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Wearable bioelectronics fabricated in situ on skins

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npj Flexible Electronics 2023年第1期7卷 229-243页

作者： Faheem Ershad Shubham patel Cunjiang Yu Department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA 16801USA Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16801USA Department of Materials Science and Engineering Materials Research InstitutePennsylvania State UniversityUniversity ParkPA 16801USA

In recent years,wearable bioelectronics has rapidly expanded for diagnosing,monitoring,and treating various pathological conditions from the skin *** the devices are typically prefabricated as soft patches for general usage,there is a growing need for devices that are customized in situ to provide accurate data and precise *** this perspective,the stateof-the-art in situ fabricated wearable bioelectronics are summarized,focusing primarily on Drawn-on-Skin(DoS)bioelectronics and other in situ fabrication *** advantages and limitations of these technologies are evaluated and potential future directions are suggested for the widespread adoption of these technologies in everyday life.

关键词： everyday electronics typically

The robot-assisted ureteral reconstruction in adult:A narrative review on the surgical techniques and contemporary outcomes

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Asian Journal of Urology 2021年第1期8卷 38-49页

作者： Kulthe ramesh Seetharam Bhat Marcio Covas Moschovas Vipul r.patel Young Hwii Ko Department of Urology AdventHealth Global Robotics InstituteCelebrationFLUnited States Department of Urology Yeungnam UniversityDaeguRepublic of Korea

Despite the rapid increase in the use of robotic surgery in urology,the majority of ureteric reconstruction procedures are still performed using laparoscopic or open *** is primarily due to uncertainty regarding the advantages of robotic approaches over conventional ones,and the unique difficulty in identifying the specific area of interest due to the lack of tactile feedback from the current robotic ***,with the potential benefits of minimal invasiveness,several pioneering reports have been published on robotic surgery in *** reviewing the literature on this topic,we aimed to summarize the techniques,considerations,and consistent findings regarding robotic ureteral reconstruction in *** applications for ureteral surgery have been primarily reported for pediatric urology,especially in the context of relieving a congenital obstruction in the ureteral pelvic ***,contemporary studies have also consistently demonstrated that robotic surgery could be a reliable option for malignant,iatrogenic,and traumatic conditions,which generally occur in adult ***,the lack of comparative studies on heterogeneous hosts and disease conditions make it difficult to determine the benefit of the robotic approach over the conventional approach in the general population;thus,qualified prospective trials are needed for wider ***,contemporary reports have demonstrated that the robotic approach could be an alternative option for ureteral construction,even in the absence of haptic feedback,which can be compensated by various surgical techniques and enhanced three-dimensional visualization.

关键词： robotic reconstructive surgery Ureteric reconstruction Surgical techniques robotic pyeloplasty

Provenance variations in proximate principles,mineral matter,total phenols and phytochemicals of Melia dubia drupes:an unexplored alternate livestock feed stock

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Journal of Forestry research 2021年第1期32卷 119-131页

作者： M.L.Sukhadiya N.S.Thakur V.r.patel r.P.Gunaga V.B.Kharadi K.K.Tyagi Susheel Singh Department of Silviculture and Agroforestry College of ForestryNavsari Agricultural UniversityNavsariGujarat 396450India Department of Animal Nutrition Vanbandhu College of Veterinary Sciences and Animal HusbandryNavsari Agricultural UniversityNavsariGujarat 396450India Food Quality Testing Laboratory N.M.College of AgricultureNavsari Agricultural UniversityNavsariGujarat 396450India Sardar Vallabhbhai patel University of Agriculture and Technology MeerutIndia

