cheng Victor Teck Chang Koh Yih chung Tham Department of Ophthalmology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Centre for Innovation and Precision Eye Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Department of Ophthalmology National University HospitalSingapore Ophthalmology and Visual Sciences(Eye ACP) Duke-NUS Medical SchoolSingapore

ackground:Uncorrected refractive error is a major cause of vision impairment worldwide and its increasing prevalent necessitates effective screening and management ***,deep learning,a subset of Artificial Intelligence,has significantly advanced ophthalmological diagnostics by automating tasks that required extensive clinical *** recent studies have investigated the use of deep learning models for refractive power detection through various imaging techniques,a comprehensive systematic review on this topic is has yet be *** review aims to summarise and evaluate the performance of ocular image-based deep learning models in predicting refractive *** text:We search on three databases(PubMed,Scopus,Web of Science)up till June 2023,focusing on deep learning applications in detecting refractive error from ocular *** included studies that had reported refractive error outcomes,regardless of publication *** systematically extracted and evaluated the continuous outcomes(sphere,SE,cylinder)and categorical outcomes(myopia),ground truth measurements,ocular imaging modalities,deep learning models,and performance metrics,adhering to PRISMA *** studies were identified and categorised into three groups:retinal photo-based(n=5),OCT-based(n=1),and external ocular photo-based(n=3).For high myopia prediction,retinal photo-based models achieved AUC between 0.91 and 0.98,sensitivity levels between 85.10%and 97.80%,and specificity levels between 76.40%and 94.50%.For continuous prediction,retinal photo-based models reported MAE ranging from 0.31D to 2.19D,and R^(2) between 0.05 and *** OCT-based model achieved an AUC of 0.79–0.81,sensitivity of 82.30%and 87.20%and specificity of 61.70%–68.90%.For external ocular photo-based models,the AUC ranged from 0.91 to 0.99,sensitivity of 81.13%–84.00%and specificity of 74.00%–86.42%,MAE ranges from 0.07D to 0.18D and accuracy ranges from 81.60%to 96.70%.The reported papers colle

关键词： Deep Learning Artificial Intelligence Refractive Error Retinal images Optical Coherence Tomography Photorefraction Ocular images Prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analytical solution for one-dimensional nonlinear consolidation of saturated multi-layered soil under time-dependent loading

引用

Journal of Ocean Engineering and Science 2021年第1期6卷 21-29页

作者： Pyol Kim Hyong-Sik Kim Chol-U Pak chung-Hyok Paek Gun-hyang Ri Hak-Bom Myong Faculty of Geology Kim Il Sung UniversityPyongyang 999093Democratic People’s Republic of Korea

This paper presents analytical solutions for one-dimensional nonlinear consolidation of saturated multi-layered soil under time-dependent *** solutions are derived for one-dimensional nonlinear consolidation of multi-layered soil subjected to constant loading and ramp *** proposed solutions are verified through the comparison with the existing solutions for double-layered soil and singlelayered soil,which shows the proposed solutions are more general ones for one-dimensional nonlinear consolidation of saturated soils subjected to time-dependent *** on the proposed solutions,nonlinear consolidation behavior of saturated multi-layered soil under time-dependent loading is investigated.

关键词： Saturated soil Multi-layered Nonlinear consolidation Analytical solution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma

引用

Neural Regeneration Research 2012年第9期7卷 645-651页

作者： Xue-song Mi Kin Chiu Geoffrey Van Justin Wai chung Leung Amy Cheuk Yin Lo sookjaKim chung Raymond Chuen-chung Chang Kwok-Fai so Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Eye Institute Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Research Centre of Heart BrainHormone and Healthy AgingLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina The Joint Laboratory for Brain Function and Health （BFAH） Jinan University and The University of Hong Kong Guangzhou 510632Guangdong Province China

Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells （RGCs） in a rat chronic ocular hypertension （COH） model. Here, we investigated the expression of endothelin-1 （ET-1）, a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure （IOP） was induced in the right eye of SD rats using argon laser photocoagulation. （1） The expression of ET-1, ETA and ETB in normal and COH retinas was studied. （2） some COH rats were fed daily with Lycium barbarum Polysaccharides （LBP） using 1 mg/kg or phosphate-buffered saline （PBS） for 3 weeks （started 1 week before photocoagulation）. The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that （1） Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. （2） After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. （3） By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature.

