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Schizophrenia with and without obsessive-compulsive symptoms:a comparative analysis of performance on trail making test and disability on WHOD AS

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General Psychiatry 2020年第6期33卷 406-412页

作者： Apala Singh Ram Pratap Beniwal Triptish Bhatia smita neelkanth deshpande Department of Psychiatry Govind Ballabh Pant Institute of Postgraduate Medical Education and Research(G.I.P.M.E.R.)New DelhiDelhiIndia Department of Psychiatry&Drug De-addiction Centre of Excellence in Mental HealthAtal Bihari Vajpayee Institute of Medical Sciences(ABVIMS)&Dr Ram Manohar Lohia HospitalNew DelhiDelhiIndia

Background Presence of obsessive-compulsive symptoms(0CS)affects performance on tests of some cognitive functions,such as the trail making test(TMT),and may affect the level of disability in schizophrenia(SZ).Aim s The aim of the present study was to compare performance on TMT and disability on WHO Disability Assessment Schedule(WHODAS)in persons with SZ with and without 0CS in a cross-sectional *** Persons with SZ(n=200)fulfilling DSM-V(Diagnostic and Statistical Manual)diagnostic criteria were assessed on Yale Brown Obsessive Compulsive Scale(YB0CS)and divided into two groups based on presence or absence of *** and WHODAS V.2.0 were *** two groups as a whole,as well as a subsample matched on age,gender and age of onset were *** Out of 200 persons with SZ,37(18.5%)reported *** OCS group took a significantly longer mean time to complete TMT-A(Z=-3.02,p=0.003)as well as TMT-B(Z=-3.551,p<0.001).Significant correlations were found between TMT-A and total YB0CS Scores(r=0.351,p=0.033),as well as TMT-A and YB0CS compulsion scores(r=0.404,p=0.013)but not with TMT-B *** OCS group reported greater disability in all domains separately as well as on average WHODAS Scores(Z=-5.969,p<0.001).Significant correlations were found between YB0CS obsession scores and YBOCS total scores with average WHODAS Scores(r=0.614,p<0.001 and r=0.406,p=0.013,respectively).We obtained essentially similar results with the matched subsample as well as with the entire *** Persons with SZ and comorbid OCS had significantly poorer performance on TMTs and greater disability in comparison to persons with SZ *** of disability correlated with severity of OCS.

关键词： trail performance matched

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Prevalence of excessive internet use and its correlation with associated psychopathology in 11th and 12th grade students

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General Psychiatry 2019年第2期32卷 84-91页

作者： Nitin Kumar Arvind Kumar Subodh Kumar Mahto Manish Kandpal smita neelkanth deshpande Parul Tanwar Department of Psychiatry Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research New Delhi India Department of Medicine Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research New Delhi India Vardhman Mahavir Medical College and Safdarjung Hospital New Delhi India

Background Globally, the number of internet users has crossed the three-billion mark, while in India users grew over 17% in the first 6 months of 2015 to 354 million. This study presented a background on internet use and the existence of excessive internet use. Aim To study the extent of internet use in 11th and 12th grade students and the psychopathology, if any, associated with excessive internet use. Methods 426 students who met the inclusion criteria were recruited from 11 th and 12th grade classes from Kendriya Vidyalaya, New Delhi, India, and were assessed by Young's Internet Addiction Test and the Strength and Difficulties Questionnaire. Results Among the 426 students, the mean internet addiction total score was 36.63 (20.78), which indicated mild level of internet addiction. 1.41%(six students) was diagnosed as excessive internet users, while 30.28% and 23.94% were classified as moderate and mild internet users, respectively. The prevalence of internet addiction between gender was 58.22% in males and 41.78% in females. While both positive (prosocial) and negative (hyperactivity, emotional, conduct and peer problem) impacts of internet use were reported by students, in the current study excessive use of internet had a negative impact on students' lives as compared with positive impact, which was statistically significant (p<0.0001). Conclusion Excessive internet use led to abnormal behaviours which cause negative consequences to users. Early diagnosis of risk factors related to excessive internet use, provides education about responsible use and supervision of students by family members.

关键词： internet psychopathology inclusion criteria

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Neuropsychiatric genetics in developing countries: Current challenges

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World Journal of Psychiatry 2014年第4期4卷 69-71页

作者： Diego A Forero Alberto Vélez-van-Meerbeke smita N deshpande Humberto Nicolini George Perry Laboratory of Neuro Psychiatric Genetics Biomedical Sciences Research Group School of Medicine Universidad Antonio Narino Bogotá 110231 Colombia Neuroscience Research Group (Ne URos) School of Medicine and Health Sciences Universidad del Rosario Bogotá 110231 Colombia Department of Psychiatry De-addiction Services and Resource Center for Tobacco Control PGIMER-Dr. Ram Manohar Lohia Hospital New Delhi 110001 India Laboratory of Psychiatric and Neurodegenerative Diseases Instituto Nacional de Medicina Genómica 14610 Ciudad de México México College of Sciences University of Texas at San Antonio San Antonio TX 78229 United States

Neuropsychiatric disorders(NPDs) constitute a heavyburden on public health systems around the world and studies have demonstrated that the negative impact of NPDs is larger in Low and Middle Income Countries(LMICs). In recent decades, several studies have come to the understanding that genetic factors play a major role in the risk for a large number of NPDs. However, few neuropsychiatric genetics studies have been published from LMICs. In this Editorial, we discuss important issues impinging on advances in neuropsychiatric genetics research in LMICs. It is essential that scientists educate policymakers and officials of funding agencies on the importance of providing adequate funding for research in these areas. Development of local well-supported research programs focused on NPD genetics should be an important asset to develop; it would facilitate the establishment of sustainable research efforts that could lead to appropriate diagnosis and specific, affordable and feasible interventions in LMICs. It is important to point out that research into the biological basis of human NPDs is not only an academic effort reserved for a few elite institutions in economically developed countries, but it is vitally important for the mental health of people around the world.

关键词： Neurogenetics Psychiatric genetics Mental health Neurosciences Public health

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