This research was carried out on nine provenances from the north Western Ghats to quantify proximate principles,mineral matter,total phenols and other phytochemicals in Melia dubia drupe *** biometric,biomass attributes,proximate principles,mineral matter and total phenols diff ered signifi cantly among the *** average drupe length and width was 26.5 and 22.3 mm,*** drupe and pulp fresh weight,pulp dry weight and stone weight were 783.1,552.1,165.1,and 179.8 g/100 drupes,***,dry matter and moisture per cent were 70.5%,29.9%and 70.0%,*** crude fi bre,protein,ether extract,total ash and nitrogen-free extract were 8.3%,7.6%,5.1%,6.3%,and 72.6%,*** Ca,Mg,P and K levels were 0.5%,0.2%,0.2%,and 2.0%,*** phenols were 0.4%.Cluster analysis showed that the study area may be divided into three distinct provenances,each having diff erent drupe traits and proximate composition,including mineral ***-chromatography mass-spectrometry analysis revealed 27 phytochemicals,many of which possess benefi cial biological *** implications of this provenance variation study should be useful for future improvement in terms of better drupe pulp nutrition for livestock *** study suggests that *** pulp could be categorized as a good feed source with low fi bre,energy,fat and mineral *** proximate parameters,mineral matter content and total phenols are within prescribed limits.

关键词： Melia dubia Drupe pulp Proximate principles Minerals Phytochemicals

Decay properties of D and D_s mesons in coulomb plus power potential (CPP_ν)

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Chinese Physics C 2010年第9期34卷 1497-1499页

作者： B.patel P.C.Vinodkumar LDrP- Institute of Technology and research Department of Physics Sardar Patel University

The decay properties of the D and D s mesons are computed in a nonrelativistic phenomenological quark-antiquark potential of the type V （r） =-4 /3 α s /r＋ Ar ν with different choices of ν.Numerical method to solve the Schrdinger equation has been used to obtain the spectroscopy of qQ *** numerically obtained radial solutions are employed to obtain the decay constant and leptonic decay *** has been observed that predictions of the ground state masses and the decay widths are consistent with other model predictions as well as with the known experimental values.

关键词： open charm mesons potential models leptonic decay widths

Self-powered transparent photodetector for subretinal visual functions of wide-field-of-view and broadband perception

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InfoMat 2023年第6期5卷 89-101页

作者： Priyanka Bhatnagar Malkeshkumar patel Kibum Lee Joondong Kim Photoelectric and Energy Device Application Lab(PEDAL) Multidisciplinary Core Institute for Future Energies(MCIFE)Incheon National UniversityIncheonRepublic of Korea Department of Electrical Engineering Incheon National UniversityIncheonRepublic of Korea Solarlight Ltd. IncheonRepublic of Korea

Natural photoreceptors enable color vision in humans,wherein the eyes detect colors and their corresponding intensities via cone and rod photoreceptors,***,we developed an artificial broadband photoreceptor with light-color intensity detection similar to that of natural *** developed photoreceptor operates in the self-powered mode and is capable of broadband perception(365–940 nm).The designed metal-oxide heterojunction(n-ZnO/p-NiO)photoreceptor with a thin tin sulfide layer embedded in between is capable of perceiving various *** exhibits good transparency in the visible range and displays excellent integration with flexible substrates,highlighting its potential for use in flexible *** fabricated structure has an exceptional response time(≈1 ms)and a wide-field-of-view(150?)compared to the human eye's sensing range(50–100 ms and 108?).The transparent photorecep-tor mimics cones and rods to detect a various wavelength-dependent signals and explicitly differentiate between the intensities of the detected signals,*** is further illustrated by employing the developed photoreceptor to detect colors in real time by generating unique signals corresponding to each *** demonstration provides the proof of concept for self-biased flexible bioelectronics emulating high-performing visual functions of artificial eyes.

