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Influence of the Percentage of Polar and Non-polar Amino-acids in the β-tubulin gene of the Nematophagous fungus: Arthrobotrys musiformis in conferring Benzimidazole resistance

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Influence of the Percentage of Polar and Non-polar Amino-aci...

Numerical analysis of hemodynamic parameters in stenosed arteries under pulsatile flow conditions

2012 4th International Conference on Bioinformatics and Biomedical Technology（ICBBT 2012）

作者： B.M.S.Jarullah K.Katudia r.B.Subramanian S.Kajal J.S.Jarullah Department of Biotechnology Kadi Sarva Vishwavidyalaya Gandhinagar-382023 Gujarat India BrD School of Biosciences Sardar Patel UniversityVallabh Vidyanagar-388120 Gujarat India King Fahad Medical research Center Faculty of Medicine King Abdul Aziz UniversityJeddah Saudi Arabia

Arthrobotrys musiformis is a biocontrol agent which can be used in the integrated pest management strategies. Although this isolate was found to show high benzimidazole resistance as compared to the other biocontrol agents, considering the dose of administration of anthelmintics, a need for developing an improved strain of this fungus resistant to chemical anthelimintics was observed. In our earlier study improved strains of Arthrobotrys musiformis were obtained using random mutagenesis technique. reports suggest benzimidazole resistance to be caused by point mutations in β-tubulin gene. The current study therefore focuses on analyzing the β-tubulin genes of the selected mutants in comparison with the wild type fungus to understand its role in benzimidazole resistance. All the mutants were analyzed for their LD50 values followed by sequencing of the β-tubulin genes. A cladogram was generated of the sequenced β-tubulin genes followed by a detailed study of the sequences in terms of their amino acid composition and mutations. The results suggest increased percentage of non-polar amino acids in the β-tubulin gene to confer higher benzimidazole resistance to this fungus.

关键词： β-tubulin genes Arthrobotrys musiformis benzimidazole non-polar amino acids

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Medicine in Novel Technology and Devices 2023年第4期20卷 32-50页

作者： Priyambada Praharaj Chandrakant Sonawane Anand Pandey Vikas Kumar Arundhati Warke Hitesh Panchal r.Ibrahim Chander Prakash Jayawant Shikshan Prasarak Mandal(JSPM)’s rajarshi Shahu College of Engineering PuneIndia Symbiosis Institute of Technology Symbiosis International Deemed UniversityPuneIndia Centre for Development of Advanced Computing(CDAC) PuneIndia Department of Mechanical Engineering Government Engineering College patanGujaratIndia Department of medical instruments engineering techniques Al-farahidi UniversityBaghdadIraq research&Developemnt SVKM’S Narsee Monjee Institute of Management StudiesMumbaiIndia Mukesh patel School of Technology Management and Engineering SVKM’S Narsee Monjee Institute of Management StudiesMumbaiIndia

This research studies the changes in flow patterns and hemodynamic parameters of diverse shapes and sizes of *** different shapes and sizes of stenosis are constructed to investigate the variations in hemodynamics as the morphology *** in shape(trapezoidal and bell-shaped)and sizes of stenosis change the stresses on the walls and their flow *** and OSI results specify that trapezoidal stenosis exerts greater stress than bell-shaped ***,as the length of the trapezoidal stenosis increases,the TAWSS increases,whereas the trend is the opposite for bell-shaped ***,this paper also studies different degrees of stenosis extracted from real *** in velocity flow patterns,wall shear stress(WSS),Time-averaged wall shear stress(TAWSS)and Oscillatory shear index(OSI)have been studied for these *** illustrate that the peak velocity rises drastically as the stenosis percentage *** velocity is seen close to the artery's walls,indicating flow *** flow separation region is seen throughout the cycle except in the accelerating flow *** increase in stenosis also increases WSS and TAWSS *** WSS is seen downstream of stenosis,indicating flow *** negative WSS in the blood vessels also promotes endothelial *** values greater than 0.2 are seen near the stenosis region,indicating atherosclerosis *** of high OSI and low TAWSS are also identified,indicating probable regions of plaque development.