关键词： retinal ganglion cell Lycium barbarum Polysaccharides glaucoma endothelin-1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The use of hydrogel microspheres as cell and drug delivery carriers for bone,cartilage,and soft tissue regeneration

引用

Biomaterials Translational 2024年第3期5卷 236-256页

作者： chung-Hsun Lin Jesse RSrioudom Wei Sun Malcolm Xing Su Yan Le Yu Jian Yang Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPAUSA Department of Bioengineering University of PennsylvaniaPhiladelphiaPAUSA Leicester International Institute Dalian University of TechnologyPanjinLiaoning ProvinceChina Department of Mechanical Engineering University of ManitobaWinnipegCanada Division of Biological and Biomedical Systems University of Missouri-Kansas CityKansas CityMOUSA Biomedical Engineering Program Westlake UniversityHangzhouZhejiang ProvinceChina Research Centre for Industries of the Future Westlake UniversityHangzhouZhejiang ProvinceChina

Bone,cartilage,and soft tissue regeneration is a complex process involving many cellular activities across various cell *** remain the“gold standard”for the regeneration of these ***,the use of autografts is associated with many disadvantages,including donor scarcity,the requirement of multiple surgeries,and the risk of *** development of tissue engineering techniques opens new avenues for enhanced tissue ***,the expectations of tissue engineering scaffolds have gone beyond merely providing physical support for cell *** scaffolds should also provide biological cues to actively boost tissue *** a new type of injectable biomaterial,hydrogel microspheres have been increasingly recognised as promising therapeutic carriers for the local delivery of cells and drugs to enhance tissue *** to traditional tissue engineering scaffolds and bulk hydrogel,hydrogel microspheres possess distinct advantages,including less invasive delivery,larger surface area,higher transparency for visualisation,and greater flexibility for ***,we review the materials characteristics of hydrogel microspheres and compare their fabrication approaches,including microfluidics,batch emulsion,electrohydrodynamic spraying,lithography,and mechanical ***,based on the different requirements for bone,cartilage,nerve,skin,and muscle tissue regeneration,we summarize the applications of hydrogel microspheres as cell and drug delivery carriers for the regeneration of these ***,hydrogel microspheres are regarded as effective therapeutic delivery carriers to enhance tissue regeneration in regenerative ***,significant effort is required before hydrogel microspheres become widely accepted as commercial products for clinical use.

关键词： drug delivery fabrication techniques hydrogel microspheres microgels tissue regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中学生领导力培养现状与优化策略研究 ——以马来西亚华文独中K中学为例

中学生领导力培养现状与优化策略研究 ——以马来西亚华文独中K中...

引用

作者：彭忠祥（Pang chung Seong）华东师范大学

学位级别：硕士

随着2018年《马来西亚华文独中教育大蓝图》的颁布,提升了独中老师对中学生领导力培养的广泛关注。中学生领导力培养策略的优化,是为马来西亚独中教师勾勒出培养学生具备领导素养、领导行为及领导技能的过程,它是学生发展核心素养的路径... 详细信息

随着2018年《马来西亚华文独中教育大蓝图》的颁布,提升了独中老师对中学生领导力培养的广泛关注。中学生领导力培养策略的优化,是为马来西亚独中教师勾勒出培养学生具备领导素养、领导行为及领导技能的过程,它是学生发展核心素养的路径,也是“21世纪技能”中所强调的育人目标。研究证明,中学生领导力培养策略的优化是提升中学生领导力的关键。然而,中学生领导力培养现状无法给予对学生综合素养带来积极的发展。现有关于中学生领导力培养现状与优化策略的研究文献,有的着重于理论构建,有的则针对特定群体进行案例研究,不过对马来西亚华文独中学生领导力培养的案例样本称得上是绝无仅有。以马来西亚中学生领导力框架为基准,我们须要思考:当前华文独立中学对学生领导力的开发与培养已有哪些具体的行动策略,有哪些不足之处,须要改进与完善的具体内容来保障优化策略的有效推进。本文采用质性研究,通过文献梳理、问卷调查及访谈法,对吉隆坡K中学学生领导力培养现阶段的实施情况展开调研,综合地把握中学生领导力培养的内在本质,进而探析学生领导力培养中的问题与成因。通过对典型学校案例的研究分析以及与受访者的访谈内容分析,本人发现:K中学在中学生领导力培养开发与管理上缺乏有系统的课程规划、资源管理结构不完善的问题。针对上述问题,本研究以中学生领导力模型与课程发展理论为切入点,提出中学生领导力培养的优化策略,通过有系统地管理来提高中学生领导力培养效能,具体为:第一,构建完善的中学生领导力培养课程;第二,统整家校社区资源,促进学生领导力的发展和提高学生综合素质;第三,建立以能力发展为导向的领导人才梯队。

关键词：中学生领导力培养课程开发资源管理

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：