关键词： artificial eye broadband retinal visual function transparent photoreceptor wide-field-of-view

Multidrug resistance associated proteins in multidrug resistance

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Chinese Journal of Cancer 2012年第2期31卷 58-72页

作者： Kamlesh Sodani Atish patel rishil J.Kathawala Department of Pharmaceutical Sciences College of Pharmacy and Allied Health ProfessionsSt.John's UniversityQueensNY 11439USA

Multidrug resistance proteins(MrPs) are members of the C family of a group of proteins named ATP-binding cassette(ABC) *** ABC transporters together form the largest branch of proteins within the human *** MrP family comprises of 13 members,of which MrP1 to MrP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the *** are mainly lipophilic anionic transporters and are reported to transport free or conjugates of glutathione(GSH),glucuronate,or *** addition,MrP1 to MrP3 can transport neutral organic drugs in free form in the presence of free ***,MrPs can transport drugs that differ structurally and mechanistically,including natural anticancer drugs,nucleoside analogs,antimetabolites,and tyrosine kinase *** of these MrPs transport physiologically important anions such as leukotriene C4,bilirubin glucuronide,and cyclic *** review focuses mainly on the physiological functions,cellular resistance characteristics,and probable in vivo role of MrP1 to MrP9.

关键词：多药耐药相关蛋白酪氨酸激酶抑制剂葡萄糖醛酸 MrPs 离子转运抗癌药物肿瘤细胞

There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes Marina C.Waiteman Liliam B.Priore Neal r.Glaviano David M.Bazett-Jones ronaldo V.Briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,SPOrTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis patellar tendinopathy patellofemoral pain

Optimization of enzymatic hydrolysis of pigeon pea for cooking quality of dhal

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International Journal of Agricultural and Biological Engineering 2014年第5期7卷 123-132页

作者： V.P.Sangani N.C.patel V.M.Bhatt P.r.Davara D.K.Antala Department of Processing and Food Engineering College of Agricultural Engineering and TechnologyJunagadh Agricultural UniversityJunagadhGujaratIndia Anand Agricultural University AnandGujaratIndia

Cooking quality of dehusked splits is influenced by the dehulling method,in particular,by the pre-milling *** effects of four enzymatic hydrolysis parameters,i.e.,enzyme concentration(20-60 mg/100 g dry matter),incubation time(3-15 h),incubation temperature(40-60℃)and tempering water pH(4.0-6.0)on cooking time of pigeon pea dhal were optimized using response surface *** kinds of enzymes,i.e.,xylanase,pectinase,and cellulas were used in combination for enzymatic pre-treatment.A quadratic model satisfactorily described the dehulling efficiency with high value for the coefficient of determination r^(2)(0.9062).It predicted a minimum cooking time of 21.91 min at enzyme concentration of 37.8 mg/100 g dry matter,incubation time 8.69 min,incubation temperature 48.5℃ and pH 5.49 of tempering *** time at optimum condition was observed to be 21.50 min and the predicted values of cooking time showed 2.19% deviation from the experimental *** of the study revealed that cooking time of enzyme treated dhal could be decreased by 19.77% compared to the oil treated dhal.

关键词： pigeon pea enzymatic hydrolysis cooking quality enzymatic pre-treatment dehulling response surface methodology

Intestinal M cells:The fallible sentinels?

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World Journal of Gastroenterology 2007年第10期13卷 1477-1486页

作者： Harvey Miller rhonda KuoLee Girishchandra B patel Institute for Biological Sciences National Research Council Canada 100 Sussex Drive Ottawa Ontario K1A 0R6 Canada

The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense against mucosal microbial pathogens and it plays a crucial role in maintaining mucosal homeostasis. Membranous or microfold cells, commonly referred to as microfold cells, are specialized epithelial cells of the gut-associated lymphoid tissues (GALT) and they play a sentinel role for the intestinal immune system by delivering luminal antigens through the follicle-associated epithelium to the underlying immune cells. M cells sample and uptake antigens at their apical membrane, encase them in vesicles to transport them to the basolateral membrane of M cells, and from there deliver antigens to the nearby lymphocytes. On the flip side, some intestinal pathogens exploit M cells as their portal of entry to invade the host and cause infections. In this article, we briefly review our current knowledge on the morphology, development, and function of M cells, with an emphasis on their dual role in the pathogenesis of gut infection and in the development of host mucosal immunity.

关键词： M cell Gastrointestinal Development Pathogenesis Mucosal immunity