关键词： Cardiovascular Stenosis morphology real geometry CFD simulation Artificial compressibility method HLLC-AC Pulsatile velocity

Search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： r.Aaij C.Abellin Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmaver J.J.Back S.Baker P.Baladron rodriguez V.Balagura W.Baldinit J.Baptista Leite r.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.r.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai r.Calabrese L.Calefice L.Calero Diaz S.Cali r.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni r.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do riode Janeiro(UFrJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di roma Tor Vergata RomaItaly INFN Sezione di roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

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1α-羟基维生素D2抑制转基因鼠眼色素性肿瘤生长中的作用

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美国医学会眼科杂志（中文版） 2005年第2期17卷 92-92页

作者： Daniel M. Albert Amit Kumar Stephen A. Strugnell Soesiawati r. Darjatmoko Janice M. Lokken Mary J. Lindstrom M. Damico Sarit patel 刘敬（译）

目的：研究羟基维生素D2（1α-OH-D2）对由病毒40T和大鼠胰蛋白酶基因控制的t抗原形成的“Tyr-Tag”转基因大鼠的眼部色素性肿瘤的抑制作用。这些动物的眼部色素性肿瘤主要来源于视网膜色素上皮，与人脉络膜黑色素瘤的生长和组织特点非... 详细信息

目的：研究羟基维生素D2（1α-OH-D2）对由病毒40T和大鼠胰蛋白酶基因控制的t抗原形成的“Tyr-Tag”转基因大鼠的眼部色素性肿瘤的抑制作用。这些动物的眼部色素性肿瘤主要来源于视网膜色素上皮，与人脉络膜黑色素瘤的生长和组织特点非常相似。方法：73只6-7周Tyr—Tag转基因大鼠，根据性别和窝别随机分为3组，分别使用0．05μg/d、0．1μg／d、0．2μg／d 1α-OH-D2；对照组服用椰子油。口服药物每周5次，连服3周。动物被麻醉后，摘除眼球，进行组织学检查。每只眼球制作3个连续切片，应用Optimus softmware version 6．5（Media Cybernetic LP，Silver Spring，Md）分析。根据致死率、体重和血钙水平评价药物的毒副作用。

关键词：羟基维生素肿瘤生长色素性维生素D2 转基因鼠转基因大鼠视网膜色素上皮脉络膜黑色素瘤 version Spring

Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction

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Chinese Physics C 2016年第1期40卷 1-16页

作者： O.Kochebina M.Kolpin I.Komarov r.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni r.Le Gac J.van Leerdam J.-P.Lees r.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington Y.Li T.Likhomanenko M.Liles r.Lindner C.Linn F.Lionetto B.Liu X.Liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri r.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab r.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris r.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada r.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess r.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko r.Oldeman C.J.G.Onderwater B.Osorio rodrigues J.M.Otalora Goicochea A.Otto P.Owen A.Oyanguren A.Palano F.Palombo M.Palutan J.Panman A.Papanestis M.Pappagallo L.L.Pappalardo C.Pappenheimer C.Parkes G.Passaleva G.D.patel M.patel C.Patrignani A.Pearce A.Pellegrino G.Penso M.Pepe Altarelli S.Perazzini P.Perret L.Pescatore K.Petridis A.Petrolini M.Petruzzo E.Picatoste Olloqui B.Pietrzyk T:.Pilar D.Pinci A.Pistone A.Piucci S.Playfer M.Plo Casasus T.Poikela F.Polci A.Poluektov I.Polyakov E.Polycarpo A.Popov D.Popov B.Popovici C.Potterat E.Price J.D.Price J.Prisciandaro A.Pritchard Centro Brasileiro de Pesquisas Ffsicas(CBPF) Rio de JaneiroBrazil Universidade Federal do rio de Janeiro(UFrJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina LAPP Universite Savoie Mont-BlancCNRS/IN2P3Annecy-Le-VieuxFrance Clermont Universite Universite Blaise PascalCNRS/IN2P3LPCclermont-FerrandFrance CPPM Aix-Marseille UniversitYCNRS/IN2P3MarseilleFrance LAL Universite Paris-SudCNRS/IN2P3OrsayFrance LPNHE Universite Pierre et Marie CurieUniversite Paris DiderotCNRS/IN2P3ParisFrance Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-lnstitut fur Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland Sezione INFN di Bari BariItaly Sezione INFN di Bologna BolognaItaly Sezione INFN di Cagliari CagliariItaly Sezione INFN di Ferrara FerraraItaly Sezione INFN di Firenze FirenzeItaly Laboratori Nazionali dell'INFN di Prascati FrascatiItaly Sezione INFN di Genova GenovaItaly Sezione INFN di Milnno Bicocca MilunoItaly Sezione INFN di Milano MilanoItaly Sezione INFN di Padova PadovaItaly Sezione INFN di Pisa PisaItaly Sezione INFN di roma Tor Vergata RomaItaly Sezione INFN di roma La Sapienza RomaItaly Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences Krak6wPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakowPoland National Center for Nuclear research(NCBJ) WarsawPoland Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest-MagureleRomania Petersburg Nuclear Physics Institute(PNPI) GatchinaRussia Institute of Theoretical and Experimental Physics(ITEP) MoscowRussia Institute of Nuclear Physics Moscow State University(SINP MSU)MoscowRussia Institute for Nuclear research of the russian Academy of Sciences(INr rAN) MoscowRussia Budker Institute of Nuclear Physics(SB rAS)and Novosibirsk State University No

The product of the ∧0/b （-B/0） differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-（-B/0→ J/ψ-K＊（892）0）is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈*** measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B（∧0/b→ J/ψ pK-）=（3.17±0.04±0.07±0.34＋0.45/-0.28）×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K＊（892）0,and the fourth is due to the knowledge of f∧0/b/*** sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and *** previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P＋c（→ J/ψp）K-are determined.

关键词： production cross-section branching fraction b hadrons proton-proton collisions

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恒河猴实施粘弹物质小管切开术

美国医学会眼科杂志（中文版） 2005年第3期17卷 F0003-F0003页

作者： Ernst r. Tamm roberto G. Carassa Daniel M. Albert B＇ Ann T. Gabelt Sarit patel Carol A. rasmussen Paul L. Kaufman 陆遥（译）

目的：在活体正常猴眼上观察粘弹物质小管切开术后的结构变化和房水外流情况。

关键词：粘弹物质切开术恒河猴房水外流结构变化

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聚酯POY和DTY的结构性能比较分析

国际纺织导报 2020年第6期48卷 6-8,40页

作者： Y.Marathe r.Turukmane 李婷(译) 于俊荣(校) Mukesh patel技术管理与工程学院(印度) 不详

聚酯长丝的结构性能主要取决于纱线类型、长丝细度和形状等被认为对变形程度不利的因素。拉伸比、加热器温度和后纺工序等决定了长丝的性质及其适用性。研究旨在确定聚酯部分取向丝(POY)和拉伸变形丝(DTY)之间的结构差异。在标准设置的... 详细信息

聚酯长丝的结构性能主要取决于纱线类型、长丝细度和形状等被认为对变形程度不利的因素。拉伸比、加热器温度和后纺工序等决定了长丝的性质及其适用性。研究旨在确定聚酯部分取向丝(POY)和拉伸变形丝(DTY)之间的结构差异。在标准设置的拉伸变形机上加工线密度为160dtex/144f的POY卷装,并对其进行强度、伸长率和沸水收缩率测试。将成本低且强度高的扁平长丝结构纱线喂入拉伸变形机,使其转变为具有卷曲/蓬松纱线结构的纱线。所有试样均显示出良好的卷曲性能。新设计的拉伸变形花式纱线将可赋予服用纺织品和家居装饰织物以较高的附加值,并增加其舒适感。

关键词：部分取向纱拉伸变形丝结构性能

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2-6 First Direct Measurement of 12C(12C, n)23Mg at Stellar Energies

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IMP & HIrFL Annual report 2015年第1期 56-58页

作者： Tang Xiaodong B. Bucher X. Fang A. Heger S. Almaraz-Calderon A. Alongi A.D. Ayangeakaa M. Beard A. Best J. Browne C. Cahillane M. Couder r.J. deBoer A. Kontos L. Lamm Y.J. Li A. Long W. Lu S. Lyons M. Notani D. patel N. Paul M. Pignatari A. roberts D. robertson K. Smith E. Stech r. Talwar W.P. Tan M. Wiescher S.E. Woosley Institute of Modern Physics Chinese Academy of Science Lanzhou 730000 China Institute for Structure and Nuclear Astrophysics Joint Institute for Nuclear AstrophysicsUniversity of Notre Dame Notre Dame Indiana 46556 USA Lawrence Livermore National Laboratory Livermore California 94550 USA Monash Center for Astrophysics School of Physics and Astronomy Monash University Victoria 3800 Australia Department of Physics and Astronomy Shanghai Jiao-Tong University CNA Shanghai 200240 China School of Physics and Astronomy University of Minnesota Minneapolis Minnesota 55455 USA China Institute of Atomic Energy Beijing 102413 China Konkoly Observatory Research Centre for Astronomy and Earth Sciences Hungarian Academy of SciencesKonkoly Thege Mikl′os′ut 15-17 H-1121 Budapest Hungary Department of Physics University of Basel Basel CH-4056 Switzerland Department of Astronomy and Astrophysics University of California Santa Cruz California 95064 USA

The first stars in the early Universe were formed about 400 million years after the big bang. Verification of the existence of these stars is important for our understanding of the evolution of the Universe[1]. It has been predicted that for Population-III stellar production yields, the abundances of odd-Z elements are remarkably deficient compared to their adjacent even-Z elements[2]. Astronomers are searching for long-lived, low mass stars with the unique nucleosynthetic pattern matching the predicted yields[3].

关键词： First Direct Measurement

Search for the doubly charmed baryon ?cc+

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Science China(Physics,Mechanics & Astronomy) 2021年第10期Mechanics & Astronomy) .卷 6-17页

作者： r. Aaij C. Abellán Beteta T. Ackernley B. Adeva M. Adinolfi H. Afsharnia C. A. Aidala S. Aiola Z. Ajaltouni S. Akar J. Albrecht F. Alessio M. Alexander A. Alfonso Albero Z. Aliouche G. Alkhazov P. Alvarez Cartelle S. Amato Y. Amhis L. An L. Anderlini A. Andreianov M. Andreotti F. Archilli A. Artamonov M. Artuso K. Arzymatov E. Aslanides M. Atzeni B. Audurier S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura W. Baldini J. Baptista Leite r. J. Barlow S. Barsuk W. Barter M. Bartolini F. Baryshnikov J. M. Basels G. Bassi B. Batsukh A. Battig A. Bay M. Becker F. Bedeschi I. Bediaga A. Beiter V. Belavin S. Belin V. Bellee K. Belous I. Belov I. Belyaev G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet D. Berninghoff H. C. Bernstein C. Bertella A. Bertolin C. Betancourt F. Betti I. Bezshyiko S. Bhasin J. Bhom L. Bian M. S. Bieker S. Bifani P. Billoir M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti M. Bj?rn M. P. Blago T. Blake F. Blanc S. Blusk D. Bobulska J. A. Boelhauve O. Boente Garcia T. Boettcher A. Boldyrev A. Bondar N. Bondar S. Borghi M. Borisyak M. Borsato J. T. Borsuk S. A. Bouchiba T. J. V. Bowcock A. Boyer C. Bozzi M. J. Bradley S. Braun A. Brea rodriguez M. Brodski J. Brodzicka A. Brossa Gonzalo D. Brundu A. Buonaura C. Burr A. Bursche A. Butkevich J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai r. Calabrese L. Calefice L. Calero Diaz S. Cali r. Calladine M. Calvi M. Calvo Gomez P. Camargo Magalhaes P. Campana A. F. Campoverde Quezada S. Capelli L. Capriotti A. Carbone G. Carboni r. Cardinale A. Cardini I. Carli P. Carniti L. Carus K. Carvalho Akiba A. Casais Vidal G. Casse M. Cattaneo G. Cavallero S. Celani J. Cerasoli A. J. Chadwick M. G. Chapman M. Charles P. Charpentier G. Chatzikonstantinidis C. A. Chavez Barajas M. Chefdeville C. Chen S. Chen A. Chernov V. Chobanova S. Cholak M. Chrzaszcz A. Chubykin V. Chulikov P. Ciambrone M. F. Cicala X. Cid Vidal G. Ciezarek P. E. L. Clarke M. Clemencic H. V. Clif J. Closier J. L. Cobbledick V. Coco J. A. B. Coelho J. Cogan E. Cogneras L. Nikhef National Institute for Subatomic Physics Physik-Institut Universit?t Zürich Oliver Lodge Laboratory University of Liverpool Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela H.H. Wills Physics Laboratory University of Bristol Université Clermont Auvergne University of Michigan Ann Arbor United States INFN Sezione di Milano University of Cincinnati Fakult?t Physik Technische Universit?t Dortmund European Organization for Nuclear research (CErN) School of Physics and Astronomy University of Glasgow ICCUB Universitat de Barcelona Department of Physics and Astronomy University of Manchester Petersburg Nuclear Physics Institute NrC Kurchatov Institute (PNPI NrC KI) Cavendish Laboratory University of Cambridge Universidade Federal do rio de Janeiro (UFrJ) Université Paris-Saclay INFN Sezione di Firenze INFN Sezione di Ferrara Physikalisches Institut ruprecht-Karls-Universit?t Heidelberg Institute for High Energy Physics NrC Kurchatov Institute (IHEP NrC KI) Syracuse University Yandex School of Data Analysis Aix Marseille Univ Laboratoire Leprince-ringuet CNrS/IN2P3 Ecole Polytechnique Institut Polytechnique de Paris Institute of Physics Ecole Polytechnique Fédérale de Lausanne (EPFL) Department of Physics University of Warwick Centro Brasileiro de Pesquisas Físicas (CBPF) Imperial College London INFN Sezione di Genova National University of Science and Technology “MISIS” I. Physikalisches Institut rWTH Aachen University INFN Sezione di Pisa INFN Sezione di Cagliari Institute of Nuclear Physics Moscow State University (SINP MSU) Institute of Theoretical and Experimental Physics NrC Kurchatov Institute (ITEP NrC KI) INFN Laboratori Nazionali di Frascati LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité Universita degli Studi di Padova Universita e INFN Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences School of Physics and Technology Wuhan University University of Birmingham Università di Modena e reggio Emilia Department of Physics U

A search for the doubly charmed baryon ?cc+with the decay mode ?cc+→Ξc+K-π+is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb-1. No significant signal is observed within the invariant mass range of 3.6 to 4.0 GeV/c2. Upper limits are set on the ratio r of the production cross-section times the total branching fraction of the ?cc+→Ξc+K-π+decay with respect to the Ξcc++→Λc+K-π+π+decay. Upper limits at 95% credibility level for r in the range 0.005 to 0.11 are obtained for diferent hypotheses on the ?cc+mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c.

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